Objective To investigate the prevalence of impaired glucose regulation （IGR） in the population of Tianjin. Methods A cross-sectional study was conducted in Tianjin from June to September in 2005. The multi-phasic s...Objective To investigate the prevalence of impaired glucose regulation （IGR） in the population of Tianjin. Methods A cross-sectional study was conducted in Tianjin from June to September in 2005. The multi-phasic stratified cluster sampling method was adopted. Totally, 21454 people were selected as survey sample. Information on risk factors was collected through face-to-face questionnaire interview. Fasting capillary whole blood glucose level and other clinical indexes were tested. Results The prevalence of impaired fasting glucose （IFG） in the population was 5.61% （5.32% in male, 5.89% in female）. The prevalence of impaired glucose tolerance （IGT） was 2.91% （2.59% in male, 3.20% in female） in whole population, and the prevalence of female was significantly higher than that of male （P = 0.04）. The prevalences of IFG and IGT increased with the increasing of age. And the prevalences were also influenced by the profession, educational level, and income level. Conclusion The prevalences oflGT and IFG in Tianjin are similar to those in the other big cities of China.展开更多
Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parame...Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parameter for continuously evaluating personal clinical statuses,the newly developed technique“continuous glucose monitoring”(CGM)can characterize glucose dynamics.By calculating the complexity of glucose time series index(CGI)with refined composite multi-scale entropy analysis of the CGM data,the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes(P for trend<0.01).Furthermore,CGI was significantly associated with various parameters such as insulin sensitivity/secretion(all P<0.01),and multiple linear stepwise regression showed that the disposition index,which reflectsβ-cell function after adjusting for insulin sensitivity,was the only independent factor correlated with CGI(P<0.01).Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis.展开更多
目的探讨健步走的干预方式对糖调节受损(IGR)人群胰岛素敏感性的影响。方法以福州地区的汉族人群为目标对象,通过病例对照研究设计,将确诊的糖调节受损人群分为试验组、对照组,对有关生活习惯进行调查,对照组进行常规生活方式干预,试验...目的探讨健步走的干预方式对糖调节受损(IGR)人群胰岛素敏感性的影响。方法以福州地区的汉族人群为目标对象,通过病例对照研究设计,将确诊的糖调节受损人群分为试验组、对照组,对有关生活习惯进行调查,对照组进行常规生活方式干预,试验组在保持原来生活方式干预的基础上进行强化健步走训练,在干预过程中两组均进行相关指标的监测。结果与对照组比较,糖调节受损(IGR)试验组FPG、2 h PG、FINS、HOMA-IR、HOMA-IS均下降,ISI提高,差异有统计学意义。结论健步走的干预对糖调节受损人群血糖水平、胰岛素敏感性、胰岛素抵抗及胰岛β细胞分泌功能均有良好调节作用。展开更多
目的分析健胰方加减对糖调节受损患者血糖、胰岛素代谢水平的影响。方法90例糖调节受损患者,采取随机法分为对照组和观察组,每组45例。对照组行生活方式干预,观察组在对照组的基础上应用健胰方加减辅助治疗。比较两组患者治疗前以及治疗...目的分析健胰方加减对糖调节受损患者血糖、胰岛素代谢水平的影响。方法90例糖调节受损患者,采取随机法分为对照组和观察组,每组45例。对照组行生活方式干预,观察组在对照组的基础上应用健胰方加减辅助治疗。比较两组患者治疗前以及治疗3个月后的糖代谢指标[空腹血糖(FBG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(HbA1c)]水平、胰岛素代谢指标[脂联素、胰岛β细胞功能指数(HOMA-β)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)]水平。结果治疗后,观察组患者FBG(4.60±0.50)mmol/L、2 h PG(7.02±1.01)mmol/L、HbA1c(4.53±0.03)%均低于对照组的(5.70±0.60)mmol/L、(7.75±1.02)mmol/L、(5.75±0.50)%,差异均具有统计学意义(P<0.05)。治疗后,观察组患者脂联素(3.10±0.80)mg/L、HOMA-β(4.84±0.50)均高于对照组的(2.53±0.80)mg/L、(4.40±0.30),FINS(7.05±0.05)mIU/L、HOMA-IR(1.45±0.30)均低于对照组的(9.20±2.02)mIU/L、(2.33±0.20),差异均具有统计学意义(P<0.05)。结论生活方式干预配合健胰方加减治疗,有助于糖调节受损患者血糖、胰岛素代谢水平调节,有效阻断疾病发展。展开更多
文摘Objective To investigate the prevalence of impaired glucose regulation （IGR） in the population of Tianjin. Methods A cross-sectional study was conducted in Tianjin from June to September in 2005. The multi-phasic stratified cluster sampling method was adopted. Totally, 21454 people were selected as survey sample. Information on risk factors was collected through face-to-face questionnaire interview. Fasting capillary whole blood glucose level and other clinical indexes were tested. Results The prevalence of impaired fasting glucose （IFG） in the population was 5.61% （5.32% in male, 5.89% in female）. The prevalence of impaired glucose tolerance （IGT） was 2.91% （2.59% in male, 3.20% in female） in whole population, and the prevalence of female was significantly higher than that of male （P = 0.04）. The prevalences of IFG and IGT increased with the increasing of age. And the prevalences were also influenced by the profession, educational level, and income level. Conclusion The prevalences oflGT and IFG in Tianjin are similar to those in the other big cities of China.
