In this paper, we first evaluated the distribution of blood pressure (BP) using a dataset containing 113,979 measurements in 48,022 individuals with the cooperation of one health insurance society in Japan from April,...In this paper, we first evaluated the distribution of blood pressure (BP) using a dataset containing 113,979 measurements in 48,022 individuals with the cooperation of one health insurance society in Japan from April, 2013 to March, 2016. The means of the systolic BP (SBP) and diastolic BP (DBP) were 125.4 and 77.6 mmHg with standard deviations of 16.5 and 11.7 mmHg, respectively. Under the 140/90 criterion, 21.6% of the measurements showed hypertension. According to the World Health Organization/International Society of Hypertension criterion, 16.4%, 4.2% and 0.96% were classified as grades 1, 2 and 3, respectively. The factors affecting BP were evaluated by a regression analysis and were found to include age, gender, some eating habits, daily activities, smoking, drinking alcohol, sleeping and wages. Age was a very important factor, and the age cohorts from the previous study might be revised based on these findings. Among factors that individuals can control, the influence of drinking alcohol is very large. Comparing to an individual who does not drink, SBP and DBP of a heavy drinker are more than 5.0 mmHg higher on the average.展开更多
In this study,single-channel photoplethysmography(PPG)signals were used to estimate the heart rate(HR),diastolic blood pressure(DBP),and systolic blood pressure(SBP).A deep learning model was proposed using a long-ter...In this study,single-channel photoplethysmography(PPG)signals were used to estimate the heart rate(HR),diastolic blood pressure(DBP),and systolic blood pressure(SBP).A deep learning model was proposed using a long-term recurrent convolutional network(LRCN)modified from a deep learning algorithm,the convolutional neural network model of the modified inception deep learning module,and a long short-term memory network(LSTM)to improve the model’s accuracy of BP and HR measurements.The PPG data of 1,551 patients were obtained from the University of California Irvine Machine Learning Repository.How to design a filter of PPG signals and how to choose the loss functions for deep learning model were also discussed in the study.Finally,the stability of the proposed model was tested using a 10-fold cross-validation,with an MAE±SD of 2.942±5.076 mmHg for SBP,1.747±3.042 mmHg for DBP,and 1.137±2.463 bpm for the HR.Compared with its existing counterparts,the model entailed less computational load and was more accurate in estimating SBP,DBP,and HR.These results established the validity of the model.展开更多
<strong>Background: </strong>The high blood pressure (BP) or hypertension is a widely prevalent disease and its costs are very high, and many studies about the relationships between BP and health condition...<strong>Background: </strong>The high blood pressure (BP) or hypertension is a widely prevalent disease and its costs are very high, and many studies about the relationships between BP and health conditions have been done. We need to know the precise distributions of BP and factors affecting BP. <strong>Data and Methods</strong><strong>:</strong> The distributions of BP are analyzed using 12,877,653 observations obtained from the JMDC Claims Database. The factors that may affect the BP are analyzed by the regression models using 4,615,346 observations. <strong>Results:</strong> The averages of systolic BP (SBP) and diastolic BP (DBP) are 120.4 and 74.2 mmHg with standard deviations of 15.9 and 11.3 mmHg, respectively. Among the nonmodifiable factors, age and gender are important factors. Among the modifiable factors, variables related to obesity are important risk factors. Taking antihypertensive drugs makes SBP and DBP 13.4 mmHg and 7.8 mmHg lower. <strong>Conclusion:</strong> The criteria of BP should be carefully determined considering age and gender. The effects of age may be a little different for SBP and DBP. It is necessary to use the proper model to evaluate the effect of antihypertensive drugs correctly. <strong>Limitations:</strong> The dataset is observatory. Although there are various types of treatment methods and antihypertension drugs, their effects are not evaluated.展开更多
