Retinopathy of prematurity(ROP)is a disease associated with the vasculogenesis of the developing retina and in particular,in preterm newborns.The long term visual outcome of this disease includes increased risk of bli...Retinopathy of prematurity(ROP)is a disease associated with the vasculogenesis of the developing retina and in particular,in preterm newborns.The long term visual outcome of this disease includes increased risk of blindness and visual disabilities.The increasing prevalence of ROP,the leading cause of blindness in infants,necessitates the implementation of preventive measures to halt this trend,and this,most certainly,calls for the thorough understanding of the pathogenesis and various risk factors associated with the disease.Risk factors for ROP are among the main targets for improving health outcomes.Angiogenic factors including VEGF and IGF-1,maternal factors,oxidative stress and others(erythropoietin and inflammatory cytokines)are among the few of the most important risk factors that need to be addressed.A growing body of evidence suggests that subjects with ROP who have prenatal or postnatal risk factors are at increased risk of more severe ROP.These consistent observations have given rise to hopes of identifying the potential new risk factors and coming up with more efficient prevention and therapeutic strategies.However,studies focusing on incidence rates of ROP over time have painted an inconsistent picture.Individual studies have unequivocally demonstrated an association with the aforementioned risk factors,whereas epidemiological data however,is at best inconclusive.We have tried to integrate the studies,past and present,to identify the pathogenesis and novel risk factors.展开更多
Diabetic retinopathy （DR） is one of the microvascular complications of diabetes, which could be divided intonon-proliferative DR and proliferative DR according to the severity of retinopathy. Diabetic microangiopath...Diabetic retinopathy （DR） is one of the microvascular complications of diabetes, which could be divided intonon-proliferative DR and proliferative DR according to the severity of retinopathy. Diabetic microangiopathy notonly affects the eyesight of patients with diabetes, but also endangers the lives of patients. Therefore, DR has drawnmore and more attention from domestic and foreign scholars. The etiology and treatment of diabetes are reviewedto explore ways of treating diabetic retinopathy.展开更多
Aim: To elucidate clinical features in patients with type 2 diabetes with advanced retinopathy but without nephropathy. Methods: This study examined 1324 patients (784 males and 540 females) with type 2 diabetes melli...Aim: To elucidate clinical features in patients with type 2 diabetes with advanced retinopathy but without nephropathy. Methods: This study examined 1324 patients (784 males and 540 females) with type 2 diabetes mellitus. Diabetic reti-nopathy was graded according to the International Clinical Classification of Diabetic Retinopathy as no diabetic reti-nopathy, mild or moderate non-proliferative diabetic retinopathy, severe non-proliferative diabetic retinopathy, and proliferative diabetic retinopathy. Diabetic nephropathy was classified into four stages of severity according to the Guideline Committee of the Japan Diabetes Society. Each patient was examined for retinopathy grade and nephropathy stage. Clinical features of patients with proliferative diabetic retinopathy were compared with regard to the four grades of diabetic nephropathy. Results: Fifty-two patients with type 2 diabetes (3.9% of the whole series of 1324 patients with type 2 diabetes and 25.7% of patients with proliferative diabetic retinopathy) had proliferative diabetic retinopathy without the presence of nephropathy. Multiple statistical analysis using a proportional odds model revealed that pa-tients with proliferative diabetic retinopathy without nephropathy had a significantly lower systolic blood pressure (p < 0.001) than those who did and were preponderantly female (p < 0.05). Conclusions: A possible susceptibility of dia-betic females to proliferative advanced retinopathy without nephropathy encourages further studies on the role of hor-mones and blood coagulation in the pathogensis of proliferative diabetic retinopathy.展开更多
