Spin Evolution of the Magnetar SGR J1935+2154

Fast radio bursts(FRBs)are short pulses observed in radio frequencies usually originating from cosmological distances.The discovery of FRB 200428 and its X-ray counterpart from the Galactic magnetar SGR J1935+2154suggests that at least some FRBs can be generated by magnetars.However,the majority of X-ray bursts from magnetars are not associated with radio emission.The fact that only in rare cases can an FRB be generated raises the question regarding the special triggering mechanism of FRBs.Here we report long time spin evolution of SGR J1935+2154 until the end of 2022.According to v and v,the spin evolution of SGR J1935+2154 could be divided into two stages.The first stage evolves relatively steady evolution until 2020 April 27.After the burst activity in2020,the spin of SGR J1935+2154 shows strong variations,especially for v.After the burst activity in 2022October,a new spin-down glitch with△v/v=(-7.2±0.6)×10^(-6)is detected around MJD 59876,which is the second event in SGR J1935+2154.At the end,spin frequency and pulse profile do not show variations around the time of FRB 200428 and radio bursts 221014 and 221021,which supply strong clues to constrain the trigger mechanism of FRBs or radio bursts.

Exploration of cardiac rehabilitation nursing for elderly patients with myocardial infarction based on individualized cardiac rehabilitation

BACKGROUND Myocardial infarction is a high-risk condition prevalent among the elderly population,often leading to adverse clinical manifestations such as reduced cardiopulmonary function,anxiety,and depression post-surgery.Consequently,cardiac rehabilitation holds immense importance in mitigating these complications.AIM To evaluate the effect of individualized cardiac rehabilitation on blood pressure variability(BPV)and baroreflex sensitivity(BRS)in elderly patients with myocardial infarction.METHODS A cohort of 74 elderly patients diagnosed with myocardial infarction and admitted to our hospital between January 2021 and January 2022 were subjected to random selection.Subsequently,all patients were divided into two groups,namely the research group(n=37)and the control group(n=37),utilizing the number table method.The control group received conventional drug treatment and nursing guidance intervention,while the study group underwent individualized cardiac rehabilitation in addition to the interventions received by the control group.All patients were continuously intervened for 12 wk,and the BPV of these two groups in the 1st wk(T0),the 4th wk(T1)and the 12th wk(T2)were compared,BRS,changes in cardiopulmonary function measures,and adverse cardiovascular events.RESULTS Of 24 h diastolic BPV,24 h systolic BPV,carbon dioxide ventilation equivalent slope of the research group were lower than those of the control group at T1 and T2,BRS,peak heart rate and systolic blood pressure product,1 min heart rate recovery were higher than those of the control group,and the incidence of adverse events in the research group was lower than that of the control group,the difference was statistically significant(P<0.05).CONCLUSION In this study,we found that after individualized cardiac rehabilitation in elderly patients with myocardial infarction,BPV and BRS can be effectively improved,cardiac function is significantly enhanced,and a better prognosis is obtained.

Application of patient-derived tumor models in anticancer drug development and individualized medicine

Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.

甘蓝型油菜SGR基因家族的全基因组鉴定与功能分析

叶绿素是植物进行光合作用的一类绿色色素,对植物生长有着直接的影响。本研究利用生物信息学方法在全基因组水平上对甘蓝型油菜(Brassica napus)、白菜(Brassica rapa)、甘蓝(Brassica oleracea)和拟南芥(Arabidopsis thaliana)中滞绿基因(STAY-GREEN,SGR)家族成员进行分析发现,28个SGR基因大多数包含4个外显子,编码碱性蛋白。染色体定位和共线性分析显示,甘蓝型油菜SGR基因家族成员中不存在串联复制,SGR基因家族成员之间具有线性关系,高度同源,且在进化过程中非常保守。此外,利用60K SNP对203份半冬性甘蓝型油菜自交系的叶绿素含量进行全基因组关联分析(Genome-wide association study,GWAS),检测到2个单体型区域Chr.A01:6,193,165~6,317,757 bp和Chr.C01:9,059,861~9,906,618 bp携带的Bna SGR1a-A01和Bna SGR1-C01与叶绿素含量显著相关。同时,结合50份半冬性甘蓝型油菜重测序数据,对这2个单体型进行进区域关联分析,检测到1个SNP定位在Bna SGR1a-A01的外显子2区域,并与叶绿素含量显著关联。共表达网络分析结果验证了Bna SGR1a-A01与Bna SGR2-A03直接相连,与Bna SGR1-C01、Bna SGR1-A08、Bna SGR2-C03、Bna SGR1-C07、Bna SGRL-C06、Bna SGRL-A10等基因间接相连形成了一个网络体系,共同调节叶绿素含量。T2拟南芥转Bna SGR1a-A01基因超表达植株的叶绿素a、叶绿素b和总的叶绿素含量相比野生型显著降低,表明Bna SGR1调控叶绿素降解。本研究为油菜SGR基因的功能研究和利用奠定了基础。

