Possible link between long-term and short-term water injections and earthquakes in salt mine and shale gas site in Changning,south Sichuan Basin, China

Late at night on 17 June 2019,a magnitude 6.0 earthquake struck Shuanghe Town and its surrounding area in Changning County,Sichuan,China,becoming the largest earthquake recorded within the southern Sichuan Basin.A series of earthquakes with magnitudes up to 5.6 occurred during a short period after the mainshock,and we thus refer to these earthquakes as the Changning M6 earthquake sequence(or swarm).The mainshock was located very close to a salt mine,into which for^3 decades fresh water had been extensively injected through several wells at a depth of 2.7–3 km.It was also near(within^15 km)the epicenter of the 18 December 2018 M5.7 Xingwen earthquake,which is thought to have been induced by shale gas hydraulic fracturing(HF),prompting questions about the possible involvement of industrial activities in the M6 sequence.Following previous studies,this paper focuses on the relationship between injection and seismicity in the Shuanghe salt field and its adjacent Shangluo shale gas block.Except for a period of serious water loss after the start of cross-well injection in 2005–2006,the frequency of earthquakes shows a slightly increasing tendency.Overall,there is a good correlation between the event rate in the Shuanghe area and the loss of injected water.More than 400 M≥3 earthquakes,including 40 M≥4 and 5 M≥5 events,had been observed by the end of August 2019.Meanwhile,in the Shangluo area,seismicity has increased during drilling and HF operations(mostly in vertical wells)since about 2009,and dramatically since the end of 2014,coincident with the start of systematic HF in the area.The event rate shows a progressively increasing background with some fluctuations,paralleling the increase in HF operations.More than 700 M≥3 earthquakes,including 10 M≥4 and 3 M≥5 in spatially and temporally clustered seismic events,are correlated closely with active fracturing platforms.Well-resolved centroid moment tensor results for M≥4 earthquakes were shown to occur at very shallow depths around shale formations with active HF,in agreement with some of the clusters,which occurred within the coverage area of temporary or new permanent monitoring stations and thus have been precisely located.After the Xingwen M5.7 earthquake,seismic activity in the salt well area increased significantly.The Xingwen earthquake may have created a unidirectional rupture to the NNW,with an end point close to the NW-trending fault of the Shuanghe earthquake.Thus,a fault in the Changning anticline might have terminated the fault rupture of the Xingwen earthquake,possibly giving the Xingwen earthquake a role in promoting the Changning M6 event.

Research of the Activity of Earthquakes Induced by Water Injection of Salt Mining in Changning County,Sichuan Province

According to information from on-the-spot investigations, the tectonics of salt mining areas and digital seismic records, we studied the activity of earthquakes induced by water pumping in and out of the salt mines in Shuanghe town, Changning county, Sichuan Province. The study found that the rates of water injection and extraction in the Shuanghe salt mining region were evenly matched before April 2006 and earthquake activity was stable. On the other hand, shallow small and moderate earthquake numbers increased sharply after the water injection rate became much larger than the water extraction rate. Large injection over a long time may causes the permeation of water through pre-existing small fractures and micro-cracks in the Changning anticlinal and accelerate the rupture of micro tectonic formations in nearby regions, inducing small earthquake swarm activity. The Q value calculated by using digital earthquake records indicates a relatively inhomogeneous medium in this area. The results of the accurate location of small earthquakes show that sources are relatively shallow and are concentrated at a depth of 2km to 3km. Focal mechanism solutions reveal a normal dip-slip character of shallow earthquakes. All of these show certain characteristics of earthquake activity induced by water injection.

Longwall surface subsidence control by technology of isolated overburden grout injection

Surface subsidence is a typical ground movement due to longwall mining, which causes a series of environmental problems and hazards. In China, intensive coal extractions are commonly operated under dense-populated coalfields, which exacerbates the negative subsequences resulted from surface settlement. Therefore, effective approaches to control the ground subsidence are in urgent need for the Chinese coal mining industry. This paper presents a newly developed subsidence control technology: isolated overburden grout injection, including the theory, technique and applications. Relevant procedures such as injection system design, grouting material selection, borehole layout, grout take estimation and injection process design are proposed. The applicability of this technology has been demonstrated through physical modelling, field measurements, and case studies. Since 2009, the technology has been successfully applied to 14 longwall areas in 9 Chinese coal mines. The ultimate surface subsidence factors vary from 0.10 to 0.15. This method has a great potential to be popularized and performed where longwall mining are implemented under villages and ground infrastructures.

