The title compound 1-(4-chlorophenyl)-2-cyano-3-amino-3a-hydroxy-3a,3b,6,7- tetrahydro-benzo[4,5]indene 2, has been synthesized by the reductive cyclization of 2-cyano-3- (4-chlorophenyl)-3-(1-tetralon-2-yl) pro...The title compound 1-(4-chlorophenyl)-2-cyano-3-amino-3a-hydroxy-3a,3b,6,7- tetrahydro-benzo[4,5]indene 2, has been synthesized by the reductive cyclization of 2-cyano-3- (4-chlorophenyl)-3-(1-tetralon-2-yl) propionitrile 1 induced by low-valent titanium reagent and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group C2/c with a = 28.244(7), b = 14.401(3), c = 21.245(3)A,β= 115.71(2)°, V = 7786(3)A^3, Mr= 696.13, Dc = 1.188 g/cm^3, Z = 8,μ(MoKα) = 0.208 mm^-1, F(000) = 2916, R = 0.0783 and wR = 0.2350. X-ray analysis reveals that the five-membered ring (C(7)~C(l l)) adopts an envelop conformation, while the six-membered ring (C(10)~C(14), C(19)) has a half-chair conformation. Meanwhile, intermolecular H-bond interactions result in the formation of polymer.展开更多
The syntheses of three novel substituted indanones namely 2,7 dimethylindan 1 one, 2 methyl 4,7 diethylindan 1 one and 2,4 dimethyl 7 methoxyindan 1 one are described. These indanones were prepared by different routes...The syntheses of three novel substituted indanones namely 2,7 dimethylindan 1 one, 2 methyl 4,7 diethylindan 1 one and 2,4 dimethyl 7 methoxyindan 1 one are described. These indanones were prepared by different routes involving intramolecular ring closure of aryl substituted compounds by Friedel Crafts reaction. The t butyl was used as the positional protective group in the selective preparation of 2,7 dimethylindan 1 one. The corresponding indenes were prepared by reduction and dehydration reactions from these indanones.展开更多
This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12...This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.展开更多
An unprecedented gold-catalyzed ketene C=O/C=C bifunctionalization method has been developed.Mechanistic studies and density function theory(DFT)calculations indicate that the reaction is initiated by gold-catalyzed W...An unprecedented gold-catalyzed ketene C=O/C=C bifunctionalization method has been developed.Mechanistic studies and density function theory(DFT)calculations indicate that the reaction is initiated by gold-catalyzed Wolff rearrangement of diazoketone to form the ketene intermediate,followed by intermolecular nucleophilic addition and terminated with two divergent cyclization processes via enol intermediates.In the case with alcohols as the nucleophiles,the reaction goes through a C-5-endodig carbocyclization to give the indene products;whereas,O-7-endo-dig cyclization occurs dominantly when indoles/pyrroles are used as the nucleophiles,delivering the 7-membered benzo[d]oxepines.In comparison with the well-documented cycloaddition and nucleophilic addition reactions,this cascade reaction features a novel reaction pattern for the ketene dual functionalization through addition with nucleophile and electrophile in sequence.展开更多
Aryl sulfonyl radical triggered cascade cyclization of phenyl-linked 1,6-enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10a,11-dihydro-10H-benzo[b]fluorines is presented.I...Aryl sulfonyl radical triggered cascade cyclization of phenyl-linked 1,6-enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10a,11-dihydro-10H-benzo[b]fluorines is presented.In these radical cascade processes,three new chemical bonds,including C—S,C—C,and C—X bonds,and three C—C bonds are formed in one step.The method is attractive and valuable due to its metal-free,mild reaction conditions,broad substrate scope and good functional group tolerance.展开更多
