Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin...Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.展开更多
Avian influenza A viruses could get across the species barrier and be fatal to humans. Highly patho-genic avian influenza H5N1 virus was an example. The mechanism of interspecies transmission is not clear as yet. In t...Avian influenza A viruses could get across the species barrier and be fatal to humans. Highly patho-genic avian influenza H5N1 virus was an example. The mechanism of interspecies transmission is not clear as yet. In this research,the protein sequences of 237 influenza A viruses with different subtypes were transformed into pseudo-signals. The energy features were extracted by the method of wavelet packet decomposition and used for virus classification by the method of hierarchical clustering. The clustering results showed that five patterns existed in avian influenza A viruses,which associated with the phenotype of interspecies transmission,and that avian viruses with patterns C and E could across species barrier and those with patterns A,B and D might not have the abilities. The results could be used to construct an early warning system to predict the transmissibility of avian influenza A viruses to humans.展开更多
基金Supported by the National Basic Research Program of China (Grant Nos. 2005CB523001, 2005CB523002)National Key Technologies Research & Devel-opment Program (Grant 2006BAD06A01/ 2006BAD06A04)+2 种基金US National Institutes of Health (NIH) (Grant 3 U19 AI051915-05S1)the National Natural Science Foun-dation of China (Grant 30599434)GAO FG is a distinguished young investigator of the NSFC (Grant No. 30525010).
文摘Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.
基金the Special Basic Research Funds of China (Grant No. 2007FY210700)Major Program of National Natural Science Foundation of China (Grant No. 90608020)+3 种基金the National Basic Research Program of China (Grant Nos. 2005CB523007 and 2005CB523004)Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20050487037)the Knowledge Innovation Project of the Chinese Academy of Sciences (Grant No. KSCX2-YW-N-065) the Sixth Framework Program in European (Grant Nos. SP5B-CT-2006-044161 and SP5B-CT-2006-044405)
文摘Avian influenza A viruses could get across the species barrier and be fatal to humans. Highly patho-genic avian influenza H5N1 virus was an example. The mechanism of interspecies transmission is not clear as yet. In this research,the protein sequences of 237 influenza A viruses with different subtypes were transformed into pseudo-signals. The energy features were extracted by the method of wavelet packet decomposition and used for virus classification by the method of hierarchical clustering. The clustering results showed that five patterns existed in avian influenza A viruses,which associated with the phenotype of interspecies transmission,and that avian viruses with patterns C and E could across species barrier and those with patterns A,B and D might not have the abilities. The results could be used to construct an early warning system to predict the transmissibility of avian influenza A viruses to humans.