早产儿视网膜病变(retinopathy of prematurity,ROP)是发展中及发达国家儿童致盲的主要因素。近年来,科研人员的不断努力使得ROP发病机理更加清晰地被认知,抗血管内皮生长因子药物治疗为ROP患儿带来了越发光明的世界。本文综述了ROP的...早产儿视网膜病变(retinopathy of prematurity,ROP)是发展中及发达国家儿童致盲的主要因素。近年来,科研人员的不断努力使得ROP发病机理更加清晰地被认知,抗血管内皮生长因子药物治疗为ROP患儿带来了越发光明的世界。本文综述了ROP的发病机理、相关的血管生成因子、血小板体积、抗VEGF药物治疗等方面的研究进展。展开更多
基金The National Natural Science Foundation of China(Grant No.81370739)The natural science foundation of Jiangsu Province(Grant No.BK20131303)
文摘Retinopathy of prematurity(ROP)is a disease associated with the vasculogenesis of the developing retina and in particular,in preterm newborns.The long term visual outcome of this disease includes increased risk of blindness and visual disabilities.The increasing prevalence of ROP,the leading cause of blindness in infants,necessitates the implementation of preventive measures to halt this trend,and this,most certainly,calls for the thorough understanding of the pathogenesis and various risk factors associated with the disease.Risk factors for ROP are among the main targets for improving health outcomes.Angiogenic factors including VEGF and IGF-1,maternal factors,oxidative stress and others(erythropoietin and inflammatory cytokines)are among the few of the most important risk factors that need to be addressed.A growing body of evidence suggests that subjects with ROP who have prenatal or postnatal risk factors are at increased risk of more severe ROP.These consistent observations have given rise to hopes of identifying the potential new risk factors and coming up with more efficient prevention and therapeutic strategies.However,studies focusing on incidence rates of ROP over time have painted an inconsistent picture.Individual studies have unequivocally demonstrated an association with the aforementioned risk factors,whereas epidemiological data however,is at best inconclusive.We have tried to integrate the studies,past and present,to identify the pathogenesis and novel risk factors.
文摘Diabetic retinopathy （DR） is one of the microvascular complications of diabetes, which could be divided intonon-proliferative DR and proliferative DR according to the severity of retinopathy. Diabetic microangiopathy notonly affects the eyesight of patients with diabetes, but also endangers the lives of patients. Therefore, DR has drawnmore and more attention from domestic and foreign scholars. The etiology and treatment of diabetes are reviewedto explore ways of treating diabetic retinopathy.
文摘Aim: To elucidate clinical features in patients with type 2 diabetes with advanced retinopathy but without nephropathy. Methods: This study examined 1324 patients (784 males and 540 females) with type 2 diabetes mellitus. Diabetic reti-nopathy was graded according to the International Clinical Classification of Diabetic Retinopathy as no diabetic reti-nopathy, mild or moderate non-proliferative diabetic retinopathy, severe non-proliferative diabetic retinopathy, and proliferative diabetic retinopathy. Diabetic nephropathy was classified into four stages of severity according to the Guideline Committee of the Japan Diabetes Society. Each patient was examined for retinopathy grade and nephropathy stage. Clinical features of patients with proliferative diabetic retinopathy were compared with regard to the four grades of diabetic nephropathy. Results: Fifty-two patients with type 2 diabetes (3.9% of the whole series of 1324 patients with type 2 diabetes and 25.7% of patients with proliferative diabetic retinopathy) had proliferative diabetic retinopathy without the presence of nephropathy. Multiple statistical analysis using a proportional odds model revealed that pa-tients with proliferative diabetic retinopathy without nephropathy had a significantly lower systolic blood pressure (p < 0.001) than those who did and were preponderantly female (p < 0.05). Conclusions: A possible susceptibility of dia-betic females to proliferative advanced retinopathy without nephropathy encourages further studies on the role of hor-mones and blood coagulation in the pathogensis of proliferative diabetic retinopathy.
文摘早产儿视网膜病变(retinopathy of prematurity,ROP)是发展中及发达国家儿童致盲的主要因素。近年来,科研人员的不断努力使得ROP发病机理更加清晰地被认知,抗血管内皮生长因子药物治疗为ROP患儿带来了越发光明的世界。本文综述了ROP的发病机理、相关的血管生成因子、血小板体积、抗VEGF药物治疗等方面的研究进展。
