Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that...Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics.展开更多
Objective To evaluate the clinical significance of intraoperative indocyanine green (ICG) videoangiography in surgical management of spinal dural ateriovenots fistulae (dAVFs) . Methods In this retrospective analysis ...Objective To evaluate the clinical significance of intraoperative indocyanine green (ICG) videoangiography in surgical management of spinal dural ateriovenots fistulae (dAVFs) . Methods In this retrospective analysis we examined nine cases of dAVFs,diagnosed by complete spinal angiography,in which laminoplasty were performed through posterior approach. An operating microscope-integrated light展开更多
Laparoscopic anatomical hepatectomy(LAH)for patients with hepatocellular carcinoma(HCC)has been advocated by many surgeons in the hope of producing better oncological outcomes.Two recent techniques,3D laparoscopic sys...Laparoscopic anatomical hepatectomy(LAH)for patients with hepatocellular carcinoma(HCC)has been advocated by many surgeons in the hope of producing better oncological outcomes.Two recent techniques,3D laparoscopic system and 2D real-time indocyanine green fluorescence imaging(r-ICG)guidance,are benefit for improving the operative precision of LAH in different aspects.However,these two techniques cannot be applied concomitantly because of the technical limitation.Although a new modern laparoscopic system with both 3D and indocyanine green(ICG)imaging mode has been designed,it has not been listed in many countries including China.Thus,we design a new procedure to perform the 3D LAH with 2D r-ICG guidance for HCCs with conventional laparoscopic systems.In this procedure,both 3D and 2D laparoscopic systems were used.A total of 11 patients with HCC received 3D laparoscopic right posterior sectionectomy(LRPS)with 2D r-ICG guidance.The right posterior Glissonian pedicle was clamped under the 3D vision.Then ICG solution was then intravenously administrated.The liver parenchyma was transected under the 3D vision and guided by 2D ICG vision simultaneously.There was no severe complications(Clavien-Dindo≥III)and operation related death.The 90-day mortality was also nil.By using this procedure,the advantages of two techniques,3D laparoscopic system and 2D r-ICG guidance,were combined so that LAH could be performed with more precision.However,it should be validated in more studies.展开更多
基金support for this research from the National Natural Science Foundation of China (Grant No. 81071249, 81171446 and 20905050)Guangdong Innovation Team of Low-cost Healthcare, Science and Technology Key Project of Guangdong (2009A030301010) and Shenzhen (CXB201005250029A, JC201005270326A, JC201005260247A, JC201104220242A)
文摘Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics.
文摘Objective To evaluate the clinical significance of intraoperative indocyanine green (ICG) videoangiography in surgical management of spinal dural ateriovenots fistulae (dAVFs) . Methods In this retrospective analysis we examined nine cases of dAVFs,diagnosed by complete spinal angiography,in which laminoplasty were performed through posterior approach. An operating microscope-integrated light
文摘Laparoscopic anatomical hepatectomy(LAH)for patients with hepatocellular carcinoma(HCC)has been advocated by many surgeons in the hope of producing better oncological outcomes.Two recent techniques,3D laparoscopic system and 2D real-time indocyanine green fluorescence imaging(r-ICG)guidance,are benefit for improving the operative precision of LAH in different aspects.However,these two techniques cannot be applied concomitantly because of the technical limitation.Although a new modern laparoscopic system with both 3D and indocyanine green(ICG)imaging mode has been designed,it has not been listed in many countries including China.Thus,we design a new procedure to perform the 3D LAH with 2D r-ICG guidance for HCCs with conventional laparoscopic systems.In this procedure,both 3D and 2D laparoscopic systems were used.A total of 11 patients with HCC received 3D laparoscopic right posterior sectionectomy(LRPS)with 2D r-ICG guidance.The right posterior Glissonian pedicle was clamped under the 3D vision.Then ICG solution was then intravenously administrated.The liver parenchyma was transected under the 3D vision and guided by 2D ICG vision simultaneously.There was no severe complications(Clavien-Dindo≥III)and operation related death.The 90-day mortality was also nil.By using this procedure,the advantages of two techniques,3D laparoscopic system and 2D r-ICG guidance,were combined so that LAH could be performed with more precision.However,it should be validated in more studies.
