Dear Editor,We present a case of acute Bacillus cereus(B.cereus)endophthalmitis in a patient with an intraocular perforation injury combined with occult intravitreal cilium implantation.B.cereus endophthalmitis is a s...Dear Editor,We present a case of acute Bacillus cereus(B.cereus)endophthalmitis in a patient with an intraocular perforation injury combined with occult intravitreal cilium implantation.B.cereus endophthalmitis is a severe intraocular infection commonly caused by post-traumatic injuries.It often leads to significant vision loss or even eye loss within 12-48h[1].The presence of an intraocular foreign body(IOFB)increases the risk of infection,while early surgical removal of IOFBs can prevent endophthalmitis,some IOFBs are difficult to detect preoperatively.The Medical Ethics Review Board of West China Hospital of Sichuan University waived application for a clinical study because this was a retrospective report of a single patient based on imaging and because no human experimentation was involved.The patient provided written informed consent to use the imaging data for publication.展开更多
BACKGROUND Osteofibrous dysplasia(OFD) is a developmental ske-letal disorder, and cases with a giant affected area in the pelvis are rare.CASE SUMMARY In this case report, a 48-year-old man presented with a large tumo...BACKGROUND Osteofibrous dysplasia(OFD) is a developmental ske-letal disorder, and cases with a giant affected area in the pelvis are rare.CASE SUMMARY In this case report, a 48-year-old man presented with a large tumor in the right iliac region that turned out to be OFD. The patient had rebound tenderness in his right hip. After radiography examination, magnetic resonance imaging examinations and some physical examination, extensive bone destruction in the right ilium was confirmed. Moreover, changes in bone mi-neral density and peripheral cortical bone sclerosis with surrounding soft tissue swelling were observed. Thus, this patient was considered to have giant monostotic OFD of the ilium. The tumor-related area was removed completely by surgery, and the remaining cavity was filled by artificial bones from the opposite ilium. According to the results of follow-up, the patient had normal flexion and extension activities of the right hip joint, and there was no evidence of recurrence of the tumor.CONCLUSION Suture of iliopsoas and gluteus medius muscle following focus curettage and bone grafting is a promising and effective method to treat giant OFD of the ilium. It is a feasible way to fill a large cavity after removing a lesion like the one is this case.展开更多
Background：Many clinical studies have been published involving the use of a high hip center （HHC）,achieved good follow-up.However,there is a little anatomic guidance in the literature regarding the amount of bone s...Background：Many clinical studies have been published involving the use of a high hip center （HHC）,achieved good follow-up.However,there is a little anatomic guidance in the literature regarding the amount of bone stock available for initial implant coverage in this area of the ilium.The purpose of this study was to evaluate the thickness and width of the human ilium and related acetabular cup coverage for guiding acetabular component placement in HHC.Methods：A total of 120 normal hips in 60 cases of adult patients from lower extremities computer tomographic angiography Digital Imaging and Communications in Medicine data were chosen for the study.After importing the data to the mimics software,we chose the cross sections every 5-mm increments from the rotational center of the hip to the cephalic of the ilium according the body sagittal axis,then we measured the thickness and width of the ilium for each cross section in axial plane,calculated the cup coverage at each chosen section.Results：At the acetabular dome,the mean thickness and width of the ilium were 49.71 ± 4.88 mm and 38.92 ± 3.67 mm,respectively,whereas at 1 cm above the dome,decreased to 41.35 ± 5.13 and 31.13 ± 3.37 respectively,and 2 cm above the dome,decreased to 31.25 ± 4.04 and 26.65 ± 3.43,respectively.Acetabular cup averaged coverage for 40-,50-,and 60-mm hemispheric shells,was 100%,89%,and 44% at the acetabular dome,100%,43.7%,and 27.5% for 1 cm above the dome,and 37.5%,21.9%,and 14.2% for 2 cm above the dome.Conclusions：HHC reconstructions within 1cm above the acetabular dome will be an acceptable and smaller diameter prosthesis would be better.展开更多
