Research on the mechanism of rockburst induced by mined coal-rock linkage of sharply inclined coal seams

In recent years,the mining depth of steeply inclined coal seams in the Urumqi mining area has gradually increased.Local deformation of mining coal-rock results in frequent rockbursts.This has become a critical issue that affects the safe mining of deep,steeply inclined coal seams.In this work,we adopt a perspective centered on localized deformation in coal-rock mining and systematically combine theoretical analyses and extensive data mining of voluminous microseismic data.We describe a mechanical model for the urgently inclined mining of both the sandwiched rock pillar and the roof,explaining the mechanical response behavior of key disaster-prone zones within the deep working face,affected by the dynamics of deep mining.By exploring the spatial correlation inherent in extensive microseismic data,we delineate the“time-space”response relationship that governs the dynamic failure of coal-rock during the progression of the sharply inclined working face.The results disclose that(1)the distinctive coal-rock occurrence structure characterized by a“sandwiched rock pillar-B6 roof”constitutes the origin of rockburst in the southern mining area of the Wudong Coal Mine,with both elements presenting different degrees of deformation localization with increasing mining depth.(2)As mining depth increases,the bending deformation and energy accumulation within the rock pillar and roof show nonlinear acceleration.The localized deformation of deep,steeply inclined coal-rock engenders the spatial superposition of squeezing and prying effects in both the strike and dip directions,increasing the energy distribution disparity and stress asymmetry of the“sandwiched rock pillar-B3+6 coal seam-B6 roof”configuration.This makes worse the propensity for frequent dynamic disasters in the working face.(3)The developed high-energy distortion zone“inner-outer”control technology effectively reduces high stress concentration and energy distortion in the surrounding rock.After implementation,the average apparent resistivity in the rock pillar and B6 roof substantially increased by 430%and 300%,respectively,thus guaranteeing the safe and efficient development of steeply inclined coal seams.

Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries

In the present study, we used a proteomics approach based on a two-dimensional electrophoresis （2-DE） reference map to investigate protein expression in the ovarian tissues of pubertal Swiss-Webster mice subjected to carbon ion radiation （CIR）. Among the identified proteins, ubiquitin carboxy-terminal hydrolase L1 （UCH-L1） is associated with the cell cycle[1] and that it influences proliferation in ovarian tissues. We analyzed the expression of UCH-L1 and the proliferation marker proliferation cell nuclear antigen （PCNA） following CIR using immunoblotting and immunofluorescence. The proteomics and biochemical results provide insight into the underlying mechanisms of CIR toxicity in ovarian tissues.

The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats

Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs[1]. However, few studies have investigated nickel carbonyl poisoning in humans.

Neuroprotection induced by NMDA preconditioning as a strategy to understand brain tolerance mechanism

Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death. Since its description, the phenomenon of glutamatergic excitotoxicity has been implicated in the physiopathology of a wide range of neurological and psychiatric disorders, from acute brain damage such as traumatic brain injury, ischemia as well as chronic condi- tions like epilepsy, depression and neurodegenerative pathologies such as Huntington＇s, Parkinson＇s and Alzheimer＇s diseases. Exces- sive stimulation of glutamatergic receptors, mainly N-methyl-D-as- partate （NMDA） receptors （NMDAR）, can have numerous adverse effects on the cell viability, including increased nitric oxide release （NO）, activation of proteases, increased production of reactive oxygen （ROS） and nitrogen （RNS） species and massive influx of calcium ions （Ca2＋）, resulting in cell death. Thus, the use of strategies that modulate the excitotoxic cell damage represents a perspective for the treatment of diseases such as Parkinson＇s and Alzheimer＇s diseases, ischemia, traumatic brain injury （TBI） and seizures.

Autonomic mechanism for chronic atrial electrical remodeling induced by rapid atrial pacing in ambulatory danines

