OBJECTIVE： To retrospectively study the preva- lence of fatigue and factors associated with fatigue among acquired immunodeficiency syndrome （AIDS） patients with antiretroviral drug adverse re- actions. METHODS： D...OBJECTIVE： To retrospectively study the preva- lence of fatigue and factors associated with fatigue among acquired immunodeficiency syndrome （AIDS） patients with antiretroviral drug adverse re- actions. METHODS： Data were collected from case reportforms （CRFs） for a project funded by the 1 lth Na- tional 5-year Special Science and Technology Pro- gram on Major Infectious Diseases. Fatigue was de- fined by patient self-report. The outcomes were the prevalence of fatigue and the potential risk factors of fatigue. Univariate and multivariate logistic re- gression analyses were conducted to identify the factors associated with fatigue. RESULTS： Among the 228 subjects, the prevalence of fatigue was 86.8%. In univariate analysis, the sig- nificant differences in demographic characteristics between patients with and without fatigue were： gender [OR=2.29; 95% CI （1.05-4.98）], education lev- el [OR=0.40; 95% CI （0.18-0.85）], anemia [OR=3.80; 95% CI （1.27-11.31）], time of HIV diagnosis [OR= 0.29; 95% CI （0.13-0.65）], and route of infection [OR= 0.14; 9.5% CI （0.06-0.32）]. Abnormal taste and rapid pulse were more commonly seen in patients with fatigue （P〈0.05）, while abdominal distension and lumbar soreness were encountered less often in pa- tients with fatigue （P〈0.05）. Multivariate analysis showed that the four main factors associated with fatigue were anemia [OR=3.S0; 95% CI （1.01 -12.15）], route of infection [OR=3.40; 95% CI （1.21-9.58）; P= 0.02〈0.05], lumbar soreness [OR=0.06; 95% CI （0.02-0.18）; P=0.000〈0.05], and rapid pulse [OR= 10.58; 95% C/（2.16-51.75）; P=0.004〈0.05]. CONCLUSION： This study demonstrated that fa- tigue is common （86.8% prevalence） in AIDS pa- tients with antiretroviral drug adverse reactions, and that anemia, route of infection （i.e., non-com- mercial blood donation） and rapid pulse were risk factors, while lumbar soreness was a protective fac- tor related to fatigue. More attention should bepaid to fatigue and more efforts should be made to find ways to prevent, control and eliminate this symptom in AIDS patients with antiretroviral drug adverse reactions.展开更多
基金Supported by 11th National 5-year Special Science and Technology Program on Major Infectious Diseases(No.2008ZX10005-003,2012ZX10005010-001)Research Projectfor Practice Development of National TCM Clinical Research Bases(No.JDZX2012020)Scientists and Technicians Troop Construction Project of Zhengzhou City(No.10CXTD140)
文摘OBJECTIVE： To retrospectively study the preva- lence of fatigue and factors associated with fatigue among acquired immunodeficiency syndrome （AIDS） patients with antiretroviral drug adverse re- actions. METHODS： Data were collected from case reportforms （CRFs） for a project funded by the 1 lth Na- tional 5-year Special Science and Technology Pro- gram on Major Infectious Diseases. Fatigue was de- fined by patient self-report. The outcomes were the prevalence of fatigue and the potential risk factors of fatigue. Univariate and multivariate logistic re- gression analyses were conducted to identify the factors associated with fatigue. RESULTS： Among the 228 subjects, the prevalence of fatigue was 86.8%. In univariate analysis, the sig- nificant differences in demographic characteristics between patients with and without fatigue were： gender [OR=2.29; 95% CI （1.05-4.98）], education lev- el [OR=0.40; 95% CI （0.18-0.85）], anemia [OR=3.80; 95% CI （1.27-11.31）], time of HIV diagnosis [OR= 0.29; 95% CI （0.13-0.65）], and route of infection [OR= 0.14; 9.5% CI （0.06-0.32）]. Abnormal taste and rapid pulse were more commonly seen in patients with fatigue （P〈0.05）, while abdominal distension and lumbar soreness were encountered less often in pa- tients with fatigue （P〈0.05）. Multivariate analysis showed that the four main factors associated with fatigue were anemia [OR=3.S0; 95% CI （1.01 -12.15）], route of infection [OR=3.40; 95% CI （1.21-9.58）; P= 0.02〈0.05], lumbar soreness [OR=0.06; 95% CI （0.02-0.18）; P=0.000〈0.05], and rapid pulse [OR= 10.58; 95% C/（2.16-51.75）; P=0.004〈0.05]. CONCLUSION： This study demonstrated that fa- tigue is common （86.8% prevalence） in AIDS pa- tients with antiretroviral drug adverse reactions, and that anemia, route of infection （i.e., non-com- mercial blood donation） and rapid pulse were risk factors, while lumbar soreness was a protective fac- tor related to fatigue. More attention should bepaid to fatigue and more efforts should be made to find ways to prevent, control and eliminate this symptom in AIDS patients with antiretroviral drug adverse reactions.
