Multimodality Medical Image Fusion Based on Pixel Significance with Edge-Preserving Processing for Clinical Applications

Multimodal medical image fusion has attained immense popularity in recent years due to its robust technology for clinical diagnosis.It fuses multiple images into a single image to improve the quality of images by retaining significant information and aiding diagnostic practitioners in diagnosing and treating many diseases.However,recent image fusion techniques have encountered several challenges,including fusion artifacts,algorithm complexity,and high computing costs.To solve these problems,this study presents a novel medical image fusion strategy by combining the benefits of pixel significance with edge-preserving processing to achieve the best fusion performance.First,the method employs a cross-bilateral filter(CBF)that utilizes one image to determine the kernel and the other for filtering,and vice versa,by considering both geometric closeness and the gray-level similarities of neighboring pixels of the images without smoothing edges.The outputs of CBF are then subtracted from the original images to obtain detailed images.It further proposes to use edge-preserving processing that combines linear lowpass filtering with a non-linear technique that enables the selection of relevant regions in detailed images while maintaining structural properties.These regions are selected using morphologically processed linear filter residuals to identify the significant regions with high-amplitude edges and adequate size.The outputs of low-pass filtering are fused with meaningfully restored regions to reconstruct the original shape of the edges.In addition,weight computations are performed using these reconstructed images,and these weights are then fused with the original input images to produce a final fusion result by estimating the strength of horizontal and vertical details.Numerous standard quality evaluation metrics with complementary properties are used for comparison with existing,well-known algorithms objectively to validate the fusion results.Experimental results from the proposed research article exhibit superior performance compared to other competing techniques in the case of both qualitative and quantitative evaluation.In addition,the proposed method advocates less computational complexity and execution time while improving diagnostic computing accuracy.Nevertheless,due to the lower complexity of the fusion algorithm,the efficiency of fusion methods is high in practical applications.The results reveal that the proposed method exceeds the latest state-of-the-art methods in terms of providing detailed information,edge contour,and overall contrast.

Multi-Modal Medical Image Fusion Based on Improved Parameter Adaptive PCNN and Latent Low-Rank Representation

Multimodal medical image fusion can help physicians provide more accurate treatment plans for patients, as unimodal images provide limited valid information. To address the insufficient ability of traditional medical image fusion solutions to protect image details and significant information, a new multimodality medical image fusion method(NSST-PAPCNNLatLRR) is proposed in this paper. Firstly, the high and low-frequency sub-band coefficients are obtained by decomposing the source image using NSST. Then, the latent low-rank representation algorithm is used to process the low-frequency sub-band coefficients;An improved PAPCNN algorithm is also proposed for the fusion of high-frequency sub-band coefficients. The improved PAPCNN model was based on the automatic setting of the parameters, and the optimal method was configured for the time decay factor αe. The experimental results show that, in comparison with the five mainstream fusion algorithms, the new algorithm has significantly improved the visual effect over the comparison algorithm,enhanced the ability to characterize important information in images, and further improved the ability to protect the detailed information;the new algorithm has achieved at least four firsts in six objective indexes.

A method based on mutual information and gradient information for medical image registration

Mutual information is widely used in medical image registration, because it does not require preprocessing the image. However, the local maximum problem in the registration is insurmountable. We combine mutual information and gradient information to solve this problem and apply it to the non-rigid deformation image registration. To improve the accuracy, we provide some implemental issues, for example, the Powell searching algorithm, gray interpolation and consideration of outlier points. The experimental results show the accuracy of the method and the feasibility in non-rigid medical image registration.

A Review of Point Feature Based Medical Image Registration

Point features, as the basis of lines, surfaces, and bodies, are commonly used in medical image registration. To obtain an elegant spatial transformation of extracted feature points, many point set matching algorithms(PMs) have been developed to match two point sets by optimizing multifarious distance functions. There are ample reviews related to medical image registration and PMs which summarize their basic principles and main algorithms separately. However,to data, detailed summary of PMs used in medical image registration in different clinical environments has not been published. In this paper, we provide a comprehensive review of the existing key techniques of the PMs applied to medical image registration according to the basic principles and clinical applications. As the core technique of the PMs, geometric transformation models are elaborated in this paper, demonstrating the mechanism of point set registration. We also focus on the clinical applications of the PMs and propose a practical classification method according to their applications in different clinical surgeries. The aim of this paper is to provide a summary of pointfeaturebased methods used in medical image registration and to guide doctors or researchers interested in this field to choose appropriate techniques in their research.