The indene moiety is an important unit because of its presence in many chemical catalysts, functional materials and biologically relevant molecules. Herein, we report a facile reaction of arylallenes with benzylic or ...The indene moiety is an important unit because of its presence in many chemical catalysts, functional materials and biologically relevant molecules. Herein, we report a facile reaction of arylallenes with benzylic or allylic alcohols through TfOH/Fe(OTf)3 cocatalyzed cleavage of sp3 carbon-oxygen. In the presence of 5 mol% TfOH and 5 mol% Fe(OTf)3, a range of arylallenes undergo carbocation initiated cyclization reaction with alkyl alcohols to give structurally diverse polysubstituted indenes in good to excellent yields. H2O is the sole byproduct that makes this transformation highly atom-economic and environmentally benign.展开更多
The crystal structure of the title compound (C18H16, Mr = 232.31) has been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 6.3449(9), b = 6.6297(9), c = 15.727(...The crystal structure of the title compound (C18H16, Mr = 232.31) has been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 6.3449(9), b = 6.6297(9), c = 15.727(2) ? ?= 94.338(3), ?= 0.71073 ? ?= 0.066 mm-1, V = 659.66(16) 3, Z = 2, Dc = 1.170 g/cm3 and F(000) = 248. The structure was refined to R = 0.0560 and wR = 0.1426 for 771 observed reflections with I > 2(I). X-ray diffraction analysis reveals that the title compound is a dimer of indene.展开更多
This paper discloses the reaction mechanism of two consecutive but different visible light photo-induced chain processes for the rapid construction of spirobi[indene]skeletons.The first process is triggered by a photo...This paper discloses the reaction mechanism of two consecutive but different visible light photo-induced chain processes for the rapid construction of spirobi[indene]skeletons.The first process is triggered by a photo-induced single-electron-transfer(SET)of an electron donor-accepter(EDA)complex.The second process is initiated by a direct SET process between aryldiazonium salt and the excited allenic intermediate.In these two processes,another SET took place respectively on the in situ formed radical intermediate to realize a redox-neutral outcome.The mechanistic studies have been carried out by control experiments,kinetic and spectroscopic analyses,deuterium labeling experiments to support these two chain processes.展开更多
基金This work was supported by the Education Committee Natural Science Foundation (No. 03KJB 150136).
文摘The title compound 1-(4-chlorophenyl)-2-cyano-3-amino-3a-hydroxy-3a,3b,6,7- tetrahydro-benzo[4,5]indene 2, has been synthesized by the reductive cyclization of 2-cyano-3- (4-chlorophenyl)-3-(1-tetralon-2-yl) propionitrile 1 induced by low-valent titanium reagent and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group C2/c with a = 28.244(7), b = 14.401(3), c = 21.245(3)A,β= 115.71(2)°, V = 7786(3)A^3, Mr= 696.13, Dc = 1.188 g/cm^3, Z = 8,μ(MoKα) = 0.208 mm^-1, F(000) = 2916, R = 0.0783 and wR = 0.2350. X-ray analysis reveals that the five-membered ring (C(7)~C(l l)) adopts an envelop conformation, while the six-membered ring (C(10)~C(14), C(19)) has a half-chair conformation. Meanwhile, intermolecular H-bond interactions result in the formation of polymer.
文摘The syntheses of three novel substituted indanones namely 2,7 dimethylindan 1 one, 2 methyl 4,7 diethylindan 1 one and 2,4 dimethyl 7 methoxyindan 1 one are described. These indanones were prepared by different routes involving intramolecular ring closure of aryl substituted compounds by Friedel Crafts reaction. The t butyl was used as the positional protective group in the selective preparation of 2,7 dimethylindan 1 one. The corresponding indenes were prepared by reduction and dehydration reactions from these indanones.
基金the National Natural Science Foundation of China(Nos.NSF22061038,NSF22067018)the Long Yuan Youth Innovative Project of Gansu Province(No.2019-39)+1 种基金the Northwest Normal University Young Scholars Research Capacity Improvement Program(No.NWNU-LKQN-2020-04)Computations reported in this paper were performed on the computer clusters at the Centre for Scientific Modeling and Computation,CUHK.
文摘This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.
