Propoxur is a widely used dithiocarbamate insecticide. In this study, the clastogenic effect of propoxur has been evaluated using chromosomal aberration assay in mouse bone marrow cells. Single i. p. administration of...Propoxur is a widely used dithiocarbamate insecticide. In this study, the clastogenic effect of propoxur has been evaluated using chromosomal aberration assay in mouse bone marrow cells. Single i. p. administration of propoxur, at 25 mg/kg b.wt., a maximum tolerated dose (MTD) and 12 .5mg/kg b.wt (50% of MTD) have significantly induced different types of aberrations after 24 h of treatment. The aberrations were dose and time dependent and reached a maximum after 24 h of exposure. The sresult suggest a genotoxic potential of propoxur.展开更多
ULF-23HU fish cell line derived from the fin ofcentral mudminnow (Umbra limi) has an idealkaryotype (2n=23) for clastogenicity test ofmutagenic carcinogens.In this connection,sensitivity of this cell line to direct ac...ULF-23HU fish cell line derived from the fin ofcentral mudminnow (Umbra limi) has an idealkaryotype (2n=23) for clastogenicity test ofmutagenic carcinogens.In this connection,sensitivity of this cell line to direct actingmutagens was evaluated at the level of inductionof chromosomal aberration.ULF-23HU cells展开更多
文摘Propoxur is a widely used dithiocarbamate insecticide. In this study, the clastogenic effect of propoxur has been evaluated using chromosomal aberration assay in mouse bone marrow cells. Single i. p. administration of propoxur, at 25 mg/kg b.wt., a maximum tolerated dose (MTD) and 12 .5mg/kg b.wt (50% of MTD) have significantly induced different types of aberrations after 24 h of treatment. The aberrations were dose and time dependent and reached a maximum after 24 h of exposure. The sresult suggest a genotoxic potential of propoxur.
文摘ULF-23HU fish cell line derived from the fin ofcentral mudminnow (Umbra limi) has an idealkaryotype (2n=23) for clastogenicity test ofmutagenic carcinogens.In this connection,sensitivity of this cell line to direct actingmutagens was evaluated at the level of inductionof chromosomal aberration.ULF-23HU cells