桃PpSGR基因功能鉴定及其对乙烯合成的调控

【目的】乙烯合成及果肉褪绿是桃果实成熟过程中相伴出现的两个生理事件。STAY-GREEN(SGR)是参与植物叶片和果实褪绿的重要基因。然而,桃SGR基因在果实成熟及褪绿过程中的功能尚不清晰,旨在初步探究PpSGR基因在桃果实成熟及褪绿过程中的功能。【方法】以秋蜜红为试验材料,对PpSGR基因进行克隆,对PpSGR的核苷酸及氨基酸序列进行分析,对不同发育时期桃果肉中PpSGR的转录水平进行检测,并对PpSGR基因调控叶绿素降解及乙烯合成的功能进行研究。【结果】PpSGR编码区全长为831 bp;该基因编码的蛋白序列含有1个高度保守的SGR域。PpSGR基因的表达水平随着果肉逐渐褪绿呈现上升的趋势。瞬时过表达PpSGR基因后,桃叶片颜色明显褪绿,并且在300 mmol·L-1NaCl的盐胁迫下,过表达PpSGR的叶片褪绿更加明显。此外,过表达PpSGR后,桃苗乙烯合成的限速基因PpACS1、PpACS4及PpACS6均表达上调,且内源乙烯释放量显著增多。【结论】对PpSGR的基因功能进行鉴定和研究,并分析了其对乙烯的调控作用,为进一步解析桃果实成熟及果肉褪绿提供了新的思路,也为不同成熟期桃品种的选育提供了理论基础。

A Note on the Anti-glitch of Magnetar SGR 1935+2154

The magnetar SGR 1935+2154 is reported to have an anti-glitch,accompanied by fast radio bursts,and transient pulsed radio emission.In the wind braking model,this triplet event tells people that(1) SGR 1935+2154 does not have a strong particle wind and can be approximated by magnetic dipole braking in the persistent state;(2) its antiglitch is due to an enhanced particle wind,similar to the first anti-glitch in magnetars;(3) its transient pulsed radio emission may be due to a decreasing emission beam during the outburst;(4) the enhanced particle acceleration potential and pulsar death line may not be the dominate factor.

Effect of individualized nutrition interventions on clinical outcomes of pregnant women with gestational diabetes mellitus

BACKGROUND Gestational diabetes mellitus(GDM)can lead to excessive pregnancy weight gain(PWG),abnormal glucolipid metabolism,and delayed lactation.Therefore,it is necessary to provide appropriate and effective interventions for pregnant women with GDM.AIM To clarify the effects of individualized nutrition interventions on PWG,glucolipid metabolism,and lactation in pregnant women with GDM.METHODS The study population consisted of 410 pregnant women with GDM who received treatment at the Northern Jiangsu People's Hospital of Jiangsu Provinceand Yangzhou Maternal and Child Health Hospital between December 2020 and December 2022,including 200 who received routine in-terventions[control(Con)group]and 210 who received individualized nutrition interventions[research(Res)group].Data on PWG,glucolipid metabolism[total cholesterol,(TC);triglycerides(TGs);fasting blood glucose(FPG);glycosylated hemoglobin(HbA1c)],lactation time,perinatal complications(cesarean section,premature rupture of membranes,postpartum hemorrhage,and pregnancy-induced hypertension),and neonatal adverse events(premature infants,fetal macrosomia,hypo-glycemia,and respiratory distress syndrome)were collected for comparative analysis.RESULTS The data revealed markedly lower PWG in the Res group vs the Con group,as well as markedly reduced TG,TC,FPG and HbA1c levels after the intervention that were lower than those in the Con group.In addition,obviously earlier lactation and statistically lower incidences of perinatal complications and neonatal adverse events were observed in the Res group.CONCLUSION Individualized nutrition interventions can reduce PWG in pregnant women with GDM,improve their glucolipid metabolism,and promote early lactation,which deserves clinical promotion.

