While the spread of COVID-19 in China is under control,the pandemic is developing rapidly around the world.Due to the normal migration of population,China is facing the high risk from imported cases.The potential spec...While the spread of COVID-19 in China is under control,the pandemic is developing rapidly around the world.Due to the normal migration of population,China is facing the high risk from imported cases.The potential specific medicine and vaccine are still in the process of clinical trials.Currently,controlling the impact of imported cases is the key to prevent new outbreak of COVID-19 in China.In this paper,we propose two impulsive systems to describe the impact of multilateral imported cases of COVID-19.Based on the published data,we simulate and analyze the epidemic trends under different control strategies.In particular,we compare four different scenarios and show the corresponding medical burden.The results can be useful in designing appropriate control strategy for imported cases in practice.展开更多
Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases...Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographics, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month follow-up.Results Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent cases.Conclusions Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.展开更多
Objective:To analyze the epidemiological and clinical characteristics of foreign-imported patients infected with SARS-CoV-2 in Chengdu City.Methods:A total of 290 foreign-imported patients infected with SARS-CoV-2 and...Objective:To analyze the epidemiological and clinical characteristics of foreign-imported patients infected with SARS-CoV-2 in Chengdu City.Methods:A total of 290 foreign-imported patients infected with SARS-CoV-2 and discharged from Public Health Clinical Center of Chengdu were included in our study,they were divided into asymptomatic infection group(131 cases)and confirmed cases group(159 cases)in order to compare the epidemiology,clinical characteristics and laboratory tests between two groups.Multi-factor logistic regression analysis was used to investigate the influence factors of becoming a dominant infection after infected with SARS-CoV-2.Results:Among the 290 cases aged from 2 months to 68 years old,83.4%were males,62.1%came from Asia,and 43.8%were complicated with fatty liver disease,the age group of 14-49 years old had the largest number(247 cases).80.5%confirmed case group cases were general type,there was only 1 severe patient.Hospital stays in asymptomatic infection group was shorter than that in confirmed cases group,lymphocyte count,CD4+T count,CD8+T count,CD4+T/CD8+T creatine kinase in two groups half a month after discharge were relatively lower than those on admission,and alanine aminotransferase,aspartate aminotransferase,albumin,lactate dehydrogenase,creatine kinase isoenzyme were relatively higher than those on admission(P<0.05).Logistic regression analysis showed that increased age,decreased lymphocyte count on admission and increased lactate dehydrogenase on admission were associated with dominant infection.Chest CT of 13 general type cases indicated an increase in lesions compared with that at discharge and 3 of them had re-detectable positive RNA test.Conclusion:The majority of foreign-imported cases in Chengdu are mainly from Asia,fewer of them are severe patients.In the early stage of recovery,some SARS-CoV-2 infected patients still have intermittent viral replication.Early isolation and early treatment of imported patients is not only conducive to epidemic prevention and control,but also may change the natural course of the disease.展开更多
基金National Natural Science Foundation of China(Grant Nos.41704116,11901234,11926104)Jilin Provincial Excellent Youth Talents Foundation(Grant No.20180520093JH)+1 种基金Scientific Research Project of Education Department of Jilin Province(Grant No.JJKH20200933KJ)Scientific Research Project of Shanghai Science and Technology Commission(Grant No.19511132000)。
文摘While the spread of COVID-19 in China is under control,the pandemic is developing rapidly around the world.Due to the normal migration of population,China is facing the high risk from imported cases.The potential specific medicine and vaccine are still in the process of clinical trials.Currently,controlling the impact of imported cases is the key to prevent new outbreak of COVID-19 in China.In this paper,we propose two impulsive systems to describe the impact of multilateral imported cases of COVID-19.Based on the published data,we simulate and analyze the epidemic trends under different control strategies.In particular,we compare four different scenarios and show the corresponding medical burden.The results can be useful in designing appropriate control strategy for imported cases in practice.
基金funded by the COVID-19 Project of Shaanxi Administration of Traditional Chinese Medicine[SZY-KJCYC-2020-YJ002]the COVID-19 Project of National Administration of Traditional Chinese Medicine[2020ZYLCYJ06-4]and the CACMS Innovation Fund[CI2021A00704].
文摘Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographics, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month follow-up.Results Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent cases.Conclusions Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.
基金Sichuan provincial department of science and technology emergency project responding to COVID-19(No.2020YFS0005,2020YFS0564)Chengdu municipal health commission project(No.2020040)。
文摘Objective:To analyze the epidemiological and clinical characteristics of foreign-imported patients infected with SARS-CoV-2 in Chengdu City.Methods:A total of 290 foreign-imported patients infected with SARS-CoV-2 and discharged from Public Health Clinical Center of Chengdu were included in our study,they were divided into asymptomatic infection group(131 cases)and confirmed cases group(159 cases)in order to compare the epidemiology,clinical characteristics and laboratory tests between two groups.Multi-factor logistic regression analysis was used to investigate the influence factors of becoming a dominant infection after infected with SARS-CoV-2.Results:Among the 290 cases aged from 2 months to 68 years old,83.4%were males,62.1%came from Asia,and 43.8%were complicated with fatty liver disease,the age group of 14-49 years old had the largest number(247 cases).80.5%confirmed case group cases were general type,there was only 1 severe patient.Hospital stays in asymptomatic infection group was shorter than that in confirmed cases group,lymphocyte count,CD4+T count,CD8+T count,CD4+T/CD8+T creatine kinase in two groups half a month after discharge were relatively lower than those on admission,and alanine aminotransferase,aspartate aminotransferase,albumin,lactate dehydrogenase,creatine kinase isoenzyme were relatively higher than those on admission(P<0.05).Logistic regression analysis showed that increased age,decreased lymphocyte count on admission and increased lactate dehydrogenase on admission were associated with dominant infection.Chest CT of 13 general type cases indicated an increase in lesions compared with that at discharge and 3 of them had re-detectable positive RNA test.Conclusion:The majority of foreign-imported cases in Chengdu are mainly from Asia,fewer of them are severe patients.In the early stage of recovery,some SARS-CoV-2 infected patients still have intermittent viral replication.Early isolation and early treatment of imported patients is not only conducive to epidemic prevention and control,but also may change the natural course of the disease.