Investigation of overburden behaviour for grout injection to control mine subsidence

This paper describes a field and numerical investigation of the overburden strata response to underground longwall mining, focusing on overburden strata movements and stress concentrations.Subsidence related high stress concentrations are believed to have caused damage to river beds in the Illawarra region, Australia. In the field study, extensometers, stressmeters and piezometers were installed in the overburden strata of a longwall panel at West Cliff Colliery. During longwall mining, a total of1000 mm tensile deformation was recorded in the overburden strata and as a result bed separation and gaps were formed. Bed separation was observed to start in the roof of the mining seam and gradually propagate toward the surface as the longwall face advanced. A substantial increase in the near-surface horizontal stresses was recorded before the longwall face reached the monitored locations. The stresses continued to increase as mining advanced and they reached a peak at about 200 m behind the longwall face. A numerical modelling study identified that the angle of breakage(i.e., the angle of the boundary of caved zone) behind the longwall face and over the goaf was 22–25° from vertical direction. This is consistent with the monitoring results showing the high gradient of stresses and strains on the surface150–320 m behind the mining face.

Effect of the computer fuzzy control on coal seam injection

To enhance the technology and efficiency of strata injection is a problem to be solved urgently. Because of effected by the rough and poor production conditions of mining and the changeable bearing condition of strata, the technological process of injection can not be controlled automatically.The fuzzy controlling technology of the coal strata injection is applied. This is the good way to ensure the effectiveness and efficiency of coal strata injection and to solve the current problems of production and safety in mining industry.

Deployment and Exploration of a Gas Storage Well Pattern Based on the Threshold Radius

To tackle the problem that wells that are deployed in a specific pattern based on the requirements of gas reservoir development are not suitable for gas storage,we have conducted concentrically circular injection and production simulation experiments for gas storage,discovered the existence of a threshold radius,denoted by Rt,and derived the expression for Rt.Based on the analysis and discussion results,we propose a strategy for deploying gas storage wells in specific patterns.The expression for Rt shows that it is affected by factors such as the gas storage gas production/injection time,the upper pressure limit,the lower pressure limit,the bottomhole flow pressure at the ends of injection and production,the and permeability.The analysis and discussion results show that the Rt of a gas storage facility is much smaller than the Rt for gas reservoir development.In the gas storage facilities in China,the Rt for gas production is less than the Rt for the gas injection,and Rt increases with the difference in the operating pressure and with permeability K.Based on the characteristics of Rt,we propose three suggestions for gas storage well pattern deployment:(1)calculate Rt according to the designed functions of the gas storage facility and deploy the well pattern according to Rt;(2)deploy sparser,large-wellbore patterns in high-permeability areas and denser,small-wellbore patterns in high-permeability areas;and(3)achieve the gas injection well pattern by new drilling,and the gas production well pattern through a combination of the gas injection well pattern and old wells.By assessing a gas storage facility with a perfect well pattern after a number of adjustments,we found that the Rt of the 12 wells calculated in this paper is basically close to the corresponding actual radius,which validates our method.The results of this study provide a methodological basis for well pattern deployment in new gas storage construction.

Optimal Deployment Patterns for k-Coverage and k-Connectivity 3D WSNs in Underground Tunnel

In this paper,we first model the mining structure as a arched shape in terms of the tunnel geometry.Based on the regularly placement of nodes in that model,a set of deployment patterns for seamless coverage and k-connectivity is proposed,i.e.1-and 2-connectivity.Further,we figure out the maximum horizontal distance of tangent plane to determine the placement of nodes for k-coverage（k=1,2）.Besides,the mathematical relations between the communication radius and the sensing radius are derived,when the network keeps k-coverage（k=1,2） and k-connectivity（k=2,3） under certain regularity constrains for various patterns.Finally,we demonstrate the optimality of several approaches that we have proposed in the aspect of energy consumption and network lifetime.

