A simple and effective image inpainting method is proposed in this paper, which is proved to be suitable for different kinds of target regions with shapes from little scraps to large unseemly objects in a wide range o...A simple and effective image inpainting method is proposed in this paper, which is proved to be suitable for different kinds of target regions with shapes from little scraps to large unseemly objects in a wide range of images. It is an important improvement upon the traditional image inpainting techniques. By introducing a new bijeetive-mapping term into the matching cost function, the artificial repetition problem in the final inpainting image is practically solved. In addition, by adopting an inpainting error map, not only the target pixels are refined gradually during the inpainting process but also the overlapped target patches are combined more seamlessly than previous method. Finally, the inpainting time is dramatically decreased by using a new acceleration method in the matching process.展开更多
Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the...Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions.展开更多
基金Supported by the National Natural Science Foundation of China （No. 60403044, No. 60373070） and partly funded by Microsoft Research Asia： Project 2004-Image-01.
文摘A simple and effective image inpainting method is proposed in this paper, which is proved to be suitable for different kinds of target regions with shapes from little scraps to large unseemly objects in a wide range of images. It is an important improvement upon the traditional image inpainting techniques. By introducing a new bijeetive-mapping term into the matching cost function, the artificial repetition problem in the final inpainting image is practically solved. In addition, by adopting an inpainting error map, not only the target pixels are refined gradually during the inpainting process but also the overlapped target patches are combined more seamlessly than previous method. Finally, the inpainting time is dramatically decreased by using a new acceleration method in the matching process.
文摘Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions.
