Backgrounds: Differences in serum lipids profiles in different type of glucose intolerance are unclear. Aims: To characterize lipid profiles in different type of glucose intolerance, and to assess relationships betwee...Backgrounds: Differences in serum lipids profiles in different type of glucose intolerance are unclear. Aims: To characterize lipid profiles in different type of glucose intolerance, and to assess relationships between serum lipids profile and disturbance of glucose metabolism in prediabetic subjects. Methods: Using the measurements in medical check-up with 75 goral glucose tolerance test (OGTT), total of 620 male subjects, who are not on medications for metabolic diseases or hypertension, were divided into normal fasting glucose and glucose tolerance (NFG/ NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT) and combined IFG and IGT (IFG/IGT) based on results of the OGTT. Results: Age and body mass index (BMI) were similar in the four groups. Matsuda index (an index of whole body insulin sensitivity) was lower in iIFG, iIGT and IFG/IGT as compared with NFG/NGT. Plasma insulin excursion during the OGTT was significantly higher in IFG/IGT versus NFG/NGT. Serum triglyceride level (TG) and TG to HDL ratio (TG/HDL) were higher in IFG/IGT versus NFG/NGT. Matsuda index was positively correlated with HDL and was inversely correlated with TG, LDL, non-HDL, TG/ HDL and LDL to HDL ratio (LDL/HDL). Backward stepwise multiple regression analysis indicated that increases in BMI, plasma insulin level at 60 min (PI60) and plasma glucose level at 120 min in the OGTT were independently associated with increases in TG and TG/HDL. Increases in BMI and PI60 were related to an increase in non-HDL and LDL/HDL and a decrease in HDL. Conclusions: These results indicate that postprandial hyperglycemia and hyperinsulinemia based on advanced insulin resistance are closely related to lipid risk factors of atherosclerotic macrovascular disease in prediabetic subjects.展开更多
目的:研究糖尿病早期筛查的意义,评估其胰岛素敏感性及分泌功能,同时预测其发生糖尿病及其相关并发症的转归情况,为临床早期干预提供指导。方法:通过对患者进行口服葡萄糖耐量试验(OGTT),计算其体质指数,同时行血脂检测,早期筛查糖尿病...目的:研究糖尿病早期筛查的意义,评估其胰岛素敏感性及分泌功能,同时预测其发生糖尿病及其相关并发症的转归情况,为临床早期干预提供指导。方法:通过对患者进行口服葡萄糖耐量试验(OGTT),计算其体质指数,同时行血脂检测,早期筛查糖尿病并评估其胰岛素敏感性。结果:糖耐量减低(IGT)组患者平均年龄低于糖尿病(DM)组(52.0±10.9vs65.1±14.3,P<0.05);与正常葡萄糖耐量(NGT)组患者相比,空腹血糖调节受损(IFG)组、IGT组患者及DM组患者胰岛素敏感性(ISI0,120)明显下降,胰岛素抵抗明显(NGT vs IFG:92.0±22.3vs69.1±22.0;NGT vs IGT:92.0±22.3vs64.7±13.1;NGT vs DM92.0±22.3vs28.5±8.2,P<0.05);IGT组患者较IFG组患者胰岛素敏感性下降更明显(IFG vs IGT69.1±22.0vs64.7±13.1,P<0.05);胰岛素生成指数(IGI)IGT组明显高于IFG组(IFG vs IGT:1.69±0.80vs1.90±1.20,P<0.05);与NGT组相比,IFG组及DM组胰岛素早期相分泌(EPIR)明显降低(NGT vs IFG1stPH:243.9±173.5vs124.2±110.2,2ndPH:99.2±33.5vs62.6±37.4;NGT vs DM1stPH:243.9±173.5vs136.7±123.2,2ndPH:99.2±33.5vs38.8±33.3,P<0.05);且IGT组高于IFG组(IFG vs IGT1stPH:124.2±110.2vs200.4±186.3,P<0.05)。结论:IFG患者与IGT患者可能存在不同的发病机制,部分患者在正常葡萄糖耐量(NGT)时已经存在β细胞功能受损,OGTT检查对于揭示胰岛分泌功能及胰岛素抵抗,早期筛查糖尿病具有重要的意义,从而对糖尿病早期诊断早期干预提供临床指导意义。展开更多
