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The total flavonoids extracted from Xiaobuxin Tang reverse the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats
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作者 AN Lei1,ZHANG You-zhi2(1.Department of Pharmacology,Dalian Medical University,Dalian 116044,China 2.Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China) 《沈阳药科大学学报》 CAS CSCD 北大核心 2008年第S1期104-104,共1页
Objective To investigate the effect of XBXT-2 on the activity of hypothalamic-pituitary-adrenal(HPA)axis in chronic mild stress(CMS)model of rats.Methods Using ELISA to test the serum corticosterone,adrenocorticotropi... Objective To investigate the effect of XBXT-2 on the activity of hypothalamic-pituitary-adrenal(HPA)axis in chronic mild stress(CMS)model of rats.Methods Using ELISA to test the serum corticosterone,adrenocorticotropic hormone(ACTH)and corticotropin-releasing hormone(CRH)level in CMS rats;Using western blot to determine hippocampal glucocorticoids receptors(GR)expression in CMS rats.Results Co-administration of XBXT-2(25,50 mg·kg-1,p.o.,28 days,the effective doses for behavioral responses)significantly decreased the serum corticosterone and ACTH level in CMS rats,while the CRH level was not markedly affected by chronic stress or drugs.Moreover,XBXT-2 significantly increased the GR expression in the hippocampus of CMS rats.The same effects were observed in the positive control drug imipramine(10 mg·kg-1,p.o.).Conclusions The decrease of serum corticosterone and ACTH level,as well as the increase of hippocampal GR expression may be the mechanisms underlying the antidepressant action of XBXT-2,which may associate with HPA axis. 展开更多
关键词 Xiaobuxin-Tang hypothalamic-pituitary-adrenal axis GLUCOCORTICOID receptors stress
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Individual Differences in Stress Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis and Its Vasopressinergic Regulation in Old Monkeys
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作者 Nadezhda D. Goncharova Victor Yu. Marenin Tamara E. Oganyan 《Journal of Behavioral and Brain Science》 2015年第7期280-294,共15页
Stress adaptation is fundamental for health, and the hypothalamic-pituitary-adrenal axis (HPA) is one of its main mechanisms. Considerable data indicate that arginine vasopressin (AVP) related disturbances of stress a... Stress adaptation is fundamental for health, and the hypothalamic-pituitary-adrenal axis (HPA) is one of its main mechanisms. Considerable data indicate that arginine vasopressin (AVP) related disturbances of stress adaptation can occur with aging. However, most studies of such kind have been performed on rodents, give contradictory results and fail to consider individual characteristics of the animals. The purpose of this study was to investigate individual HPA responsiveness to acute stress and its vasopressinergic regulation in old female rhesus monkeys that differ in their behavioral responses to stress. Animals with depression-like or anxiety-like behavior (DAB) responded with higher plasma levels of ACTH and AVP, lower levels of corticosteroids and higher cortisol/DHEAS molar ratios to restraint stress and to insulin-induced hypoglycemia compared with animals with healthy adaptive behavior. AVP and ACTH dynamics were closely correlated in most animals. AVP treatment produced differences in HPA responses similar to those produced by the stressors. The ACTH response to hypoglycemic stress in the DAB animal with highest HPA responsiveness was dramatically reduced by prior administration of a V1b receptor antagonist. These results suggest that the dysfunctions of HPA observed in old animals with DAB are caused by increased tone of the vasopressinergic system in regulation of HPA stress reactivity. 展开更多
关键词 hypothalamic-pituitary-adrenal axis STRESS RESPONSIVENESS Vasopressinergic REGULATION Different Types of Adaptive Behavior Aging
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Electroacupuncture (EA) Speeds Up the Regulation of Hypothalamic Pituitary Adrenal Axis Dysfunction in Acute Surgical Trauma Rats: Mediated by Hypothalamic Gamma-Aminobutyric Acid (GABA)<sub>A</sub>Receptors 被引量:1