The personal protective equipment(PPE)based on individual combat:A systematic review and trend analysis

With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce casualties and maintain military combat effectiveness,is widely developed.This paper systematically reviewed various PPE based on individual combat through literature research and comprehensive discussion,and introduced in detail the latest application progress of PPE in terms of material and technology from three aspects:individual integrated protection system,traditional protection equipment,and intelligent protection equipment,respectively,and discussed in depth the functional improvement and optimization status brought by advanced technology for PPE,focusing on the achievements of individual equipment technology application.Finally,the problems and technical bottlenecks in the development of PPE were analyzed and summarized,and the development trend of PPE were pointed out.The results of the review will provide a forward-looking reference for the current development of individual PPE,and are important guidance for the design and technological innovation of advanced equipment based on the future technological battlefield.

Individual tree segmentation and biomass estimation based on UAV Digital aerial photograph

Digital aerial photograph(DAP)data is processed based on Structure from Motion(Sf M)algorithm and regional net adjustment method to generate digital surface discrete point clouds similar to Light Detection and Ranging(LiDAR)and digital orthophoto mosaic(DOM)similar to optical remote sensing image.In this study,we obtained highresolution images of mature forests of Chinese fir by unmanned aerial vehicle(UAV)flying through crossroute flight,and then reconstructed the threedimensional point clouds in the UAV aerial area by SfM technique.The point cloud segmentation(PCS)algorithm was used for the individual tree segmentation,and the F-score of the three sample plots were 0.91,0.94,and 0.94,respectively.Individual tree biomass modeling was conducted using 155 mature Chinese fir forests which were correctly segmented.The relative root mean squared error(rRMSE)values of random forest(RF),bagged tree(BT)and support vector regression(SVR)were 34.48%,35.74%and 40.93%,respectively.Our study demonstrated that DAP point clouds had great potential to extract forest vertical parameters and could be applied successfully in individual tree segmentation and individual tree biomass modeling.

Characterization of Atypical Individuals of Lannea in Burkina Faso

Background and Objectives: The species to the Lannea genus are trees, shrubs with compound leaves. Thus, individuals called atypical Lannea with single leaves and of socio-economic interests have been identified in the central plateau region (Burkina Faso). This study aimed to contribute to the identification of atypical species. Material and Methods: The Polymerase Chain Reaction (PCR) method using specific primers was performed and consisted of extracting DNA from young leaves of Lannea individuals, amplifying and then sequencing portions of discriminating DNA (matK, rbcL and rps16). Results: It was shown that individuals belong to the Lannea genus, but are subdivided into three subgroups: a first subgroup containing Lannea microcarpa and two subgroups with no previously identified Lannea species. Conclusion: These atypical individuals are ecotypes or mutants of Lannea microcarpa.

Establishment of organoid models for pancreatic ductal adenocarcinoma and screening of individualized therapy strategy

Background:Patients with pancreatic ductal adenocarcinoma(PDAC)who undergo surgical resection and receive effective chemotherapy have the best chance for longterm survival.Unfortunately,because of the heterogeneity of pancreatic cancer,it is difficult to find a personalized treatment strategy for patients.Organoids are ideal preclinical models for personalized medicine.Therefore,we explore the cultivation conditions and construction methods of PDAC organoid models to screen the individualized therapy strategy.Methods:Fresh PDAC tissues from surgical resection were collected and digested with digestive enzymes;then the tumor cells were embedded in Matrigel with a suitable medium to establish the PDAC organoid models.The genetic stability of the organoids was analyzed using whole exon sequencing;hematoxylin and eosin staining and immunohistochemistry of organoids were performed to analyze their consistency with the pathological morphology of the patient's tumor tissue;After 2 days of organoid culture,we selected four commonly used clinical chemotherapy drugs for single or combined treatment to analyze drug sensitivity.Results:Two cases of PDAC organoid models were successfully established,and the results of their pathological characteristics and exome sequencing were consistent with those of the patient's tumor tissue.Both PDAC organoids showed more sensitivity to gemcitabine and cisplatin,and the combined treatment was more effective than monotherapy.Conclusion:Both organoids better retained the pathological characteristics,genomic stability,and heterogeneity with the original tumor.Individual PDAC organoids exhibited different sensitivities to the same drugs.Thus,this study provided ideal experimental models for screening individualized therapy strategy for patients with PDAC.

