BACKGROUND Immunoglobulin G4-related prostate disease(IgG4-RPD)characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological findings.Here we report a case of a patient who w...BACKGROUND Immunoglobulin G4-related prostate disease(IgG4-RPD)characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological findings.Here we report a case of a patient who was successfully treated for IgG4-RPD,which manifested as frequent micturition,dysuric,and systemic lymphadenopathy.CASE SUMMARY The patient was a 33-year-old man who was referred to our hospital because of urinary tract symptoms that had persisted for 4 years.A physical examination revealed systemic lymphadenopathy and blood tests showed hyperglobulinemia with an IgG level of 18.90 g/L and an IgG4 level of 18.40 g/L.Computed tomography(CT)revealed bilateral lacrimal gland,right parotid gland and prostatic enlargement.Based on these findings,IgG4-RD was suspected,and further pathological examination and follow-up results showed expected results.Finally,the patient was diagnosed with IgG4-RPD based on clinical symptoms,pathological examination,therapeutic effects,and follow-up results.He received 50 mg oral prednisolone(the dose was gradually reduced and a low dose was used for long-term maintenance)in combination with cyclophosphamide 1.0 g via an intravenous drip for 6 mo.One year after the treatment was initiated,he was free of urinary or other complaints and his serum IgG4 level normalized.CONCLUSION In IgG4-RPD with severe urinary tract symptoms,radiological findings should be carefully examined.IgG4-RPD prognosis is good because the disease responds well to glucocorticoids.Furthermore,it is urgent for clinicians and pathologists to improve their understanding of IgG4-RPD.展开更多
为了解决最大频繁项目集算法DMFIA(discover maximum frequent itemsets algorithm)在挖掘候选项目集维数较大而最大频繁项目集维数较小的情况下产生大量候选项目集的问题,提出一种改进的基于FP-Tree(frequent pattern tree)的最大频繁...为了解决最大频繁项目集算法DMFIA(discover maximum frequent itemsets algorithm)在挖掘候选项目集维数较大而最大频繁项目集维数较小的情况下产生大量候选项目集的问题,提出一种改进的基于FP-Tree(frequent pattern tree)的最大频繁项目集挖掘的FP-EMFIA算法;该算法在挖掘过程中根据项目头表,采用自上而下和自下而上的双向搜索策略,并通过条件模式基中的频繁项目和较小维数的非频繁项目集对候选项目集进行降维和剪枝,以减少候选项目集的数量,加速对候选集计数的操作。在经典数据集mushroom、chess和connect上的实验结果表明,FP-EMFIA算法在支持度较小时的时间效率优于DMFIA、IDMFIA(improved algorithm of DMFIA)和BDRFI(algorithm for mining frequent itemsets based on decreasing dimensionality reduction of frequent itemsets)算法的,说明FP-EMFIA算法在候选项目集维数较大时有相对优势。展开更多
基金Supported by the Guangdong Provincial Bureau of Traditional Chinese Medicine,No.20222065Science and Technology Planning Project of Guangdong Province of China,No.A2021100National Natural Science Foundation of China,No.82104989。
文摘BACKGROUND Immunoglobulin G4-related prostate disease(IgG4-RPD)characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological findings.Here we report a case of a patient who was successfully treated for IgG4-RPD,which manifested as frequent micturition,dysuric,and systemic lymphadenopathy.CASE SUMMARY The patient was a 33-year-old man who was referred to our hospital because of urinary tract symptoms that had persisted for 4 years.A physical examination revealed systemic lymphadenopathy and blood tests showed hyperglobulinemia with an IgG level of 18.90 g/L and an IgG4 level of 18.40 g/L.Computed tomography(CT)revealed bilateral lacrimal gland,right parotid gland and prostatic enlargement.Based on these findings,IgG4-RD was suspected,and further pathological examination and follow-up results showed expected results.Finally,the patient was diagnosed with IgG4-RPD based on clinical symptoms,pathological examination,therapeutic effects,and follow-up results.He received 50 mg oral prednisolone(the dose was gradually reduced and a low dose was used for long-term maintenance)in combination with cyclophosphamide 1.0 g via an intravenous drip for 6 mo.One year after the treatment was initiated,he was free of urinary or other complaints and his serum IgG4 level normalized.CONCLUSION In IgG4-RPD with severe urinary tract symptoms,radiological findings should be carefully examined.IgG4-RPD prognosis is good because the disease responds well to glucocorticoids.Furthermore,it is urgent for clinicians and pathologists to improve their understanding of IgG4-RPD.
文摘为了解决最大频繁项目集算法DMFIA(discover maximum frequent itemsets algorithm)在挖掘候选项目集维数较大而最大频繁项目集维数较小的情况下产生大量候选项目集的问题,提出一种改进的基于FP-Tree(frequent pattern tree)的最大频繁项目集挖掘的FP-EMFIA算法;该算法在挖掘过程中根据项目头表,采用自上而下和自下而上的双向搜索策略,并通过条件模式基中的频繁项目和较小维数的非频繁项目集对候选项目集进行降维和剪枝,以减少候选项目集的数量,加速对候选集计数的操作。在经典数据集mushroom、chess和connect上的实验结果表明,FP-EMFIA算法在支持度较小时的时间效率优于DMFIA、IDMFIA(improved algorithm of DMFIA)和BDRFI(algorithm for mining frequent itemsets based on decreasing dimensionality reduction of frequent itemsets)算法的,说明FP-EMFIA算法在候选项目集维数较大时有相对优势。
