The effect of selenium (Se) supplement on pregnancy was studied in 52 pregnant women with high risk factors of pregnancy induced hypertension (PIH). They were given natural Se dietetic liquid (100 μg / d) for 6-8 wee...The effect of selenium (Se) supplement on pregnancy was studied in 52 pregnant women with high risk factors of pregnancy induced hypertension (PIH). They were given natural Se dietetic liquid (100 μg / d) for 6-8 weeks during late pregnancy, and 48 controls were given placebo. They received similar routine prenatal care. The results revealed that Se supplement on the pregnant women prevented and decreased the incidence of PIH and gestational edema, and elevated the mother's blood Se level by 0.1008± 0.091 ppm in the treated group while decreased by 0.0402±0.046 ppm in the control group (P<0.01). The umbilical blood Se level was 0.2756± 0.100 ppm in the treated group and 0.1544 ± 0.051 ppm in the control (P<0.01). The differences of the neonatal birth weight and the amount of postpartum hemorrhage between the two groups were not significant.展开更多
Pregnancy induced hypertension (PIH) is a common complication in pregnancy and prenatal stage. Because the direct and indirect relationship between low calcium intake and many diseases, such as rachitis, young age myo...Pregnancy induced hypertension (PIH) is a common complication in pregnancy and prenatal stage. Because the direct and indirect relationship between low calcium intake and many diseases, such as rachitis, young age myopia and hypertension, calcium supplementation has been a hot topic among nutritionists, Randomized trials of calcium supplementation during pregnancy were conducted in 212 healthy primipara. They were divided into 4 groups and pave 120mg, 240mg, Ig or 2g of calcium daily from 20 to 28wks of gestation up to delivery respectively. As a result, the incidence of PIH was 8.9%, 7.5%, 8% and 4% respectively in these groups, The control group (106 pregnant women) who did not receive calcium gave an incidence of 18%. Supplementation of 2g of calcium daily showed significant resutls in lowering the incidence of PM (P<0.05) without any adverse effects. In 1992 calcium supplementation was widely used in antenatal clinic. 200 cases with intake of 2g calcium were compared with corresponding non-calcium supplementation cases, and the incidence of PIH was 7.5% and 16.5% (P< 0.005) respectively. Mediating parathyroid hormone and renin activity are thought to be the effect of calcium on decreasing the incidence of PIH,展开更多
目的探讨超声脐血流收缩末期峰值(S)与舒张末期峰值(D)的比值(S/D)联合血清可溶性CD40配体(sCD40L)、热休克蛋白70(HSP70)对妊娠期高血压母婴结局的预测价值。方法回顾性分析2020年6月至2022年6月于保定第一中心医院诊治的160例妊娠期...目的探讨超声脐血流收缩末期峰值(S)与舒张末期峰值(D)的比值(S/D)联合血清可溶性CD40配体(sCD40L)、热休克蛋白70(HSP70)对妊娠期高血压母婴结局的预测价值。方法回顾性分析2020年6月至2022年6月于保定第一中心医院诊治的160例妊娠期高血压患者临床资料。根据母婴结局将患者分为母婴结局正常组(n=120)和母婴结局异常组(n=40)。所有患者均行超声检查脐血流S/D比值;酶联免疫吸附(ELISA)法测定患者血清中sCD40L、HSP70水平;对影响妊娠期高血压母婴结局的因素进行Logistic回归分析;受试者工作特征(ROC)曲线分析超声脐血流S/D比值联合血清sCD40L、HSP70对妊娠期高血压母婴结局的预测价值。结果与母婴结局正常组比较,异常组妊娠期高血压患者超声脐血流S/D比值显著升高(3.86±1.01 vs 2.57±0.65,P<0.05),血清sCD40L[(3.65±0.91)ng/L vs(6.04±1.42)ng/L]、HSP70水平[(2.01±0.46)μg/L vs(2.90±0.52)μg/L]均明显升高(P<0.05);Logistic回归分析发现,超声脐血流S/D比值、sCD40L、HSP70是影响妊娠期高血压患者母婴结局的危险因素(P<0.05)。超声脐血流S/D比值联合血清sCD40L、HSP70预测妊娠期高血压母婴结局的ROC曲线下面积(AUC)为0.993,均优于其各自单独预测(Z三者联合-超声脐血流S/D比值=4.030,P<0.001;Z三者联合-sCD40L=2.409,P=0.008;Z三者联合-HSP70=4.302,P<0.001)。结论妊娠期高血压患者超声脐血流S/D比值、血清sCD40L、HSP70水平升高,且与母婴结局有关,临床可用以预测患者母婴结局。展开更多
文摘The effect of selenium (Se) supplement on pregnancy was studied in 52 pregnant women with high risk factors of pregnancy induced hypertension (PIH). They were given natural Se dietetic liquid (100 μg / d) for 6-8 weeks during late pregnancy, and 48 controls were given placebo. They received similar routine prenatal care. The results revealed that Se supplement on the pregnant women prevented and decreased the incidence of PIH and gestational edema, and elevated the mother's blood Se level by 0.1008± 0.091 ppm in the treated group while decreased by 0.0402±0.046 ppm in the control group (P<0.01). The umbilical blood Se level was 0.2756± 0.100 ppm in the treated group and 0.1544 ± 0.051 ppm in the control (P<0.01). The differences of the neonatal birth weight and the amount of postpartum hemorrhage between the two groups were not significant.
