Oxygen variation in titanium powder and metal injection molding

The control of oxygen is paramount in achieving high-performance titanium(Ti)parts by powder metallurgy such as metal in-jection molding(MIM).In this study,we purposely selected the Ti and Ti-6Al-4V powders as the reference materials since these two are the most representative Ti materials in the industry.Herein,hydride-dehydride(HDH)Ti powders were pre-oxidized to examine the ef-fect of oxygen variation on the characteristics of oxide layer on the particle surface and its resultant color feature.The results indicate that the thickness and Ti oxide level(Ti^(0)→Ti^(4+))of the oxide layer on the HDH Ti powders increased as the oxygen content increased,lead-ing to the transition of color appearance from grey,brown to blue.This work aids in the powder feedstock selection at the initial stage in powder metallurgy.In addition,the development of oxygen content was comprehensively studied during the MIM process using the gas-atomized(GA)Ti-6Al-4V powders.Particularly,the oxygen variation in the form of oxide layer,the change of oxygen content in the powders,and the relevant parts were investigated during the processes of kneading,injection,debinding,and sintering.The oxygen vari-ation was mainly concentrated in the sintering stage,and the content increased with the increase of sintering temperature.The variation of oxygen content during the MIM process demonstrates the crucial role of powder feedstock and sintering stage in controlling oxygen con-tent.This work provides a piece of valuable information on oxygen detecting,control,and manipulation for the powder and processing in the industry of Ti and its alloys by powder metallurgy.

基于 Moldflow 的汽车中控台框架翘曲变形分析及优化

以某汽车中控台框架为研究对象,测量试模样品发现其翘曲变形量超过了装配要求。通过Moldflow软件模拟了该塑件实际的注塑过程,翘曲变形量的模拟值与实测平均值的最大误差为5.98%,发现该塑件翘曲变形的主要因素为冷却不均和收缩不均。本文在原物料中添加质量分数为25%的玻璃纤维以及优化工艺参数后,翘曲变形量的模拟值与初始方案相比降低了86.22%。试模验证表明,优化后的翘曲变形量模拟值与实测平均值的最大误差为4.35%,证明了Moldflow软件模拟分析的准确性。试模后各检测点的最大翘曲变形量降到了1.6 mm以下,较优化之前降低了80%以上,为类似大型复杂注塑件的翘曲变形分析及优化提供了思路。

基于Moldex 3D与正交试验的离心泵泵头注塑工艺优化

以商用离心泵泵头为研究对象,运用Moldex3D模流分析软件对其注塑成型过程进行了模拟。根据产品的结构特点设置了三种浇口方案,通过对注塑过程的模拟分析选出最佳方案来获得模具设计思路并预测制品成型后可能存在的质量问题。结果表明,平衡进浇方案的制品具有最好的综合性能,制品的翘曲变形量为1.588 mm,体积收缩率为2.444%。确认最佳浇口方案后,将充填时间(A)、保压时间(B)、冷却时间(C)和模具温度(D)作为实验因素,采用田口法构建五因素四水平的正交试验来获得最佳工艺参数,并使用极差和方差分析对结果进行置信度检测。以翘曲总位移结果为主要权重对象,通过极差分析确定了成型参数的最优组合为A_(1)B_(1)C_(1)D_(1),方差分析则验证了极差分析的结果置信度高于99%。相较于初始方案,制品的翘曲变形量从1.588 mm降低至1.214 mm,降低了23.6%;冷却时间降低至10 s,降低了40%。得知模流分析技术的使用让产品的质量和生产效率都得到了明显的优化,为预测塑件性能、降低生产成本、提高生产效率提供了一种可行的方式。

基于Moldflow的汽车把手气辅注塑工艺多目标优化

汽车内饰把手是典型的棒状类零件,常采用气体辅助注射成型(GAIM)技术进行生产,以满足把手强度和轻量化要求。由于GAIM技术的成型参数多,塑件成型质量控制难度大,通过运用Moldflow模流仿真分析并结合Taguchi试验方法,以塑件的气体穿透长度和横截面最小壁厚为质量目标来优化成型工艺参数,选择熔体温度、模具温度、气体压力、气体保压时间和预注射量5个主要因素进行正交试验,采用极差分析研究上述5个工艺参数对气体穿透长度和横截面最小壁厚的影响规律,应用多目标综合平衡法得到优化的工艺参数组合,即熔体温度为250℃、模具温度为50℃、气体压力为10 MPa、气体保压时间为10 s、预注射量为75%。通过实际GAIM验证,塑件气体穿透效果良好,满足穿透长度和横截面最小壁厚的要求,塑件质量减轻25%以上,并具有良好的表面质量和尺寸精度,能够显著缩短成型周期,节约塑料材料,提高生产质量和效率,并满足汽车轻量化要求。