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作者 Liting Zhu Jing Zhu +5 位作者 Zhejun Chen Zehui Meng Mingda Ju Mizhen Zhang Gencheng Wu Zhanzhuang Tian 《Journal of Behavioral and Brain Science》 2018年第12期697-710,共14页
Hypothalamic Corticotropin-releasing factor (CRF) directly activates the hypothalamic pituitary adrenal axis (HPA axis) during the surgical trauma induced stress response. Electroacupuncture (EA) has been demonstrated... Hypothalamic Corticotropin-releasing factor (CRF) directly activates the hypothalamic pituitary adrenal axis (HPA axis) during the surgical trauma induced stress response. Electroacupuncture (EA) has been demonstrated to have stress relieving effects in breast surgery, colorectal surgery, prostatectomy and craniotomy. This study was aimed to investigate the hypothesis that EA could regulate hypothalamic CRF in surgical trauma rats. In experiment one, Sprague-Dawley (SD) male rats were divided into intact, model (10% partial hepatectomy), sham EA and EA group. Rats from the Sham EA and EA group were stimulated at ST36-Zusanli and SP6-Sanyiniiao acupoints twice, 24 hours before the surgery and immediately after the surgery. Expressions of hypothalamic CRF and CRFR, GABA receptors, glutamate decarboxylase (GAD), serum adrenocorticotropic hormone (ACTH) and Corticosterone (CORT) were observed at 2, 4, 8 and 24 h after the surgery by radioimmunoassay (RIA), western blot, real-time PCR and immunohistochemistry. In the experiment two, SD male rats were divided into the intact, model, model + vehicle, model + L-838,417 EA and EA + L838,417 group. It was found that hypothalamus CRF, serum ACTH and CORT levels were increased in model group compared with the intact group, and those in the EA group decreased in comparison with the model group. Compared with the model group, hypothalamus-aminobutyric acid (GABA) receptor Aα3 mRNA and protein expressions of the EA group raised strikingly. In conclusion, EA alleviated surgical stress response by improving the GABA synthesis in hypothalamus, thus enhancing GABA receptors’ inhibitory regulation of the HPA axis dysfunction in rats with acute surgical trauma. 展开更多
关键词 ELECTROACUPUNCTURE hypothalamic Pituitary Adrenal axis γ-Aminobutyric Acid (GABA) Receptor CORTICOTROPIN Releasing Factor Surgery
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Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary-testicular axis secretion in aging rats 被引量:3
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作者 Siyun Niu Suru Kou +1 位作者 Xiaochun Zhou Liang Ding 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第21期1611-1617,共7页
An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treate... An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Epimedii, Radix Salviae Miltiorrhiae, and Poria). Heshouwu pill treated rats were the positive control group. Radioimmunoassay, immunohistochemical staining, and western blot assay showed hypothalamic gonadotropin-releasing hormone, hypothalamic substance P, and serum gonadotropin levels to be significantly increased in the model rats; the concentrations of hypothalamic ~3-endorphin, and serum levels of insulin-like growth factor I and testosterone were significantly decreased. 1713- and 3[3-hydroxysteroid dehydrogenase expression in testicular tissue was also decreased. Intragastric administration of Heshouwu decoction at high (9.6 g/mL/100 g), medium (4.8 g/mL/100 g), and low (2.4 g/mlJ100 g) doses, Heshouwu decoction pretreatment at a medium dose (4.8 g/mL/100 g), and Heshouwu pill (2.06 g/mL/100 g) significantly reversed these changes. Heshouwu decoction pretreatment and high-dose Heshouwu decoction had the greatest anti-aging effects. These experimental findings indicate that Heshouwu decoction can improve hypothalamic-pituitary-testicular axis secretion in a subacute aging rat model, and prevent and delay gonadal axis aging, with an effect superior to that of Heshouwu pill. 展开更多
关键词 Heshouwu decoction pituitary gonadal axis aging gonadotropin-releasing hormone gonadotropin hydroxysteroid dehydrogenase hypothalamic-pituitary-testicular axis neural regeneration
