内斯比特(KateNesbitt)在她的Theorizing A New Agenda for Architecture,An Anthology of Architectural Theory,1965～1995一书中较为全面地介绍了当代西方建筑理论界所关心的主要问题及其相关的思考。对于这些问题,国内建筑理论界也...内斯比特(KateNesbitt)在她的Theorizing A New Agenda for Architecture,An Anthology of Architectural Theory,1965～1995一书中较为全面地介绍了当代西方建筑理论界所关心的主要问题及其相关的思考。对于这些问题,国内建筑理论界也有自己的认识。该文通过对两者的比较,试图理清建筑理论的基本意义,那就是提出问题并引起思考。展开更多
背景:程序性细胞死亡受体1(programmed death receptor-1,PD-1)在高糖环境下影响骨髓间充质干细胞成骨分化的作用机制尚不清楚。目的:探讨高糖环境中PD-1对大鼠骨髓间充质干细胞成骨分化的影响及其调控机制。方法:将大鼠骨髓间充质干细...背景:程序性细胞死亡受体1(programmed death receptor-1,PD-1)在高糖环境下影响骨髓间充质干细胞成骨分化的作用机制尚不清楚。目的:探讨高糖环境中PD-1对大鼠骨髓间充质干细胞成骨分化的影响及其调控机制。方法:将大鼠骨髓间充质干细胞随机分为正常糖组(5.6 mmol/L)、高糖组(30 mmol/L)、PD-1过表达组、PD-1过表达空载组、PD-1敲低组、PD-1敲低空载组、PI3K/AKT通路抑制剂组(PD-1敲低+5μmol/L LY294002)。通过在高糖培养基中培养大鼠骨髓间充质干细胞来模拟体外糖尿病环境,采用qRT-PCR检测大鼠骨髓间充质干细胞中PD-1及其配体PD-L1和成骨标志物Runx2、OSX的mRNA表达,采用碱性磷酸酶染色和茜素红S染色观察成骨分化能力,采用CCK-8检测细胞增殖情况,采用Western blot检测PD-1、PD-L1、p-PI3K、p-AKT的蛋白表达。结果与结论:①高糖组PD-1及PD-L1表达显著高于正常糖组,高糖组骨髓间充质干细胞的成骨分化能力较正常糖组显著下降;②敲低PD-1表达可以促进骨髓间充质干细胞的成骨分化、增加细胞增殖活性,同时激活PI3K/AKT通路;③加入PI3K/AKT通路抑制剂LY294002后,骨髓间充质干细胞成骨分化能力显著下降。结果表明:PD-1依赖于PI3K/AKT信号通路抑制高糖环境下大鼠骨髓间充质干细胞的成骨分化。展开更多
This conference report summarizes recent progress in plasma theory and simulation that was presented in contributed papers and discussions at the 11th Conference on Magnetic Confined Fusion Theory and Simulation(CMCFT...This conference report summarizes recent progress in plasma theory and simulation that was presented in contributed papers and discussions at the 11th Conference on Magnetic Confined Fusion Theory and Simulation(CMCFTS)held in Chengdu,China,27–30 October,2023.Progress in various fields has been achieved.For example,results on zonal flow generation by mode coupling,simulations of the key physics of divertor detachment,energetic particle effects on magnetohydrodynamic(MHD)modes in addition to ion-and electron-scale turbulence,physics of edge coherent modes and edge-localized modes,and the optimization of ion heating schemes as well as confinement scenarios using advanced integrated modeling are presented at the conference.In this conference,the scientific research groups were organized into six categories:(a)edge and divertor physics;(b)impurity,heating,and current drive;(c)energetic particle physics;(d)turbulent transport;(e)MHD instability;and(f)integrated modeling and code development.A summary of the highlighted progress in these working groups is presented.展开更多
The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice space.The reduced B(E3)transition...The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice space.The reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole moments.The available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well reproduced.Furthermore,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).展开更多
文摘内斯比特(KateNesbitt)在她的Theorizing A New Agenda for Architecture,An Anthology of Architectural Theory,1965～1995一书中较为全面地介绍了当代西方建筑理论界所关心的主要问题及其相关的思考。对于这些问题,国内建筑理论界也有自己的认识。该文通过对两者的比较,试图理清建筑理论的基本意义,那就是提出问题并引起思考。
文摘This conference report summarizes recent progress in plasma theory and simulation that was presented in contributed papers and discussions at the 11th Conference on Magnetic Confined Fusion Theory and Simulation(CMCFTS)held in Chengdu,China,27–30 October,2023.Progress in various fields has been achieved.For example,results on zonal flow generation by mode coupling,simulations of the key physics of divertor detachment,energetic particle effects on magnetohydrodynamic(MHD)modes in addition to ion-and electron-scale turbulence,physics of edge coherent modes and edge-localized modes,and the optimization of ion heating schemes as well as confinement scenarios using advanced integrated modeling are presented at the conference.In this conference,the scientific research groups were organized into six categories:(a)edge and divertor physics;(b)impurity,heating,and current drive;(c)energetic particle physics;(d)turbulent transport;(e)MHD instability;and(f)integrated modeling and code development.A summary of the highlighted progress in these working groups is presented.
基金supported by the National Natural Science Foundation of China(NSFC)(No.12205097)the Fundamental Research Funds for the Central Universities(No.2024MS071)。
文摘The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice space.The reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole moments.The available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well reproduced.Furthermore,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).