The geomechanics of Shenhua carbon dioxide capture and storage(CCS) demonstration project in Ordos Basin,China

Carbon dioxide(CO2) capture and storage(CCS) is considered widely as one of promising options for CO2emissions reduction,especially for those countries with coal-dominant energy mix like China.Injecting and storing a huge volume of CO2in deep formations are likely to cause a series of geomechanical issues,including ground surface uplift,damage of caprock integrity,and fault reactivation.The Shenhua CCS demonstration project in Ordos Basin,China,is the first and the largest full-chain saline aquifer storage project of CO2in Asia.The injection started in 2010 and ended in 2015.during which totally 0.3 million tonnes(Mt) CO2was injected.The project is unique in which CO2was injected into 18 sandstone formations simultaneously and the overlying coal seams will be mined after the injection stopped in 2015.Hence,intense geomechanical studies and monitoring works have been conducted in recent years,including possible damage resulting from the temperature difference between injected CO2and formations,injection induced stress and deformation change,potential failure mode and safety factor,interaction between coal mining and CO2geological storage,determination of injection pressure limit,and surface monitoring by the interferometric synthetic aperture radar(InSAR) technology.In this paper,we first described the background and its geological conditions of the Shenhua CCS demonstration project.Then,we gave an introduction to the coupled thermo-hydro-mechano-chemical(THMC) processes in CO2geological storage,and mapped the key geomechanical issues into the THMC processes accordingly.Next,we proposed a generalized geomechanical research flowchart for CO2geological storage projects.After that,we addressed and discussed some typical geomechanical issues,including design of injection pressure limit.CO2injection induced near-field damage,and interaction between CO2geological storage and coal mining,in the Shenhua CCS demonstration project.Finally,we concluded some insights to this CCS project.

Risk assessment of fault water inrush during deep mining

With the gradual depletion of shallow coal resources,the Yanzhou mine in China will enter the lower coal seam mining phase.However,as mining depth increases,lower coal seam mining in Yanzhou is threatened by water inrush in the Benxi Formation limestone and Ordovician limestone.The existing prediction models for the water burst at the bottom of the coal seam are less accurate than expected owing to various controlling factors and their intrinsic links.By analyzing the hydrogeological exploration data of the Baodian lower seam and combining the results of the water inrush coefficient method and the Yanzhou mine pressure seepage test,an evaluation model of the seepage barrier capacity of the fault was established.The evaluation results show the water of the underlying limestone aquifer in the Baodian mine area mainly threatens the lower coal mining through the fault fracture zone.The security of mining above confined aquifer in the Baodian mine area gradually decreases from southwest to northeast.By comparing the water inrush coefficient method and the evaluation model of fault impermeability,the results show the evaluation model based on seepage barrier conditions is closer to the actual situation when analyzing the water breakout situation at the working face.

Sleep disturbances and predictors of nondeployability among active-duty army soldiers: an odds ratio analysis of medical healthcare data from fiscal year 2018

Background:The impact of sleep disorders on active-duty soldiers’medical readiness is not currently quantified.Patient data generated at military treatment facilities can be accessed to create research reports and thus can be used to estimate the prevalence of sleep disturbances and the role of sleep on overall health in service members.The current study aimed to quantify sleep-related health issues and their impact on health and nondeployability through the analysis of U.S.military healthcare records from fiscal year 2018(FY2018).Methods:Medical diagnosis information and deployability profiles(e-Profiles)were queried for all active-duty U.S.Army patients with a concurrent sleep disorder diagnosis receiving medical care within FY2018.Nondeployability was predicted from medical reasons for having an e-Profile(categorized as sleep,behavioral health,musculoskeletal,cardiometabolic,injury,or accident)using binomial logistic regression.Sleep e-Profiles were investigated as a moderator between other e-Profile categories and nondeployability.Results:Out of 582,031 soldiers,48.4%(n=281,738)had a sleep-related diagnosis in their healthcare records,9.7%(n=56,247)of soldiers had e-Profiles,and 1.9%(n=10,885)had a sleep e-Profile.Soldiers with sleep e-Profiles were more likely to have had a motor vehicle accident(p OR(prevalence odds ratio)=4.7,95%CI 2.63–8.39,P≤0.001)or work/duty-related injury(p OR=1.6,95%CI 1.32–1.94,P≤0.001).The likelihood of nondeployability was greater in soldiers with a sleep e-Profile and a musculoskeletal e-Profile(p OR=4.25,95%CI 3.75–4.81,P≤0.001)or work/dutyrelated injury(p OR=2.62,95%CI 1.63–4.21,P≤0.001).Conclusion:Nearly half of soldiers had a sleep disorder or sleep-related medical diagnosis in 2018,but their sleep problems are largely not profiled as limitations to medical readiness.Musculoskeletal issues and physical injury predict nondeployability,and nondeployability is more likely to occur in soldiers who have sleep e-Profiles in addition to these issues.Addressing sleep problems may prevent accidents and injuries that could render a soldier nondeployable.