Objetives The mechanism for changes in the electrophysiological properties of the atria during rapid pacing induced atrial fibrillation(AF) is not well understood.We aimed to investigate the contribution of intrinsic cardiac autonomic nervous system(ICANS) in chronic atrial electrical remodeling and AF induced by rapid atrial pacing for 4 weeks. Methods Twelve adult mongrel dogs weighing 15 to 20 kg were assigned to two groups;group 1(experimental group,n= 7) and group 2(control group,n =5).All dogs were anesthetized with propofol and mechanically ventilated via endotracheal tubes.The chest was entered via bilateral mini-thoracotomy at the fourth intercostals space.Bipolar pacing electrode was sutured to the right atrial appendage.Four-electrode catheters(Biosense-Webster,Diamond Bar,CA) were secured to allow recording at the right and left atriaum.All tracings from the electrode catheters were amplified and digitally recorded using a computer-based Bard Laboratory System (CR Bard Inc,Billerica,MA).Electrograms were filtered at 50 to 500 Hz.Continuous rapid pacing(600 bpm, 2×threshold[TH]) was performed at the right atrial appendage. Ganglionated Plexi(GP) was localized by applying high frequency stimulation(HFS;20 Hz,0.1ms duration, 0.5 to 4.5 V)with a bipolar stimulation-ablation probe electrode (AtriCure,West Chester,OH).Group1 underwent ablation of bilateral GP and ligament of Marshall followed by 4-week pacing.Group 2 underwent sham operaton without ablation of GP and ligament of Marshall followed by 4-week pacing.The effective refractory period(ERP) and window of vulnerability(WOV) were measured at 2×TH before(baseline) and every week after GP ablation.WOV was defined as the difference between the longest and the shortest coupling interval of the premature stimulus that induced AF.GP consist of the anterior right ganglionated plexi(ARGP) located in the fat pad at the right superior pulmonary vein(RSPV)-atrial junction;the inferior right ganglionated plexi(IRGP) located at the inferior vena cava/right atrial junction;the superior left ganglionated plexi(SLGP) at the left superior pulmonary vein(LSPV) /left atrial junction and the inferior left ganglionated plexi(ILGP) at the left inferior pulmonary vein (LIPV)/left atrial junction.Results Immediately after ablation, the ERP in Group 1 became markedly longer and started to shorten gradually during the first 2 weeks,then stabilized at the 4th week.Compared to Group2,the ERP of Group1 was significantly longer in the first 3 weeks(P【 0.05),but no obvious difference at the 4th week in either the right or left atrium(P】0.05).In Group 1,AF could not be induced(WOV=0)in the first 3 weeks after ablation, and at the 4th week,AF was induced in 2 of 7 dogs.In Group2,WOV progressively widened during the 4-week period. AF could not be induced in 5 of 7 dogs in Group 1 and 1 of 5 dogs in Group 2 during the 4-week pacing period. Conclusions The intrinsic cardiac autonomic nervous system (ICANS) plays an important role in the early stage of atrial electrical remodeling induced by rapid atrial pacing.On the other hand,with time passing by,its effect on the formation of AF decreases gradually,which suggests that ICANS may account for a non-dominant factor in the late stage of the rapid pacing-induced chronic atrial fibrillation.

INVESTIGATION OF HYDROGEN INDUCED DUCTILE BRITTLE TRANSITION IN 7175 ALUMINUM ALLOY

Effects of hydrogen on the mechanical properties of differently aged 7175 aluminum alloys were investigated by using cathodic H-permeation, slow strain rate tension and so on. The results indicate that both the yield stress and the percentage reduction of area decrease with increasing hydrogen charging time, and the degree of reduction decreases as aging time increases for the same hydrogen charging time.

Microthrombosis induced by mechanical factors and light-dye treatment

Introduction Thrombosis is the formation of a blood clot in a blood vessel. When thrombosis happens in the brain,it would cause stroke; when happens in the heart,it would cause heart attack. If a thrombus breaks and travels to the lung,it would

Mechanically induced Cu active sites for selective C–C coupling in CO_(2)electroreduction

Developing a convenient method to endow bulk Cu-based electrode with high activity of electrocatalytic CO_(2)reduction reaction(CO_(2)RR)to multicarbon(C_(2+))products is desirable but challenging.Herein,for the first time,we report that mechanical polishing induces highly reactive Cu sites for selective C-C coupling in CO_(2)RR.We find that mechanical polishing could endow Cu foil with abundant nanocavity surface structure,which efficiently confines the carbonaceous intermediates to enhance the probability of C-C coupling reaction.By confining the carbonaceous intermediates with Cu nanocavity,the as-prepared electrode delivers a Faradaic efficiency toward C_(2+)products of 65.7%at-1.3 V vs.RHE,which is enhanced up to 1.7 folds compared with that of commercial Cu foil.This work provides a new method to enable Cu foil with high activity of CO_(2)RR to C_(2+)products.

Model test of the mechanism underpinning water-and-mud inrush disasters during tunnel excavation in sandstone and slate interbedded Presinian strata

Water-and-mud inrush disasters have become a major challenge in underground engineering for the construction of tunnels in sandstone and slate interbedded Presinian strata.Disaster prediction and prevention rely in part on realistic modeling and observation of the disaster process,as well as the identification and examination of the underlying mechanisms.Based on the geological conditions and the historical records of the Xinping Tunnel on the China–Laos Railway,an engineering geological model of the water-and-mud inrush was established.A physical model test that accurately reproduced water-and-mud inrush during tunnel excavation in sandstone and slate interbedded strata was also carried out.Then,testing was conducted that examined the stress and strain,seepage pressure,and high-leakage flow of the surrounding rock.The results indicated that the water-and-mud inrush proceeded through three stages:seepage stage,high-leakage flow stage,and attenuation stage.In essence,the disaster was a catastrophic process,during which the water-resistant stratum was reduced to a critical safety thickness,a water-inrush channel formed,and the water-resistant stratum gradually failed under the influence of excavation unloading and in situ stress–seepage coupling.Parameters such as the stress and strain,seepage pressure,and flow of the surrounding rock had evident stage-related features during water-and-mud inrush,and their variation indicated the formation,development,and evolution of the disaster.As the tunnel face advanced,the trend of the stress–strain curve of the surrounding rock shifted from sluggish to rapid in its speed of increase.The characteristics of strain energy density revealed the erosion and weakening effect of groundwater on the surrounding rock.The seepage pressure and the thickness of the water-resistant stratum had a positive linear relationship,and the flow and thickness a negative linear relationship.There was a pivotal point at which the seepage pressure changed from high to low and the flow shifted from low to high.The thickness of the water-resistant stratum corresponding to the pivotal point was deemed the critical safety thickness.