Primary cilium,which protrudes from the cell,is a microtubule-based structure ensheathed by a highly specialized plasma membrane(PM).It serves as a signaling hub for sensing and transducing various external stimuli in...Primary cilium,which protrudes from the cell,is a microtubule-based structure ensheathed by a highly specialized plasma membrane(PM).It serves as a signaling hub for sensing and transducing various external stimuli including fluids,light,odorants as well as extracellular molecules.Of various signal transduction pathways that act through the primary cilium,the Hedgehog(Hh)pathway draws the most attention owing to its essential role in vertebrate development and its intimate link to carcinogenesis(Bangs and Anderson,2017).The major components of the Hh pathway include the secreted ligand Hh,two transmembrane proteins Patched(Ptch)and Smoothened(Smo),and the transcription factor glioma-associated oncogene(Gli).Ptch is the receptor for Hh which,in the absence of Hh,resides at the primary cilium and prevents ciliary localization and activation of Smo.Upon Hh binding,however,Ptch is suppressed and displaced from the ciliary membrane.This permits Smo to enter the primary cilium and initiate a cascade of events that lead to the activation of Gli transcription factors and transcription of downstream target genes.展开更多
目的观察锁定钢板结合同种异体髂骨移植与腓骨移植治疗肱骨近端粉碎性骨折的临床效果。方法纳入肱骨近端粉碎性骨折患者39例,分为髂骨植骨组20例和腓骨植骨组患者19例,分别采用锁定钢板结合同种异体髂骨移植与同种异体腓骨移植治疗,并...目的观察锁定钢板结合同种异体髂骨移植与腓骨移植治疗肱骨近端粉碎性骨折的临床效果。方法纳入肱骨近端粉碎性骨折患者39例,分为髂骨植骨组20例和腓骨植骨组患者19例,分别采用锁定钢板结合同种异体髂骨移植与同种异体腓骨移植治疗,并定期随访,比较2组骨折愈合时间、视觉模拟评分法(visual analogue scale,VAS)评分、SF-36健康调查简表(the MOS item short from health survey,SF-36)评分和术后肩关节活动范围。结果所有患者切口均甲级愈合,临床及放射学检查均取得骨性愈合。髂骨植骨组骨折愈合时间明显短于腓骨植骨组(P<0.05)。术后屈曲、外旋及外展活动范围明显优于腓骨植骨组(P<0.05)。髂骨植骨组末次随访疼痛程度显著低于腓骨植骨组(P<0.05)。SF-36评分显著高于腓骨植骨组(P<0.05)。结论对于需行植骨治疗的肱骨近端粉碎性骨折患者,在制定手术方案时应尽量采用髂骨植骨。展开更多
文摘Dear Editor,We present a case of acute Bacillus cereus(B.cereus)endophthalmitis in a patient with an intraocular perforation injury combined with occult intravitreal cilium implantation.B.cereus endophthalmitis is a severe intraocular infection commonly caused by post-traumatic injuries.It often leads to significant vision loss or even eye loss within 12-48h[1].The presence of an intraocular foreign body(IOFB)increases the risk of infection,while early surgical removal of IOFBs can prevent endophthalmitis,some IOFBs are difficult to detect preoperatively.The Medical Ethics Review Board of West China Hospital of Sichuan University waived application for a clinical study because this was a retrospective report of a single patient based on imaging and because no human experimentation was involved.The patient provided written informed consent to use the imaging data for publication.
文摘BACKGROUND Osteofibrous dysplasia(OFD) is a developmental ske-letal disorder, and cases with a giant affected area in the pelvis are rare.CASE SUMMARY In this case report, a 48-year-old man presented with a large tumor in the right iliac region that turned out to be OFD. The patient had rebound tenderness in his right hip. After radiography examination, magnetic resonance imaging examinations and some physical examination, extensive bone destruction in the right ilium was confirmed. Moreover, changes in bone mi-neral density and peripheral cortical bone sclerosis with surrounding soft tissue swelling were observed. Thus, this patient was considered to have giant monostotic OFD of the ilium. The tumor-related area was removed completely by surgery, and the remaining cavity was filled by artificial bones from the opposite ilium. According to the results of follow-up, the patient had normal flexion and extension activities of the right hip joint, and there was no evidence of recurrence of the tumor.CONCLUSION Suture of iliopsoas and gluteus medius muscle following focus curettage and bone grafting is a promising and effective method to treat giant OFD of the ilium. It is a feasible way to fill a large cavity after removing a lesion like the one is this case.