原研门冬胰岛素30注射液的药品不良反应/药品不良事件风险信号挖掘与用药启示

目的:挖掘门冬胰岛素30注射液原研品种的药品不良反应/药品不良事件(ADR/ADE)风险信号,为我国仿制品种的临床安全应用提供参考。方法:运用报告比值比法(ROR)、比例报告比法(PRR)和综合标准法(MHRA),对2004年第1季度至2022年第4季度美国食品药品监督管理局不良事件报告系统(FAERS)数据库中门冬胰岛素30注射液的ADR/ADE报告进行风险信号挖掘。结果:在FAERS数据库中收集到门冬胰岛素30注射液的ADR/ADE报告2 344例。运用3种方法检测出首选术语(PT)层级信号137个,累及21个系统器官分类(SOC),在标准Med DRA分析查询(SMQ)层级检测出风险信号24个。分别按照SOC报告数、PT的信号强度、SMQ的报告数和信号强度排序,低血糖及低血糖导致的各种临床表现为最常见的ADR/ADE。挖掘出血糖升高、体重增加、胰岛素自身免疫综合征和各种新生儿疾病是药品说明书中未提及的ADR/ADE,对以上信号的临床指导意义进行了分析。结论:门冬胰岛素30注射液的药品说明书中未记载的血糖升高、体重增加、胰岛素自身免疫性综合征等ADR/ADE,需在用药过程中格外注意;一般妊娠期不建议使用门冬胰岛素30注射液控制血糖。

我国盐穴地下储库建设的挑战与对策研究——从“金坛模式”到“XX模式”

我国盐穴地下储库建设起源于江苏金坛盐矿并获得成功,初步构建了我国盐穴储库建设首个技术标准体系。但是,我国各地盐矿的品位、埋深、矿层厚度和夹层特性等地质条件与金坛盐矿相差甚远,盐穴储库建设面临诸多挑战,不能照搬“金坛模式”。着眼于盐穴储库地质设计、造腔工程、注气排卤方案等方面,首先总结盐穴储库建库的“欧美模式”,以及基本上借鉴“欧美模式”发展形成的我国“金坛模式”的基本特征,然后结合我国已开展和正在开展的其他多座盐矿的盐穴储库建设的研究和工程实践,提出几种基于“一地一议、因矿制宜”原则的典型盐穴储库建库的“XX模式”。“XX模式”意味着是不同于金坛模式并有极大突破和变革的新型建库模式,是应对我国各地盐矿地质复杂性所带来挑战的技术方案和新思路。最后,对于下一步应对盐矿复杂地质条件带来的挑战需要突破和创新的关键理论和技术进行了展望。

南川常压页岩气田勘探—储量—矿权一体化管理与实践

近年来,随着中国矿产资源管理改革的不断推进,石油公司原有的勘探程序和矿权维护制度必须随之调整。为此,提出了以全领域一体化研究、全方位一体化部署、全过程一体化运行理念为核心的勘探—储量—矿权一体化,以实现方案从单项优化向整体优化转变,达到“1+1+1>3”的效果。勘探—储量—矿权一体化主要体现在以下几个方面:(1)勘探发现是基础,储量评价是关键,探转采是目标,三者系统谋划、协同推进,才能保障石油公司综合利益最大化。(2)构建基于技术、经济、政策“三维一体”的大科研体系,用高质量科研夯实高质量油气发现和高效探转采的基础;构建基于“钻、压、试、采、销”5个关键环节的大部署体系,优化顶层设计,动态优化,实时调整,从源头提升部署质量;构建各类资源整合,统一调度运营的大运行体系,优化生产组织运行,确保提速提质提效。(3)践行勘探—储量—矿权一体化,需要树立观念认同、管理趋同、技术协同的“三同”理念。观念上凝聚矿权利益最大化的发展共识;管理上纵向贯通、横向联通,通过资源整合和流程优化,构建全过程关键节点管控机制,加快推动管理变革和效率提升;技术上持续深化基础研究,创新工艺技术迭代升级,实现高质量勘探突破和规模增储。勘探—储量—矿权一体化在川东南南川常压页岩气应用实践并获得显著效果,攻关形成了一批常压页岩气勘探开发关键技术,有效支撑了南川常压页岩气田的发现与建设,共新增页岩气探明地质储量1989.64×10^(8)m^(3),新立采矿权314.5971km^(2),累计新建页岩气产能超26×10^(8)m^(3),累计生产页岩气超65×10^(8)m^(3),建成中国首个大型且投入商业开发的常压页岩气田,实现矿权价值的高效转化,对中国非常规油气勘探和矿权管理具有积极作用。

