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Transient hyperphosphatasemia:Possible association with pediatric acute respiratory infection 被引量:1
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作者 Yoshihiko Sakurai Takafumi Higashiguchi 《Pediatric Investigation》 CSCD 2021年第2期94-98,共5页
Importance Acute respiratory infections are quite prevalent in children.Transient hyperphosphatasemia(TH)is defined as the transient elevation of serum alkaline phosphatase(ALP)level,which occurs mainly in infants and... Importance Acute respiratory infections are quite prevalent in children.Transient hyperphosphatasemia(TH)is defined as the transient elevation of serum alkaline phosphatase(ALP)level,which occurs mainly in infants and children without liver or bone disorders.Although no apparent cause has been identified,a possible association of respiratory infections with TH has been reported in the literature.Objective In this study,we aimed to investigate the association between TH and respiratory infectious diseases.Methods We collected the results of biochemical investigations,including ALP level,for a period of 5 years in our hospital.We then examined the patients with transiently elevated ALP levels of>2000 U/L.Results During the observation period,1501 blood samples were collected from 1097 patients.Marked elevation of serum ALP level was observed in 12 patients.All patients with hyperphosphatasemia,except for one with Fanconi syndrome attributable to the underlying Wilson’s disease,were aged<5 years and were diagnosed with TH.Ten of these 11 patients with TH had acute respiratory infections.Marked ALP elevation was not found in any patients with non-inflammatory diseases.ALP isoenzyme profiles showed a characteristic pattern in all six patients in whom the ALP isoenzyme test was conducted.Interpretation Our results suggest an association between respiratory infections and TH.The consideration of TH in patients with acute respiratory infections may lead to earlier and accurate diagnosis of this condition,thereby avoiding unnecessary medical interventions. 展开更多
关键词 Alkaline phosphatase Respiratory infection Transient hyperphosphatasemia ISOENZYME
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婴幼儿暂时性高磷酸酶血症的研究进展 被引量:2
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作者 孙雨 胡青华 缪东幸 《医学综述》 2011年第19期2971-2973,共3页
婴幼儿暂时性高磷酸酶血症(THI)通常在健康或患轻微疾病的儿童中偶然被发现。THI患儿的显著特征是其血清碱性磷酸酶(ALP)活性异常升高,且ALP活性一般在数月内可自行恢复至正常水平。THI并不威胁患者的生命,是一种良性现象,其预后良好。... 婴幼儿暂时性高磷酸酶血症(THI)通常在健康或患轻微疾病的儿童中偶然被发现。THI患儿的显著特征是其血清碱性磷酸酶(ALP)活性异常升高,且ALP活性一般在数月内可自行恢复至正常水平。THI并不威胁患者的生命,是一种良性现象,其预后良好。现对THI的病因、发病机制以及诊疗等方面的研究进展进行综述,旨在加深对THI的认识,从而避免对其误诊误治。 展开更多
关键词 高磷酸酶血症 暂时性 婴幼儿
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