文摘Background：Many clinical studies have been published involving the use of a high hip center （HHC）,achieved good follow-up.However,there is a little anatomic guidance in the literature regarding the amount of bone stock available for initial implant coverage in this area of the ilium.The purpose of this study was to evaluate the thickness and width of the human ilium and related acetabular cup coverage for guiding acetabular component placement in HHC.Methods：A total of 120 normal hips in 60 cases of adult patients from lower extremities computer tomographic angiography Digital Imaging and Communications in Medicine data were chosen for the study.After importing the data to the mimics software,we chose the cross sections every 5-mm increments from the rotational center of the hip to the cephalic of the ilium according the body sagittal axis,then we measured the thickness and width of the ilium for each cross section in axial plane,calculated the cup coverage at each chosen section.Results：At the acetabular dome,the mean thickness and width of the ilium were 49.71 ± 4.88 mm and 38.92 ± 3.67 mm,respectively,whereas at 1 cm above the dome,decreased to 41.35 ± 5.13 and 31.13 ± 3.37 respectively,and 2 cm above the dome,decreased to 31.25 ± 4.04 and 26.65 ± 3.43,respectively.Acetabular cup averaged coverage for 40-,50-,and 60-mm hemispheric shells,was 100%,89%,and 44% at the acetabular dome,100%,43.7%,and 27.5% for 1 cm above the dome,and 37.5%,21.9%,and 14.2% for 2 cm above the dome.Conclusions：HHC reconstructions within 1cm above the acetabular dome will be an acceptable and smaller diameter prosthesis would be better.
基金the National Natural Science Foundation of China(31771568,32021003 and 91954203)the Ministry of Science and Technology of China(2016YFA0500100).
文摘Primary cilium,which protrudes from the cell,is a microtubule-based structure ensheathed by a highly specialized plasma membrane(PM).It serves as a signaling hub for sensing and transducing various external stimuli including fluids,light,odorants as well as extracellular molecules.Of various signal transduction pathways that act through the primary cilium,the Hedgehog(Hh)pathway draws the most attention owing to its essential role in vertebrate development and its intimate link to carcinogenesis(Bangs and Anderson,2017).The major components of the Hh pathway include the secreted ligand Hh,two transmembrane proteins Patched(Ptch)and Smoothened(Smo),and the transcription factor glioma-associated oncogene(Gli).Ptch is the receptor for Hh which,in the absence of Hh,resides at the primary cilium and prevents ciliary localization and activation of Smo.Upon Hh binding,however,Ptch is suppressed and displaced from the ciliary membrane.This permits Smo to enter the primary cilium and initiate a cascade of events that lead to the activation of Gli transcription factors and transcription of downstream target genes.
文摘目的观察锁定钢板结合同种异体髂骨移植与腓骨移植治疗肱骨近端粉碎性骨折的临床效果。方法纳入肱骨近端粉碎性骨折患者39例,分为髂骨植骨组20例和腓骨植骨组患者19例,分别采用锁定钢板结合同种异体髂骨移植与同种异体腓骨移植治疗,并定期随访,比较2组骨折愈合时间、视觉模拟评分法(visual analogue scale,VAS)评分、SF-36健康调查简表(the MOS item short from health survey,SF-36)评分和术后肩关节活动范围。结果所有患者切口均甲级愈合,临床及放射学检查均取得骨性愈合。髂骨植骨组骨折愈合时间明显短于腓骨植骨组(P<0.05)。术后屈曲、外旋及外展活动范围明显优于腓骨植骨组(P<0.05)。髂骨植骨组末次随访疼痛程度显著低于腓骨植骨组(P<0.05)。SF-36评分显著高于腓骨植骨组(P<0.05)。结论对于需行植骨治疗的肱骨近端粉碎性骨折患者,在制定手术方案时应尽量采用髂骨植骨。