基于Moldflow软件对薄壁件某塑料喷嘴的注塑方案优化研究

喷嘴注塑产品的质量和性能很大程度上由注塑方案和工艺参数所决定,不当的注塑方案和工艺参数会导致充填不足、熔接线过多、翘曲变形量大等问题。为了可以减少生产周期,节约生产成本,利用三维软件UG对喷嘴进行建模,基于模流分析软件Moldflow软件对喷嘴注塑产品进行分析和优化,通过比较点浇口和侧浇口两种方案的分析结果,最终确定该产品点浇口的方案更好。并通过设计正交实验,得到优化后的工艺参数。

基于Moldflow的排水泵过滤网注塑工艺优化与模具设计

利用Moldflow对塑料排水泵过滤网的注塑成型过程进行仿真,通过对其结构分析制定了合理的浇口位置和冷却水路。利用三因素三水平正交试验,研究了熔体温度(A)、充填压力(B)和开模时间(C)对于塑件翘曲变形的影响,得出较优的工艺参数组合为A_(1)B_(3)C_(3),即熔体温度220℃,充填压力80%,开模时间6 s,此时塑件的最大翘曲变形量为0.632 8 mm,与优化前相比降低了10.37%。最后依据Moldflow的分析结果,利用UG软件对注塑模具的结构进行了设计,根据塑件卡扣的结构特点,型腔采用整体式结构,型芯设计为组合式(主型芯+滑块)结构,并采用三组“斜导柱+滑块”式侧向抽芯机构解决脱模问题。为实现顺序脱模,借助尼龙塞以增加定模板与动模板之间的开模阻力,设计了内置式“小拉杆+拉杆套”结构的定距分型机构;考虑到塑件形状和模具结构与成本,设计了沿塑件侧壁轮廓排布的圆推杆脱模机构;为避免气纹、气穴等缺陷的形成,在型腔处设计了排气槽结构。该模具结构设计较为合理,可为其他结构相似塑件的模具设计提供有益参考和指导。

基于MoldFlow太阳能储能系统下盖成型模拟及应用

以太阳能储能系统下盖模流分析为例,反复修改流道和浇口截面尺寸与长度以及主流道位置,确定流道尺寸。运用MoldFlow对设计好的流道进行充填分析,以使成型达到流动平衡,并进行冷却、翘曲分析,预测成型缺陷,提出解决措施,为模具设计提供浇注系统和冷却系统方案和注射成型工艺参数,并应用于模具设计和实际生产。

基于Moldex3D的油漆桶桶盖注塑成型过程分析

利用模流分析软件Moldex3D模拟油漆桶桶盖注塑成型过程,研究桶盖模具使用阀式热流道与开式热流道两种不同浇注方案的成型差异,并结合仿真结果设计热流道。通过设计Taguchi DOE实验的因素与水平,优化桶盖产品的注塑工艺参数。结果表明:设定工艺参数为熔体温度250℃,保压时间2 s,冷却时间18 s时,产品没有短射、包封等外观质量问题;优化后的注塑工艺参数有效降低了产品的冷却时间。

基于Moldflow的绗缝机夹子注塑模设计

以绗缝机夹子的短板为例,基于Moldflow有限元分析软件,合理确定了塑件的浇口位置和浇口形式,精确预测出塑件的充型时间、注射压力、锁模力等工艺参数,并分析出塑件的体积收缩率及熔接线、气穴等潜在缺陷的位置。有限元模拟结果为注塑成型设备的选型和成型工艺参数的合理制定提供了可靠依据,为模具的优化设计提供了方向。基于Moldflow分析结果,设计出一套一模两腔侧浇口、带斜导柱侧向分型与抽芯机构的注塑模具并一次性试模成功。Moldflow有限元分析软件在注塑模设计中的应用不仅有效降低了模具设计的成本和周期,也为同类零件的模具优化设计提供了参考。

Irregular initial solidification by mold thermal monitoring in the continuous casting of steels:A review

Occasional irregular initial solidification phenomena,including stickers,deep oscillation marks,depressions,and surface cracks of strand shells in continuous casting molds,are important limitations for developing the high-efficiency continuous casting of steels.The application of mold thermal monitoring(MTM) systems,which use thermocouples to detect and respond to temperature variations in molds,has become an effective method to address irregular initial solidification phenomena.Such systems are widely applied in numerous steel companies for sticker breakout prediction.However,monitoring the surface defects of strands remains immature.Hence,indepth research is necessary to utilize the potential advantages and comprehensive monitoring of MTM systems.This paper summarizes what is included in the irregular initial solidification phenomena and systematically reviews the current state of research on these phenomena by the MTM systems.Furthermore,the influences of mold slag behavior on monitoring these phenomena are analyzed.Finally,the remaining problems of the formation mechanisms and investigations of irregular initial solidification phenomena are discussed,and future research directions are proposed.