基金This work was supported by the National Natural Science Foundation of China(21971262,92056201)the National Postdoctoral Program for Innovative Talents(BX20190399)+3 种基金Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery(2019B030301005)the National Mega-project for Innovative Drugs(2019ZX09721001-006-001)the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2016ZT06Y337)the Fundamental Research Funds for the Central Universities(20ykpy113,18843407).
文摘An unprecedented gold-catalyzed ketene C=O/C=C bifunctionalization method has been developed.Mechanistic studies and density function theory(DFT)calculations indicate that the reaction is initiated by gold-catalyzed Wolff rearrangement of diazoketone to form the ketene intermediate,followed by intermolecular nucleophilic addition and terminated with two divergent cyclization processes via enol intermediates.In the case with alcohols as the nucleophiles,the reaction goes through a C-5-endodig carbocyclization to give the indene products;whereas,O-7-endo-dig cyclization occurs dominantly when indoles/pyrroles are used as the nucleophiles,delivering the 7-membered benzo[d]oxepines.In comparison with the well-documented cycloaddition and nucleophilic addition reactions,this cascade reaction features a novel reaction pattern for the ketene dual functionalization through addition with nucleophile and electrophile in sequence.
基金the National Natural Science Foundation of China(No.21861043)the Yunnan Fundamental Research Projects(No.2019FB016)Scientific and Technological Innovation Team of Optical Functional Materials of Yunnan Provincial Education Department forfinancial support.
文摘Aryl sulfonyl radical triggered cascade cyclization of phenyl-linked 1,6-enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10a,11-dihydro-10H-benzo[b]fluorines is presented.In these radical cascade processes,three new chemical bonds,including C—S,C—C,and C—X bonds,and three C—C bonds are formed in one step.The method is attractive and valuable due to its metal-free,mild reaction conditions,broad substrate scope and good functional group tolerance.
基金We are grateful for the financial support from the National Natural Science Foundation of China (No. 21202154), the Natural Science Foundation of The Jiangsu Higher Education Institutes of China (15KJB150007), the Nanjing Institute of Technology Scientific Research Foundation for Introducing Talents (No. ZKJ201614), and Nanjing Institute of Technology.
文摘The indene moiety is an important unit because of its presence in many chemical catalysts, functional materials and biologically relevant molecules. Herein, we report a facile reaction of arylallenes with benzylic or allylic alcohols through TfOH/Fe(OTf)3 cocatalyzed cleavage of sp3 carbon-oxygen. In the presence of 5 mol% TfOH and 5 mol% Fe(OTf)3, a range of arylallenes undergo carbocation initiated cyclization reaction with alkyl alcohols to give structurally diverse polysubstituted indenes in good to excellent yields. H2O is the sole byproduct that makes this transformation highly atom-economic and environmentally benign.
文摘The crystal structure of the title compound (C18H16, Mr = 232.31) has been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 6.3449(9), b = 6.6297(9), c = 15.727(2) ? ?= 94.338(3), ?= 0.71073 ? ?= 0.066 mm-1, V = 659.66(16) 3, Z = 2, Dc = 1.170 g/cm3 and F(000) = 248. The structure was refined to R = 0.0560 and wR = 0.1426 for 771 observed reflections with I > 2(I). X-ray diffraction analysis reveals that the title compound is a dimer of indene.
基金support from the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XD2000000)the National Natural Science Foundation of China(21421091,21372250,21121062,21302203,20732008,21772037,21772226,21861132014 and 91956115).
文摘This paper discloses the reaction mechanism of two consecutive but different visible light photo-induced chain processes for the rapid construction of spirobi[indene]skeletons.The first process is triggered by a photo-induced single-electron-transfer(SET)of an electron donor-accepter(EDA)complex.The second process is initiated by a direct SET process between aryldiazonium salt and the excited allenic intermediate.In these two processes,another SET took place respectively on the in situ formed radical intermediate to realize a redox-neutral outcome.The mechanistic studies have been carried out by control experiments,kinetic and spectroscopic analyses,deuterium labeling experiments to support these two chain processes.