Early efficacy of individual regimens containing bedaquiline in patients with drug resistant tuberculosis

Objective:To evaluate early efficacy of sputum conversion within 6 months of individual regimens containing bedaquiline in patients with drug resistant tuberculosis.Methods:We conducted a retrospective study among patients with drug resistant tuberculosis who were receiving individual regimens containing bedaquiline.The primary outcome was sputum conversion of both smear and culture within 6 months of treatment.We used medical records of drug resistant tuberculosis patients from January 2020 to December 2021.The study was conducted at Dr.Soetomo Hospital,Indonesia from August to October 2022.Results:In this study,44 eligible drug resistant tuberculosis patients were initiated on regimens containing bedaquiline.There were 52.3%males and the median age was 45.5 years.The rates of previous treatment(70.5%)and lung cavity(36.4%)were high.The most common companion drugs included clofazimine,cycloserine,levofloxacin,and linezolid.Sputum smear and culture conversion was seen in 79.4%and 82.1%at the 2nd month,respectively.More than 97%patients had smear and culture conversion at the end of 6 months.Conclusions:Among drug resistant tuberculosis patients,individual regimens containing bedaquiline were associated with high rates of smear and culture conversion at the end of 6 months.Early efficacy of regimens containing bedaquiline can be used to predict cure rate at the end of treatment.

Effects of site productivity on individual tree maximum basal area growth rates of Eucalyptus pilularis in subtropical Australia

Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was developed relating the maximum possible stem basal area growth rate of individual trees to their stem basal area.For any tree size,this maximum increased as site productivity increased.However,the size at which this maximum occurred decreased as productivity increased.Much research has shown that,at any stand age,trees of a particular stem basal area are taller on more productive sites than on less productive ones.Taller trees incur greater respiratory costs to ensure maintenance of the photo synthetic capacity of their canopies;this reduces their growth rates.It was concluded that trees with larger basal areas will have the maximum possible growth rate on a less productive site,whilst trees with smaller basal areas will have the maximum possible on a more productive site.The model developed may constitute the first stage of a complete individual tree growth model system to predict wood yields from these forests.

Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults,especially in obese individuals:a prospective cohort study

Background:Mushrooms are a good source of many nutrients which are potentially beneficial for chronic diseases.We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction(SCTD).Therefore,we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in adults.Methods:This prospective cohort study investigated 6631 participants(mean age:(45.0±10.2)years;55.1%men).Edible mushrooms consumption was measured at baseline using a validated food frequency questionnaire.SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine.Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD.Results:During follow-up period,a total of 262 new cases of SCTD were identified,the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 person-years.After adjusting potential confounding factors,the multivariable hazard ratios(95%confidence intervals)for subclinical hypothyroidism were 1.00(reference)for almost never,0.53(0.29,0.97)for 1-3 times/week and 0.30(0.10,0.87)for≥4 times/week(P for trend=0.02).It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals,the final hazard ratios(95%confidence intervals)were 0.14(0.03,0.73)(P for trend<0.01).Conclusions:This population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population,especially in obese individuals.

Interpersonal Perception in Virtual Groups: Examining Homophily, Identification and Individual Attraction Using Social Relations Model in Network

With the penetration of the Internet, virtual groups have become more and more popular. The reliability and accuracy of interpersonal perception in the virtual environment is an intriguing issue. Using the Social relations model (SRM) [1], this paper investigates interpersonal perception in virtual groups from a multilevel perspective. In particular, it examines the following three areas: homophily, identification, and individual attraction, and explores how much of these directional and dyadic relational evaluations can be attributed to the effect of the actor, the partner, and the relationship.

Effect of Individualized Nutrition Intervention Care Combined with Swallowing Training on Postoperative Nutritional Status in Patients with Laryngeal Cancer

Introduction: Laryngeal carcinoma accounts for 13.9% of head and neck tumors, and squamous cell carcinoma is the main pathological type. At present, the treatment of laryngeal cancer is mainly surgical treatment or postoperative radiotherapy. The surgery is delicate, complex, time-consuming and traumatic. Postoperative patients are prone to dysphagia, leading to an increase in the incidence of malnutrition. Malnutrition can cause a series of negative effects, including weight loss, increased incidence of infection, reduced tolerance of anti-tumor treatment, and extended length of hospital stay. Therefore, how to effectively improve the nutritional status of laryngeal cancer patients through nursing intervention has become an important topic of nursing research. Objective: Investigate the effect of individualized nutrition intervention care combined with swallowing training on postoperative nutritional status in patients with laryngeal cancer. Methods: A total of 120 consecutive patients who underwent laryngeal surgery at our hospital for the first time between May 2018 and May 2021 were selected for the study and equally divided into the control group and the study group by the random number table method, with 60 patients in each group. Patients in the control group were given swallowing function training and health counseling, and the study group adopted individualized nutrition intervention care based on the control group. The nutritional status, swallowing function, and quality of life (QOL) of the patients were assessed using the Patient-generated Subjective Global Assessment (PG-SGA), MD Anderson Dysphagia Inventory (MDADI), and Quality of Life Questionnaire-Core30 (QLQ-C30) before the intervention and three months after the intervention. Results: Before the intervention, the scores of MDADI, PG-SGA, and QLQ-C30 were not significantly different between the two groups (P > 0.05), and three months after the intervention, the scores of MDADI and QLQ-C30 increased and the score of PG-SGA decreased in the study group, with significant differences (P 0.05). At three months after the intervention, patients in the study group had higher scores on MDADI, QLQ-C30 and lower scores on PG-SGA than the control group, with significant differences (P Conclusion: Combining individualized nutrition intervention care with swallowing training improves the postoperative nutritional status, swallowing function, and QOL of patients with laryngeal cancer.

