Two novel water-soluble indocyanine dyes were synthesized. Their chemical structures were confirmed by 1H NMR, IR, MS and UV-vis techniques. The absorptions of the prepared dyes in different solvents were measured. Tw...Two novel water-soluble indocyanine dyes were synthesized. Their chemical structures were confirmed by 1H NMR, IR, MS and UV-vis techniques. The absorptions of the prepared dyes in different solvents were measured. Two dyes exhibited negative solvatochromism, with a blue shift of the absorption and an emission maximum in （bovine serum albumin） protonic solvent relative to non protonic solvent. The fluorescence properties of the dyes in both free state and BSA were investigated. Significant enhancement of the fluorescence intensity for the Dye2 was observed in the presence of BSA. Dye2 could be proposed as fluorescent dyes for BSA detection in aqueous solution.展开更多
Our research has identified a couple of near-infrared(NIR)heptamethine indocyanine dyes exhibiting preferential tumor accumnulation property for in vriwo imaging.On the basis of our foregoing work,we describe here a p...Our research has identified a couple of near-infrared(NIR)heptamethine indocyanine dyes exhibiting preferential tumor accumnulation property for in vriwo imaging.On the basis of our foregoing work,we describe here a preliminary structure-activity relationship(SAR)study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging.展开更多
基金Project supported by the Natural Science Foundation of Shaanxi Province （No. SJ08B04）, the Special Science Research Foundation of Education Committee （No. 08JK458）, NWU Graduate Cross-discipline Funds （No. 09YJC20） and NWU Excellent Doctoral Dissertation Foundation （No. 08YYB04）.
文摘Two novel water-soluble indocyanine dyes were synthesized. Their chemical structures were confirmed by 1H NMR, IR, MS and UV-vis techniques. The absorptions of the prepared dyes in different solvents were measured. Two dyes exhibited negative solvatochromism, with a blue shift of the absorption and an emission maximum in （bovine serum albumin） protonic solvent relative to non protonic solvent. The fluorescence properties of the dyes in both free state and BSA were investigated. Significant enhancement of the fluorescence intensity for the Dye2 was observed in the presence of BSA. Dye2 could be proposed as fluorescent dyes for BSA detection in aqueous solution.
基金supported by State Key Basic Research Development Program(2012CB518103)Natural Science Foundation Programs(81072523 and 81130026)+1 种基金Chongqing Municipal Natural Sci-ence Foundation Program(CSTC2009BA5043)a program of New Century Excellent Talents in University(NCET)from Ministry of Education to C.S.
文摘Our research has identified a couple of near-infrared(NIR)heptamethine indocyanine dyes exhibiting preferential tumor accumnulation property for in vriwo imaging.On the basis of our foregoing work,we describe here a preliminary structure-activity relationship(SAR)study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging.
