Determination on Heavy Metals Content of Achyranthes bidentata Blume. through Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

[Objective] The inductively coupled plasma mass spectrometry(ICP-MS)was constructed to determine the contents of lead,cadmium,mercury and arsenic in Archyranthes bidentata Blume.[Method]Under the optimum operation condition of ICP-MS,the samples were digested by microwave.The element 114In was taken as an internal standard element to compensate body effect and ICP-MS method was used to determine the contents of lead,cadmium,mercury and arsenic.[Result]For the determined elements,the correlation coefficient(r)of standard curve was over 0.9995 and recovery rate was from 96.7% to 106.4% while RSD was less than 11.2%.The result of determination showed that the heavy metal content in Archyranthes bidentata Blume.beyond standard was serious.[Conclusion]The constructed ICP-MS method with simple operation,rapid response,accuracy and high sensitivity in this experiment could be used for quality control of Chinese medicinal materials by detecting heavy metal contents in different Chinese medicinal materials from original places.

Inductively coupled plasma mass spectrometry (ICP-MS) and its application in life sciences

Inductively-coupled plasma mass spectrometry (ICP-MS) has made much progress since its birth in the late 1990s. This paper will give a rather systematic overview on the use of this technique in new devices and technologies related to plasma source, sample-introducing device and detecting spectrometer etc. In this overview, an emphasis will be put on the evaluation of the ICP- MS technique in combination with a series of physical, chemical and biological techniques, such as laser ablation (LA), capillary electrophoresis (CE) and high performance liquid chromatograph (HPLC), along with their representative high accuracy and high sensitivity. Finally, comprehensive and fruitful applications of the ICP-MS and its combinative techniques in the detection of trace metallic elements and isotopes in complex biological and environmental samples will be revealed.

Determination of impurity elements in MnZn ferrites by inductively coupled plasma mass spectrometry

An inductively coupled plasma mass spectrometry(ICP-MS) method was developed for the determination of Na, Mg, Al,K, Ca, Ti, Cr, Co, Ni, Cu, Ga, As, Mo, Ag, Cd and Pb in MnZn ferrites. The sample was digested by HNO3+HCl with microwave digestion followed by dilution with ultrapure water, then the above 16 impurity elements in the solution were analyzed directly by ICP-MS. The impurity elements were introduced by the helium gas or hydrogen gas into the octopole reaction system(ORS) to eliminate the polyatomic interferences caused by the high salty matrixes. The matrix effect was minimized through matrix matching,and Be, Y and Rh were used as internal standard elements. The working parameters of the instrument were optimized. The results show that the method has good precision and high accuracy. The detection limits for the investigated elements are in the range of0.9-37.5 ng/L, the relative standard deviation of each element is within 1.1%-4.8%, and the recovery of each element is 90%-108%.

Uncertainty Evaluation of Simultaneous Determination of Lead, Cadmium and Arsenic in Cosmetics by Inductively Coupled Plasma Mass Spectrometry

This study aimed to evaluate the uncertainty of simultaneous determination of lead(Pb),cadmium(Cd)and arsenic(As)in cosmetics by microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS)with ^72Ge,^115In and ^209Bi as internal standards.According to the method of Safety and Technical Standards for Cosmetics(2015),a mathematical model was established to evaluate the sources and components of uncertainty for the determination of lead,cadmium and arsenic in cosmetics.The results showed that the uncertainties in the determination of lead,cadmium,and arsenic elements in cosmetics were(10.1±0.6)mg/kg,k=2,(4.84±0.28)mg/kg,k=2,(2.04±0.18)mg/kg,k=2,respectively.The main factors that affect the uncertainty of determination results were standard substance,calibration curve,recovery and measurement repeatability.

ICP-MS法分析过氧化氢、硝酸、硫酸中的金属杂质

Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect trace metal impurities in reagents such as H2O2, HNO3and H2SO4. The limit of detection to metal elements can be down to 2-20 ng/L in H2O2 and HNO3 and 0.1-1.0 ng/L in H2SO4.

ICP-MS测定硼矿区饮用水和尿样中的硼及多种元素

The application of inductively coupled plasma mass spectrometry (ICP-MS) for determination of boron in water and urine samples was described. The detect limit (3σ) was 0.057 μg/L. The precision of the method was less than 2%. Multi-elements including Cr, Cu, Cd, Ba, Sr, Mn, Co, Tl, Li, Pb, Ca, Fe, K, Na, Mg, P, Si and Zn could be measured simultaneously. The method was successfully used in practice.