A novel TRPC6-dependent mechanism of TGF-β-induced migration and invasion of human hepatocellular carcinoma cells

Mechanisms on cancer cell migration and invasion have been major topics of cancer research and anti-cancer therapy development. Among the multiple cell signaling pathways involved in cell migration, those elicited by transforming growth factorβ（TGF-β） have attracted tremendous attention. The TGF-βpolypeptide cytokines include four isoforms：TGF-β1, TGF-β2, TGF-β3, and TGF-β4, which are secreted mainly from cells of white blood cell lineage, such as macrophages, T cells and platelets.

DEGENERATIVE MECHANISM OF ARTICULAR CARTILAGE INDUCED BY LOW STRESS A MORPHOLOGICAL STUDY

Immobilization leads not only to diminished joint movement but also low stress of articular cartilage. The present investigation was undertaken to observe the morphological changes which arose in articular cartilage with low stress. The joint motion remained intact. Articular cartilage from the left knees of 66 rats whose left calcaneal tendons had been transected was examined under transmission electron microscope and light microscope. The degenerative changes were observed: decreased functional activity of chondrocytes progressively degenerated cartilage and lack of compensatory proliferation of chondrocytes at the early stage. We propose that the degeneration of articular cartilage induced by immobilization is the result of combination of low stress and lack of joint motion. The following degenerative mechanism begins with chondrocytes. Chondrocyte and matrix influence each other in a vicious cycle. Low stress may restrain the repair activities.

Ionic Mechanisms for the Acute Nociceptive Signals Induced by Bradykinin

Bradykinin is an inflammatory mediator and one of the most potent endogenous pain-inducing substances. When released at the site of tissue damage or inflammation

MgF_(2):Mn^(2+):novel material with mechanically-induced luminescence

Mechanoluminescent(ML)materials can directly convert external mechanical stimulation into light without the need for excitation from other forms of energy,such as light or electricity.This alluring characteristic makes ML materials potentially applicable in a wide range of areas,including dynamic imaging of force,advanced displays,information code,storage,and anti-counterfeiting encryption.However,current reproducible ML materials are restricted to sulfide-and oxide-based materials.In addition,most of the reported ML materials require pre-irradiation with ultraviolet(UV)lamps or other light sources,which seriously hinders their practical applications.Here,we report a novel ML material,MgF_(2):Mn^(2+),which emits bright red light under an external dynamic force without the need for pre-charging with UV light.The luminescence properties were systematically studied,and the piezophotonic application was demonstrated.More interestingly,unlike the well-known zinc sulfide ML complexes reported previously,a highly transparent ML film was successfully fabricated by incorporating MgF_(2):Mn^(2+)into polydimethylsiloxane(PDMS)matrices.This film is expected to find applications in advanced flexible optoelectronics such as integrated piezophotonics,artificial skin,athletic analytics in sports.

Microstructures and mechanical properties of ferrite-based lightweight steel with different compositions

The microstructures and mechanical properties of ferrite-based lightweight steel with different compositions were investigated by tensile test,scanning electron microscopy（SEM）,transmission electron microscopy（TEM）,X-ray diffraction（XRD）and thermodynamic calculation（TC）.It was shown that the ferrite-based lightweight steels with 5wt.%or 8wt.%Al were basically composed of ferrite,austenite andκ-carbide.As the annealing temperature increased,the content of the austenite in the steel gradually increased,while theκ-carbide gradually decomposed and finally disappeared.The mechanical properties of the steel with 5wt.%Al and 2wt.%Cr,composed of ferrite and Cr7C3carbide at different annealing temperatures,were significantly inferior to those of others.The steel containing 5wt.%Al,annealed at 820°C for 50sthen rapidly cooled to 400°C and held for 180s,can obtain the best product of strength and elongation（PSE）of 31242MPa·%.The austenite stability of the steel is better,and its PSE is higher.In addition,the steel with higher PSE has a more stable instantaneous strain hardening exponent（n value）,which is mainly caused by the effect of transformation induced plasticity（TRIP）.When theκ-carbide or Cr7C3carbide existed in the microstructure of the steel,there was an obvious yield plateau in the tensile curve,while its PSE decreased significantly.