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Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus 被引量:7
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作者 HWEI-HSIEN CHEN TANGENG MA +1 位作者 ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1998年第1期61-69,共9页
Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has ... Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. 展开更多
关键词 ACTIVITY PB Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the rat Hippocampus
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Diazinon Toxicokinetics, Tissue Distribution and Anticholinesterase Activity in the Rat
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作者 H. X. WU CL. EVREUX-GROS AND J. DESCOTESa (Department of Pharmacology and Medical Toxicology, INSERM U80,LYON-RTH Laennec Faculty of Medicine, 69008 Lyon France) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1996年第4期359-369,共11页
The toxicokinetics, tissue distribution, and anticholinesteruse (antiChE ) activity of diazinon were investigated in the rat. Plasma concentrations most adequately fitted a two-compartment open model after iv adminis... The toxicokinetics, tissue distribution, and anticholinesteruse (antiChE ) activity of diazinon were investigated in the rat. Plasma concentrations most adequately fitted a two-compartment open model after iv administration of 10 mg/kg and a one-compartment model after oral administration of 80 mg/kg. Diazinon elimination half-life following iv and oral dosing was 4.70 and 2.86 h, respectively. The oral bioavailabllity was found to be low (35.5%). Hepatic extraction ratios after iv administration of 5 or 10 mg 展开更多
关键词 ACTIVITY Diazinon Toxicokinetics Tissue Distribution and Anticholinesterase Activity in the rat
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Effect of Selenium on Aflatoxin Hepatocarcinogenesis in the Rat
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作者 BORIS H.RUEBNER DENNIS P. H. HSIEH 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1990年第1期65-80,共16页
The effects of selenium (Na_2SeO_3) on aflatoxin B_1 (AFB_1)-induced hepatic neoplasia were studied in the rat. Putative preneoplastic foci and nodules composed of basophilic, eosinophilic, and clear cells developed e... The effects of selenium (Na_2SeO_3) on aflatoxin B_1 (AFB_1)-induced hepatic neoplasia were studied in the rat. Putative preneoplastic foci and nodules composed of basophilic, eosinophilic, and clear cells developed early. Basophilic foci were seen first; in the later stages basophilic and eosinophilic nodules predominated. At each stage the AFB_1 + Se groups showed fewer and smaller foci and nodules than the AFB_1 -Se group. The number of foci in the AFB_1 + 3 ppm Se group and their mean area were smaller than those in the 6 ppm Se + AFB_1 group. At the end of the experiment hepatocellular carcinoma (HCC) was found in 11/18 rats (61%) of the AFB_1-Se group. HCC was not found in either of the groups given AFB_1 +Se. We conclude that Se had an inhibitory effect on the initiation and promotion stages of AFB_1-induced preneoplastic foci and nodules. Se also prevented progression of these nodules to HCC even after cessation of AFB_1 administration. The inhibitory effect of Se at 3 ppm was greater than at 6 ppm. The 6 ppm Se group also showed evidence of toxicity. 1990 Academic Press.Inc. 展开更多
关键词 Effect of Selenium on Aflatoxin Hepatocarcinogenesis in the rat
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Effect of oxidative stress-associated damage to the lung tissue caused by different body mass index in the rat models
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作者 李筱妍 《China Medical Abstracts(Internal Medicine)》 2017年第1期40-41,共2页
Objective To investigate the influence of different diets on serum protein expression levels of 4-hydroxynonenal(4-HNE),thioredoxin(Trx),thioredoxin reductase(TrxR)and the sctivities of Trx and TrxR,and to explore the... Objective To investigate the influence of different diets on serum protein expression levels of 4-hydroxynonenal(4-HNE),thioredoxin(Trx),thioredoxin reductase(TrxR)and the sctivities of Trx and TrxR,and to explore the effect of damage to the lung tissue and the underlying mechanisms of different body mass index caused by different diets in the rat models.Methods 展开更多
关键词 Effect of oxidative stress-associated damage to the lung tissue caused by different body mass index in the rat models lung body
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