Einstein Hybrid Structure of q-Rung Orthopair Fuzzy Soft Set and Its Application for Diagnosis of Waterborne Infectious Disease

This research is devoted to diagnosing water-borne infectious diseases caused by floods employing a novel diagnosis approach,the Einstein hybrid structure of q-rung orthopair fuzzy soft set.This approach integrates parts of fuzzy logic and soft set theory to develop a robust alternative for disease detection in stressful situations,especially in areas affected by floods.Compared to the traditional intuitionistic fuzzy soft set and Pythagorean fuzzy soft set,the q-rung orthopair fuzzy soft set(q-ROFSS)adequately incorporates unclear and indeterminate facts.The major objective of this investigation is to formulate the q-rung orthopair fuzzy soft Einstein hybrid weighted average(q-ROFSEHWA)operator and its specific characteristics.Moreover,our stated operator is implementing intelligentmulti-criteria group decision-making(MCGDM)methodology.Floods are severe natural catastrophes that raise the risk of diseases and epidemics,particularly those caused by contaminants in the water,such as gastrointestinal diseases,respiratory infections,vector-borne diseases,skin infections,and water-borne parasites.The designed MCGDM strategy tackles the prevalence of certain conditions in flood-affected patients.A comparative investigation determined that the suggested method for detecting water-borne infectious disease due to floods is more effective and productive than conventional methods because of its logical structure.

Hepatitis B virus infection in patients with Wilson disease:A large retrospective study

BACKGROUND Wilson disease(WD)is the most common genetic metabolic liver disease.Some studies have shown that comorbidities may have important effects on WD.Data on hepatitis B virus(HBV)infection in patients with WD are limited.AIM To investigate the prevalence and clinical impact of HBV infection in patients with WD.METHODS The clinical data of patients with WD were analyzed retrospectively,and the data of patients with concurrent WD and HBV infection were compared with those of patients with isolated WD.RESULTS Among a total of 915 WD patients recruited,the total prevalence of current and previous HBV infection was 2.1%[95%confidence interval(CI):1.2%-3.0%]and 9.2%(95%CI:7.3%-11.1%),respectively.The main finding of this study was the identification of 19 patients with concurrent WD and chronic hepatitis B(CHB)infection.The diagnosis of WD was missed in all but two patients with CHB infection.The mean delay in the diagnosis of WD in patients with concurrent WD and CHB infection was 32.5 mo,which was significantly longer than that in patients with isolated WD(10.5 mo).The rates of severe liver disease and mortality in patients with concurrent WD and CHB infection were significantly higher than those in patients with isolated WD(63.1%vs 19.3%,P=0.000 and 36.8%vs 4.1%,P<0.001,respectively).Binary logistic regression analysis revealed a significantly higher risk of severe liver disease at the diagnosis of WD in patients with current HBV infection[odds ratio(OR)=7.748;95%CI:2.890-20.774;P=0.000)]or previous HBV infection(OR=5.525;95%CI:3.159-8.739;P=0.000)than in patients with isolated WD.CONCLUSION The total prevalence of current HBV infection in patients with WD was 2.1%.The diagnosis of WD in CHB patients is usually missed.HBV infection is an independent risk factor for severe liver disease in WD patients.The diagnosis of WD should be ruled out in some patients with CHB infection.

Impact of environmental and dietary factors on the course of inflammatory bowel disease

Besides their possible effects on the development of inflammatory bowel disease(IBD),some environmental factors can modulate the clinical course of both ulcerative colitis(UC) and Crohn's disease(CD).This review is mainly devoted to describing the current knowledge of the impact of some of these factors on the outcome of IBD,with special emphasis on smoking and diet.Although the impact of smoking on the susceptibility to develop CD and UC is firmly established,its influence on the clinical course of both diseases is still debatable.In CD,active smoking is a risk factor for postoperative recurrence.Beyond this clinical setting,smoking cessation seems to be advantageous in those CD patients who were smokers at disease diagnosis,while smoking resumption may be of benefit in ex-smokers with resistant UC.The role of dietary habits on the development of IBD is far from being well established.Also,food intolerances are very frequent,but usually inconsistent among IBD patients,and therefore no general dietary recommendations can be made in these patients.In general,IBD patients should eat a diet as varied as possible.Regarding the possible therapeutic role of some dietary components in IBD,lessons should be drawn from the investigation of the primary therapeutic effect of enteral nutrition in CD.Low-fat diets seem to be particularly useful.Also,some lipid sources,such as olive oil,medium-chain triglycerides,and perhaps omega-3 fatty acids,might have a therapeutic effect.Fermentable fiber may have a role in preventing relapses in inactive UC.

