Effect of Lumbar Spinal Point Injection on Sitting Function in Children with Cerebral Palsy

Objective: To observe the effect of lumbar spinal point injection on sitting function in children with cerebral palsy. Method: Sixty-two children with post-confirmed cerebral palsy were randomly divided into control group and treatment group, 31 each. The control group was given conventional rehabilitation treatment, and the treatment group was given lumbar chiropspinal acupoint injection on the basis of the treatment method of the control group. After 3 consecutive courses of treatment, the sitting score of the two groups before and after treatment (GMFM88) was used to evaluate the sitting score before and after treatment. Outcome: Before treatment, the two groups were evaluated and the differences were not statistically significant (p > 0.05), which was comparable. The two groups (GMFM88) after treatment had significantly increased the differential values, and the difference was statistically significant compared with the same group before treatment (p Conclusion: Conventional rehabilitation combined with lumbar spinal point injection can effectively improve the sitting motor function of children with cerebral palsy.

Meta-analysis of neostigmine injections given at the Zusanli （ST 36） acupoint in thetreatment of postpartum urinary retention

Objective： We aimed to determine the effect of neostigmine injections given at the Zusanli （ST 36） acupoint whentreating postpartum urinary retention. Methods： We conducted a systematic review to identify randomized controlledtrials （RCTs） involving neostigmine injections given at the Zusanli （ST 36） acupoint for treating postpartum urinaryretention. We searched the Cochrane Library, Pubmed, Web of Science, Chinese National Knowledge Infrastructure, VipDatabase, and Chinese Biomedical Literature Database from the creation of the database to December 30, 2016. Bias riskassessment was performed using Revman 5.3 software from Cochrane based on the criteria set out in the CochraneHandbook for Systematic Reviews of Interventions, version 5.1.0. Results： Thirteen studies were included with 627participants in the treatment group and 584 participants in the control group. （1） Overall response rate： neostigmineinjections given at the Zusanli （ST 36） acupoint have a better curative effect than injections given in muscle, odds ratio（OR） = 8.74, 95% confidence interval （CI） [5.83, 13.10], Z = 10.49 （P 〈 0.001）; （2） Comparison of effects at differentdosages： （i） 0.5 mg of neostigmine Zusanli （ST 36） acupoint injection group has better effect than 1 mg of neostigmineintramuscular injection group, OR = 15.84, 95% CI [5.74, 43.72],Z = 5.34 （P 〈 0.001）, （ii） 0.5 mg of neostigmineinjection given at the Zusanli acupoint has a better curative effect than 0.5 mg of neostigmine injection given in muscle ,OR = 7.30, 95% CI [3.47, 15.34], Z = 5.24 （P 〈 0.001）; （iii） 1 mg of neostigmine injection at the Zusanli （ST 36）acupoint has better efficacy than 1 mg of neostigmine injection in muscle, OR = 7.76, 95% CI [4.46, 13.52], Z = 7.25 （P〈 0.001）. Conclusion： Neostigmine injections at the Zusanli （ST 36） acupoint have beneficial effects in treatingpostpartum urinary retention. However, the low quality of the studies included in the meta-analysis raises questions overthe reliability of the results. Further studies are still needed.

OBSERVATION ON EFFECT OF POINT INJECTION AS THE MAIN TREATMENT FOR OBSTETRIC BRACHIAL PLEXUS PALSY

To discuss the best way of treatment for obstetric brachial plexus palsy （OBPP）. Method： The 102 cases of OBPP were randomized into two groups： the observation group （51 cases） and the control group （51 cases）. The observation group was treated by point injection with nerve growth factor （NGF）, acupuncture, and moxibustion. The control group was treated by acupuncture and moxibustion. Result： The result was compared after two courses of treatment. The curative rate of observation group was 35.3% and that of control group 11.8%. The curative and remarkably effective rate was 78.4% and 43.2% respectively. In the two-two comparison, the difference was significant （ P〈 0. 01 ）. Conclusion： The effect of NGF point injection as the main treatment for OBPP was good, worth spreading.

Clinical Observation on Brachial Plexus Block with “One Injection Two Points” Method Guiding by Ultrasound

OBJECTIVE: To compare the clinical effect of brachial plexus block with "One Injection Two Points" guided under ultrasound and the conventional method guiding by ultrasound. METHODS: 70 patients were randomized evenly into 2 groups, with 35 patients in each group, while the Experiment Group(Group B) received One Injection Two Points" method, the Control Group(Group A) received the conventional method.The nerve block every 5 s, the success rate of anesthesia, the dosage of local anesthetics, second remedial anesthesia, adverse reactions, etc.were recorded. RESULTS: Group B was superior to group A in the success rate of anesthesia; There were 6 patients in group A who required constant pump injection of Remifentanil to remedy, while no patients in Group B needed remedy treatment. There were no serious adverse reactions in both groups.CONCLUSIONS: The clinical effect of brachial plexus block with "One Injection Two Points" method guided under ultrasoundguiding by ultrasound was superior to that of the conventional method.

