Parameter optimization of pharmacokinetics based on artificial immune network

A new method for parameter optimization of pharmacokinetics based on an artificial immune network named PKAIN is proposed. To improve local searching ability of the artificial immune network, a partition-based concurrent simplex mutation is developed. By means of evolution of network cells in the PKAIN artificial immune network, an optimal set of parameters of a given pharmacokinetic model is obtained. The Laplace transform is applied to the pharmacokinetic differential equations of remifentanil and its major metabolite, remifentanil acid. The PKAIN method is used to optimize parameters of the derived compartment models. Experimental results show that the twocompartment model is sufficient for the pharmacokinetic study of remifentanil acid for patients with mild degree of renal impairment.

A Multi-Agent Immune Network Algorithm and Its Application to Murphree Efficiency Determination for the Distillation Column

Artificial Immune Network （aiNet） algorithms have become popular for global optimization in many modem industrial applications. However, high-dimensional systems using such models suffer from a potential premature convergence problem. In the existing aiNet algorithms, the premature convergence problem can be avoided by implementing various clonal selection methods, such as immune suppression and mutation approaches, both for single population and multi-population cases. This paper presents a new Multi-Agent Artificial Immune Network （Ma-aiNet） algorithm, which combines immune mechanics and multiagent technology, to overcome the premature convergence problem in high-dimensional systems and to efficiently use the agent ability of sensing and acting on the environment. Ma-aiNet integrates global and local search algorithms. The perform- ance of the proposed method is evaluated using 10 benchmark problems, and the results are compared with other well-known intelligent algorithms. The study demonstrates that Ma-aiNet outperforms other algorithms tested. Ma-aiNet is also used to determine the Murphree efficiency of a distillation column with satisfactory results.

Anomaly Detection with Artificial Immune Network

Inspired by the immune network theory, an adaptive anomaly detection paradigm based on artificial immune network, referred as APAI, is proposed. The implementation of the paradigm includes： initially, the first is to create the initial antibody network; then, through the learning of each training antigen, the antibody network is evolved and updated by the optimal antibodies. Finally, anomaly detection process is accomplished by majority vote of the k nearest neighbor antibodies in the network. The experiments used the famous Sonar Benchmark dataset in our study, which is taken from the UCI machine learning database. The obtained detection accuracy of APAI was 97.7%, which was very promising with regard to the other classification applications in the literature for this problem. In addition to its nonlinear classification properties, APAI possesses biological immune network properties such as clonal selection, immune network, and immune memory, which can be applied to pattern recognition, classification, and etc.

Learning Bayesian network structure with immune algorithm

Finding out reasonable structures from bulky data is one of the difficulties in modeling of Bayesian network （BN）, which is also necessary in promoting the application of BN. This pa- per proposes an immune algorithm based method （BN-IA） for the learning of the BN structure with the idea of vaccination. Further- more, the methods on how to extract the effective vaccines from local optimal structure and root nodes are also described in details. Finally, the simulation studies are implemented with the helicopter convertor BN model and the car start BN model. The comparison results show that the proposed vaccines and the BN-IA can learn the BN structure effectively and efficiently.

Optimizing control of coal flotation by neuro-immune algorithm

Coal flotation is widely used to separate commercially valuable coal from the fine ore slurry, and is an industrial process with nonlinear, multivariable, time-varying and long time-delay characteristics. The online detection of ash content of products as the operation performance evaluation in the flotation system is extraordinarily difficult because of the low solid content and numerous micro-bubbles in the slurry. Moreover, it is time-consuming by manual analysis. Consequently, the optimal separation is not usually maintained. A novel technique, called the neuro-immune algorithm (NIA) inspired by the biological nervous and immune systems, is presented in this paper for predicting the ash content of clean coal and performing the optimizing control to the coal flotation system. The proposed algorithm integrates the deeply-studied artificial neural network (ANN) and the developing artificial immune system (AIS). A two-layer back-propagation network was constructed offline based on the historical process data under the best system situation, using five parameters: the flow and the density of raw slurry, the input flows of water, the kerosene and the GF oil, as the inputs and the ash content of clean coal as the output. The immune cell of AIS is made up of six parameters above as the antigen. The cytokine based clone selection algorithm is used to produce the relative antibody. The detailed computation procedures about the hybrid neuro-immune algorithm are minutely discussed. The ash content of clean coal was predicted by NIA using the practical process data s: (308.6 174.7 146.1 43.6 4.0 9.4), and the absolute difference between the actual and computed ash content values was 0.0967%. The optimizing control on NIA was simulated considering two different situations where the ash content of clean coal was controlled downward from 10.00% or upward from 9.20% predicted by ANN to the target value 9.50%. The results indicate that the target ash content and the value of controlling parameters are obtained after several control cycles.