Elemental Concentrations in Biological Samples of Coronavirus Disease (COVID-19) and Other Pulmonary Disease Patients

Background: Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health anxiety. At this time, the treatment options for this disease are only moderately successful. Smoking has been related to COVID-19 and its mortality, and it has the potential to affect bacteriological and viral conversion, clinical effects, and treatment outcomes. Methods: The aim of this study was to determine the relationship between critical essential trace {zinc (Zn), iron (Fe), and copper (Cu)} and toxic {cadmium (Cd) and nickel (Ni)} elements in human biological samples such as scalp hair, serum, saliva, blood, nasal fluid, and sputum of smoking and nonsmoking male COVID-19 patients (n = 139, age range 25 - 38 years) from Hyderabad, Pakistan. For comparative purposes, the biological specimens of referent persons (n = 83), pulmonary Tuberculosis (T.B) patients (n = 67), Pneumonia (n = 56) of the same age groups were also be analyzed. Microwave oven mediated digestion method was employed, and digestion of samples was carried out with the help of 2:1 mixture solution of HNO3 (65%) and H2O2 (30%). Atomic absorption spectrometry was employed for the determination of elemental concentrations from the microwave oven employed digested samples. Results: The found average of essential elements (Zn, Fe, and Cu) in biological specimens of smoker and nonsmoker male COVID-19, T.B, and Pneumonia patients was found to lower, whilst cadmium and nickel were found to be higher when compared with samples from referents (p < 0.001). Conclusions: Improved elemental (Cu, Fe, Zn) concentrations may also decrease the risk of bacterial co-infection by enhancing the mucociliary clearance and respiratory epithelial barrier function, in addition to providing direct antibacterial effects against S. pneumoniae. Our findings also suggest that higher Cd and Ni concentrations are linked to cigarette smoking, which could lead to COVID-19 and other lung-infected diseased recurrences. However, further clinical and experimental research is required.

Assessing Animal Disease Prevalence and Mortality in Smallholder Dairy Farms under Contrasting Management Practices and Stressful Environments in Tanzania

In dairy farming, deploying effective animal husbandry practices minimise disease infections and animal mortality. This improves animal health and welfare status, which is important in tropical smallholder dairy farming, where animals are persistently exposed to multiple environmental stresses. The hypothesis of this study was that animals managed in positive deviants and typical farms suffer different levels of disease infections and mortality, whether under low- or high-stress environments. The study adopted a two-factor nested design with farms contrasting in the level of animal husbandry (positive deviants and typical farms) nested within environments contrasting in the level of environmental stresses (low- and high-stress). A total of 1,999 animals were observed over 42 month period in the coastal lowlands and highlands of Tanzania. The disease prevalence was lower (p < 0.05) in positive deviant farms than in typical farms under low-stress (10.13 vs. 33.61 per 100 animal-years at risk) and high-stress (9.56 vs. 57.30 per 100 animal-years at risk). Cumulative disease incidence rate was also lower (p < 0.05) in positive deviant farms than in typical farms under low-stress (2.74% vs. 8.44%) and high-stress (2.58% vs. 14.34%). The probability of death for a disease infected dairy cattle was relatively lower in positive deviant farms compared to typical farms under low-stress (0.57% vs. 8.33%) and high-stress (0.60% vs. 6.99%). Per 100 animal-years at risk, the mortality density of cattle was lower (p < 0.05) in positive deviant farms compared to typical farms, 15.10 lower in low-stress and 2.60 lower in high-stress. These results show that compared to typical farms, positive deviant farms consistently attained (p < 0.05) lower animal disease infections and subsequent deaths, regardless of the level of environmental stress that the animals were exposed to. This implies that positive deviant farms deployed animal husbandry practices that more effectively minimised animal disease infections and deaths and therefore could maintain their animals in better health and welfare status.

