A potentiometric study on the complexes of His,Gly-His,ALa-His,Gly-Gly and Gly—Gly—Gly with Zn(Ⅱ)and Cd(Ⅱ)has been reported.Small-scale potentiometric titrations were car- ried out to determine stabil ity constant...A potentiometric study on the complexes of His,Gly-His,ALa-His,Gly-Gly and Gly—Gly—Gly with Zn(Ⅱ)and Cd(Ⅱ)has been reported.Small-scale potentiometric titrations were car- ried out to determine stabil ity constants of complexes at 25℃ with I=0.10 mol dm^(-3)(KNO_3).The com- puter programs SUPERQUAD were applied for data treatment with satisfactory results.展开更多
Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Z...Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Zn-ions and 4-phenylimidazole(PI),the latter of which is an inhibitor of indoleamine 2,3-dioxygenase(IDO)and acts as an organic bridging ligand via Zn–N coordination bonds.展开更多
Dengue is an acute arthropode-borne virus,belonging to the family Flaviviridae.Currently,there are no vaccines or treatments available against dengue.Thus it is important to understand the dynamics of dengue in order ...Dengue is an acute arthropode-borne virus,belonging to the family Flaviviridae.Currently,there are no vaccines or treatments available against dengue.Thus it is important to understand the dynamics of dengue in order to control the infection.In this paper,we study the long-term dynamics of the model that is presented in[S.D.Peera and S.S.N.Perera,Simulation model for dynamics of dengue with innate and humoral immune responses,Comput.Math.Methods Med.2018(2018)8798057,18 pp.doi:10.1155/2018/8798057]which describes the interaction of virus with infected and uninfected cells in the presence of innate and humoral immune responses.It was found the model has three equilibria,namely:infection free equilibrium,no immune equilibrium and endemic equilibrium,then analyzed its stability analytically.The analytical findings of each model have been exemplified by numerical simulations.Given the fact that intensity of dengue virus replication at early times of infection could determine clinical outcomes,it is important to understand the impact of innate immunity,which is believed to be the first line of defense against an invading pathogen.For this we carry out a simulation case study to investigate the importance of innate immune response on dengue virus dynamics.A comparison was done assurming that innate immunity was active;innate immunity was in quasi-steady state and innate immunity was inactive during the virus replication process.By a further analysis of the qualitative behavior of the quasi-steady state,it was observed that innate immune response plays a pivotal role in dengue virus dynamics.It can change the dynamical behavior of the system and is essential for the virus clearance.展开更多
文摘A potentiometric study on the complexes of His,Gly-His,ALa-His,Gly-Gly and Gly—Gly—Gly with Zn(Ⅱ)and Cd(Ⅱ)has been reported.Small-scale potentiometric titrations were car- ried out to determine stabil ity constants of complexes at 25℃ with I=0.10 mol dm^(-3)(KNO_3).The com- puter programs SUPERQUAD were applied for data treatment with satisfactory results.
基金supported by the National Research Programs of China(no.2016YFA0201200)the National Natural Science Foundation of China(nos.51525203,51761145041,and 51572180)+2 种基金the China Postdoctoral Science Foundation(no.2020M671143)Collaborative Innovation Center of Suzhou Nano Science and Technology,a Jiangsu Natural Science Fund for Distinguished Young Scholars(no.BK20170063)and a Project Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,and a Project Funded for Postgraduate Research&Practice Innovation Program of Jiangsu Province(no.2019 SJKY19_2282).
文摘Nanoscale coordination polymers(NCPs)constructed by metal ions and organic ligands via metal–ligand bonds have attracted great attention for their biomedical application.Herein,a new type of NCP is constructed from Zn-ions and 4-phenylimidazole(PI),the latter of which is an inhibitor of indoleamine 2,3-dioxygenase(IDO)and acts as an organic bridging ligand via Zn–N coordination bonds.
文摘Dengue is an acute arthropode-borne virus,belonging to the family Flaviviridae.Currently,there are no vaccines or treatments available against dengue.Thus it is important to understand the dynamics of dengue in order to control the infection.In this paper,we study the long-term dynamics of the model that is presented in[S.D.Peera and S.S.N.Perera,Simulation model for dynamics of dengue with innate and humoral immune responses,Comput.Math.Methods Med.2018(2018)8798057,18 pp.doi:10.1155/2018/8798057]which describes the interaction of virus with infected and uninfected cells in the presence of innate and humoral immune responses.It was found the model has three equilibria,namely:infection free equilibrium,no immune equilibrium and endemic equilibrium,then analyzed its stability analytically.The analytical findings of each model have been exemplified by numerical simulations.Given the fact that intensity of dengue virus replication at early times of infection could determine clinical outcomes,it is important to understand the impact of innate immunity,which is believed to be the first line of defense against an invading pathogen.For this we carry out a simulation case study to investigate the importance of innate immune response on dengue virus dynamics.A comparison was done assurming that innate immunity was active;innate immunity was in quasi-steady state and innate immunity was inactive during the virus replication process.By a further analysis of the qualitative behavior of the quasi-steady state,it was observed that innate immune response plays a pivotal role in dengue virus dynamics.It can change the dynamical behavior of the system and is essential for the virus clearance.
