A New Safety Electric Initiating System

Based on the analysis of weakness on the safety of traditional electric detonators, a BJ-l safety electric detonator initiatingsystem and its corresponding safe examination technique were successfully developed. By leading false foot wires and taking advantageof the transmitting frequency band of Mo-Zn ferrite, detonators in this new system can completely impede the direct induction of outsidecrosstalk that may cause casual firing in the ordinary as well as eleclromagnetic ones. Possible causality by lightning was discussed. Results are presented, of its safety tests on resistance to direct and alternating current, electrostatic, and crosstalk induced by damp leakagein saturated salty water.

Allyl chloride/AlCl_3/ether cationic initiating systems for polymerization of 1,3-pentadiene

Various ethers were used to mediate the polymerizations of 1,3-pentadiene (PD) initiated by AlCl3 and by allyl chloride (AllyCl)/AlCl3. The introduction of the ethers exert considerable effects on polymer yield and molecular weight due to its interaction with the propagating carbocation. The carbocation reactivity is reduced by this interaction which is subject to the ether's nucleophilicity determined by the steric hindrance of groups adjacent to oxygen. The reduction of carbocation reactivity gives rise to a decrease of polymer yield owing to inhibition of propagation but results in an augmentation of molecular weight due to suppression of various side reactions such as terminations. By using suitably nucleophilic ethers such as diphenyl ether, the polymerization can be mediated to give an high molecular weight polymer in high yield.

SYNTHESIS OF HIGHLY REACTIVE POLYISOBUTYLENES WITH BF_3·CYCLOHEXANOL INITIATING SYSTEM

The selective cationic polymerization of isobutylene （IB） initiated by a BF3-cyclohexanol （CL） complex was carried out from the mixed Ca fraction feed containing the 4C saturated and unsaturated hydrocarbons at -20℃. The effects of CL concentration, BF3 concentration, solvent for preparing BF3·CL complex and polymerization time on the chemical structure of end groups, number-average molecular weight （Mn） and molecular weight distribution （MWD, Mw/Mn） of the resulting polymers were investigated. The experimental results indicate that the BF3·CL complex initiating system exhibited an extremely high selectivity toward the cationic polymerization of IB in the mixed C4 fraction feed and low molecular weight （Mn = 900-3600） polyisobutylenes （PIBs） with large proportion of exo-double bond end groups were obtained. The exo-double bond content in PIB chain ends increased by increasing CL concentration or by decreasing solvent polarity in initiating system, BF3 concentration and polymerization time. The M, and MWD of the resulting PIBs were dependent on the concentrations of CL and BF3. Highly reactive PIBs with around 90 mol% of exo-double bonds were successfully synthesized by the selective polymerization of IB from the mixed Ca fraction feed, providing a potentially practical process for its simplicity and low costs.

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[J.Pharm.Anal.14(2024)100919]

Original statement in the Section 2:2.Literature search Our primary screening of 180 articles yielded the relevant data for this study.2.1.Study selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially screened.During the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

Numerical simulation for the initial state of avalanche in polydisperse particle systems

Numerical simulation is employed to investigate the initial state of avalanche in polydisperse particle systems.Nucleation and propagation processes are illustrated for pentadisperse and triadisperse particle systems,respectively.In these processes,particles involved in the avalanche grow slowly in the early stage and explosively in the later stage,which is clearly different from the continuous and steady growth trend in the monodisperse system.By examining the avalanche propagation,the number growth of particles involved in the avalanche and the slope of the number growth,the initial state can be divided into three stages:T1(nucleation stage),T2(propagation stage),T3(overall avalanche stage).We focus on the characteristics of the avalanche in the T2 stage,and find that propagation distances increase almost linearly in both axial and radial directions in polydisperse systems.We also consider the distribution characteristics of the average coordination number and average velocity for the moving particles.The results support that the polydisperse particle systems are more stable in the T2 stage.

Drone systems for delivering defibrillators for sudden cardiac arrests

Unmanned aerial vehicles(UAVs),or drones,that were initially developed for military use during World War I[1],have evolved into highly sophisticated aircraft that can be navigated remotely using global positioning systems.With constant improvements,drones have become more efficient,and cost-effective,with longer battery life and greater loading capacity.Today,UAVs have proven to be an effective and affordable solution for enhancing healthcare accessibility for patients who face geographical or infrastructural barriers.Using drone networks can greatly reduce the time transporting life-saving equipment,such as delivering automated external defibrillators(AEDs),to cardiac arrest victims,and can provide quick assistance to reduce travel time for the patients.