文摘Backgrounds: Differences in serum lipids profiles in different type of glucose intolerance are unclear. Aims: To characterize lipid profiles in different type of glucose intolerance, and to assess relationships between serum lipids profile and disturbance of glucose metabolism in prediabetic subjects. Methods: Using the measurements in medical check-up with 75 goral glucose tolerance test (OGTT), total of 620 male subjects, who are not on medications for metabolic diseases or hypertension, were divided into normal fasting glucose and glucose tolerance (NFG/ NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT) and combined IFG and IGT (IFG/IGT) based on results of the OGTT. Results: Age and body mass index (BMI) were similar in the four groups. Matsuda index (an index of whole body insulin sensitivity) was lower in iIFG, iIGT and IFG/IGT as compared with NFG/NGT. Plasma insulin excursion during the OGTT was significantly higher in IFG/IGT versus NFG/NGT. Serum triglyceride level (TG) and TG to HDL ratio (TG/HDL) were higher in IFG/IGT versus NFG/NGT. Matsuda index was positively correlated with HDL and was inversely correlated with TG, LDL, non-HDL, TG/ HDL and LDL to HDL ratio (LDL/HDL). Backward stepwise multiple regression analysis indicated that increases in BMI, plasma insulin level at 60 min (PI60) and plasma glucose level at 120 min in the OGTT were independently associated with increases in TG and TG/HDL. Increases in BMI and PI60 were related to an increase in non-HDL and LDL/HDL and a decrease in HDL. Conclusions: These results indicate that postprandial hyperglycemia and hyperinsulinemia based on advanced insulin resistance are closely related to lipid risk factors of atherosclerotic macrovascular disease in prediabetic subjects.
文摘目的:研究糖尿病早期筛查的意义,评估其胰岛素敏感性及分泌功能,同时预测其发生糖尿病及其相关并发症的转归情况,为临床早期干预提供指导。方法:通过对患者进行口服葡萄糖耐量试验(OGTT),计算其体质指数,同时行血脂检测,早期筛查糖尿病并评估其胰岛素敏感性。结果:糖耐量减低(IGT)组患者平均年龄低于糖尿病(DM)组(52.0±10.9vs65.1±14.3,P<0.05);与正常葡萄糖耐量(NGT)组患者相比,空腹血糖调节受损(IFG)组、IGT组患者及DM组患者胰岛素敏感性(ISI0,120)明显下降,胰岛素抵抗明显(NGT vs IFG:92.0±22.3vs69.1±22.0;NGT vs IGT:92.0±22.3vs64.7±13.1;NGT vs DM92.0±22.3vs28.5±8.2,P<0.05);IGT组患者较IFG组患者胰岛素敏感性下降更明显(IFG vs IGT69.1±22.0vs64.7±13.1,P<0.05);胰岛素生成指数(IGI)IGT组明显高于IFG组(IFG vs IGT:1.69±0.80vs1.90±1.20,P<0.05);与NGT组相比,IFG组及DM组胰岛素早期相分泌(EPIR)明显降低(NGT vs IFG1stPH:243.9±173.5vs124.2±110.2,2ndPH:99.2±33.5vs62.6±37.4;NGT vs DM1stPH:243.9±173.5vs136.7±123.2,2ndPH:99.2±33.5vs38.8±33.3,P<0.05);且IGT组高于IFG组(IFG vs IGT1stPH:124.2±110.2vs200.4±186.3,P<0.05)。结论:IFG患者与IGT患者可能存在不同的发病机制,部分患者在正常葡萄糖耐量(NGT)时已经存在β细胞功能受损,OGTT检查对于揭示胰岛分泌功能及胰岛素抵抗,早期筛查糖尿病具有重要的意义,从而对糖尿病早期诊断早期干预提供临床指导意义。
