Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale

BACKGROUND Our study expand upon a large body of evidence in the field of neuropsychiatric imaging with cognitive,affective and behavioral tasks,adapted for the functional magnetic resonance imaging(MRI)(fMRI)experimental environment.There is sufficient evidence that common networks underpin activations in task-based fMRI across different mental disorders.AIM To investigate whether there exist specific neural circuits which underpin differ-ential item responses to depressive,paranoid and neutral items(DN)in patients respectively with schizophrenia(SCZ)and major depressive disorder(MDD).METHODS 60 patients were recruited with SCZ and MDD.All patients have been scanned on 3T magnetic resonance tomography platform with functional MRI paradigm,comprised of block design,including blocks with items from diagnostic paranoid(DP),depression specific(DS)and DN from general interest scale.We performed a two-sample t-test between the two groups-SCZ patients and depressive patients.Our purpose was to observe different brain networks which were activated during a specific condition of the task,respectively DS,DP,DN.RESULTS Several significant results are demonstrated in the comparison between SCZ and depressive groups while performing this task.We identified one component that is task-related and independent of condition(shared between all three conditions),composed by regions within the temporal(right superior and middle temporal gyri),frontal(left middle and inferior frontal gyri)and limbic/salience system(right anterior insula).Another com-ponent is related to both diagnostic specific conditions(DS and DP)e.g.It is shared between DEP and SCZ,and includes frontal motor/language and parietal areas.One specific component is modulated preferentially by to the DP condition,and is related mainly to prefrontal regions,whereas other two components are significantly modulated with the DS condition and include clusters within the default mode network such as posterior cingulate and precuneus,several occipital areas,including lingual and fusiform gyrus,as well as parahippocampal gyrus.Finally,component 12 appeared to be unique for the neutral condition.In addition,there have been determined circuits across components,which are either common,or distinct in the preferential processing of the sub-scales of the task.CONCLUSION This study has delivers further evidence in support of the model of trans-disciplinary cross-validation in psychiatry.

Investigating Neural Representation of Finger-Movement Directions Using Electroencephalography Independent Components

There are few EEG studies on finger movement directions because ocular artifacts also convey directional information, which makes it hard to separate the contribution of EEG from that of the ocular artifacts. To overcome this issue, we designed an experiment in which EEG’s temporal dynamics and spatial information are evaluated together to improve the performance of brain-computer interface (BCI) for classifying finger movement directions. Six volunteers participated in the study. We examined their EEG using decoding analyses. Independent components (ICs) that represented brain-source signals successfully classified the directions of the finger movements with higher rates than chance level. The weight analyses of the classifiers revealed that maximal performance of the classification was recorded at the latencies prior to the onset of finger movements. The weight analyses also revealed the relevant cortical areas including the right lingual, left posterior cingulate, left inferior temporal gyrus, and right precuneus, which indicated the involvement of the visuospatial processing. We concluded that combining spatial distribution and temporal dynamics of the scalp EEG may improve BCI performance.

Comparison of Principal Components Analysis,Independent Components Analysis and Common Components Analysis

The aim of this work is to describe and compare three exploratory chemometrical tools,principal components analysis,independent components analysis and common components analysis,the last one being a modification of the multi-block statistical method known as common components and specific weights analysis.The three methods were applied to a set of data to show the differences and similarities of the results obtained,highlighting their complementarity.

Classification of schizophrenic patients and healthy controls using multiple spatially independent components of structural MRI data

Several meta-analyses were recently conducted in attempts to identify the core brain regions exhibiting pathological changes in schizophrenia,which could potentially act as disease markers.Based on the findings of these meta-analyses,we developed a multivariate pattern analysis method to classify schizophrenic patients and healthy controls using structural magnetic resonance imaging(sMRI)data.Independent component analysis(ICA)was used to decompose gray matter density images into a set of spatially independent components.Spatial multiple regression of a region of interest(ROI)mask with each of the components was then performed to determine pathological patterns,in which the voxels were taken as features for classification.After dimensionality reduction using principal component analysis(PCA),a nonlinear support vector machine(SVM)classifier was trained to discriminate schizophrenic patients from healthy controls.The performance of the classifier was tested using a 10-fold cross-validation strategy.Experimental results showed that two distinct spatial patterns displayed discriminative power for schizophrenia,which mainly included the prefrontal cortex(PFC)and subcortical regions respectively.It was found that simultaneous usage of these two patterns improved the classification performance compared to using either of them alone.Moreover,the two pathological patterns constitute a prefronto-subcortical network,suggesting that schizophrenia involves abnormalities in networks of brain regions.