A COMPARATIVE STUDY ON HYPOTHALAMIC MECHANISMS OF ANALGESIA INDUCED BY FOUR KINDS OF ACUPUNCTURE THERAPIES IN ADJUVANT ARTHRITIS RATS

Objective.. To compare the mechanisms of analgesia induced by four kinds of acupunture therapies at the trypothalamic level in adjuvant arthritic rats. Methods： Forty-eight SD rats were randomized into normal, model, electroacupuncture （EA）, filiform needle （FN）, pricking blood-letting （BL） and point injection （PI） groups, with 8 cases in each. EA （20-100 Hz, 2-4 V and duration of 20 min）, FN, BL PI were respectively applied to “Kunlun” （昆仑 BL 60）. Arthritis model was established by injecting complete Freund＇s adjuvant （0.1 mL） into the rat＇s right foot pad. Behavioral reactions, pain threshold （latancy of tail flick to heat stimulation） and local swelling severity （foot volurne） were detected; the cordents of β-endorphin （β-EP） and α- drenocortiootropin （ACTH） were assayed with radioimmunoassay; and the expression of pro-opi-omelanocortin （POMC） mRNA in hypot were determined with hybridization method. Results： The pain threshold was significantly enhanced by all the four kinds of acupuncture therapies, and the effects of EA and PI were more obvious （P〈0.05, P〈0.01）. The severity of local swelling was markedly alleviated by all the four kinds of acupuncture therapies （ P〈 0.01 ） without significant differences among them （P 〉 0.05）. The content of β-EP in the hypothalamus was obviously elevated by EA and FN （P〈 0.05, P 〈 0.01 ）, and the effect of EA was more obvious, but no marked effect of BL or PI on β-EP was found （ P 〉0.05）. The content of ACTH in hypothalamus was considerably elevated by PI （P〈0.05）, but not by the other three therapies. The expression of PCMCmRNA in hypothalamus was significantly strengthened by EA and FN （P〈0. 01）, but not by the other two therapies. Conclusion：EA, flliform needle, blood-letting and point-injection all can produce analgesic effect in adjuvant arthritis rats, the effect of EA and filiform needie may be related to their resultant increase of hypothalamic β-EP, and that of point-injectiON related to the increase of hypothalamic ACTH level.

Therapeutic effect of acupuncture point injection with placental extract in knee osteoarthritis

OBJECTIVE： This study evaluated the effectiveness of acupuncture point injection （API） with placenta extract on pain reduction and joint function in patients with knee osteoarthritis （OA）. METHODS： Fifty-two patients with knee OA, with an average age of 64, and having a symptom duration of more than 3 months were studied in this report. Placental extract was injected weekly into acupuncture point ST35, BL23, BL24 and BL25 for 5 weeks; 8 mL of placental extract into ST35 on the affected side, and 1 mL of placental extract to BL23, BL24 and BL25 bilaterally. RESULTS： After a five-week treatment of API with placental extract, pain was substantially decreased in patients of all Kellgren-Lawrence （KL） grades. Improvement of knee joint swelling was also apparent Decrease of pain and joint swelling improved daily working productive time among patients of all KL grades. CONCLUSION： Study results imply that API with placental extract is a potentially useful therapy to control pain and maintain joint functions in knee OA patients.

Observation on Efficacy of Acupoint Injection Combined with Traction for Cervical Radiculopathy

Objective： To observe the therapeutic effect of acupoint injection combined with traction for cervical radiculopathy. Methods： A hundred and twenty-two patients with cervical radiculopathy were randomly divided into 3 groups, including an observation group （42 cases）, an acupoint injection group （40 cases） and a traction group （40 cases）. The patients in the first group received acupoint injection combined traction therapy, while the ones in the second and the third group received acupoint injection and traction respectively. The differences of therapeutic effect were evaluated after the treatments. Results： The total effective rate of the observation group was 92.9%, while it was 72.5% in the acupoint injection group and 75.0% in the traction group. There were significant differences between the observation group and the other two groups respectively （P〈0.05） , but there was no statistic difference between the acupoint injection group and the traction group. Conclusion： Acupoint injection combined with traction treatment was more effective for the cervical radiculopathy than either acupoint injection or traction.

Comparison of the effects of carbamyl-β-methylcholine chloride ad ministered by intravenous,intramuscular and intra-acupuncture point injections

OBJECTIVE:To compare the effects of carbamylβ-methylcholine chloride(CMCC) administered by intra-acupuncture point injection(IAI),intramuscular injection(IMI),and intravenous injection(IVI),and to analyze the mechanisms.METHODS:In the IAI group,CMCC was injected into the Zusanli acupoint(ST 36) immediately after 30-min stimulation by electro-acupuncture(EA) at the acupoints,and into the femoral vein and skeletal muscle in IVI and IMI groups,respectively.Intra-gastric pressure was detected.The plasma concentration of CMCC was measured at various times.RESULTS:The gastric effect of CMCC in the IVI group was enhanced and attenuated more rapidly than in the other groups.In the IAI group,this effect was significantly stronger than that in the IMI group at 2 min and 15 min,but not significantly different between the two groups at 5 min and 30 min.Plasma concentration of CMCC in the IAI group was similar to that in the IVI group at 2 min,but higher than that in the IMI group.The concentration in the IAI group was higher than that in the IV group and similar to that in the IMI group at 5,15 and 30 min,indicating rapid increase and slower reduction of the plasma concentration of the drug in the IAI group.There was a positive correlation between the plasma concentration of CMCC and intragastric pressure in all groups.CONCLUSION:The effect of IAI with CMCC was stronger than that of IMI and longer-lasting than that of IVI,which correlated with the blood concentration of CMCC.

