A series of new 4-substituted benzoxazolone derivatives were synthesized according to a convenient method,their anti-inflammatory and analgesic activities in vivo were evaluated.All of them were new compounds,the stru...A series of new 4-substituted benzoxazolone derivatives were synthesized according to a convenient method,their anti-inflammatory and analgesic activities in vivo were evaluated.All of them were new compounds,the structures of all the synthesized compounds were confirmed by ~1H NMR,^(13)C NMR,ESI-MS and HR-MS.Most of the compounds exhibited anti-inflammatory activity.展开更多
To design 3,5-dimethoxystyrene-linked cyclic ketone derivatitves as new anti-inflammatory drugs,eight target compounds were synthesized through 3,5-dimethoxy benzaldehyde and heterocycle or alicyclic ring condensation...To design 3,5-dimethoxystyrene-linked cyclic ketone derivatitves as new anti-inflammatory drugs,eight target compounds were synthesized through 3,5-dimethoxy benzaldehyde and heterocycle or alicyclic ring condensation.Their structures were identified by IR,HR-MS and 1H NMR,and their reaction conditions were studied.展开更多
基金supports form the National"863"program of China(No.2006AA09Z446)from the overseas scholar supporting program(No.2008-51)+1 种基金from Shanxi Province Science Foundation for Youths(No.2009021041-1)from the innovative program of Shanxi Medical University(No.38) is gratefully acknowledged.
文摘A series of new 4-substituted benzoxazolone derivatives were synthesized according to a convenient method,their anti-inflammatory and analgesic activities in vivo were evaluated.All of them were new compounds,the structures of all the synthesized compounds were confirmed by ~1H NMR,^(13)C NMR,ESI-MS and HR-MS.Most of the compounds exhibited anti-inflammatory activity.
文摘To design 3,5-dimethoxystyrene-linked cyclic ketone derivatitves as new anti-inflammatory drugs,eight target compounds were synthesized through 3,5-dimethoxy benzaldehyde and heterocycle or alicyclic ring condensation.Their structures were identified by IR,HR-MS and 1H NMR,and their reaction conditions were studied.
