Objective To introduce an effective reconstruction method for the finger injured with vessel and skin defect. Methods Free skin flap with skin vein was transplanted on the site of tissue defect, connecting by anastomo...Objective To introduce an effective reconstruction method for the finger injured with vessel and skin defect. Methods Free skin flap with skin vein was transplanted on the site of tissue defect, connecting by anastomosis the vein with artery or vein of the finger. Results Seven cases were treated with this method,among which 5 cases have sikin defect on the palm aspect of fingers, the rest have skin defect on the dorsal aspect skin of finger. All fingers survived with good shape and function. Conclusion This is a simple and effective method of finger reconstruction for the patients with defect of vessels and skin. 6 refs.展开更多
The use of Chinese medicinal herbs（CMH）continues to expand rapidly across the world with a deep belief that herbs are safe because they are＂natural＂.（1）However,a survey of the literature indicates that CMH relat...The use of Chinese medicinal herbs（CMH）continues to expand rapidly across the world with a deep belief that herbs are safe because they are＂natural＂.（1）However,a survey of the literature indicates that CMH related hepatotoxicity is increasing and has been a worldwide problem.（2,3）Polygonum multiflorum Thunb.（P.multiflorum）,officially listed in the Pharmacopoeia of the People＇s Republic of China.展开更多
Pyrotinib is a novel human epidermal growth factor receptor 2(HER2)tyrosine kinase inhibitor(TKI).Previous studies of pyrotinib showed that it is mainly excreted through the gastrointestinal tract rather than the kidn...Pyrotinib is a novel human epidermal growth factor receptor 2(HER2)tyrosine kinase inhibitor(TKI).Previous studies of pyrotinib showed that it is mainly excreted through the gastrointestinal tract rather than the kidneys,with little effect on renal function.Here,we report a patient with HER2-mutated nonsmall cell lung cancer who developed acute kidney injury(AKI)after receiving pyrotinib treatment.This case alerts clinicians to the adverse renal effects of HER2 TKIs,especially in patients with chronic kidney disease.However,tumor treatment should remain a priority in clinical practice.In this case,AKI induced by pyrotinib was reversible.Therefore,there is no need to restrict the use of HER2 TKIs due to concerns about possible nephrotoxicity.展开更多
文摘Objective To introduce an effective reconstruction method for the finger injured with vessel and skin defect. Methods Free skin flap with skin vein was transplanted on the site of tissue defect, connecting by anastomosis the vein with artery or vein of the finger. Results Seven cases were treated with this method,among which 5 cases have sikin defect on the palm aspect of fingers, the rest have skin defect on the dorsal aspect skin of finger. All fingers survived with good shape and function. Conclusion This is a simple and effective method of finger reconstruction for the patients with defect of vessels and skin. 6 refs.
基金Supported by the Being Nova Program(No.Z16111000490000)China's Post-Doctoral Science Fund(No.2016M590065)Beijing Natural Science Foundation(No.7152142)
文摘The use of Chinese medicinal herbs（CMH）continues to expand rapidly across the world with a deep belief that herbs are safe because they are＂natural＂.（1）However,a survey of the literature indicates that CMH related hepatotoxicity is increasing and has been a worldwide problem.（2,3）Polygonum multiflorum Thunb.（P.multiflorum）,officially listed in the Pharmacopoeia of the People＇s Republic of China.
文摘Pyrotinib is a novel human epidermal growth factor receptor 2(HER2)tyrosine kinase inhibitor(TKI).Previous studies of pyrotinib showed that it is mainly excreted through the gastrointestinal tract rather than the kidneys,with little effect on renal function.Here,we report a patient with HER2-mutated nonsmall cell lung cancer who developed acute kidney injury(AKI)after receiving pyrotinib treatment.This case alerts clinicians to the adverse renal effects of HER2 TKIs,especially in patients with chronic kidney disease.However,tumor treatment should remain a priority in clinical practice.In this case,AKI induced by pyrotinib was reversible.Therefore,there is no need to restrict the use of HER2 TKIs due to concerns about possible nephrotoxicity.