Modeling dam deformation using independent component regression method

In the application of regression analysis method to model dam deformation, the ill-condition problem occurred in coefficient matrix always prevents an accurate modeling mainly due to the multicollinearity of the variables. Independent component regression （ICR） was proposed to model the dam deformation and identify the physical origins of the deformation. Simulation experiment shows that ICR can successfully resolve the problem of ill-condition and produce a reliable deformation model. After that, the method is applied to model the deformation of the Wuqiangxi Dam in Hunan province, China. The result shows that ICR can not only accurately model the deformation of the dam, but also help to identify the physical factors that affect the deformation through the extracted independent components.

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.

Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health concern.Epidemiological surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of suicide.In studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is sparse.Some researchers even mistakenly regard the signals generated by the WM as noise points.In fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal fluctuations.The alterations in WM signals and their relationship with disease severity in adolescents with MDD remain unclear.AIM To explore potential abnormalities in WM functional signals in adolescents with MDD.METHODS This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide inventory.In addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image data.The DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC groups.Independent component analysis(ICA)was also used to evaluate the WM functional signal.Pearson’s correlation was performed to assess the relationship between statistical test results and clinical scales.RESULTS Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel correction).The ICA results of WM overlapped with those of regional homogeneity.The fALFF of WM signal in the left posterior limb of the internal capsule was negatively correlated with the MINI suicide scale(P=0.026,r=-0.32),and the right posterior corona radiata was also negatively correlated with the MINI suicide scale(P=0.047,r=-0.288).CONCLUSION Adolescents with MDD involves changes in WM functional signals,and these differences in brain regions may increase the risk of suicide.

Source Separation of Diesel Engine Vibration Based on the Empirical Mode Decomposition and Independent Component Analysis

Vibration signals from diesel engine contain many different components mainly caused by combustion and mechanism operations,several blind source separation techniques are available for decomposing the signal into its components in the case of multichannel measurements,such as independent component analysis（ICA）.However,the source separation of vibration signal from single-channel is impossible.In order to study the source separation from single-channel signal for the purpose of source extraction,the combination method of empirical mode decomposition（EMD） and ICA is proposed in diesel engine signal processing.The performance of the described methods of EMD-wavelet and EMD-ICA in vibration signal application is compared,and the results show that EMD-ICA method outperforms the other,and overcomes the drawback of ICA in the case of single-channel measurement.The independent source signal components can be separated and identified effectively from one-channel measurement by EMD-ICA.Hence,EMD-ICA improves the extraction and identification abilities of source signals from diesel engine vibration measurements.

SIGNAL FEATURE EXTRACTION BASED UPON INDEPENDENT COMPONENT ANALYSIS AND WAVELET TRANSFORM

It is an important precondition for machine fault diagnosis that vibrationsignal can be extracted effectively. Based on the characteristic of noise interfused during thecourse of sampling vibration signal, independent component analysis (ICA) method is combined withwavelet to de-noise. Firstly, The sampled signal can be separated with ICA, then the function offrequency band chosen with multi-resolution wavelet transform can be used to judge whether thestochastic disturbance singular signal is interfused. By these ways, the vibration signals can beextracted effectively, which provides favorable condition for subsequent feature detection ofvibration signal and fault diagnosis.

Independent component analysis approach for fault diagnosis of condenser system in thermal power plant

A statistical signal processing technique was proposed and verified as independent component analysis(ICA) for fault detection and diagnosis of industrial systems without exact and detailed model.Actually,the aim is to utilize system as a black box.The system studied is condenser system of one of MAPNA's power plants.At first,principal component analysis(PCA) approach was applied to reduce the dimensionality of the real acquired data set and to identify the essential and useful ones.Then,the fault sources were diagnosed by ICA technique.The results show that ICA approach is valid and effective for faults detection and diagnosis even in noisy states,and it can distinguish main factors of abnormality among many diverse parts of a power plant's condenser system.This selectivity problem is left unsolved in many plants,because the main factors often become unnoticed by fault expansion through other parts of the plants.

Study of engine noise based on independent component analysis

Independent component analysis was applied to analyze the acoustic signals from diesel engine. First the basic prin-ciple of independent component analysis (ICA) was reviewed. Diesel engine acoustic signal was decomposed into several inde-pendent components (ICs); Fourier transform and continuous wavelet transform (CWT) were applied to analyze the independent components. Different noise sources of the diesel engine were separated, based on the characteristics of different component in time-frequency domain.

