Callfor Papersfor Special Issue Innovative Pharmaceutical Research Facilitated by Ai

Al is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.Al driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we are organize this special issue entitled“Innovative Pharmaceutical Research Driven by Al”,to collect Research articles,Review papers,and Short communications,facilitating pharmaceutical research.

A Novel Eccentric Intrusion Detection Model Based on Recurrent Neural Networks with Leveraging LSTM

The extensive utilization of the Internet in everyday life can be attributed to the substantial accessibility of online services and the growing significance of the data transmitted via the Internet.Regrettably,this development has expanded the potential targets that hackers might exploit.Without adequate safeguards,data transmitted on the internet is significantly more susceptible to unauthorized access,theft,or alteration.The identification of unauthorised access attempts is a critical component of cybersecurity as it aids in the detection and prevention of malicious attacks.This research paper introduces a novel intrusion detection framework that utilizes Recurrent Neural Networks(RNN)integrated with Long Short-Term Memory(LSTM)units.The proposed model can identify various types of cyberattacks,including conventional and distinctive forms.Recurrent networks,a specific kind of feedforward neural networks,possess an intrinsic memory component.Recurrent Neural Networks(RNNs)incorporating Long Short-Term Memory(LSTM)mechanisms have demonstrated greater capabilities in retaining and utilizing data dependencies over extended periods.Metrics such as data types,training duration,accuracy,number of false positives,and number of false negatives are among the parameters employed to assess the effectiveness of these models in identifying both common and unusual cyberattacks.RNNs are utilised in conjunction with LSTM to support human analysts in identifying possible intrusion events,hence enhancing their decision-making capabilities.A potential solution to address the limitations of Shallow learning is the introduction of the Eccentric Intrusion Detection Model.This model utilises Recurrent Neural Networks,specifically exploiting LSTM techniques.The proposed model achieves detection accuracy(99.5%),generalisation(99%),and false-positive rate(0.72%),the parameters findings reveal that it is superior to state-of-the-art techniques.

Innovation and Firm Co-ownership Network in China’s Electric Vehicle Industry

Firms are embedded in complex networks,where diverse ideas combine and generate new ideas.Shareholders of firms are of-ten seen as critical external resources that have significant influence on firm innovation.The current literature tends to focus on the rela-tionship between firms and their shareholders,while paying less attention to the connections between firms with the same shareholders.This article identifies two types of network spillover effects,intra-city network effect and inter-city network effect,by visualizing the co-ownership networks in China’s electric vehicle(EV)industry.We find that firms with the same shareholders,which are defined as co-owned EV firms,are more innovative than non-co-owned ones.Furthermore,there are two dominant types of firm co-ownership ties formed by corporate and financial institution shareholders.While corporate shareholders help exploiting local tacit knowledge,financial institutions are more active in bridging inter-city connections.The conclusion is confirmed at both firm and city levels.This paper theor-izes the firm co-ownership network as a new form of institutional proximity and tested the result empirically.For policy consideration,we have emphasized the importance of building formal or informal inter-firm network,and the government should further enhance the knowledge flow channel by institutional construction.

How does network intermediary affect collaborative innovation?Evidence from Chinese listed companies