Determination of Pb, Cr, Ni and Mn in Tap Water of Riyadh Metropolitan City Using ICP-MS after Preconcentration with Multiwalled Carbon Nanotubes

The determination of toxic metals in water using multiwalled carbon nanotubes （MWNTs） as a solid-phase extraction adsorbent prior to their determination by inductively coupled plasma mass spectrometry （ICP-MS） has been investigated. Standard addition method was applied for the calibration using aqueous solutions. Multiwalled carbon nanotubes （MWNTs） absorb these metals at pH 8.0, HNO3 of 1.0 mol-Ll is used for complete elusion of these metals from MWNTs. Previously investigated parameters have been applied for the determination of Pb, Cr, Ni and Mn in tap water samples. Fifteen tap water samples from different locations of Riyadh metropolitan area have been determined by ICP-MS after preconcentration with MWNTs.

Determination of Fe, Cu, and Zn in Water Samples by Microcolumn Packed with Multiwalled Carbon Nanotubes as a Solid Phase Extraction Adsorbent Using ICP-MS

The heavy metals determination in tap water samples using microcolumn packed with multiwalled carbon nanotubes （MWNTs） as a solid-phase extraction adsorbent before to their determination by inductively coupled plasma mass spectrometry （ICP-MS） has been studied. Standard addition method was applied for the calibration using aqueous solutions. The metals ions absorption were achieved by multiwalled carbon nanotubes （MWNTs） at pH 8.0, and then these retained metals on MWNTs column were eluted by 1.0 mol.L^-1 HNO3. The analytical parameters for the determination ofFe, Cu, and Zn in tap water samples which have been investigated previously were applied. Fifteen tap water samples were collected from different locations of Riyadh metropolitan area and then determined the concentration ofFe, Cu, and Zn by ICP-MS after preconcentration with MWNTs. The concentration range for Fe, Cu, and Zn measured （μg/L） in water samples are 23.37-137.91, 2.12-121.36, and 14.43-202.47 respectively. The level of Fe exceeded the limits set by WHO and SASO for drinking water.

Pt-Os同位素系统定年方法研究

Six massive ores in the Jinchuan deposit were dated by Re-Os technique. The Os concentrations and isotopic ratios were determined by N-TIMS, while Re and Pt concentrations were determined by ICP-MS. The samples gave an isochron age of (852±25) Ma with an initial 187Os/188Os ratio of 0.255 ± 0.014. A 7-point Pt-Os isochrone gives an age of (870±38) Ma with an initial 186Os/188Os ratio of 0.119 84±0.000 27.

烟用接装纸质控样品的制备与应用

采用深珠光印字烟用接装纸作为质控样品,用微波消解处理质控样品,以电感耦合等离子体质谱法(ICP–MS)对样品的铬、砷、铅含量进行定值,并进行不确定度评定。利用方差分析评价均匀性,ADF检验评价稳定性。经F检验表明在95%的置信区间,制备的烟用接装纸质控样品均匀性良好;经ADF检验表明,各元素在1%的显著水平下稳定可靠,样品稳定性良好。将烟用接装纸质控样品用于质控,并绘制Levy–Jennings质控图,质控效果良好。

碰撞反应池等离子体质谱测定有机酸盐中杂质元素

建立有机酸盐中Pb、Cd,Cr、As、Fe、Cu、Mn、Co、Ni、Sb等10种杂质元素的微波消解碰撞反应池技术电感耦合等离子体质谱法。通过基体匹配、正确选择测量同位素及内标元素后,有效地克服了因高钙、高钠基体效应带来的测量偏差,极大的消除了多原子离子对待测元素的干扰,使有机酸盐中杂质元素的测试更为准确。方法的检出限为0.015 mg/kg^1.5 mg/kg之间,回收率均在90.0%~110.0%之间,相对标准偏差为2.01%~10.3%。

硒化枸杞多糖的制备及其抗氧化性研究

以亚硒酸钠和枸杞多糖为原料合成硒化枸杞多糖,电感耦合等离子体质谱法(ICP-MS)测定其中硒含量为64.42 mg/g。利用紫外-可见光谱、红外光谱两种表征手段,证实了硒化枸杞多糖的合成。采用邻二氮菲-Fe2+氧化法和邻苯三酚自氧化法测定硒化枸杞多糖的抗氧化能力,结果表明,在实验设置的浓度范围内,硒化枸杞多糖的抗氧化能力随着浓度的增加而增加,且高于枸杞多糖。2.0 mg/mL的枸杞多糖和硒化枸杞多糖对超氧阴离子自由基的清除率分别为51.48%和59.34%,对羟自由基的清除率分别为50.23%和56.16%。本实验为进一步研究硒化枸杞多糖作为抗氧化能力较强的食品和药品的可能性奠定了基础。

电感耦合等离子体质谱测定大气铅污染物

Inductively coupled plasma mass spectrometry(ICP-MS) was used to determine the concentration of Pb in atmospheric particulate samples,and the enrichment factor was calculated.The causes of the results were also discussed.