Localized Theoretical Analysis of Thermal Performance of Individually Finned Heat Pipe Heat Exchanger for Air Conditioning with Freon R404A as Working Fluid

This work contributes to the improvement of energy-saving in air conditioning systems. The objective is to apply the thermal efficiency of heat exchangers for localized determination of the thermal performance of heat exchangers with individually finned heat pipes. The fundamental parameters used for performance analysis were the number of fins per heat pipe, the number of heat pipes, the inlet temperatures, and the flow rates of hot and cold fluids. The heat exchanger under analysis uses Freon 404A as a working fluid in an air conditioning system for cooling in the Evaporator and energy recovery in the Condenser. The theoretical model is localized and applied individually to the Evaporator, Condenser, and heat exchanger regions. The results obtained through the simulation are compared with experimental results that use a global approach for the heat exchanger. The thermal quantities obtained through the theoretical model in the mentioned regions are air velocity, Nusselt number, thermal effectiveness, heat transfer rate, and outlet temperature. The comparisons made with global experimental results are in excellent agreement, demonstrating that the localized theoretical approach developed is consistent and can be used as a comprehensive analysis tool for heat exchangers using heat pipes.

Detection of Quasi-periodic Oscillations in SGR 150228213

The detection of quasi-periodic oscillations(QPOs)in magnetar giant flares(GFs)has brought a new perspective to studies of the mechanism of magnetar bursts.Due to the scarcity of GFs,searching for QPOs in magnetar short bursts is reasonable.Here we report the detection of a narrow QPO at approximately 110 Hz and a wide QPO at approximately 60 Hz in the short magnetar burst SGR 150228213,with a confidence level of 3.35σ.This burst was initially attributed to 4U 0142+61 by Fermi/GBM on location,but we have not detected such QPOs in other bursts from this magnetar.We also found that there was a repeating fast radio burst associated with SGR 150228213 on location.Finally,we discuss the possible origins of SGR 150228213.

SGR-PLC在中水回用控制系统中的实例应用

企业末端治理后的中水再生水回用是节约水资源、循环综合利用极其重要的一环,而中水回用采用的超滤膜(UF)+反渗透(RO)膜工艺是大多数企业的首选,也是目前较为成熟的处理工艺之一。控制系统的设计性能、匹配度,决定了整套系统的运行可靠度,无论是从各处理单元点的控制还是整套系统工艺流程自动化的控制,都是运行的重中之重。结合应用实例详细介绍了SGR-PLC自动控制系统在安徽某化工股份有限公司的高效运行,并就如何更安全可靠地应用在中水回用双膜法系统中,对膜系统运行控制出现的常见问题进行罗列并提出应对措施。

Localized Theoretical Analysis of Thermal Performance of Individually Finned Heat Pipe Heat Exchanger for Air Conditioning with Freon R404A as Working Fluid

This work contributes to the improvement of energy-saving in air conditioning systems. The objective is to apply the thermal efficiency of heat exchangers for localized determination of the thermal performance of heat exchangers with individually finned heat pipes. The fundamental parameters used for performance analysis were the number of fins per heat pipe, the number of heat pipes, the inlet temperatures, and the flow rates of hot and cold fluids. The heat exchanger under analysis uses Freon 404A as a working fluid in an air conditioning system for cooling in the Evaporator and energy recovery in the Condenser. The theoretical model is localized and applied individually to the Evaporator, Condenser, and heat exchanger regions. The results obtained through the simulation are compared with experimental results that use a global approach for the heat exchanger. The thermal quantities obtained through the theoretical model in the mentioned regions are air velocity, Nusselt number, thermal effectiveness, heat transfer rate, and outlet temperature. The comparisons made with global experimental results are in excellent agreement, demonstrating that the localized theoretical approach developed is consistent and can be used as a comprehensive analysis tool for heat exchangers using heat pipes.