Research and Realization of Medical Image Fusion Based on Three-Dimensional Reconstruction

A new medical image fusion technique is presented.The method is based on three-dimensional reconstruction.After reconstruction,the three-dimensional volume data is normalized by three-dimensional coordinate conversion in the same way and intercepted through setting up cutting plane including anatomical structure,as a result two images in entire registration on space and geometry are obtained and the images are fused at last.Compared with traditional two-dimensional fusion technique,three-dimensional fusion technique can not only resolve the different problems existed in the two kinds of images,but also avoid the registration error of the two kinds of images when they have different scan and imaging parameter.The research proves this fusion technique is more exact and has no registration,so it is more adapt to arbitrary medical image fusion with different equipments.

An Improved Medical Image Fusion Algorithm for Anatomical and Functional Medical Images

In recent years,many medical image fusion methods had been exploited to derive useful information from multimodality medical image data,but,not an appropriate fusion algorithm for anatomical and functional medical images.In this paper,the traditional method of wavelet fusion is improved and a new fusion algorithm of anatomical and functional medical images,in which high-frequency and low-frequency coefficients are studied respectively.When choosing high-frequency coefficients,the global gradient of each sub-image is calculated to realize adaptive fusion,so that the fused image can reserve the functional information;while choosing the low coefficients is based on the analysis of the neighborbood region energy,so that the fused image can reserve the anatomical image's edge and texture feature.Experimental results and the quality evaluation parameters show that the improved fusion algorithm can enhance the edge and texture feature and retain the function information and anatomical information effectively.

A novel image fusion algorithm based on 2D scale-mixing complex wavelet transform and Bayesian MAP estimation for multimodal medical images

In this paper,we propose a new image fusion algorithm based on two-dimensional Scale-Mixing Complex Wavelet Transform(2D-SMCWT).The fusion of the detail 2D-SMCWT cofficients is performed via a Bayesian Maximum a Posteriori(MAP)approach by considering a trivariate statistical model for the local neighboring of 2D-SMCWT coefficients.For the approx imation coefficients,a new fusion rule based on the Principal Component Analysis(PCA)is applied.We conduct several experiments using three different groups of multimodal medical images to evaluate the performance of the proposed method.The obt ained results prove the superiority of the proposed method over the state of the art fusion methods in terms of visual quality and several commonly used metrics.Robustness of the proposed method is further tested against different types of noise.The plots of fusion met rics establish the accuracy of the proposed fusion method.

Wavelet Packet-based Feedback System for Medical Image Fusion

In order to meet the requirements of medical research,diagnosis and treatment,a new algorithm for image fusion based on the wavelet packet transform in conjunction with both subjective and objective assessments is put forward in the paper.Compared to the wavelet transform,the wavelet packet transform is more intricate and effective for the medical image fusion.As indicated by the experimental results,parameters of the feedback system of the new algorithm are significantly superior to those of the wavelet transform,with practicability and accuracy.

Combining Entropy Optimization and Sobel Operator for Medical Image Fusion

Fusing medical images is a topic of interest in processing medical images.This is achieved to through fusing information from multimodality images for the purpose of increasing the clinical diagnosis accuracy.This fusion aims to improve the image quality and preserve the specific features.The methods of medical image fusion generally use knowledge in many differentfields such as clinical medicine,computer vision,digital imaging,machine learning,pattern recognition to fuse different medical images.There are two main approaches in fusing image,including spatial domain approach and transform domain approachs.This paper proposes a new algorithm to fusion multimodal images.This algorithm is based on Entropy optimization and the Sobel operator.Wavelet transform is used to split the input images into components over the low and high frequency domains.Then,two fusion rules are used for obtaining the fusing images.Thefirst rule,based on the Sobel operator,is used for high frequency components.The second rule,based on Entropy optimization by using Particle Swarm Optimization(PSO)algorithm,is used for low frequency components.Proposed algorithm is implemented on the images related to central nervous system diseases.The experimental results of the paper show that the proposed algorithm is better than some recent methods in term of brightness level,the contrast,the entropy,the gradient and visual informationfidelity for fusion(VIFF),Feature Mutual Information(FMI)indices.

Non Sub-Sampled Contourlet with Joint Sparse Representation Based Medical Image Fusion

Medical Image Fusion is the synthesizing technology for fusing multi-modal medical information using mathematical procedures to generate better visual on the image content and high-quality image output.Medical image fusion represents an indispensible role infixing major solutions for the complicated medical predicaments,while the recent research results have an enhanced affinity towards the preservation of medical image details,leaving color distortion and halo artifacts to remain unaddressed.This paper proposes a novel method of fusing Computer Tomography(CT)and Magnetic Resonance Imaging(MRI)using a hybrid model of Non Sub-sampled Contourlet Transform(NSCT)and Joint Sparse Representation(JSR).This model gratifies the need for precise integration of medical images of different modalities,which is an essential requirement in the diagnosing process towards clinical activities and treating the patients accordingly.In the proposed model,the medical image is decomposed using NSCT which is an efficient shift variant decomposition transformation method.JSR is exercised to extricate the common features of the medical image for the fusion process.The performance analysis of the proposed system proves that the proposed image fusion technique for medical image fusion is more efficient,provides better results,and a high level of distinctness by integrating the advantages of complementary images.The comparative analysis proves that the proposed technique exhibits better-quality than the existing medical image fusion practices.