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Reversing the negative effects of co-inhaled manganese and iron on dopamine levels and prolactin production in the rat hypothalamus-pituitary axis
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作者 Chae Kwan Lee 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第7期525-530,共6页
BACKGROUND: Manganese (Mn) and iron (Fe) are the primary elements of welding rods. Mn has been shown to increase prolactin (PRL) production by decreasing dopamine (DA) levels in the hypothalamus. However, Fe ... BACKGROUND: Manganese (Mn) and iron (Fe) are the primary elements of welding rods. Mn has been shown to increase prolactin (PRL) production by decreasing dopamine (DA) levels in the hypothalamus. However, Fe increases DA levels and decreases PRL levels. The toxic mechanism of Mn and Fe co-inhalation-induced regulation of the hypothalamic-hypophyseal-pituitary axis remains unclear. OBJECTIVE: To evaluate the effects of co-inhaled Mn and Fe on hypothalamic DA levels and pituitary PRL production, to investigate whether these changes are reversible, and to determine the role of co-inhaled Mn and Fe. DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment based on inhalation toxicity via whole-body exposure was performed. Hypothalamic DA levels, serum PRL, and PRL and PiN mRNA levels were analyzed at the Institute of Environmental and Occupational Medicine, Inje University, Busan, Korea, from August 2007 to May 2009. MATERIALS: MnSO4 and FeSO4 were purchased from Sigma-Aldrich, St. Louis, MO, USA. High-performance liquid chromatography (HPLC) using an electrochemical detector (ECD) was purchased from Waters Corporation, Milford, MA, USA. mRNA Capture Kit and reverse transcription-polymerase chain reaction (RT-PCR) kit were obtained from Roche Molecular Biochemicals, Mannheim, Germany and Perkin-Elmer, Wellesley, MA, USA, respectively. Rat PRL enzyme-linked immunosorbent assay kit was purchased from Biocode Hycel, Liege, Belgium. METHODS: Eighty 15-week-old, male, Fischer 344 rats were assigned to two groups: one group treated with Mn and Fe and a control group. Each group was sub-divided into four groups on the basis of treatment period (0- and 13-week treated groups with both chemicals) and recovery periods (4- and 13-week recovery groups following 13-week exposure to both chemicals). The treatment condition was 6 hours per day, 5 days per week, for the entire body. Mn and Fe co-inhalation concentrations were 1.5 mg/m3 and 3.0 mg/m3, respectively. MAIN OUTCOME MEASURES: Hypothalamic DA levels were measured using HPLC-ECD analysis mRNA levels of PRL and Pit-1 were analyzed by Northern blot hybridization and RT-PCR, respectively. Serum PRL levels were measured by enzyme-linked immunosorbent assay. RESULTS: HPLC-ECD analysis revealed that following 13-week co-inhalation of Mn and Fe, hypothalamic DA levels significantly deceased, whereas pituitary PRL mRNA, Pit-1 mRNA, and serum PRL levels significantly increased. At 4 weeks of recovery, DA level in the hypothalamic tissue was significantly increased, and PRL and Pit-1 mRNA levels in the pituitary were significantly decreased. After 13 weeks of recovery, DA and PRL levels recovered to normal. The changing pattern of serum PRL levels was in accordance with pituitary PRL mRNA levels. CONCLUSION: Subchronic co-inhalation of Mn and Fe significantly decreased hypothalamic DA levels, but induced pituitary PRL production, both of which were mediated by Pit-1. These results suggested that Mn dominates over Fe in terms of hypothalamic DA levels and pituitary PRL production, and these effects are reversible in a subchronic inhalation condition. Therefore, changes in hypothalamic DA levels and serum PRL production could be used as biomarkers for welders, who are exposed to Mn and Fe. 展开更多
关键词 DOPAMINE hypothalamic-hypophyseal-pituitary axis IRON MANGANESE Pit-1 PROLACTIN
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Childhood stressful events, HPA axis and anxiety disorders 被引量:5
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作者 Carlo Faravelli Carolina Lo Sauro +7 位作者 Lucia Godini Lorenzo Lelli Laura Benni Francesco Pietrini Lisa Lazzeretti Gabriela Alina Talamba Giulia Fioravanti Valdo Ricca 《World Journal of Psychiatry》 SCIE 2012年第1期13-25,共13页