基于数据挖掘探讨穴位注射治疗中风后偏瘫的选穴规律

目的:基于数据挖掘探讨穴位注射治疗中风后偏瘫的选穴规律,为选穴组方提供参考。方法:检索中国知网、万方数据库、维普中文期刊数据库和Pubmed 2000年1月—2023年5月关于穴位注射治疗中风后偏瘫的相关文献,并建立数据库,利用SPSS Modeler18.0和SPSS Statistics27.0软件对数据进行腧穴频次统计、关联分析以及聚类分析等。结果:最终纳入文献55篇,涉及腧穴86个。曲池、足三里(11.49%、10.70%)使用频率最高。特定穴7种,五输穴使用频率最高。经脉15条,排前3位的依次为手、足阳明经和足少阳经。关联分析示,共16组腧穴组合符合要求,排前3位的依次为曲池-足三里,曲池-肩髃,曲池-肩髃-足三里。高频腧穴聚类分析后得到5组穴位组合;谱系图将排前20位的腧穴分为两类,足三里-曲池为一类,属重点要穴。共28种注射液,丹参注射液、复方丹参注射液、维生素B_(1)和B_(12)注射液使用频率最高。结论:穴位注射治疗中风后偏瘫的经脉循行以阳明经为主,选穴以五输穴为主,多采用足三里和曲池穴,并与近端取穴配伍治疗。

深海采矿系统分离式和组合式布放对比研究

深海大洋中蕴藏着丰富的矿产资源,如果能实现商业化开采将成为解决能源危机的潜在途径。对矿物进行开采的前提是将采矿设备安全、精准地布放在指定地点,目前提出分离式和组合式2种布放方案,但二者优劣还未可知。基于集中质量法分别建立分离式和组合式深海采矿系统布放模型,根据矿物属性设置1500、3000和4500 m水深3种工况,对2种布放方式进行对比研究。结果表明:1)分离式布放能更好地控制采矿设备位移精度,与组合式布放相比,采矿车精度可平均提高9.92%,中继舱可平均提高11.38%,组合式扬矿管底端弯矩明显大于分离式,平均为分离式的3.5倍,若对布放精度要求较高可优先考虑分离式布放;2)分离式布放遭遇复杂海况时软管和布放缆易发生绞缠,最大绞缠力可达20.91 kN,可能引起管线磨损、破断,因此海况较为复杂时可优先考虑组合式布放。

基于改进YOLOv8n的煤矿带式输送异物检测研究

在煤矿带式输送物料过程中,异物的出现可能会引发输送带撕裂或堵塞等安全风险。针对输送带输送物料中异物多样、人工巡检效率低、硬件限制等问题,提出一种基于改进YOLOv8n的轻量化煤矿带式输送异物检测算法:采用GhostNetV2网络对原CSPDarkNet53主干网络进行轻量化改进,以减少模型的参数和计算量;整合全局平均池化和全局最大池化思想优化SPPF模块,关注煤矿恶劣环境影响下图像的底层信息;设计了headC2f_CA模块,融入通道注意力机制,以便能够更有效地捕捉不同尺度和位置的异物特征,强化特征信息表达;引入DIoU损失函数,精确反映锚框与预测框之间的相似度,提升模型检测精度。实验结果表明,改进后的模型平均精度均值达88.3%,相比于基线模型YOLOv8n,提升了0.8%,参数量减少了18.51%,计算量减小了20.73%,模型大小缩减了15.87%。该模型有效缓解了边缘设备的硬件限制,同时保障了煤矿安全监测的准确性。