Observations on Curative Effect of Point Injection on Postchemotherapeutic Leukopenia

Objective： To investigate the effect of point injection on post-chemotherapeutic leukopenia. Methods： Three hundred patients were randomly divided into two groups. In the treatment group, 0.6 ml granulocyte colony stimulating factor was injected into bilateral Xuehai （SP 10） and in the control group, the same dose subcutaneously into the deltoid muscle in the upper arm, once daily, three consecutive times as a course of treatment. A peripheral leukocyte count was examined at 3rd, 5th and 7th day after injection. Results and Conclusion： Under three courses of chemotherapy, therewas no significant difference in leukocyte increase between the two methods at 3rd and 5th day after treatment but a leukocyte count was significantly higher at 7th day in the treatment group than in the control group （P〈0.05）. After over half courses of chemotherapy, a peripheral leukocyte count was significantly higher in the treatment group than in the control group （P〈0.05） and it did not rise to the normal at 5-7 days after treatment in the control group. It is showed that point injection raised leukocyte quickly and kept the effect long in comparison with subcutaneous injection and the adverse responses were significantly less in the treatment group than in the control group.

Therapeutic Efficacy Observation on Mild Lifting and Superficial Pulling Point-towards-point Needling for Intractable Facial Palsy

Objective: To observe and compare the clinical effects of combining mild lifting and superficial pulling point-towards-point needling and point injection and integrated standard electroacupuncture(EA) with intramuscular injection of Mecobalamin for intractable facial palsy. Methods: Eighty cases with intractable facial palsy were randomized into a treatment group and a control group, 40 in each group. Cases in the treatment group were treated with mild lifting and superficial pulling point-towards-point needling Xiaguan(ST 7) coupled with point injection of Mecobalamin. Cases in the control group were treated with standard EA coupled with intramuscular injection of Mecobalamin. After three courses of treatment, the between-group comparisons of Portmann scores and clinical effects were conducted. Results: After three courses of treatment, the Portmann scores in both groups were higher than the scores before treatment(P<0.01); the Portmann score in the treatment group was higher than that in the control group(P<0.05) and the total effective rate in the treatment group was higher than that in the control group(P<0.05). Conclusion: Combining mild lifting and superficial pulling point-towardspoint needling and point injection of Mecobalamin could obtain better effect for intractable facial palsy than standard EA coupled with intramuscular injection of Mecobalamin.

Effect of Scalp Needle plus Acupoint Injection on Intelligence of Microcephalic Children

Objective： To observe the influence of scalp acupuncture plus point injection on intelligence quotient in microcephaly children. Methods： Twenty-five children with microcephaly were treated by scalp acupuncture as main therapy plus point injection. The children＇s intelligence was tested by China-Wechsler＇s intelligence scale before and after treatment. Results and Conclusion： Acupuncture can improve intelligence and especially has significant effect on verbal intelligence quotient in microcephaly children.

Tender spot injection at meridian and collateral for acute simple appendicitis

Objective To explore the curative effect and mechanism of tender spot injection at meridian and collateral for acute simple appendicitis. Methods Sixty-eight inpatients with acute simple appendicitis were treated by adopting tender spot injection at meridian and collateral, tender spot was usually near Zusanli （足三里 ST 36）. Immediate injection with 0.9% sodium chloride in the dosage of 2-4 mL, then injection for another time after 4-6 h were given, and injection for 2-3 times a day according to the state of illness were given, injection for once a day after 2 days until pressing pain on abdomen disappeared were given. Results After 5-7 injections, the cured were 56 cases （82%）, improved were 8 cases （12%, including 4 cases with chronic appendicitis of acute attack）, ineffective were 4 cases （6%）. The total effective rate was 94%. Abdominal pain was alleviated within 1/2-1 h on average, and alleviated obviously within 8-12 h. Pressing pain and rebound tenderness were relieved obviously and disappeared gradually within 24-48 h, the average length of stay was 4-5 days. Conclusion Tender spot injection at meridian and collateral for acute simple appendicitis can rapidly alleviate abdominal pain, and gradually relieve the abdominal signs. Compared with acupuncture therapy, this thrapy has some advantages such as simple manipulation, quick effect, reliable curative effect and lower treatment cost, so it has been applied by the author for a long time.