Interpolation Algorithm Research for Medical Image Registration

Owing to its property of applying multi-modality imaging information into the clinical usage has the Medical Image Registration been the research focus. The gray nearest neighbor interpolation and bilinear interpolation and cubic convolution interpolation method used to medical image interpolation algorithm. It compares the characteristics of the three gray interpolations. Combined with the characteristics of the above algorithm is proposed based on gray-scale pixel intensity interpolation. The algorithm can be improved in the time and registration accuracy. It combined with the improved optimization algorithm in the proposed image registration of the simulation experiment, experimental precision subpixel image to verify the validity of the method.

Total Variation Constrained Non-Negative Matrix Factorization for Medical Image Registration

This paper presents a novel medical image registration algorithm named total variation constrained graphregularization for non-negative matrix factorization(TV-GNMF).The method utilizes non-negative matrix factorization by total variation constraint and graph regularization.The main contributions of our work are the following.First,total variation is incorporated into NMF to control the diffusion speed.The purpose is to denoise in smooth regions and preserve features or details of the data in edge regions by using a diffusion coefficient based on gradient information.Second,we add graph regularization into NMF to reveal intrinsic geometry and structure information of features to enhance the discrimination power.Third,the multiplicative update rules and proof of convergence of the TV-GNMF algorithm are given.Experiments conducted on datasets show that the proposed TV-GNMF method outperforms other state-of-the-art algorithms.

Medical Image Fusion Based on Anisotropic Diffusion and Non-Subsampled Contourlet Transform

The synthesis of visual information from multiple medical imaging inputs to a single fused image without any loss of detail and distortion is known as multimodal medical image fusion.It improves the quality of biomedical images by preserving detailed features to advance the clinical utility of medical imaging meant for the analysis and treatment of medical disor-ders.This study develops a novel approach to fuse multimodal medical images utilizing anisotropic diffusion(AD)and non-subsampled contourlet transform(NSCT).First,the method employs anisotropic diffusion for decomposing input images to their base and detail layers to coarsely split two features of input images such as structural and textural information.The detail and base layers are further combined utilizing a sum-based fusion rule which maximizes noise filtering contrast level by effectively preserving most of the structural and textural details.NSCT is utilized to further decompose these images into their low and high-frequency coefficients.These coefficients are then combined utilizing the principal component analysis/Karhunen-Loeve(PCA/KL)based fusion rule independently by substantiating eigenfeature reinforcement in the fusion results.An NSCT-based multiresolution analysis is performed on the combined salient feature information and the contrast-enhanced fusion coefficients.Finally,an inverse NSCT is applied to each coef-ficient to produce the final fusion result.Experimental results demonstrate an advantage of the proposed technique using a publicly accessible dataset and conducted comparative studies on three pairs of medical images from different modalities and health.Our approach offers better visual and robust performance with better objective measurements for research development since it excellently preserves significant salient features and precision without producing abnormal information in the case of qualitative and quantitative analysis.

Multimodal Medical Image Fusion in Non-Subsampled Contourlet Transform Domain

Multimodal medical image fusion is a powerful tool for diagnosing diseases in medical field. The main objective is to capture the relevant information from input images into a single output image, which plays an important role in clinical applications. In this paper, an image fusion technique for the fusion of multimodal medical images is proposed based on Non-Subsampled Contourlet Transform. The proposed technique uses the Non-Subsampled Contourlet Transform (NSCT) to decompose the images into lowpass and highpass subbands. The lowpass and highpass subbands are fused by using mean based and variance based fusion rules. The reconstructed image is obtained by taking Inverse Non-Subsampled Contourlet Transform (INSCT) on fused subbands. The experimental results on six pairs of medical images are compared in terms of entropy, mean, standard deviation, QAB/F as performance parameters. It reveals that the proposed image fusion technique outperforms the existing image fusion techniques in terms of quantitative and qualitative outcomes of the images. The percentage improvement in entropy is 0% - 40%, mean is 3% - 42%, standard deviation is 1% - 42%, QAB/Fis 0.4% - 48% in proposed method comparing to conventional methods for six pairs of medical images.