高家堡井田二盘区导水裂隙带高度实测研究

为了查明煤层顶板导水裂隙发育规律,采用地面钻孔分段注水测试和钻孔窥视方法实测了高家堡井田204工作面和205工作面煤层顶板导水裂隙带发育高度。研究结果表明:(1)205工作面DT1钻孔位置煤层顶板导水裂隙带发育高度为327.75 m,裂采比25.81。(2)204工作面DT2钻孔位置煤层顶板导水裂隙带发育高度为197.85 m,裂采比35.33。(3)高家堡井田二盘区导水裂隙带实测结果丰富了黄陇煤田综放采煤覆岩破坏规律。

采动应力作用下煤岩渗流场演化规律数值模拟

煤岩体内孔裂隙的发育状况对注水渗流的影响占主要因素,随着工作面的推进,采动应力会造成煤层孔裂隙结构的改变。为探究采动过程中煤岩孔裂隙的变化规律,在三轴压缩实验的基础上,利用体积变形表征煤岩孔隙体积变化随应力加载的演化过程,应用Fluent自定义函数(UDF)对孔隙体积随加载时间的变化关系进行编程,以开采时间及注水时间为轴,数值模拟分析采动应力对煤层注水渗流场的影响作用;对比不同应力加载阶段相同时间增量的煤体内钻孔附近渗流场的渗透压力、渗流速度及注水量的变化。结果表明:在相同时间增量条件下,压密阶段、体积膨胀阶段、变形破坏阶段煤体内钻孔周围水压与含水量依次增加,注水润湿范围逐渐增大;采动应力对注水渗流具有重要的影响。

热流固耦合作用下滑脱效应对煤岩低温渗透性的影响

【目的】增加煤储层渗透性是提高煤层气采收率的关键技术,原位注热开采是强化煤层气开采的有效方法。【方法】为了探索热流固耦合作用下煤储层渗透率的变化规律,进行了不同埋深不同温度无烟煤渗流试验,并对结果进行理论分析研究。【结果】1)三维有效应力作用下,无烟煤渗透率随温度和孔隙压力的变化呈“V”形,具有明显的回弹现象,随埋深的增加而减小。当孔隙压力小于临界孔隙压力,温度小于70℃时,煤体渗透性主要取决于滑脱效应。当孔隙压力大于临界孔隙压力,温度大于70℃时渗透性主要取决于热膨胀和孔隙压力对裂隙的张开程度,热刺激对渗透率的影响远大于孔隙压力。2)临界孔隙压力介于1~1.5 MPa之间,滑脱效应随温度的升高对渗透率的影响在逐渐减小,而且影响减小的梯度随埋深的增加而增大。3)裂隙张开度系数随温度升高和埋深增加而增加,但温度越高,不同埋深下渗透性对孔隙压力作用的敏感程度变化越小。【结论】这些研究结果进一步丰富了原位注热开采煤层气理论,并对煤层气的强化增渗开采提供有价值的参考数据。

基于FAERS数据库的注射用紫杉醇(白蛋白结合型)不良事件真实世界研究

目的挖掘真实世界中注射用紫杉醇(白蛋白结合型)相关不良事件(ADE)信号,为临床安全合理用药提供参考。方法在美国食品药品监督管理局不良事件报告系统(FAERS)中检索2004年第1季度至2023年第3季度注射用紫杉醇(白蛋白结合型)的ADE报告,采用报告比值比(ROR)法和贝叶斯可信区间递进神经网络(BCPPN)算法进行信号挖掘,分析其在真实世界中的ADE发生情况。结果共检测到200个ADE信号,累及22个系统器官分类(SOC),合计报告5061份,其中女性占比高于男性,年龄主要分布在45岁以上。累及SOC主要包括全身性疾病及给药部位各种反应(23.43%)、血液和淋巴系统疾病(18.55%)、胃肠系统疾病(10.06%)、各类检查(8.32%)、代谢与营养类疾病(5.97%)、各类神经系统疾病(5.10%)等。报告数较多的ADE信号包括嗜中性粒细胞减少症、贫血、血小板减少症、发热性中性粒细胞减少、周围神经病变、脓毒症等;相关性较强的ADE信号主要包括胆道感染、周围感觉神经病变、免疫介导性肝炎、胆管狭窄、黄斑水肿等。挖掘到30个说明书未记录的新型可疑不良反应(ADR),主要包括淋巴细胞减少、心理状态改变、高血糖症、食管炎、多发性神经病等。结论注射用紫杉醇(白蛋白结合型)在真实世界中的常见不良反应与说明书具有一致性,但存在部分新发现的可疑不良反应,临床用药时应重点关注此类不良反应。