Neurocognitive Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in Kinshasa in the Dolutegravir Era, Democratic Republic of Congo

Context: Antiretroviral therapies improve the prognosis of NeuroAIDS contrasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: The objective of this study is to present the neurological and cognitive profile of People Living with HIV (PLHIV) initiating antiretroviral treatment in Kinshasa in the era of Dolutegravir (DTG). Methods: This is a multicenter, cross-sectional study with a descriptive aim carried out in 16 HIV Outpatient Treatment Centers (OTC) in Kinshasa from October 4, 2021 to February 15, 2022. The International HIV Dementia Scale (IHDS) correlated with the Activities of Daily Living (IADL) scale facilitated the categorization of NeuroCognitive Disorders (NCD) of PLHIV evaluated after carrying out a summary neurological examination. Results: Of the 96 patients recruited, 56.3% were women with a sex ratio of 0.68. The average age was 40.1 ± 12.1 years. The secondary education level was the majority at 64.6%. Malaria (44.8%) and tuberculosis (32.3%) were more common as opportunistic infections. They were alcoholics in (30.2%). Their history was heart disease (15.6%), high blood pressure (18.8%);drug abuse (10.4%). The IHDS score was light in 55.2% of cases. The correlation between IHDS/IADL watches asymptomatic neurocognitive impairments (ANI) in 77.1%, almost all of subjects are found with normal overall functioning (94.8%) and a disturbed neurological examination in 53.1% of cases with a predominance of motor impairments in 79.1%. Conclusion: In view of these results, early and systematic screening of NCD and associated factors remains necessary in our context. .

Initiating system Me_3SiCl/AlCl_3 for cationic polymerization of 1,3-pentadiene in toluene

Cationic polymerization of 1,3-pentadiene (PD) initiated by trimethylsilyl chloride/aluminium chloride (TMSCl/AlCl3) was carried out in toluene at 30℃.The polymer yield was increased by the addition of TMSC1.However,introduction of TMSC1 gave rise to a drop of the polymer molecular weight.Kinetic results demonstrated that the polymerization initiated by TMSCl/AlCl3 was 2.8 times faster than that induced by AlCl3 alone.Various ethers and ketones were used to mediate the initiating system TMSCl/AlCl3.The polymer yield and molecular weight of the polymer were decreased in the presence of ether.Ketones and ethers had different effects on the polymerization,and the polymer yield and molecular weight were lower than those initiated by AlCl3 alone or TMSCl/AlCl3 Structural evidence revealed that the polymerization was indeed initiated by AlCl3 and HCl rcsulting from hydrolysis of TMSC1 by adventitious water.

THE IMPLICIT CONTINUITY OF DISCONTINUOUS SYSTEMS

An example is presented to introduce the concept of implicit continuity proposed as contrasted with the explicit continuity.A sufficient and necessary condition of the implicit continuity is given and proved in forms of implicit system.This condition also offers the solution of initial values at the points where the dynamic system is discontinuous.Some discussions are contributed to the physical significance of implicit continuity.

The multiple pleiotropic effects of sodium-glucose cotransporter 2 inhibitors on cardiorenal system

Sodium-glucose cotransporter-2 inhibitors(SGLT2i),including empagliflozin,dapagliflozin,and canagliflozin,are now widely approved antihyperglycemic therapies.Although initially considered to be only glucose-lowering agents,the effects of SGLT2i have expanded far beyond that,and their use is now being studied in the treatment of heart failure and chronic kidney disease,even in patients without diabetes.Because of their unique glycosuric mechanism,SGLT2i also reduce weight.Perhaps more important are the osmotic diuretic and natriuretic effects contributing to plasma volume contraction,and decreases in systolic and diastolic blood pressures by 4 to 6 and 1 to 2 mm Hg,respectively,which may underlie cardiovascular and kidney benefits.

Study on Multi-Scale Blending Initial Condition Perturbations for a Regional Ensemble Prediction System

An initial conditions （ICs） perturbation method was developed with the aim to improve an operational regional ensemble prediction system （REPS）. Three issues were identified and investigated： （1） the impacts of perturbation scale on the ensemble spread and forecast skill of the REPS; （2） the scale characteristic of the IC perturbations of the REPS; and （3） whether the REPS＇s skill could be improved by adding large-scale information to the IC perturbations. Numerical experiments were conducted to reveal the impact of perturbation scale on the ensemble spread and forecast skill. The scales of IC perturbations from the REPS and an operational global ensemble prediction system （GEPS） were analyzed. A ＂multi-scale blending＂ （MSB） IC perturbation scheme was developed, and the main findings can be summarized as follows： The growth rates of the ensemble spread of the REPS are sensitive to the scale of the IC perturbations; the ensemble forecast skills can benefit from large-scale perturbations; the global ensemble IC perturbations exhibit more power at larger scales, while the regional ensemble IC perturbations contain more power at smaller scales; the MSB method can generate IC perturbations by combining the small-scale component from the REPS and the large-scale component from the GEPS; the energy norm growth of the MSB-generated perturbations can be appropriate at all forecast lead times; and the MSB-based REPS shows higher skill than the original system, as determined by ensemble forecast verification.