Based on the differ—ent theories,TCM andWestern medicine(WM)have their owndifferent understandingsabout the pathogenesisand treatment of highblood pressure(HBP).In TCM the balancesbetween blood-qi,vis—cera—bowel, a...Based on the differ—ent theories,TCM andWestern medicine(WM)have their owndifferent understandingsabout the pathogenesisand treatment of highblood pressure(HBP).In TCM the balancesbetween blood-qi,vis—cera—bowel, and yin—yang are all highly展开更多
Objective To explore the mediating effect of hemoglobin(Hb)and hematocrit(HCT)on the association between alcohol consumption and blood pressure,and provide evidence for the prevention and control of alcohol-attributed...Objective To explore the mediating effect of hemoglobin(Hb)and hematocrit(HCT)on the association between alcohol consumption and blood pressure,and provide evidence for the prevention and control of alcohol-attributed hypertension.Methods 1 091 male(age>50 years old)participants with drinking habit were selected from the Guangzhou biobank cohort study(GBCS).Mediation analysis was used to evaluate the mediating effect of Hb and HCT on the association of alcohol consumption(unit/day)with systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP)and mean arterial pressure(MAP).Results After adjusting for age,body mass index,education level,personal annual income,smoking,occupation and physical activity,the associations of alcohol consumption with SBP,DBP,PP and MAP were partly mediated by Hb,the proportion of mediating effect was 11.8%(95% CI 4.8%-24.7%),15.3%(95% CI 6.5%-32.0%),8.4%(95% CI 2.2%-22.5%)and 13.5%(95% CI 5.9%-27.5%),respectively.The association of alcohol consumption with SBP,DBP,and MAP were also partly mediated by HCT,the proportion of mediating effect was 6.3%(95% CI 1.0%-16.0%),8.7%(95% CI 1.4%-21.4%),and 7.5%(95% CI 1.0%-18.6%),respectively.Conclusion There is a significant mediating effect of Hb and HCT on the association between alcohol consumption and blood pressure.Besides effects on alcohol control,the potential effects of alcohol-induced increase on Hb and HCT,which might also increase the blood pressure,need to be considered to achieve optimal monitoring and prevention of alcohol-related hypertension.展开更多
目的:系统评价夜间低血压与正常眼压性青光眼(Normal-Tension Glaucoma,NTG)发生、发展的相关性,为NTG的临床诊断、预防和治疗提供理论指导。方法:搜索在PubMed、Embase、中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)...目的:系统评价夜间低血压与正常眼压性青光眼(Normal-Tension Glaucoma,NTG)发生、发展的相关性,为NTG的临床诊断、预防和治疗提供理论指导。方法:搜索在PubMed、Embase、中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知网数据库(China National Knowledge Infrastructure,CNKI)、万方数据库等数据库公开发表的,并且符合标准的关于比较NTG与正常人群夜间血压的前瞻性研究和横断面研究。研究文献的筛选是基于文献的研究类型、纳入标准和排除标准,而文献质量评估则采用美国医疗保健研究与质量局(The Agency for Healthcare Research and Quality,AHRQ)公布的11项评估表。研究的合并效应值加权均数差(Weighted Mean Difference,WMD)则是使用Review Manager 5.2软件来计算。结果:最终纳入3项前瞻性研究和1项横断面研究,共计247例参与者。使用随机效应模型下的NTG患者与正常对照组相比夜间收缩压(Systolic Blood Pressure,SBP)在统计学上显著降低(P=0.04),异质性检验(χ^2=7.43,P=0.06,I 2=60%)。使用固定效应模型下的NTG患者与正常对照组相比夜间舒张压(Diastolic Blood Pressure,DBP)在统计学上显著降低(P=0.0002),异质性检验(χ^2=3.28,P=0.35,I 2=9%)。结论:Meta分析表明,与正常对照组相比,NTG患者夜间血压(包括收缩压和舒张压)均发生明显降低,提示夜间低血压有可能是NTG发病的一项重要的危险因素,这无疑为NTG的临床诊断、预防和治疗提供了一种非常有价值的思路和方法。展开更多
Objective: To compare the efficacy of Oxytocin versus Methylergometrine in active management of third stage of labour in reducing risk of postpartum hemorrhage. Methods: This study was carried out by randomly assignin...Objective: To compare the efficacy of Oxytocin versus Methylergometrine in active management of third stage of labour in reducing risk of postpartum hemorrhage. Methods: This study was carried out by randomly assigning into two groups with 150 women in each group.?Group 1 included patients who received injection Oxytocin 10 IU intramuscular within one minute of the birth of the baby. Injection?Methylergometrine?(0.2 mg) was given intravenously at the delivery of anterior shoulder of the baby to women in Group 2. Outcome measures were the duration of third stage, blood loss, pre and post-delivery hematocrit, side effects and incidence of PPH. Statistical analysis was done using Chi square test, Fischers test, Mann Whitney test, and t test. p < 0.05 was considered significant. Results: Mean duration of third stage of labour, mean blood loss, post-delivery fall in hematocrit and need for additional uterotonics were significantly less in the Group 2. However side effects like nausea, vomiting and rise in blood pressure were significantly higher in women in Group 2 (p = 0.000). Conclusion: Methylergometrine is more effective than Oxytocin in reducing the duration of third stage of labour and blood loss but has significant side effects like nausea, vomiting and rise in blood pressure.展开更多