Anxiety disorders are among the most common of all mental disorders and their pathogenesis is a major topic in psychiatry, both for prevention and treatment. Early stressful life events and alterations of hypothalamic... Anxiety disorders are among the most common of all mental disorders and their pathogenesis is a major topic in psychiatry, both for prevention and treatment. Early stressful life events and alterations of hypothalamic pituitary adrenal(HPA) axis function seem to have a significant role in the onset of anxiety. Existing data appear to support the mediating effect of the HPA axis between childhood traumata and posttraumatic stress disorder. Findings on the HPA axis activity at baseline and after stimuli in panic disordered patients are inconclusive, even if stressful life events may have a triggering function in the development of this disorder. Data on the relationship between stress, HPA axis functioning and obsessive-compulsive disorder(OCD) are scarce and discordant, but an increased activity of the HPA axis is reported in OCD patients. Moreover, normal basal cortisol levels and hyperresponsiveness of the adrenal cortex during a psychosocial stressor are observed in social phobics. Finally,abnormal HPA axis activity has also been observed in generalized anxiety disordered patients. While several hypothesis have attempted to explain these findings over time, currently the most widely accepted theory is that early stressful life events may provoke alterations of the stress response and thus of the HPA axis, that can endure during adulthood, predisposing individuals to develop psychopathology. All theories are reviewed and the authors conclude that childhood life events and HPA abnormalities may be specifically and transnosographically related to all anxiety disorders, as well as, more broadly, to all psychiatric disorders. 展开更多
关键词 Anxiety disorders Early stressful life events CHILDHOOD traumata CORTISOL hypothalamic PITUITARY ADRENAL axis Vulnerability PSYCHOPATHOLOGY
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Endocrine disruptors and estrogenic effects on male reproductive axis 被引量:12
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作者 Suresh C. Sikka Run Wang 《Asian Journal of Andrology》 SCIE CAS CSCD 2008年第1期134-145,共12页
Endocrine disruptors (e.g., polychlorinated biphenyls [PCBs], dichlorodiphenyl-trichloroethane [DDT], dioxin, and some pesticides) are estrogen-like and anti-androgenic chemicals in the environment. They mimic natur... Endocrine disruptors (e.g., polychlorinated biphenyls [PCBs], dichlorodiphenyl-trichloroethane [DDT], dioxin, and some pesticides) are estrogen-like and anti-androgenic chemicals in the environment. They mimic natural hormones, inhibit the action of hormones, or alter the normal regulatory function of the endocrine system and have potential hazardous effects on male reproductive axis causing infertility. Although testicular and prostate cancers, abnormal sexual development, undescended testis, chronic inflammation, Sertoli-cell-only pattern, hypospadias, altered pituitary and thyroid gland functions are also observed, the available data are insufficient to deduce worldwide conclusions. The development of intra-cytoplasmic sperm injection (ICSI) is beyond doubt the most important recent breakthrough in the treatment of male infertility, but it does not necessarily treat the cause and may inadvertently pass on adverse genetic consequences. Many well-controlled clinical studies and basic scientific discoveries in the physiology, biochemistry, and molecular and cellular biology of the male reproductive system have helped in the identification of greater numbers of men with male factor problems. Newer tools for the detection of Y-chromosome deletions have further strengthened the hypothesis that the decline in male reproductive health and fertility may be related to the presence of certain toxic chemicals in the environment. Thus the etiology, diagnosis, and treatment of male factor infertility remain a real challenge. Clinicians should always attempt to identify the etiology of a possible testicular toxicity, assess the degree of risk to the patient being evaluated for infertility, and initiate a plan to control and prevent exposure to others once an association between occupation/toxicant and infertility has been established. 展开更多