基于Moldflow的车身后护板微孔发泡注塑工艺多目标优化

使用Moldflow软件模拟车身后护板注塑工艺,采用正交试验及灰色关联分析结合熵权法优化注塑工艺参数,并进行了实际试模验证。结果表明:使用微孔发泡注塑成型可实现车身后护板减重及降低翘曲变形量;优化的工艺参数为熔体温度235℃,模具温度35℃,充填时间3.5 s,充填体积百分比92%,初始气体含量1.2%(w),所制零件总质量为1362.2 g,z方向翘曲变形量为1.006 mm,较采用微孔发泡默认工艺组合分别减少了18.4 g,0.478 mm;采用灰色关联分析结合熵权法对工艺优化能满足产品减重和降低翘曲变形量的要求。

Management of Strawberry Grey Mold Disease Using Biocontrol Agents and Plant Extracts

Strawberry (Fragaria × ananassa Duch.) is a significant global soft fruit crop, prized for its nutrient content and pleasant flavor. However, diseases, particularly grey mold caused by Botrytis cinerea Pers. Fr. poses major constraints to strawberry production and productivity. Grey mold severely impacts fruit quality and quantity, diminishing market value. This study evaluated five B. cinerea isolates from various locations in the Ri-Bhoi district of Meghalaya. All isolates were pathogenic, with isolate SGM 2 identified as highly virulent. Host range studies showed the pathogen-producing symptoms in the fava bean pods, marigold, gerbera, and chrysanthemum flowers and in the fava bean, gerbera, and lettuce leaves. In vitro tests revealed that neem extract (15% w/v) achieved the highest mycelial growth inhibition at 76.66%, while black turmeric extract (5% w/v) had the lowest inhibition at 9.62%. Dual culture methods with bio-control agents indicated that Bacillus subtilis recorded the highest mean inhibition at 77.03%, while Pseudomonas fluorescens had the lowest at 20.36% against the two virulent isolates. Pot evaluations demonstrated that B. subtilis resulted in the lowest percent disease index at 20.59%, followed by neem extract at 23.31%, with the highest disease index in the control group at 42.51%. Additionally, B. subtilis significantly improved plant growth, yielding an average of 0.32 kg compared to 0.14 kg in the control. The promising results of B. subtilis and neem leaf extract from this study suggest their potential for eco-friendly managing grey mold in strawberries under field conditions.

Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often overlooked.Chemotherapeutic drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine functions.Understanding hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

Effects of the Water-Cement Ratio and the Molding Temperature on the Hydration Heat of Cement

The effects of the water-cement ratio and the molding temperature on the hydration heat of cement were investigated with semi-adiabatic calorimetry.The specimens were prepared with water-cement ratios of 0.31,0.38,and 0.45,and the molding temperature was specified at 10 and 20℃.The experimental results show that,as the water-binder ratio increases,the value of the second temperature peak on the temperature curve of the cement paste decreases,and the age at which the peak appears is delayed.The higher the water-cement ratio,the higher the hydration heat release in the early period of cement hydration,but this trend reverses in the late period.There are intersection points of the total hydration heat curve of the cement pastes under the influence of the water-cement ratio,and this law can be observed at both molding temperatures.With the increase in the molding temperature,the age of the second temperature peak on the temperature curve of the cement paste will advance,but the temperature peak will decrease.The higher the molding temperature,the earlier the acceleration period of the cement hydration began,and the larger the hydration heat of the cement in the early stage,but the smaller the total heat in the late period.A subsection function calculation model of the hydration heat,which was based on the existing models,was proposed in order to predict the heat of the hydration of the concrete.

Does HSP27 injection induce glaucoma damage in mice?