文摘In this paper, we first evaluated the distribution of blood pressure (BP) using a dataset containing 113,979 measurements in 48,022 individuals with the cooperation of one health insurance society in Japan from April, 2013 to March, 2016. The means of the systolic BP (SBP) and diastolic BP (DBP) were 125.4 and 77.6 mmHg with standard deviations of 16.5 and 11.7 mmHg, respectively. Under the 140/90 criterion, 21.6% of the measurements showed hypertension. According to the World Health Organization/International Society of Hypertension criterion, 16.4%, 4.2% and 0.96% were classified as grades 1, 2 and 3, respectively. The factors affecting BP were evaluated by a regression analysis and were found to include age, gender, some eating habits, daily activities, smoking, drinking alcohol, sleeping and wages. Age was a very important factor, and the age cohorts from the previous study might be revised based on these findings. Among factors that individuals can control, the influence of drinking alcohol is very large. Comparing to an individual who does not drink, SBP and DBP of a heavy drinker are more than 5.0 mmHg higher on the average.
基金This study was supported in part by the Ministry of Science and Technology MOST108-2221-E-150-022-MY3 and Taiwan Ocean University.
文摘In this study,single-channel photoplethysmography(PPG)signals were used to estimate the heart rate(HR),diastolic blood pressure(DBP),and systolic blood pressure(SBP).A deep learning model was proposed using a long-term recurrent convolutional network(LRCN)modified from a deep learning algorithm,the convolutional neural network model of the modified inception deep learning module,and a long short-term memory network(LSTM)to improve the model’s accuracy of BP and HR measurements.The PPG data of 1,551 patients were obtained from the University of California Irvine Machine Learning Repository.How to design a filter of PPG signals and how to choose the loss functions for deep learning model were also discussed in the study.Finally,the stability of the proposed model was tested using a 10-fold cross-validation,with an MAE±SD of 2.942±5.076 mmHg for SBP,1.747±3.042 mmHg for DBP,and 1.137±2.463 bpm for the HR.Compared with its existing counterparts,the model entailed less computational load and was more accurate in estimating SBP,DBP,and HR.These results established the validity of the model.
文摘<strong>Background: </strong>The high blood pressure (BP) or hypertension is a widely prevalent disease and its costs are very high, and many studies about the relationships between BP and health conditions have been done. We need to know the precise distributions of BP and factors affecting BP. <strong>Data and Methods</strong><strong>:</strong> The distributions of BP are analyzed using 12,877,653 observations obtained from the JMDC Claims Database. The factors that may affect the BP are analyzed by the regression models using 4,615,346 observations. <strong>Results:</strong> The averages of systolic BP (SBP) and diastolic BP (DBP) are 120.4 and 74.2 mmHg with standard deviations of 15.9 and 11.3 mmHg, respectively. Among the nonmodifiable factors, age and gender are important factors. Among the modifiable factors, variables related to obesity are important risk factors. Taking antihypertensive drugs makes SBP and DBP 13.4 mmHg and 7.8 mmHg lower. <strong>Conclusion:</strong> The criteria of BP should be carefully determined considering age and gender. The effects of age may be a little different for SBP and DBP. It is necessary to use the proper model to evaluate the effect of antihypertensive drugs correctly. <strong>Limitations:</strong> The dataset is observatory. Although there are various types of treatment methods and antihypertension drugs, their effects are not evaluated.