Independent Component Analysis Based Blind Adaptive Interference Reduction and Symbol Recovery for OFDM Systems

To overcome the inter-carrier interference （ICI） of orthogonal frequency division multiplexing （OFDM） systems subject to unknown carrier frequency offset （CFO） and multipath, this paper develops a blind adaptive interference suppression scheme based on independent component analysis （ICA）. Taking into account statistical independence of subcarriers＇ signals of OFDM, the signal recovery mechanism is investigated to achieve the goal of blind equalization. The received OFDM signals can be considered as the mixed observation signals. The effect of CFO and multipath corresponds to the mixing matrix in the problem of blind source separation （BSS） framework. In this paper, the ICA- based OFDM system model is built, and the proposed ICA-based detector is exploited to extract source signals from the observation of a received mixture based on the assumption of statistical independence between the sources. The blind separation technique can increase spectral efficiency and provide robustness performance against erroneous parameter estimation problem. Theoretical analysis and simulation results show that compared with the conventional pilot-based scheme, the improved performance of OFDM systems is obtained by the proposed ICA-based detection technique.

Small Target Extraction Based on Independent Component Analysis for Hyperspectral Imagery

A small target detection approach based on independent component analysis for hyperspectral data is put forward. In this algorithm, firstly the fast independent component analysis(FICA) is used to collect target information hided in high-dimensional data and projects them into low-dimensional space.Secondly, the feature images are selected with kurtosis .At last, small targets are extracted with histogram image segmentation which has been labeled by skewness.

Blind Separation of Speech Signals Based on Wavelet Transform and Independent Component Analysis

Speech signals in frequency domain were separated based on discrete wavelet transform (DWT) and independent component analysis (ICA). First, mixed speech signals were decomposed into different frequency domains by DWT and the subbands of speech signals were separated using ICA in each wavelet domain; then, the permutation and scaling problems of frequency domain blind source separation (BSS) were solved by utilizing the correlation between adjacent bins in speech signals; at last, source signals were reconstructed from single branches. Experiments were carried out with 2 sources and 6 microphones using speech signals at sampling rate of 40 kHz. The microphones were aligned with 2 sources in front of them, on the left and right. The separation of one male and one female speeches lasted 2.5 s. It is proved that the new method is better than single ICA method and the signal to noise ratio is improved by 1 dB approximately.

A new process monitoring method based on noisy time structure independent component analysis

Conventional process monitoring method based on fast independent component analysis(Fast ICA) cannot take the ubiquitous measurement noises into account and may exhibit degraded monitoring performance under the adverse effects of the measurement noises. In this paper, a new process monitoring approach based on noisy time structure ICA(Noisy TSICA) is proposed to solve such problem. A Noisy TSICA algorithm which can consider the measurement noises explicitly is firstly developed to estimate the mixing matrix and extract the independent components(ICs). Subsequently, a monitoring statistic is built to detect process faults on the basis of the recursive kurtosis estimations of the dominant ICs. Lastly, a contribution plot for the monitoring statistic is constructed to identify the fault variables based on the sensitivity analysis. Simulation studies on the continuous stirred tank reactor system demonstrate that the proposed Noisy TSICA-based monitoring method outperforms the conventional Fast ICA-based monitoring method.

Altered intra- and inter-network brain functional connectivity in upper-limb amputees revealed through independent component analysis

Although cerebral neuroplasticity following amputation has been observed, little is understood about how network-level functional reorganization occurs in the brain following upper-limb amputation. The objective of this study was to analyze alterations in brain network functional connectivity(FC) in upper-limb amputees(ULAs). This observational study included 40 ULAs and 40 healthy control subjects;all participants underwent resting-state functional magnetic resonance imaging. Changes in intra-and inter-network FC in ULAs were quantified using independent component analysis and brain network FC analysis. We also analyzed the correlation between FC and clinical manifestations, such as pain. We identified 11 independent components using independent component analysis from all subjects. In ULAs, intra-network FC was decreased in the left precuneus(precuneus gyrus) within the dorsal attention network and left precentral(precentral gyrus) within the auditory network;but increased in the left Parietal_Inf(inferior parietal, but supramarginal and angular gyri) within the ventral sensorimotor network, right Cerebelum_Crus2(crus Ⅱ of cerebellum) and left Temporal_Mid(middle temporal gyrus) within the ventral attention network, and left Rolandic_Oper(rolandic operculum) within the auditory network. ULAs also showed decreased inter-network FCs between the dorsal sensorimotor network and ventral sensorimotor network, the dorsal sensorimotor network and right frontoparietal network, and the dorsal sensorimotor network and dorsal attention network. Correlation analyses revealed negative correlations between inter-network FC changes and residual limb pain and phantom limb pain scores, but positive correlations between inter-network FC changes and daily activity hours of stump limb. These results show that post-amputation plasticity in ULAs is not restricted to local remapping;rather, it also occurs at a network level across several cortical regions. This observation provides additional insights into the plasticity of brain networks after upper-limb amputation, and could contribute to identification of the mechanisms underlying post-amputation pain.