文摘Pregnancy induced hypertension (PIH) is a common complication in pregnancy and prenatal stage. Because the direct and indirect relationship between low calcium intake and many diseases, such as rachitis, young age myopia and hypertension, calcium supplementation has been a hot topic among nutritionists, Randomized trials of calcium supplementation during pregnancy were conducted in 212 healthy primipara. They were divided into 4 groups and pave 120mg, 240mg, Ig or 2g of calcium daily from 20 to 28wks of gestation up to delivery respectively. As a result, the incidence of PIH was 8.9%, 7.5%, 8% and 4% respectively in these groups, The control group (106 pregnant women) who did not receive calcium gave an incidence of 18%. Supplementation of 2g of calcium daily showed significant resutls in lowering the incidence of PM (P<0.05) without any adverse effects. In 1992 calcium supplementation was widely used in antenatal clinic. 200 cases with intake of 2g calcium were compared with corresponding non-calcium supplementation cases, and the incidence of PIH was 7.5% and 16.5% (P< 0.005) respectively. Mediating parathyroid hormone and renin activity are thought to be the effect of calcium on decreasing the incidence of PIH,
文摘目的探讨超声脐血流收缩末期峰值(S)与舒张末期峰值(D)的比值(S/D)联合血清可溶性CD40配体(sCD40L)、热休克蛋白70(HSP70)对妊娠期高血压母婴结局的预测价值。方法回顾性分析2020年6月至2022年6月于保定第一中心医院诊治的160例妊娠期高血压患者临床资料。根据母婴结局将患者分为母婴结局正常组(n=120)和母婴结局异常组(n=40)。所有患者均行超声检查脐血流S/D比值;酶联免疫吸附(ELISA)法测定患者血清中sCD40L、HSP70水平;对影响妊娠期高血压母婴结局的因素进行Logistic回归分析;受试者工作特征(ROC)曲线分析超声脐血流S/D比值联合血清sCD40L、HSP70对妊娠期高血压母婴结局的预测价值。结果与母婴结局正常组比较,异常组妊娠期高血压患者超声脐血流S/D比值显著升高(3.86±1.01 vs 2.57±0.65,P<0.05),血清sCD40L[(3.65±0.91)ng/L vs(6.04±1.42)ng/L]、HSP70水平[(2.01±0.46)μg/L vs(2.90±0.52)μg/L]均明显升高(P<0.05);Logistic回归分析发现,超声脐血流S/D比值、sCD40L、HSP70是影响妊娠期高血压患者母婴结局的危险因素(P<0.05)。超声脐血流S/D比值联合血清sCD40L、HSP70预测妊娠期高血压母婴结局的ROC曲线下面积(AUC)为0.993,均优于其各自单独预测(Z三者联合-超声脐血流S/D比值=4.030,P<0.001;Z三者联合-sCD40L=2.409,P=0.008;Z三者联合-HSP70=4.302,P<0.001)。结论妊娠期高血压患者超声脐血流S/D比值、血清sCD40L、HSP70水平升高,且与母婴结局有关,临床可用以预测患者母婴结局。