Adults with Congenital Heart Disease during the COVID-19 Era:One-Year Tertiary Center Experience

Background:Adult patients with congenital heart disease(ACHD)might be at high risk of Coronavirus disease-2019(COVID-19).This study aimed to report on a one-year tertiary center experience regards COVID-19 infection in ACHD patients.Methods:This is a one-year(March-2020 to March-2021)tertiary-center retrospective study that enrolled all ACHD patients;COVID-19 positive patients’medical records,and management were reported.Results:We recorded 542 patients,205(37.8%)COVID-19-positive,and 337(62.2%)COVID-19-negative patients.Palliated single ventricle and Eisenmenger syndrome patients were more vulnerable to COVID-19 infection(P<0.05*).Cardiovascular COVID-19 complications were arrhythmias in 47(22.9%)patients,heart failure in 39(19.0%)patients,cyanosis in 12(5.9%)patients,stroke/TIA in 5(2.4%)patients,hypertension and infective endocarditis in 2(1.0%)patients for each,pulmonary hypertension and pulmonary embolism in 1(0.5%)patient for each.11(5.4%)patients were managed with home isolation,147(71.7%)patients required antibiotics,32(15.6%)patients required intensive care unit(ICU),8(3.9%)patients required inotropes,7(3.4%)patients required mechanical ventilation,and 2(1.0%)patients required extracorporeal membrane oxygenation(ECMO).Thromboprophylaxis was given to all 46(22.4%)hospitalized patients.American College of Cardiology/American Heart Association classification revealed that complex lesions,and FC-C/D categories were more likely to develop severe/critical symptoms,that required mechanical ventilation and ECMO(P<0.05*).Mortality was reported in 3(0.6%)patients with no difference between groups(P=0.872).193(35.6%)patients were vaccinated.Conclusions:COVID-19 infection in ACHD patients require individualized risk stratification and management.Eisenmenger syndrome,single ventricle palliation,complex lesions,and FC-C/D patients were more vulnerable to severe/critical symptoms that required ICU admission,mechanical ventilation,and ECMO.The vaccine was mostly tolerable.

Liver transplantation in patients with SARS-CoV-2:Two case reports

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19).This disease was declared a worldwide health problem with the characteristics of a pandemic.Most patients have mild symptoms and a good prognosis.Information on the evolution and prognosis of COVID-19 in solid organ recipients is scarce.CASE SUMMARY We describe two patients who underwent liver transplantation with a positive test result for detection of the viral sequence for COVID-19,using reversetranscription polymerase chain reaction(RT-PCR),immediately before transplantation.The patients showed good evolution in the postoperative period,without signs of graft dysfunction.The immunosuppressive therapy was not modified.Both patients were discharged for subsequent outpatient follow-up.CONCLUSION In conclusion,it is expected that the experience at this center can be used as an example,aimed at the continuation of transplantations by other services and,thus,the morbidity and mortality of patients with liver disease on the transplantation waiting list can be reduced.Transplant centers must be able to readjust daily to the evolution of the COVID-19 pandemic.

Study on the psychological reaction and coping strategies of nursing students under the spread of COVID-19

Background:To understand the psychological reaction and coping strategies of infectious diseases among nursing students.Methods:A convenience sampling method was used to select 455 nursing students in the school,and a questionnaire survey was conducted on the general data table and the psychological reaction and coping strategy scale of infectious diseases of college students and coronavirus disease 2019(COVID-19)was used as an example of the infectious diseases.Results:the psychological reaction of nursing students was related to gender(P=0.006),age(P=0.001),education level(P=0.019),professional category of senior high school(P=0.014),whether they were student cadres(P<0.001)and whether there were immediate relatives engaged in medical and health related work(P=0.022).Different education level(P=0.017),different age(P=0.041),different residence(P=0.003),high school professional category(P=0.008)and whether there are immediate relatives engaged in medical and health related work(P=0.021)are related to their coping strategies.Conclusion:Nursing students with different demographic data have different psychological reactions and coping strategies.In the future research on the infectious diseases related to nursing students,it is suggested to focus on the female,the younger,the less educated,the liberal arts students and the nursing students who have no immediate family members engaged in medical and health related work,so as to promote the physical and mental health development of the nursing students in school.

