The protective ability of host defense system is largely dependent on germ-line encoded pattern-recogni-tion receptors(PRRs).These PRRs respond to a variety of exogenous pathogens or endogenous danger signals,by recog...The protective ability of host defense system is largely dependent on germ-line encoded pattern-recogni-tion receptors(PRRs).These PRRs respond to a variety of exogenous pathogens or endogenous danger signals,by recognizing some highly conserved structures such as pathogen-associated molecular patterns(PAMPs)and danger/damage associated molecular patterns(DAMPs).The most studied PRRs are Toll-like receptors(TLRs).Activation of TLRs triggers production of inflammatory cytokines and type I interferons(IFNs)via myeloid differentiation primary response gene 88(MyD88)-depen-dent or-independent signaling respectively,thereby modulating innate and adaptive immunity,as well as inflammatory responses.This review introduces the classification,structure,and specific ligands of TLRs,and focuses on their signal pathways and biological activities,as well as clinical relevance.These studies of TLRs in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases,including tuberculosis(TB),microbial keratitis,and hepatitis B and C.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.30972763 and U0832006)American NIH grant(No.5R01EY19021).
文摘The protective ability of host defense system is largely dependent on germ-line encoded pattern-recogni-tion receptors(PRRs).These PRRs respond to a variety of exogenous pathogens or endogenous danger signals,by recognizing some highly conserved structures such as pathogen-associated molecular patterns(PAMPs)and danger/damage associated molecular patterns(DAMPs).The most studied PRRs are Toll-like receptors(TLRs).Activation of TLRs triggers production of inflammatory cytokines and type I interferons(IFNs)via myeloid differentiation primary response gene 88(MyD88)-depen-dent or-independent signaling respectively,thereby modulating innate and adaptive immunity,as well as inflammatory responses.This review introduces the classification,structure,and specific ligands of TLRs,and focuses on their signal pathways and biological activities,as well as clinical relevance.These studies of TLRs in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases,including tuberculosis(TB),microbial keratitis,and hepatitis B and C.