Medical Image Registration Based on Phase Congruency and Regional Mutual Information

In this paper, a new approach of muhi-modality image registration is represented with not only image intensity, but also features describing image structure. There are two novelties in the proposed method. Firstly, instead of standard mutual information （ MI ） based on joint intensity histogram, regional mutual information （ RMI ） is employed, which allows neighborhood information to be taken into account. Secondly, a new feature images obtained by means of phase congruency are invariants to brightness or contrast changes. By incorporating these features and intensity into RMI, we can combine the aspects of both structural and neighborhood information together, which offers a more robust and a high level of registration accuracy.

Multimodal Medical Image Fusion Based on Parameter Adaptive PCNN and Latent Low-rank Representation

Medical image fusion has been developed as an efficient assistive technology in various clinical applications such as medical diagnosis and treatment planning.Aiming at the problem of insufficient protection of image contour and detail information by traditional image fusion methods,a new multimodal medical image fusion method is proposed.This method first uses non-subsampled shearlet transform to decompose the source image to obtain high and low frequency subband coefficients,then uses the latent low rank representation algorithm to fuse the low frequency subband coefficients,and applies the improved PAPCNN algorithm to fuse the high frequency subband coefficients.Finally,based on the automatic setting of parameters,the optimization method configuration of the time decay factorαe is carried out.The experimental results show that the proposed method solves the problems of difficult parameter setting and insufficient detail protection ability in traditional PCNN algorithm fusion images,and at the same time,it has achieved great improvement in visual quality and objective evaluation indicators.

Congruent Feature Selection Method to Improve the Efficacy of Machine Learning-Based Classification in Medical Image Processing

Machine learning(ML)is increasingly applied for medical image processing with appropriate learning paradigms.These applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify specific flaws/diseases for diagnosis.The primary concern of ML applications is the precise selection of flexible image features for pattern detection and region classification.Most of the extracted image features are irrelevant and lead to an increase in computation time.Therefore,this article uses an analytical learning paradigm to design a Congruent Feature Selection Method to select the most relevant image features.This process trains the learning paradigm using similarity and correlation-based features over different textural intensities and pixel distributions.The similarity between the pixels over the various distribution patterns with high indexes is recommended for disease diagnosis.Later,the correlation based on intensity and distribution is analyzed to improve the feature selection congruency.Therefore,the more congruent pixels are sorted in the descending order of the selection,which identifies better regions than the distribution.Now,the learning paradigm is trained using intensity and region-based similarity to maximize the chances of selection.Therefore,the probability of feature selection,regardless of the textures and medical image patterns,is improved.This process enhances the performance of ML applications for different medical image processing.The proposed method improves the accuracy,precision,and training rate by 13.19%,10.69%,and 11.06%,respectively,compared to other models for the selected dataset.The mean error and selection time is also reduced by 12.56%and 13.56%,respectively,compared to the same models and dataset.

Medical Image Registration Using the Fourier Transform

A Fourier Transform (FT) based pattern-matching algorithm was adapted for use in medical image registration. This algorithm obtained the FT of two images, determined the normalized cross-power spectrum of the transformed images, and then applied an inverse FT. The result was a delta function with a maximum value at the location corresponding to the distance between the two images;a similar method was used to recover rotations. This algorithm was first tested using a simple two-dimensional image, with induced shifts of ±20 pixels and ±10 degrees. All translations were recovered with no error and all rotations were recovered within 0.18 degrees. Subsequently, this algorithm was tested on eight clinical kV images drawn from four different body sites. Twenty-five random shifts and rotations were applied to each image. The average mean error of the registration solution was -0.002 ± 0.077 mm in the x direction, 0.002 ± 0.075 mm in the y direction, and -0.012 ± 0.099 degrees. These initial results suggest that a FT algorithm has a high degree of accuracy when registering clinical kV images.

Medical image fusion based on pulse coupled neural networks and multi-feature fuzzy clustering

Medical image fusion plays an important role in clinical applications such as image-guided surgery, image-guided radiotherapy, noninvasive diagnosis, and treatment planning. In order to retain useful information and get more reliable results, a novel medical image fusion algorithm based on pulse coupled neural networks (PCNN) and multi-feature fuzzy clustering is proposed, which makes use of the multi-feature of image and combines the advantages of the local entropy and variance of local entropy based PCNN. The results of experiments indicate that the proposed image fusion method can better preserve the image details and robustness and significantly improve the image visual effect than the other fusion methods with less information distortion.

Medical Image Fusion Based on Wavelet Multi-Scale Decomposition

This paper describes a method to decompose multi-scale information from different source medical image using wavelet transformation. The data fusion between CT image and MRI image is implemented based on the coefficients fusion rule which included choice of regional variance and weighted average wavelet information. The result indicates that this method is better than WMF, LEF and RVF on fusion results, details and target distortion.