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Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation:A minireview 被引量:2
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作者 Danilo Candido de Almeida Laura Sibele Martins Evangelista Niels Olsen Saraiva Camara 《World Journal of Stem Cells》 2017年第9期152-158,共7页
Mesenchymal stromal cells(MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation.MSC activation via specific... Mesenchymal stromal cells(MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation.MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response.The aryl-hydrocarbon receptor(Ah R) is a sensitive molecule for external signals and it is expressed in MSCs and,upon positive activation,may potentially regulate the MSC-associated immunomodulatory function.Consequently,signalling pathways linked to Ah R activation can elucidate some of the molecular cascades involved in MSC-mediated immunosuppression.In this minireview,we have noted some important findings concerning MSC regulation via Ah R,highlighting that its activation is associated with improvement in migration and immunoregulation,as well as an increase in pro-regenerative potential.Thus,Ah R-mediated MSC activation can contribute to new perspectives on MSC-based therapies,particularly those directed at immune-associated disorders. 展开更多
关键词 Mesenchymal stromal cells Aryl-hydrocarbon receptor cell activation and immunosuppression
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Regulatory T Cell Activity in Immunosuppresive Mice Model of Pseudomonas Aeruginosa Pneumonia 被引量:1
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作者 李鋆璐 陈渟桑 +5 位作者 袁聪聪 赵国强 徐岷 李晓燕 曹杰 邢丽华 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2017年第4期505-509,共5页
Pseudomonas aeruginosa(PA) pneumonia is a refractory, even lethal complication in immunosuppressive individuals and immune disturbances may promote the pathological process. We aimed to investigate the regulatory T... Pseudomonas aeruginosa(PA) pneumonia is a refractory, even lethal complication in immunosuppressive individuals and immune disturbances may promote the pathological process. We aimed to investigate the regulatory T(Treg) cell activity in an immunosuppressive mice model of PA pneumonia by estimating levels of main transcription factor and the main effector of Treg cells, i.e., Forkhead box protein 3(FOXP3) and interleukine-10(IL-10). Seventy-two BALB/c mice were divided into four groups randomly: control(A), PA pneumonia(B), immunosuppression(C) and immunosuppression with PA pneumonia(D). Mice were sacrificed at 4, 8 and 24 h after establishing experimental models. The pathological changes of lung tissue were graded, and the FOXP3 m RNA and serum IL-10 levels were detected. Histological analysis of lung tissues showed there were no significantly pathological changes in groups A and C, but significantly pathological changes were found in groups B and D, especially in group D at 8 h(P〈0.05). The expression levels of FOXP3 m RNA in groups A and C showed no significant changes at the three time points, which were significantly lower than those in groups B and D(P〈0.05). FOXP3 m RNA levels were lowest at 4 h, and there was significant difference between groups B and D(P〈0.05). The serum levels of IL-10 in groups A and C were almost normal at the three time points, but decreased significantly in groups B and D(P〈0.05). The serum levels of IL-10 decreased to the lowest at 8 h, especially in group D(P〈0.05). The results indicate that PA pneumonia in immunosuppressive individuals worsens rapidly, which may be associated with Treg cells function disturbance. And Treg cells may be promising as adjuvant therapeutics for PA pneumonia in immunosuppressive individuals. 展开更多
关键词 regulatory T cells immunosuppression pseudomonas aeruginosa pneumonia
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Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy
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作者 Qi Chen Adeline Chia +16 位作者 Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2023年第11期1300-1312,共13页
Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe COVID-19.Here,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group ... Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe COVID-19.Here,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different ISDs.We demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response.Such defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough infection.To then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron variants.This strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients. 展开更多
关键词 T cell therapy TRANSPLANTATION SARS-CoV-2 immunosuppressive drug resistant T cells
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