Multielement determination in orange juice by ICP-MS associated with data mining for the classification of organic samples

The aim of this study was to discriminate organic from conventional orange juice based on chemical elements and data mining applications.A comprehensive sampling of organic and conventional oranges was carried out in Borborema,state of Sao Paulo,Brazil.The fruits of the variety Valencia(Citrus sinensis(L.)Osbeck)budded on Rangpur lime(Citrus limonia Osbeck)were analyzed.Eleven chemical elements were determined in 57 orange samples grown in organic and conventional systems.In order to classify these samples,data mining techniques(Support Vector Machine(SVM)and Multilayer Perceptron(MLP))were combined with feature selection(F-score and chi-squared).SVM with chi-squared had a better performance compared with the other techniques because it reached 93.00% accuracy using only seven chemical components(Cu,Cs,Zn,Al,Mn,Rb and Sr),and correctly classified 96.73% of the samples grown in an organic system.

盐酸罗哌卡因注射液中29种元素杂质的含量测定

目的:建立盐酸罗哌卡因注射液中29种具有潜在风险的元素杂质镉、铅、砷、汞、钴、钒、镍、铊、硒、银、金、钯、铱、锇、铑、钌、铂、锂、锑、钡、钼、铜、锡、铬、铝、铁、锌、硼、硅的电感耦合等离子体质谱检测方法并对相容性进行了考察。方法:以硝酸-盐酸-水(4∶1∶95)稀释样品,采用电感耦合等离子体质谱(ICP-MS)法对盐酸罗哌卡因注射液中元素杂质进行含量分析,运用碰撞模式消除双电荷干扰。结果:29种元素杂质的检测限为0.0138~361.1 ng·mL^(-1),加标回收率在93.8%~126.0%,30批样品中29种元素杂质含量均未超过限度。结论:本方法准确,灵敏度高,简便可行,可以为盐酸罗哌卡因注射液元素杂质评估和控制提供有力的技术保障。

卷柏总黄酮片及其原料和药材中汞的含量测定不同方法的比较

目的:分析比较中药中汞(Hg)含量测定的电感耦合等离子体质谱(ICP-MS)法、测汞仪(MV)法、原子荧光分光光度(AFS)法和原子吸收分光光度(AAS)法,并采用4种方法测定卷柏总黄酮片及其原料和药材中的汞含量。方法:建立ICP-MS、MV、AFS和AAS测定汞的方法;采用微波消解法处理样品,分别采用ICP-MS、AFS和AAS方法测定卷柏总黄酮片及其原料和药材中汞的含量;直接进样法用MV测定样品中汞的含量,并对结果进行分析。结果:卷柏中均未检出汞;AAS除一批总黄酮中汞小于定量限0.0500mg·kg^(-1)外,其余均未检出汞;总黄酮中汞含量:批号14092101中0.0139(AFS)、0.0146(ICP-MS)、0.0121(MV)mg·kg^(-1),批号14092102中0.0142(AFS)、0.0131(ICP-MS)、0.0150(MV)mg·kg^(-1),批号14092103中0.0151(AFS)、0.0167(ICP-MS)、0.0141(MV)mg·kg^(-1),批号14040101中0.0087(AFS)、0.0084(ICP-MS)、0.0078(MV)mg·kg^(-1);片剂中汞含量:批号15082801中0.0035(AFS)、0.0033(ICP-MS)、0.0024(MV)mg·kg^(-1),批号15082802中0.0023(AFS)、0.0022(ICP-MS)、0.0028(MV)mg·kg^(-1),批号15082803中0.0031(AFS)、0.0033(ICP-MS)、0.0033(MV)mg·kg^(-1),4种方法测定结果一致。汞的检测限:ICP-MS为0.0001 mg·kg^(-1),MV法为0.0001 mg·kg^(-1),AFS法为0.0006 mg·kg^(-1),AAS法为0.0150 mg·kg^(-1)。4种汞含量测定方法学考察结果良好,标准曲线r均在0.9986以上,回收率范围为87.4%~100.3%(RSD≤2.9%)。结论:4种方法均可适用于中药中汞的限量控制,ICP-MS法灵敏度高,可同时检测;MV法不用消解直接进样,简便、快捷、灵敏度高;AFS法简便易行,灵敏度较高;AAS灵敏度较低。