HOPF BIFURCATION AND OTHER DYNAMICAL BEHAVIORS FOR A FOURTH ORDER DIFFERENTIAL EQUATION IN MODELS OF INFECTIOUS DISEASE

Periodic solutions of Hopf type and other dynamical behaviors for a four-order differential equation which occurs in the model of infections disease are investigated. The extended theorem about the conditions for the existence of Hopf bifurcation is proved in higher-order differential equations with several parameters. The Hopf bifurcation value is given through the medium of the corresponding coordinate at the Hopf bifurcation point, and depends on one parameter.The paper reveals that the model of Holt and Picker has periodic solutions, and proves the reliability of the numerical solution which is given by Liu Winmin.

Analysis of a hand-foot-mouth disease model

In this paper, we have introduced a six-compartmental epidemic model with hand, foot and mouth disease （HFMD） infection. The total population is divided into six subclasses, namely susceptible, exposed, infective in asymptomatic phase, infective in symptomatic phase, quarantined and recovered class. Some basic properties such as boundedness and non-negativity of solutions are discussed. The basic reproduction number （R0） of the system is obtained using next generation matrix method. Then the deterministic dynamical behaviors of the system are studied. Our study includes the existence and stability analysis of equilibrium points of the system. The sensitivity analysis of our system helps us to find out the parameters of greater interest. Next, we deal with the epidemic model with three controls （two treatment controls with quarantine control）. We show that there exists an optimal control, which is effective in controlling the disease outbreak in a cost effective way. Numerical simulation is presented with the help of MATLAB, which shows tile reliability of our model from the practical point of view.

Improvement of the software for modeling the dynamics of epidemics and developing a user-friendly interface

The challenges humanity is facing due to the Covid-19 pandemic require timely and accurate forecasting of the dynamics of various epidemics to minimize the negative consequences for public health and the economy.One can use a variety of well-known and new mathematical models,taking into account a huge number of factors.However,complex models contain a large number of unknown parameters,the values of which must be determined using a limited number of observations,e.g.,the daily datasets for the accumulated number of cases.Successful experience in modeling the COVID-19 pandemic has shown that it is possible to apply the simplest SIR model,which contains 4 unknown parameters.Application of the original algo-rithm of the model parameter identification for the first waves of the COVID-19 pandemic in China,South Korea,Austria,Italy,Germany,France,Spain has shown its high accuracy in pre-dicting their duration and number of diseases.To simulate different epidemic waves and take into account the incompleteness of statistical data,the generalized SIR model and algorithms for determining the values of its parameters were proposed.The interference of the previous waves,changes in testing levels,quarantine or social behavior require constant monitoring of the epidemic dynamics and performing SIR simulations as often as possible with the use of a user-friendly interface.Such tool will allow predicting the dynamics of any epidemic using the data on the number of diseases over a limited period(e.g.,14 days).It will be possible to predict the daily number of new cases for the country as a whole or for its separate region,to estimate the number of carriers of the infection and the probability of facing such a carrier,as well as to estimate the number of deaths.Results of three SIR simulations of the COVID-19 epidemic wave in Japan in the summer of 2022 are presented and discussed.The predicted accumulated and daily numbers of cases agree with the results of observations,especially for the simulation based on the datasets corresponding to the period from July 3 to July 16,2022.A user-friendly interface also has to ensure an opportunity to compare the epidemic dynamics in different countries/regions and in different years in order to estimate the impact of vaccination levels,quarantine restrictions,social behavior,etc.on the numbers of new infections,death,and mortality rates.As example,the comparison of the COVID-19 pandemic dynamics in Japan in the summer of 2020,2021 and 2022 is presented.The high level of vaccinations achieved in the summer of 2022 did not save Japan from a powerful pandemic wave.The daily numbers of cases were about ten times higher than in the corresponding period of 2021.Nevertheless,the death per case ratio in 2022 was much lower than in 2020.