关键词 endocrine disruptors environmental estogens hypothalamic-pituitary-testicular axis oxidative stress male infertility
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Essence of"Shen(Kidney)Controlling Bones":Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis 被引量:17
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作者 XU Tao-tao JIN Hong-ting TONG Pei-jian 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2018年第11期806-808,共3页
As a traditional concept of Chinese medicine(CM), the theory of "Shen(Kidney) controlling bones" has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development ... As a traditional concept of Chinese medicine(CM), the theory of "Shen(Kidney) controlling bones" has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body, specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal(HPA) axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore, we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis: cells that comprise bone tissue(osteo-related cells) are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis. 展开更多
关键词 Chinese medicine Shen (Kidney) controlling bones hypothalamic-pituitary-adrenal axis bone homeostasis osteoporosis
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Expression of hippocampal corticosteroid receptors,as well as corticotrophin-releasing hormone and vasopressin in the hypothalamic paraventricular nucleus,in fornix transected rats 被引量:4
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作者 Fang Han Hong Liu Yanhui Zhang Yuxiu Shi 《Neural Regeneration Research》 SCIE CAS CSCD 2009年第5期325-332,共8页
BACKGROUND: The hippocampus regulates the hypothalamic-pituitary-adrenal axis through negative feedback. The hypothalamic paraventricular nucleus receives neuronal input from the hippocampus via the fomix, OBJECTIVE... BACKGROUND: The hippocampus regulates the hypothalamic-pituitary-adrenal axis through negative feedback. The hypothalamic paraventricular nucleus receives neuronal input from the hippocampus via the fomix, OBJECTIVE: To explore whether the negative feedback effect of the hippocampus on the hypothalamic-pituitary-adrenal axis is contributed to the inhibitory effect of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the hippocampus on the paraventricular nucleus via the fornix. DESIGN, TIME AND SETTING: Randomized, controlled, animal experiment. The study was performed at the Department of Histology and Embryology, China Medical University between September 2006 and September 2008. MATERIALS: Rabbit anti-rat anti-MR and rabbit anti-rat anti-GR antibodies were purchased from Santa Cruz Biotechnology, USA. Rabbit anti-rat anti-corticotrophin releasing hormone (CRH) and rabbit anti-rat anti-arginine vasopressin antibodies were purchased from Wuhan Boster. METHODS: A total of 90 male, Wistar rats were randomly divided into model and sham-surgery groups (n = 45). Fornix transection was performed in the model group, while the sham-surgery group underwent surgery, but no fornix transection. MAIN OUTCOME MEASURES: Immunohistochemistry was used to examine MR and GR expression in the hippocampus, as well as CRH and anti-arginine vasopressin in the paraventricular nucleus. Western blot was used to measure alterations in MR, GR, and CRH protein expression following fomix transection. RESULTS: Compared with the sham-surgery group, there were no obvious changes in MR and GR expression in the hippocampus, or CRH and anti-arginine vasopressin expression in the paraventdcular nucleus within 4 days of fornix transection. However, after 7-10 days, significantly decreased MR and GR expression in the hippocampus, and increased CRH and anti-arginine vasopmssin expression in the paraventricular nucleus were observed (P 〈 0.05-0.01). CONCLUSION: Negative feedback from the hippocampus on the hypothalamic-pituitary-adrenal axis might be mediated through the fornix, and the corticosterene actions mediated by hippocampal corticosteroid receptors indirectly modulated the hypothalamic-pituitary-adrenal axis. 展开更多