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of life.Preserving good vision is crucial to maintaining mobility,independence,and mental health.There can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

Numerical Simulation of Asphaltene Precipitation and Deposition during Natural Gas and CO_(2) Injection

Asphaltene deposition is a significant problem during gas injection processes,as it can block the porous medium,the wellbore,and the involved facilities,significantly impacting reservoir productivity and ultimate oil recovery.Only a few studies have investigated the numerical modeling of this potential effect in porous media.This study focuses on asphaltene deposition due to natural gas and CO_(2) injection.Predictions of the effect of gas injection on asphaltene deposition behavior have been made using a 3D numerical simulation model.The results indicate that the injection of natural gas exacerbates asphaltene deposition,leading to a significant reduction in permeability near the injection well and throughout the reservoir.This reduction in permeability strongly affects the ability of gas toflow through the reservoir,resulting in an improvement of the displacement front.The displacement effi-ciency of the injection gas process increases by up to 1.40%when gas is injected at 5500 psi,compared to the scenario where the asphaltene model is not considered.CO_(2) injection leads to a miscible process with crude oil,extracting light and intermediate components,which intensifies asphaltene precipitation and increases the viscosity of the remaining crude oil,ultimately reducing the recovery rate.

Tofacitinib combined with local low-dose ixekizumab injection benefits those with peripheral psoriatic arthritis

Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability issues.Drugs injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of PsA.The limited treatment options for PsA present a challenge.

Numerical simulation study on the mold strength of magnetic mold casting based on a coupled electromagnetic-structural method

The properties of the magnetic mold in magnetic mold casting directly determine the quality of the final cast parts.In this study,the magnetic mold properties in magnetic mold casting,were studied utilizing a coupled electromagnetic-structural method through numerical simulation.This study investigated key factors including equivalent stress,the distribution of tensile and compressive stresses,and the area ratio of tensile stress.It compared molds made entirely of magnetic materials with those made partially of magnetic materials.Simulation results indicate that as current increases from 4 A to 8 A,both the initial magnetic mold and the material-replaced magnetic mold initially show an increasing trend in equivalent stress,tensile-compressive stress,and the area ratio of tensile stress,peaking at 6 A before declining.After material replacement,the area ratio of tensile stress at 6 A decreases to 19.84%,representing a reduction of 29.72%.Magnetic molds comprising a combination of magnetic and non-magnetic materials exhibit sufficient strength and a reduced area ratio of tensile stress compared to those made entirely from magnetic materials.This study provides valuable insights for optimizing magnetic mold casting processes and offers practical guidance for advancing the application of magnetic molds.

Experimental study of the influencing factors and mechanisms of the pressure-reduction and augmented injection effect by nanoparticles in ultra-low permeability reservoirs

Nanoparticles(NPs)have gained significant attention as a functional material due to their ability to effectively enhance pressure reduction in injection processes in ultra-low permeability reservoirs.NPs are typically studied in controlled laboratory conditions,and their behavior in real-world,complex environments such as ultra-low permeability reservoirs,is not well understood due to the limited scope of their applications.This study investigates the efficacy and underlying mechanisms of NPs in decreasing injection pressure under various injection conditions(25—85℃,10—25 MPa).The results reveal that under optimal injection conditions,NPs effectively reduce injection pressure by a maximum of 22.77%in core experiment.The pressure reduction rate is found to be positively correlated with oil saturation and permeability,and negatively correlated with temperature and salinity.Furthermore,particle image velocimetry(PIV)experiments(25℃,atmospheric pressure)indicate that the pressure reduction is achieved by NPs through the reduction of wall shear resistance and wettability change.This work has important implications for the design of water injection strategies in ultra-low permeability reservoirs.

Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

●AIM:To evaluate the effect of background diseases and number of previous intravitreal aflibercept injections(IVAIs)on immediate intraocular pressure(IOP)increase and vitreous reflux(VR)rate and to evaluate the correlation of both age and axial length with immediate IOP increase and VR rate.●METHODS:This study included 105 patients with cystoid macular edema secondary to retinal vein occlusion,35 patients with diabetic macular edema,69 patients with neovascular age-related macular degeneration(nAMD),and 12 patients with myopic choroidal neovascularization,which underwent first-time IVAI.The correlation of immediate IOP increase and VR rates with the four background diseases was investigated.Moreover,the correlation of age with immediate IOP increase and VR rate as well as correlation of axial length with immediate IOP increase and VR rate were evaluated.Further,54 patients with nAMD were treated with IVAI>10 times(multiple IVAIs).Moreover,the correlation of immediate IOP increase and VR rates with first-time and multiple IVAIs in nAMD was determined.●RESULTS:The immediate IOP increase(P=0.16)and VR rates(P=0.50)were almost similar among the four background diseases.The immediate postinjection IOP and age,VR rate and age,immediate postinjection IOP and axial length,or VR rate and axial length were not correlated in the four background diseases.The immediate IOP increase(P=0.66)and VR rates(P=0.28)did not significantly differ between first-time and multiple IVAIs in nAMD.●CONCLUSION:Background diseases and number of previous IVAIs have no effect on immediate IOP increase and VR rate.Further,age and axial length have no correlation on immediate IOP increase and VR rate.