THE SINGULARLY PERTURBED NONLOCAL REACTION DIFFUSION SYSTEM

In this paper the singularly perturbed initial boundary value problems for the nonlocal reaction diffusion system are considered. Unsing the iteration method and the comparison theorem, the existence, uniqueness and its asymptotic behavior of solution for the problem are studied.

A fast and accurate initial alignment method for strapdown inertial navigation system on stationary base

In this work,a fast and accurate stationary alignment method for strapdown inertial navigation system （SINS） is proposed. It has been demonstrated that the stationary alignment of SINS can be improved by employing the multiposition technique,but the alignment time of the azimuth error is relatively longer. Over here, the two-position alignment principle is presented. On the basis of this SINS error model, a fast estimation algorithm of the azimuth error for the initial alignment of SINS on stationary base is derived fully from the horizontal velocity outputs and the output rates, and the novel azimuth error estimation algorithm is used for the two-position alignment. Consequently, the speed and accuracy of the SINS＇ s initial alignment is enhanced greatly. The computer simulation results illustrate the efficiency of this alignment method.

ENSO hindcast skill of the IAP-DecPreS near-term climate prediction system:comparison of full-field and anomaly initialization

Model initialization is a key process of climate predictions using dynamical models. In this study, the authors evaluated the performances of two distinct initialization approaches--anomaly and full-field initializations--in ENSO predictions conducted using the IAP-DecPreS near-term climate prediction system developed by the Institute of Atmospheric Physics （lAP）. IAP-DecPreS is composed of the FGOALS-s2 coupled general circulation model and a newly developed ocean data assimilation scheme called＇ensemble optimal interpolation-incremental analysis update＇ （EnOI-IAU）. It was found that, for IAP-DecPreS, the hindcast runs using the anomaly initialization have higher predictive skills for both conventional ENSO and El Nino Modoki, as compared to using the full-field initialization. The anomaly hindcasts can predict super El Nino/La Nina 10 months in advance and have good skill for most moderate and weak ENSO events about 4-7 months in advance.The predictive skill of the anomaly hindcasts for El Nino Modoki is close to that for conventional ENSO. On the other hand, the anomaly hindcasts at 1- and 4-month lead time can reproduce the major features of large-scale patterns of sea surface temperature, precipitation and atmospheric circulation anomalies during conventional ENSO and El Nino Modoki winter.

Algorithm for Calculating Torque Base in Vehicle Traction Control System

Existing research on the traction control system（TCS） mainly focuses on control methods, such as the PID control, fuzzy logic control, etc, aiming at achieving an ideal slip rate of the drive wheel over long control periods. The initial output of the TCS （referred to as the torque base in this paper）, which has a great impact on the driving performance of the vehicle in early cycles, remains to be investigated. In order to improve the control performance of the TCS in the first several cycles, an algorithm is proposed to determine the torque base. First, torque bases are calculated by two different methods, one based on states judgment and the other based on the vehicle dynamics. The confidence level of the torque base calculated based on the vehicle dynamics is also obtained. The final torque base is then determined based on the two torque bases and the confidence level. Hardware-in-the-loop（HIL） simulation and vehicle tests emulating sudden start on low friction roads have been conducted to verify the proposed algorithm. The control performance of a PID-controlled TCS with and without the proposed torque base algorithm is compared, showing that the proposed algorithm improves the performance of the TCS over the first several cycles and enhances about 5% vehicle speed by contrast. The proposed research provides a more proper initial value for TCS control, and improves the performance of the first several control cycles of the TCS.

Sensitivity of intrinsic mode functions of Lorenz system to initial values based on EMD method

Extreme sensitivity to initial values is an intrinsic character of chaotic systems. The evolution of a chaotic system has a spatiotemporal structure containing quasi-periodic changes of different spatiotemporal scales. This paper uses an empirical mode decomposition （EMD） method to decompose and compare the evolution of the time-dependent evolutions of the x-component of the Lorenz system. The results indicate that the sensitivity of intrinsic mode function （IMF） component is dependent on initial values, which provides some scientific evidence for the possibility of long-range climatic prediction.