基金the National Natural Science Foundation of China(Nos.81873646 and 61903071)the Shanghai United Developing Technology Project of Municipal Hospitals(Nos.SHDC12006101 and SHDC12010115)the Shanghai Municipal Education Commission Gaofeng Clinical Medicine grant support(Nos.20161430).
文摘Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parameter for continuously evaluating personal clinical statuses,the newly developed technique“continuous glucose monitoring”(CGM)can characterize glucose dynamics.By calculating the complexity of glucose time series index(CGI)with refined composite multi-scale entropy analysis of the CGM data,the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes(P for trend<0.01).Furthermore,CGI was significantly associated with various parameters such as insulin sensitivity/secretion(all P<0.01),and multiple linear stepwise regression showed that the disposition index,which reflectsβ-cell function after adjusting for insulin sensitivity,was the only independent factor correlated with CGI(P<0.01).Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis.
文摘目的探讨健步走的干预方式对糖调节受损(IGR)人群胰岛素敏感性的影响。方法以福州地区的汉族人群为目标对象,通过病例对照研究设计,将确诊的糖调节受损人群分为试验组、对照组,对有关生活习惯进行调查,对照组进行常规生活方式干预,试验组在保持原来生活方式干预的基础上进行强化健步走训练,在干预过程中两组均进行相关指标的监测。结果与对照组比较,糖调节受损(IGR)试验组FPG、2 h PG、FINS、HOMA-IR、HOMA-IS均下降,ISI提高,差异有统计学意义。结论健步走的干预对糖调节受损人群血糖水平、胰岛素敏感性、胰岛素抵抗及胰岛β细胞分泌功能均有良好调节作用。
文摘目的分析健胰方加减对糖调节受损患者血糖、胰岛素代谢水平的影响。方法90例糖调节受损患者,采取随机法分为对照组和观察组,每组45例。对照组行生活方式干预,观察组在对照组的基础上应用健胰方加减辅助治疗。比较两组患者治疗前以及治疗3个月后的糖代谢指标[空腹血糖(FBG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(HbA1c)]水平、胰岛素代谢指标[脂联素、胰岛β细胞功能指数(HOMA-β)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)]水平。结果治疗后,观察组患者FBG(4.60±0.50)mmol/L、2 h PG(7.02±1.01)mmol/L、HbA1c(4.53±0.03)%均低于对照组的(5.70±0.60)mmol/L、(7.75±1.02)mmol/L、(5.75±0.50)%,差异均具有统计学意义(P<0.05)。治疗后,观察组患者脂联素(3.10±0.80)mg/L、HOMA-β(4.84±0.50)均高于对照组的(2.53±0.80)mg/L、(4.40±0.30),FINS(7.05±0.05)mIU/L、HOMA-IR(1.45±0.30)均低于对照组的(9.20±2.02)mIU/L、(2.33±0.20),差异均具有统计学意义(P<0.05)。结论生活方式干预配合健胰方加减治疗,有助于糖调节受损患者血糖、胰岛素代谢水平调节,有效阻断疾病发展。