文摘Based on the differ—ent theories,TCM andWestern medicine(WM)have their owndifferent understandingsabout the pathogenesisand treatment of highblood pressure(HBP).In TCM the balancesbetween blood-qi,vis—cera—bowel, and yin—yang are all highly
文摘Objective To explore the mediating effect of hemoglobin(Hb)and hematocrit(HCT)on the association between alcohol consumption and blood pressure,and provide evidence for the prevention and control of alcohol-attributed hypertension.Methods 1 091 male(age>50 years old)participants with drinking habit were selected from the Guangzhou biobank cohort study(GBCS).Mediation analysis was used to evaluate the mediating effect of Hb and HCT on the association of alcohol consumption(unit/day)with systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP)and mean arterial pressure(MAP).Results After adjusting for age,body mass index,education level,personal annual income,smoking,occupation and physical activity,the associations of alcohol consumption with SBP,DBP,PP and MAP were partly mediated by Hb,the proportion of mediating effect was 11.8%(95% CI 4.8%-24.7%),15.3%(95% CI 6.5%-32.0%),8.4%(95% CI 2.2%-22.5%)and 13.5%(95% CI 5.9%-27.5%),respectively.The association of alcohol consumption with SBP,DBP,and MAP were also partly mediated by HCT,the proportion of mediating effect was 6.3%(95% CI 1.0%-16.0%),8.7%(95% CI 1.4%-21.4%),and 7.5%(95% CI 1.0%-18.6%),respectively.Conclusion There is a significant mediating effect of Hb and HCT on the association between alcohol consumption and blood pressure.Besides effects on alcohol control,the potential effects of alcohol-induced increase on Hb and HCT,which might also increase the blood pressure,need to be considered to achieve optimal monitoring and prevention of alcohol-related hypertension.
文摘目的:系统评价夜间低血压与正常眼压性青光眼(Normal-Tension Glaucoma,NTG)发生、发展的相关性,为NTG的临床诊断、预防和治疗提供理论指导。方法:搜索在PubMed、Embase、中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知网数据库(China National Knowledge Infrastructure,CNKI)、万方数据库等数据库公开发表的,并且符合标准的关于比较NTG与正常人群夜间血压的前瞻性研究和横断面研究。研究文献的筛选是基于文献的研究类型、纳入标准和排除标准,而文献质量评估则采用美国医疗保健研究与质量局(The Agency for Healthcare Research and Quality,AHRQ)公布的11项评估表。研究的合并效应值加权均数差(Weighted Mean Difference,WMD)则是使用Review Manager 5.2软件来计算。结果:最终纳入3项前瞻性研究和1项横断面研究,共计247例参与者。使用随机效应模型下的NTG患者与正常对照组相比夜间收缩压(Systolic Blood Pressure,SBP)在统计学上显著降低(P=0.04),异质性检验(χ^2=7.43,P=0.06,I 2=60%)。使用固定效应模型下的NTG患者与正常对照组相比夜间舒张压(Diastolic Blood Pressure,DBP)在统计学上显著降低(P=0.0002),异质性检验(χ^2=3.28,P=0.35,I 2=9%)。结论:Meta分析表明,与正常对照组相比,NTG患者夜间血压(包括收缩压和舒张压)均发生明显降低,提示夜间低血压有可能是NTG发病的一项重要的危险因素,这无疑为NTG的临床诊断、预防和治疗提供了一种非常有价值的思路和方法。
文摘Objective: To compare the efficacy of Oxytocin versus Methylergometrine in active management of third stage of labour in reducing risk of postpartum hemorrhage. Methods: This study was carried out by randomly assigning into two groups with 150 women in each group.?Group 1 included patients who received injection Oxytocin 10 IU intramuscular within one minute of the birth of the baby. Injection?Methylergometrine?(0.2 mg) was given intravenously at the delivery of anterior shoulder of the baby to women in Group 2. Outcome measures were the duration of third stage, blood loss, pre and post-delivery hematocrit, side effects and incidence of PPH. Statistical analysis was done using Chi square test, Fischers test, Mann Whitney test, and t test. p < 0.05 was considered significant. Results: Mean duration of third stage of labour, mean blood loss, post-delivery fall in hematocrit and need for additional uterotonics were significantly less in the Group 2. However side effects like nausea, vomiting and rise in blood pressure were significantly higher in women in Group 2 (p = 0.000). Conclusion: Methylergometrine is more effective than Oxytocin in reducing the duration of third stage of labour and blood loss but has significant side effects like nausea, vomiting and rise in blood pressure.