Species Distribution and In Vitro Antifungal Susceptibility of Vulvovaginal Candida Isolates in China

Background： Vulvovaginal candidiasis （WC） was a common infection associated with lifelong harassment of woman＇s social and sexual life. The purpose of this study was to describe the species distribution and in vitro antifungal susceptibility of Candida species （Candida spp.） isolated from patients with VVC over 8 years. Methods： Species which isolated from patients with VVC in Peking University First Hospital were identified using chromogenic culture media. Susceptibility to common antifungal agents was determined using agar diffusion method based on CLSI M44-A2 document. SPSS software （version 14.0, Inc., Chicago, IL, USA） was used for statistical analysis, involving statistical description and Chi-square test. Results： The most common strains were Candida （C.） albicans, 80.5% （n = 1775） followed by C. glabrata, 18.1% （n = 400）. Nystatin exhibited excellent activity against all species （〈4% resistant JR]）. Resistance to azole drugs varied among different species. C. albicans： clotrimazole （3.1% R） 〈 fluconazole （ 16.6% R） 〈 itraconazole （51.5% R） 〈 mieonazole （54.0% R）, C. glabrata： miconazole （25.6% R） 〈 clotrimazole （50.5% R） 〈 itraconazole （61.9% R） 〈 fluconazole （73.3% R）; Candida krusei： clotrimazole （0 R） 〈 fluconazole （57.7% R） 〈 miconazole （73.1% R） 〈 itraconazole （83.3% R）. The susceptibility of fluconazole was noticeably decreasing among all species in the study period. Conclusions： Nystatin was the optimal choice for the treatment of VVC at present. The species distribution and in ~＇itro antifungal susceptibility of Candida spp. isolated from patients with VVC had changed over time.

Importance of community containment measures in combating the COVID-19 epidemic:From the perspective of urban planning

To contain the outbreak of COVID-19 in Wuhan,unprecedented interventions,including city lockdown and community closure,have been implemented.However,most of the current studies focused on evaluation of the city lockdown,but paid limited attention to the impacts of the community containment measures within the city.This research addressed this important issue from the perspective of urban planning,based on the epidemic and remote sensing data of 194 communities of Wuhan.We found that the number of confirmed cases of communities is highly related to urban planning factors,e.g.area percentage of buildings and density of neighboring markets.These factors are relevant to the residents’activity patterns,which therefore impact the mode of virus transmission.Our research confirmed the effectiveness of the community-oriented control strategies,provided a valuable reference for other cities that are suffering from the epidemic,and exhibited new thoughts into future urban planning.

Osteonecrosis of the jaw in a patient with acute myeloid leukemia,who received azacitidine

The first case of osteonecrosis of the jaw(ONJ)related to azacitidine therapy was reported.A 64-year-old male with acute myeloid leukemia,who received 5-azacitidine,presented with pain and purulence of the right second premolar.An unsuccessful endodontic therapy resulted in dental extraction 6 months later.The post-extraction non-healing socket was managed with antibiotics and multiple surgical debridements without response.ONJ stage 2 was diagnosed 12 months after the initial symptoms of pain and purulence and was managed conservatively.Currently the patient is still receiving 5-azacitidine therapy,while ONJ remains asymptomatic.This case highlights the presence of alveolar bone disease prior to the appearance of ONJ.Osteonecrosis in chemotherapy,although rare,may increase as long-term survival of cancer patients,who receive those medications increases.Health care professionals need to be alert,while collaboration with an experienced oral/dental oncologist would be beneficial to the patient.

Major advances in respiratory medicine in China

Respiratory disease is the term for diseases of the respiratory system. These diseases range from mild and self-limiting such as the common cold to life-threatening such as bacterial pneumonia or pulmonary embolism. They are common and important causes of illness and death. In the US, people suffer 1 billion colds per year. One out of 7 people in the UK are affected by some kinds of chronic lung diseases, most commonly chronic obstructive pulmonary disease （COPD） and asthma. Respiratory disease accounts for over 10% of hospitalizations and over 16% of deaths in Canada.