关键词 fomix transection hippocampus mineralocorticoid receptor glucocorticoid receptor corticotrephin-releasing hormone arginine vasopressin hypothalamic-pituitary-adrenal axis
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Changes of HPA axis function in rats with attention deficit hyperactivity disorder 被引量:1
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作者 Tang Yan Xiao-Yu Jing +1 位作者 Yu-Ping Wang Yin Xu 《Journal of Hainan Medical University》 2019年第11期14-17,共4页
Objective:To observe the Levels of serum CORT, ACTH and CRH in SHR rats, the expression of GR, MR and CRH mRNA in hypothalamus and GR, MR mRNA in hippocampus of the ADHD model animal SHR rat, and to explore the HPA ax... Objective:To observe the Levels of serum CORT, ACTH and CRH in SHR rats, the expression of GR, MR and CRH mRNA in hypothalamus and GR, MR mRNA in hippocampus of the ADHD model animal SHR rat, and to explore the HPA axis function and related factors in SHR rats.Methods: Junior SHR rats were used as ADHD model group and WKY rats as control group. The levels of CORT, ACTH and CRH in serum were detected by ELISA, and the mRNA expressions of GR, MR, CRH in hypothalamus and GR, MR in hippocampus were detected by RT-PCR.Results:The levels of serum CORT and ACTH in SHR rats were significantly lower than those in WKY rats (P < 0.01), and the levels of serum CRH were significantly higher than those in WKY rats (P < 0.01). GR and MR mRNA expression levels in hypothalamus and hippocampus were significantly higher than those in WKY rats (P < 0.01), while CRH mRNA expression in hypothalamus was significantly lower than that in WKY rats (P < 0.01).Conclusion:The HPA axis of SHR rats showed hyporesponsiveness, which may be related to CRH priming disorder and high expression of GR and MR mRNA in hypothalamus and hippocampus. 展开更多
关键词 Attention DEFICIT HYPERACTIVITY DISORDER Spontaneous HYPERTENSIVE rat hypothalamic PITUITARY gonadal axis
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Clinical Significance of Multiple Hypothalamic-Pituitary Functions Assessment in Patients with Turner's Syndrome
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作者 宁聪 魏虹 +5 位作者 舒丹 胡晓峰 陶德定 林汉华 王珊 王慕逖 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1994年第4期220-223,共4页
Hypothalamic-pituitary functions in 26 cases of Turner syndrome were assessed with a combined stimulation test.The results showed that the peak GH levels of 12 cases were less than 10 μg/L; 3 patients were demonstrat... Hypothalamic-pituitary functions in 26 cases of Turner syndrome were assessed with a combined stimulation test.The results showed that the peak GH levels of 12 cases were less than 10 μg/L; 3 patients were demonstrated as having an even TSH response, while another one with a delayed TSH peak, and other 4 had high basal values and consistent exaggerated TSH responses to TRH; all patients showed increased basal and peak LH and FSH levels but 5, whose LH and FSH secretion patterns were similar to normal. 12 cases have been treated with individualized protocols and followed up for 12 months or more, of them the growth velocity all increased, especially those with hypothyroidism or with a BA less than 13. It is suggested that multiple functions of hypothalamic-pituitary axis in Turner patients be evaluated as early as possible, in order that proper treatment could be adopted and their growth and development improved. 展开更多
关键词 Turner's syndrome hypothalamic-pituitary axis HYPOTHYROIDISM
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青少年非自杀性自伤患者自杀未遂与HPT轴和HPA轴功能改变的研究
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作者 王丹 王雪 +3 位作者 吴涵 金文青 王雯 任艳萍 《首都医科大学学报》 CAS 北大核心 2024年第1期68-74,共7页