A new nudging scheme for the current operational climate prediction system of the National Marine Environmental Forecasting Center of China

A new nudging scheme is proposed for the operational prediction system of the National Marine Environmental Forecasting Center(NMEFC)of China,mainly aimed at improving El Niño–Southern Oscillation(ENSO)and Indian Ocean Dipole(IOD)predictions.Compared with the origin nudging scheme of NMEFC,the new scheme adds a nudge assimilation for wind components,and increases the nudging weight at the subsurface.Increasing the nudging weight at the subsurface directly improved the simulation performance of the ocean component,while assimilating low-level wind components not only affected the atmospheric component but also benefited the oceanic simulation.Hindcast experiments showed that the new scheme remarkably improved both ENSO and IOD prediction skills.The skillful prediction lead time of ENSO was up to 11 months,1 month longer than a hindcast using the original nudging scheme.Skillful prediction of IOD could be made 4–5 months ahead by the new scheme,with a 0.2 higher correlation at a 3-month lead time.These prediction skills approach the level of some of the best state-of-the-art coupled general circulation models.Improved ENSO and IOD predictions occurred across all seasons,but mainly for target months in the boreal spring for the ENSO and the boreal spring and summer for the IOD.

Diagnosing SST Error Growth during ENSO Developing Phase in the BCC_CSM1.1(m) Prediction System

In this study, the predictability of the El Nino-South Oscillation(ENSO) in an operational prediction model from the perspective of initial errors is diagnosed using the seasonal hindcasts of the Beijing Climate Center System Model,BCC;SM1.1(m). Forecast skills during the different ENSO phases are analyzed and it is shown that the ENSO forecasts appear to be more challenging during the developing phase, compared to the decay phase. During ENSO development, the SST prediction errors are significantly negative and cover a large area in the central and eastern tropical Pacific, thus limiting the model skill in predicting the intensity of El Nino. The large-scale SST errors, at their early stage, are generated gradually in terms of negative anomalies in the subsurface ocean temperature over the central-western equatorial Pacific,featuring an error evolutionary process similar to that of El Nino decay and the transition to the La Nina growth phase.Meanwhile, for short lead-time ENSO predictions, the initial wind errors begin to play an increasing role, particularly in linking with the subsurface heat content errors in the central-western Pacific. By comparing the multiple samples of initial fields in the model, it is clearly found that poor SST predictions of the Nino-3.4 region are largely due to contributions of the initial errors in certain specific locations in the tropical Pacific. This demonstrates that those sensitive areas for initial fields in ENSO prediction are fairly consistent in both previous ideal experiments and our operational predictions,indicating the need for targeted observations to further improve operational forecasts of ENSO.

New methods to find solutions and analyze stability of equilibrium of nonholonomic mechanical systems

A large proportion of constrained mechanical systems result in nonlinear ordinary differential equations,for which it is quite difficult to find analytical solutions.The initial motions method proposed by Whittaker is effective to deal with such problems for various constrained mechanical systems,including the nonholonomic systems discussed in the first part of this paper,where in addition to differential equations of motion,nonholonomic constraints apply.The final equations of motion for these systems are obtained in the form of corresponding power series.Also,an alternative,direct method to determine the initial values of higher-order derivatives(q)0,(q)0,…is proposed,being different from that of Whittaker.The second part of this work analyzes the stability of equilibrium of less complex,nonholonomic mechanical systems represented by gradient systems.We discuss the stability of equilibrium of such systems based on the properties of the gradient system.The advantage of this novel method is its avoidance of the difficulty of directly establishing Lyapunov functions aimed at such unsteady nonlinear systems.Finally,these theoretical considerations are illustrated through four examples.

Impacts of Land Process on the Onset and Evolution of Asian Summer Monsoon in the NCEP Climate Forecast System

Impacts of land models and initial land conditions （ICs） on the Asian summer monsoon, especially its onset, were investigated using the NCEP Climate Forecast System （CFS）. Two land models, the Oregon State University （OSU） land model and the NCEP, OSU, Air Force, and Hydrologic Research Laboratory （Noah） land model, were used to get parallel experiments NCEP/Department of Energy （DOE） Global Reanalysis 2 System （GLDAS）. The experiments also used land ICs from the （GR2） and the Global Land Data Assimilation Previous studies have demonstrated that, a systematic weak bias appears in the modeled monsoon, and this bias may be related to a cold bias over the Asian land mass. Results of the current study show that replacement of the OSU land model by the Noah land model improved the model＇s cold bias and produced improved monsoon precipitation and circulation patterns. The CFS predicted monsoon with greater proficiency in E1 Nifio years, compared to La Nifia years model in monsoon predictions for individual years. and the Noah model performed better than the OSU These improvements occurred not only in relation to monsoon onset in late spring but also to monsoon intensity in summer. Our analysis of the monsoon features over the India peninsula, the Indo-China peninsula, and the South Chinese Sea indicates different degrees of improvement. Furthermore, a change in the land models led to more remarkable improvement in monsoon prediction than did a change from the GR2 land ICs to the GLDAS land ICs.