Dynamic analysis of a sexually transmitted disease model on complex networks

In this paper,a sexually transmitted disease model is proposed on complex networks,where contacts between humans are treated as a scale-free social network.There are three groups in our model,which are dangerous male,non-dangerous male,and female.By mathematical analysis,we obtain the basic reproduction number for the existence of endemic equilibrium and study the effects of various immunization schemes about different groups.Furthermore,numerical simulations are undertaken to verify more conclusions.

Real-time immune-inspired optimum state-of-charge trajectory estimation using upcoming route information preview and neural networks for plug-in hybrid electric vehicles fuel economy

The main proposition of the current investigation is to develop a computational intelligence-based framework which can be used for the real-time estimation of optimum battery state-of-charge （SOC） trajectory in plug-in hybrid electric vehicles （PHEVs）. The estimated SOC trajectory can be then employed for an intelligent power management to significantly improve the fuel economy of the vehicle. The devised intelligent SOC trajectory builder takes advantage of the upcoming route information preview to achieve the lowest possible total cost of electricity and fossil fuel. To reduce the complexity of real-time optimization, the authors propose an immune system-based clustering approach which allows categoriz- ing the route information into a predefined number of segments. The intelligent real-time optimizer is also inspired on the basis of interactions in biological immune systems, and is called artificial immune algorithm （AIA）. The objective function of the optimizer is derived from a computationally efficient artificial neural network （ANN） which is trained by a database obtained from a high-fidelity model of the vehicle built in the Autonomic software. The simulation results demonstrate that the integration of immune inspired clustering tool, AIA and ANN, will result in a powerful framework which can generate a near global optimum SOC trajectory for the baseline vehicle, that is, the Toyota Prius PHEV. The outcomes of the current investigation prove that by taking advantage of intelligent approaches, it is possible to design a computationally efficient and powerful SOC trajectory builder for the intelligent power management of PHEVs.

Comparative Effects of Avoidance and Immunization on Epidemic Spreading in a Dynamic Small-World Network with Community Structure

Considering the actual behavior of people’s short-term travel,we propose a dynamic small-world community network model with tunable community strength which has constant local links and time varying long-range jumps.Then an epidemic model of susceptible-infected-recovered is established based on the mean-field method to evaluate the inhibitory effects of avoidance and immunization on epidemic spreading.And an approximate formula for the epidemic threshold is obtained by mathematical analysis.The simulation results show that the epidemic threshold decreases with the increase of inner-community motivation rate and inter-community long-range motivation rate,while it increases with the increase of immunization rate or avoidance rate.It indicates that the inhibitory effect on epidemic spreading of immunization works better than that of avoidance.

Future View and Development of Immunology:Exploring the Immunology Based on Chinese Medicine and Culture

The immunologically mediated disease is a big family which affects many people in the world, since the cures are not yet available for most immune diseases, the patients face a lifetime of illness and treatment. Chinese medicine inspires us to develop new methods for the treatment of immune diseases. Previous researches of immune system have revealed that an immune network exists. The immune system is like a complex highway; if we travel on these highways, we must have a map to avoid travelling in the wrong direction. Drawing the map of immune network will provide new tools for us to look directly at the basis of the immune system.