目的探讨伴非自杀性自伤(non-suicidal self-injury,NSSI)行为的青少年心境障碍患者发生自杀未遂(suicide attempt,SA)与下丘脑-垂体-甲状腺(hypothalamic-pituitary-thyroid,HPT)轴功能和下丘脑-垂体-肾上腺(hypothalamic-pituitary-ad... 目的探讨伴非自杀性自伤(non-suicidal self-injury,NSSI)行为的青少年心境障碍患者发生自杀未遂(suicide attempt,SA)与下丘脑-垂体-甲状腺(hypothalamic-pituitary-thyroid,HPT)轴功能和下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴功能改变的相关性。方法选取2020年12月至2022年5月在首都医科大学附属北京安定医院住院的近1年有NSSI史的13~19岁青少年心境障碍患者进行横断面调查,根据近一年是否存在SA将患者分为非SA组和SA组。根据SA发生的时间段(1个月)将SA组患者分为近期SA和既往SA。收集患者临床特征、甲状腺功能[游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)、总三碘甲状腺原氨酸(total triiodothyronine,TT3)、总甲状腺素(total thyroxine,TT4)、促甲状腺激素(thyroid stimulating hormone,TSH)]及促肾上腺皮质激素(adrenocorticotropin,ACTH)、皮质醇(cortisol,CORT)水平。采用多因素Logistic回归分析SA的影响因素。结果共入组79例伴NSSI青少年心境障碍患者,其中49例(62.03%)发生SA,其中29例(59.18%)患者为近1个月内发生SA。单因素分析显示,SA组和非SA组患者在首次发病年龄、性别、教育水平方面差异有统计学意义(P<0.05)。近期SA组患者和既往SA组患者在年龄、TSH、ACTH水平存在差异(P<0.05)。Logistic回归分析显示,女性(P=0.027,OR=2.941,95%CI:1.131~7.649)是患者发生SA的独立危险因素,ACTH水平降低(P=0.043,OR=1.019,95%CI:1.001~1.037)是近期发生SA的相关因素。结论女性伴NSSI青少年心境障碍患者易发生SA,ACTH水平低是近期发生SA的危险因素。 展开更多
关键词 青少年 非自杀性自伤 自杀未遂 下丘脑-垂体-甲状腺轴 下丘脑-垂体-肾上腺轴
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柴胡疏肝散合半夏厚朴汤联合五行针灸对脑卒中后焦虑抑郁的神经调控作用及对免疫炎症反应、认知功能损害和HPG、HPT的影响
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作者 王珊珊 薛秀娟 +5 位作者 王文刚 相希 赵鑫 王亚静 陈爱霞 董文静 《中国医院用药评价与分析》 2024年第3期303-307,共5页
目的:观察柴胡疏肝散合半夏厚朴汤联合五行针灸对脑卒中后焦虑抑郁患者的神经调控作用及对免疫炎症反应、认知功能损害和下丘脑-垂体-性腺轴(HPG)、下丘脑-垂体-甲状腺轴(HPT)的影响。方法:选择2021年3月至2023年5月于该院治疗的脑卒中... 目的:观察柴胡疏肝散合半夏厚朴汤联合五行针灸对脑卒中后焦虑抑郁患者的神经调控作用及对免疫炎症反应、认知功能损害和下丘脑-垂体-性腺轴(HPG)、下丘脑-垂体-甲状腺轴(HPT)的影响。方法:选择2021年3月至2023年5月于该院治疗的脑卒中后焦虑抑郁患者102例,根据随机数字表法分组,其中五行针灸组51例(脱落2例,最终纳入49例),方剂联合组51例(脱落2例,最终纳入49例)。两组患者同时给予常规西医基础治疗,五行针灸组患者在常规西医基础治疗的基础上给予五行针灸治疗,方剂联合组患者在五行针灸组的基础上给予柴胡疏肝散合半夏厚朴汤治疗。观察两组患者的临床疗效,比较患者治疗前后的中医证候评分、简易精神状态量表(MMSE)评分、广泛性焦虑障碍量表(GAD-7)评分、汉密顿抑郁量表(HAMD)评分和简明幸福与生活质量满意度问卷(Q-LES-Q-SF)评分,检测患者治疗前后血清神经生长因子(NGF)、白细胞介素1β(IL-1β)、胶质纤维酸性蛋白(GFAP)、白细胞介素17a(IL-17a)、促甲状腺激素(TSH)、5-羟色胺(5-HT)和雌二醇(E2)水平。结果:方剂联合组患者的总有效率为97.96%(48/49),高于五行针灸组的81.63%(40/49),差异有统计学意义(P<0.05)。治疗后,方剂联合组患者精神焦虑抑郁、脘痞、胸胁作胀、善太息和嗳气频作等中医证候评分较五行针灸组降低,HAMD、GAD-7评分较五行针灸组降低,MMSE、Q-LES-Q-SF评分较五行针灸组升高,差异均有统计学意义(P<0.05)。治疗后,方剂联合组患者的IL-1β、IL-17a和GFAP水平较五行针灸组降低,NGF水平较五行针灸组升高,5-HT、E2和TSH水平较五行针灸组升高,差异均有统计学意义(P<0.05)。结论:柴胡疏肝散合半夏厚朴汤联合五行针灸治疗脑卒中后焦虑抑郁患者,可减少免疫炎症反应,减少神经及认知功能损害,调节HPG、HPT,改善焦虑及抑郁情绪,缓解病情,提高生活质量及临床疗效。 展开更多
关键词 柴胡疏肝散合半夏厚朴汤 五行针灸 脑卒中后焦虑抑郁 免疫炎症反应 下丘脑-垂体-性腺轴 下丘脑-垂体-甲状腺轴
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慢性应激导致卵巢早衰的中西医机制探讨
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作者 边心会 王佳捷 樊荣亮 《医学综述》 CAS 2024年第17期2116-2122,共7页
随着生物-心理-社会医学模式的不断深化,慢性应激已成为威胁机体身心健康的重要因素。卵巢早衰是妇科常见疑难内分泌疾病,发病率呈逐年增长趋势,且患病群体日益年轻化。慢性应激是导致卵巢早衰的重要原因之一。慢性应激可导致下丘脑-垂... 随着生物-心理-社会医学模式的不断深化,慢性应激已成为威胁机体身心健康的重要因素。卵巢早衰是妇科常见疑难内分泌疾病,发病率呈逐年增长趋势,且患病群体日益年轻化。慢性应激是导致卵巢早衰的重要原因之一。慢性应激可导致下丘脑-垂体-肾上腺轴功能持续亢进,引发机体神经内分泌代谢紊乱,抑制下丘脑-垂体-卵巢轴的正常功能,进而发展为卵巢早衰。中医情志致病理论与现代应激理论一致,中医的“肝”是机体调节心理应激反应的核心,“肾”是调节卵巢发挥正常功能的根本保障。肾虚肝郁是导致卵巢早衰的根本病因。因此,身心同治、调畅情志将成为临床治疗卵巢早衰的新趋势。 展开更多
关键词 卵巢早衰 慢性应激 下丘脑-垂体-肾上腺轴 下丘脑-垂体-卵巢轴 肾虚肝郁
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加味百合地黄汤对围绝经期抑郁症模型大鼠HPO轴和雌激素受体表达的影响
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作者 陈思源 蔡娜 +3 位作者 赵洪庆 欧阳舒雯 王宇红 尹抗抗 《湖南中医药大学学报》 CAS 2024年第3期343-349,共7页
目的基于下丘脑-垂体-卵巢(hypothalamic-pituitary-ovarian,HPO)轴及雌激素受体(estrogen receptor,ER)探明加味百合地黄汤治疗围绝经期抑郁症的功效及潜在机制。方法将大鼠随机分为正常对照组、模型组、阳性药物组(氟哌噻吨美利曲水溶... 目的基于下丘脑-垂体-卵巢(hypothalamic-pituitary-ovarian,HPO)轴及雌激素受体(estrogen receptor,ER)探明加味百合地黄汤治疗围绝经期抑郁症的功效及潜在机制。方法将大鼠随机分为正常对照组、模型组、阳性药物组(氟哌噻吨美利曲水溶液1.89 mg/kg)以及加味百合汤高、中、低剂量组(16.2 g/kg、8.1 g/kg、4.05 g/kg),每组10只。除正常对照组外,其他组均采用双侧卵巢摘除联合慢性不可预见性应激建立围绝经期抑郁症大鼠模型。各组给药21 d后采用糖水偏好实验和强迫游泳实验评价大鼠抑郁样行为,酶联免疫吸附法检测血清促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)、卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)含量,HE染色观察下丘脑、垂体、海马等组织病理损伤情况,RT-PCR和Western blot法检测下丘脑、海马组织雌激素受体基因及蛋白的表达。结果与正常对照组比较,模型组大鼠糖水偏好度显著下降(P<0.01),强迫游泳不动时间显著增加(P<0.01),表现出明显抑郁样行为,血清GnRH、FSH、LH含量均显著升高(P<0.01或P<0.05),E2降低(P<0.01),下丘脑、垂体及海马组织受损,雌激素受体表达显著降低(P<0.01);经加味百合地黄汤干预治疗后,模型组大鼠抑郁样行为显著改善(P<0.01或P<0.05),HPO轴亢进状态及海马损伤得以缓解,下丘脑、海马雌激素受体表达均显著增加(P<0.01或P<0.05)。与阳性药物组比较,加味百合地黄汤高剂量组下丘脑雌激素受体基因表达显著增加(P<0.05)。结论加味百合地黄汤通过抑制HPO轴亢进及增加脑内雌激素受体水平,发挥抗围绝经期抑郁症作用。 展开更多
关键词 加味百合地黄汤 围绝经期抑郁症 下丘脑-垂体-卵巢轴 雌激素受体 下丘脑 海马
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基于下丘脑-垂体-肾上腺轴探讨电针对功能性消化不良大鼠的作用机制
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作者 乐薇 姚函伶 +2 位作者 杨格格 吴贻森 徐派的 《世界科学技术-中医药现代化》 CSCD 北大核心 2024年第1期259-267,共9页