Abundance quantification by independent component analysis of hyperspectral imagery for oil spill coverage calculation

The estimation of oil spill coverage is an important part of monitoring of oil spills at sea.The spatial resolution of images collected by airborne hyper-spectral remote sensing limits both the detection of oil spills and the accuracy of estimates of their size.We consider at-sea oil spills with zonal distribution in this paper and improve the traditional independent component analysis algorithm.For each independent component we added two constraint conditions:non-negativity and constant sum.We use priority weighting by higher-order statistics,and then the spectral angle match method to overcome the order nondeterminacy.By these steps,endmembers can be extracted and abundance quantified simultaneously.To examine the coverage of a real oil spill and correct our estimate,a simulation experiment and a real experiment were designed using the algorithm described above.The result indicated that,for the simulation data,the abundance estimation error is 2.52% and minimum root mean square error of the reconstructed image is 0.030 6.We estimated the oil spill rate and area based on eight hyper-spectral remote sensing images collected by an airborne survey of Shandong Changdao in 2011.The total oil spill area was 0.224 km^2,and the oil spill rate was 22.89%.The method we demonstrate in this paper can be used for the automatic monitoring of oil spill coverage rates.It also allows the accurate estimation of the oil spill area.

DISCRIMINANT INDEPENDENT COMPONENT ANALYSIS AS A SUBSPACE REPRESENTATION

Subspace modeling plays an important role in face recognition. Independent Component Analysis （ICA）, a multivariable statistical analysis technique, can be seen as an extension of traditional Principal Com- ponent Analysis （PCA） technique, which addresses high order statistics as well as second order statistics. In this paper, a new scheme of subspace-based representation called Discriminant Independent Component Analysis （DICA） is proposed, which combines the strength＂ of unsupervised learning of ICA and supcrvised learning of Linear Discriminant Analysis （LDA）, and efficiently enhances the generalization ability of ICA-based representation method. Based on DICA subspace analysis, a set of optimal vectors called ＂discriminant independent faces＂ are learned from face samples. The effectiveness of our method is demonstrated by performance comparisons with some popular methods such as ICA, PCA, and PCA＋LDA. On the large scale database of IIS, significant improvements are observed when there are fewer training samples per person available.

Denoising of chaotic signal using independent component analysis and empirical mode decomposition with circulate translating

In this paper, a new method to reduce noises within chaotic signals based on ICA （independent component analysis） and EMD （empirical mode decomposition） is proposed. The basic idea is decomposing chaotic signals and constructing multidimensional input vectors, firstly, on the base of EMD and its translation invariance. Secondly, it makes the indepen- dent component analysis on the input vectors, which means that a self adapting denoising is carried out for the intrinsic mode functions （IMFs） of chaotic signals. Finally, all IMFs compose the new denoised chaotic signal. Experiments on the Lorenz chaotic signal composed of different Gaussian noises and the monthly observed chaotic sequence on sunspots were put into practice. The results proved that the method proposed in this paper is effective in denoising of chaotic signals. Moreover, it can correct the center point in the phase space effectively, which makes it approach the real track of the chaotic attractor.

Online Batch Process Monitoring Based on Just-in-Time Learning and Independent Component Analysis

A new method was developed for batch process monitoring in this paper. In the devdopad method, just-in-time learning （ JITL ） and independent component analysis （ICA） were integrated to build JITL-ICA monitoring scheme. JITL was employed to tackle with the characteristics of batch process such as inherent time- varying dynamics, multiple operating phases, and especially the case of uneven length stage. According to new coming test data, the most correlated segmentation was obtained from batch-wise unfolded training data by JITL. Then, ICA served as the principal components extraction approach. Therefore, the non.Gaussian distributed data can also be addressed under this modeling framework. The effectiveness and superiority of JITL-ICA based monitoring method was demonstrated by fed-batch penicillin fermentation.