目的探讨电针印堂、内关、足三里对FD大鼠下丘脑-垂体-肾上腺轴的可能作用机制。方法40只SD大鼠随机分为空白组、模型组和电针组。采用夹尾、不规律饮食以及冰生理盐水灌胃法复制FD模型。造模后,电针组行针刺干预,每天1次,每次30 min,连... 目的探讨电针印堂、内关、足三里对FD大鼠下丘脑-垂体-肾上腺轴的可能作用机制。方法40只SD大鼠随机分为空白组、模型组和电针组。采用夹尾、不规律饮食以及冰生理盐水灌胃法复制FD模型。造模后,电针组行针刺干预,每天1次,每次30 min,连续14天。记录大鼠的一般状态;旷场实验检测大鼠的自主行为及紧张度;HE染色法观察大鼠胃黏膜形态及炎症反应;实时荧光定量PCR法检测大鼠下丘脑5-羟色胺3受体(5-HT3R)、促肾上腺皮质激素释放激素(CRH)的表达;蛋白免疫印迹法检测大鼠十二指肠促肾上腺皮质激素释放激素受体2(CRHR2)、NOD样受体蛋白6(NLRP6)蛋白表达;阿利新蓝染色观察大鼠十二指肠黏膜上皮形态及杯状细胞的阳性表达。结果与空白组相比,模型组大鼠一般状态、旷场自主运动距离、运动速度、十二指肠CRHR2、NLRP6蛋白均大幅下降(P<0.05),下丘脑5-HT3R、CRH mRNA明显升高(P<0.05)。与模型组相比,电针组大鼠一般状态、旷场自主运动距离、运动速度、十二指肠CRHR2、NLRP6蛋白及杯状细胞的表达均明显提高(P<0.05),下丘脑5-HT3R、CRH mRNA大幅下降(P<0.05)。模型组大鼠胃黏膜可见疏松的结缔组织,黏膜下层轻度水肿,淋巴细胞增生;空白组和电针组大鼠胃黏膜结缔组织排列紧密,胃腺间质无明显增生,未见炎症细胞。结论电针印堂、内关、足三里可能是通过提升十二指肠CRHR2、NLRP6蛋白和杯状细胞表达,抑制下丘脑5-HT3R、CRH的表达,来提高FD大鼠自主运动水平,缓解焦虑,修复缺损的肠道黏膜屏障,恢复下丘脑-垂体-肾上腺轴的正常功能。 展开更多
关键词 功能性胃肠病 电针 下丘脑-垂体-肾上腺轴 动物实验
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诱导抑郁症患者小胶质细胞炎性反应的机制 被引量:1
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作者 张昊 孙浩 廖红 《基础医学与临床》 CAS 2024年第7期1029-1033,共5页
小胶质细胞炎性反应是抑郁症患者及相关动物模型中广泛观察到的病理现象,与抑郁症密切相关。抑郁症中诱导小胶质细胞炎性反应的机制包括下丘脑-垂体-肾上腺(HPA)轴激活后糖皮质激素水平变化直接或间接的调控作用、肠道微生物代谢物通过... 小胶质细胞炎性反应是抑郁症患者及相关动物模型中广泛观察到的病理现象,与抑郁症密切相关。抑郁症中诱导小胶质细胞炎性反应的机制包括下丘脑-垂体-肾上腺(HPA)轴激活后糖皮质激素水平变化直接或间接的调控作用、肠道微生物代谢物通过脑肠轴中免疫与神经途径的作用以及损伤相关分子模式(DAMPs)对小胶质细胞的直接激活作用等。 展开更多
关键词 抑郁症 小胶质细胞炎性反应 下丘脑-垂体-肾上腺(HPA)轴 脑肠轴 损伤相关分子模式(DAMPs)
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基于“肾主生殖”理论探讨中医治疗DOR型不孕症的生物学机制 被引量:3
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作者 赵昱璇 梁启惠 +2 位作者 陈雯 韩昀芮 吴海萃 《湖南中医药大学学报》 CAS 2024年第2期320-326,共7页
在中医学“肾主生殖”的理论指导下,中医治疗不孕症多以补肾为主。卵巢储备功能下降(diminished ovarian reserve,DOR)是临床导致不孕症的主要病因,DOR型不孕症的发病率逐年增加且发病年龄呈年轻化趋势。中医补肾法在治疗DOR型不孕症方... 在中医学“肾主生殖”的理论指导下,中医治疗不孕症多以补肾为主。卵巢储备功能下降(diminished ovarian reserve,DOR)是临床导致不孕症的主要病因,DOR型不孕症的发病率逐年增加且发病年龄呈年轻化趋势。中医补肾法在治疗DOR型不孕症方面具有独特优势,其生物学机制主要是调节下丘脑-垂体-卵巢轴神经内分泌功能、抑制卵巢颗粒细胞异常程序性死亡、调节免疫功能、改善卵巢过度氧化应激状态、改善线粒体功能、调节子宫内膜容受性,从而改善卵巢功能,提高生育能力。对近年来中医补肾法治疗DOR型不孕症的生物学机制进行总结,为临床应用“肾主生殖”理论治疗DOR型不孕症提供新思路。 展开更多
关键词 肾主生殖 卵巢储备功能下降 不孕症 补肾法 下丘脑-垂体-卵巢轴 生物学机制
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非自杀性自伤的内分泌免疫研究进展
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作者 周洛慧 苏颖芮 +1 位作者 柳绪珍 孙静 《临床精神医学杂志》 CAS 2024年第1期78-80,共3页
非自杀性自伤(NSSI)多发生在青少年和成年早期,与情绪相关疾病发生率增高及发展至难治性等相关,是自杀的重要危险因素。NSSI人群其内分泌和免疫发生一些变化,探讨NSSI发生的内分泌免疫机制,可能有助于NSSI早期预防与干预。本文从下丘脑... 非自杀性自伤(NSSI)多发生在青少年和成年早期,与情绪相关疾病发生率增高及发展至难治性等相关,是自杀的重要危险因素。NSSI人群其内分泌和免疫发生一些变化,探讨NSSI发生的内分泌免疫机制,可能有助于NSSI早期预防与干预。本文从下丘脑-垂体-肾上腺轴(HPA轴)、下丘脑-垂体-甲状腺轴(HPT轴)、下丘脑-垂体-性腺轴(HPG轴)及免疫炎症与NSSI发生的相关研究进展作一综述。 展开更多
关键词 非自杀性自伤 青少年及成年早期 下丘脑-垂体-肾上腺轴 下丘脑-垂体-甲状腺轴 下丘脑-垂体-性腺轴 免疫炎症
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孤啡肽改善尼古丁戒断大鼠的焦虑样行为及其对HPA轴与炎症因子的调控机制
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作者 吴朋烊 赵容杰 +4 位作者 李露露 李秋月 张春晶 吴丽娜 赵正林 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第10期1926-1933,共8页
目的:探讨孤啡肽(nociceptin/orphanin FQ,N/OFQ)对尼古丁(nicotine,NIC)戒断大鼠焦虑样行为的改善作用及其对下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴神经递质与炎症因子表达的调控机制。方法:成年雄性Sprague-Dawle... 目的:探讨孤啡肽(nociceptin/orphanin FQ,N/OFQ)对尼古丁(nicotine,NIC)戒断大鼠焦虑样行为的改善作用及其对下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴神经递质与炎症因子表达的调控机制。方法:成年雄性Sprague-Dawley大鼠32只,随机分为正常对照组、NIC戒断模型组、N/OFQ低剂量治疗组和N/OFQ高剂量治疗组,每组各8只。模型组和N/OFQ治疗组大鼠每次皮下注射NIC(0.4 mg/kg),每天2次,连续7 d,然后戒断3 d制备大鼠尼古丁戒断焦虑模型。戒断期间N/OFQ低、高剂量治疗组大鼠每天一次侧脑室注射N/OFQ 1nmol和N/OFQ 10 nmol,连续3 d。第3次给药10 min后,利用旷场实验(open filed,OF)和高架十字迷宫实验(elevated plus maze,EPM)检测大鼠行为学变化;ELISA检测血清中促肾上腺皮质激素释放激素(corticotrophin-releasing hormone,CRH)、促肾上腺皮质激素(adrenocor ticotropic hormore,ACTH)和皮质酮(coritosterone,CORT)浓度以及血清中炎症因子肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素1β(interleukin-1β,IL-1β)和IL-6的浓度;用RT-qPCR检测大脑杏仁核中央核(centraln nucleus of amygdala,CeA)中TNF-α、IL-1β和IL-6的mRNA表达水平;HE染色光镜下观察海马组织CA1区神经元形态学变化;利用高效液相色谱检测大脑CeA的去甲肾上腺素(norepinephrine,NE)水平;利用Western blot检测大脑CeA的酪氨酸羟化酶(tyrosine hydroxylase,TH)蛋白表达。结果:与模型组比较,N/OFQ低、高剂量治疗组大鼠在OF中央区活动距离和活动时间显著升高(P<0.05或P<0.01),EPM的开放臂进入次数和停留时间百分率显著升高(P<0.05或P<0.01);同时,N/OFQ低、高剂量治疗组显著抑制NIC戒断大鼠血清中CRH、ACTH和CORT浓度(P<0.01);显著抑制血清中TNF-α、IL-1β和IL-6等炎症因子水平以及大脑CeA中TNF-α、IL-1β和IL-6 mRNA表达水平(P<0.05或P<0.01);N/OFQ低、高剂量治疗组显著减轻大鼠海马CA1区神经元损伤;并且显著降低NIC戒断大鼠大脑CeA中NE的水平和TH蛋白的表达(P<0.01)。结论:N/OFQ改善NIC戒断大鼠焦虑样行为,其机制通过HPA轴神经递质与炎症因子的调控所介导。 展开更多
关键词 孤啡肽 尼古丁戒断焦虑 下丘脑-垂体-肾上腺轴 炎症因子 去甲肾上腺素 酪氨酸羟化酶
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