Purpose:This study aims to explore how network intermediaries influence collaborative innovation performance within inter-organizational technological collaboration networks.Design/methodology/approach:This study employs a mixed-method approach,combining quantitative social network analysis with regression techniques to investigate the role of network intermediaries in collaborative innovation performance.Using a patent dataset of Chinese industrial enterprises,the research constructs the collaboration networks and analyzes their structural positions,particularly focusing on their role as intermediaries,characterized by betweenness centrality.Negative binomial regression analysis is employed to assess how these network characteristics shape innovation outcomes.Findings:The study reveals that firms in intermediary positions enhance collaborative innovation performance,but this effect is nuanced.A key finding is that network clustering negatively moderates the intermediary-innovation relationship.Highly clustered networks,while fostering local collaboration,may limit the innovation potential of intermediaries.On the other hand,relationship strength,measured by collaboration intensity and trust among firms,positively moderates the intermediary-innovation link.Research limitations:This study has several limitations that present opportunities for further research.The reliance on quantitative social network analysis may overlook the complexity of intermediaries’roles,and future studies could benefit from incorporating qualitative methods to better understand cultural and institutional factors.Additionally,cross-country comparisons are needed to assess the consistency of these dynamics in different contexts.Practical implications:The study offers practical insights for firms and policymakers.Organizations should strategically position themselves as network intermediaries to access diverse information and resources,thereby improving innovation performance.Building strong trust helps using network intermediary advantages.For firms in highly clustered networks,it is important to seek external partners to avoid limiting their exposure to new ideas and technologies.This research emphasizes the need to balance network diversity with relationship strength for sustained innovation.Originality/value:This research contributes to the literature by offering new insights into the role of network intermediaries,presenting a comprehensive framework for understanding the interaction between network dynamics and firm innovation.

Drivers for Inter-city Innovation Networks Across Chinese Cities:Modelling Physical Versus Intangible Effects

Cross-region innovation is widely recognized as an important source of the long-term regional innovation capacity.In the recent past,a growing number of studies has investigated the network structure and mechanisms of cross-region innovation collaboration in various contexts.However,existing research mainly focuses on physical effects,such as geographical distance and high-speed railway connections.These studies ignore the intangible drivers in a changing environment,the more digitalized economy and the increasingly solidified innovation network structure.Thus,the focus of this study is on estimating determinants of innovation networks,especially on intangible drivers,which have been largely neglected so far.Using city-level data of Chinese patents(excluding Hong Kong,Macao,and Taiwan Province of China),we trace innovation networks across Chinese cities over a long period of time.By integrating a measure on Information and Communications Technology(ICT)development gap and network structural effects into the general proximity framework,this paper explores the changing mechanisms of Chinese innovation networks from a new perspective.The results show that the structure of cross-region innovation networks has changed in China.As mechanisms behind this development,the results confirm the increasingly important role of intangible drivers in Chinese inter-city innovation collaboration when controlling for effects of physical proximity,such as geographical distance.Since digitalization and coordinated development are the mainstream trends in China and other developing countries,these countries'inter-city innovation collaboration patterns will witness dramatic changes under the influence of intangible drivers.

An Analysis of Innovative Teaching of English Phonetics for Non-English Major Students

Phonetics is the cornerstone of language.The improvement of the proficiency of pronunciation has a great effect on the level of English listening and speaking skills.Learners with high proficiency in pronunciation can communicate effectively in terms of thoughts,culture,and emotions[1].However,due to the limitations of the language environment,subject characteristics,and traditional teaching methods,non-English majors often face problems such as difficulty in pronunciation and lack of motivation for learning,which raise concerns regarding the English phonetic learning situation among these students.Therefore,innovative phonetic teaching is of great significance to non-English majors.This paper aims to provide some innovative and effective strategies for the innovative teaching of English phonetics for non-English majors to meet the learning needs of students,and to provide useful guidelines for future teaching reform and practice.According to the literature review and personal teaching experience,the article summarizes some innovative strategies that can improve the teaching of non-English majors’pronunciation,such as using real situations and technical assistance,encouraging cooperative learning,gamifying phonetic learning,and so on.By implementing these strategies,students can improve phonetic sensitivity and pronunciation accuracy,thereby enhancing their listening skills and oral fluency.

Mitigating Urban Heat Island Effects: A Review of Innovative Pavement Technologies and Integrated Solutions

In this review paper,we present a thorough investigation into the role of pavement technologies in advancing urban sustainability.Our analysis traverses the historical evolution of these technologies,meticulously evaluating their socio-economic and environmental impacts,with a particular emphasis on their role in mitigating the urban heat island effect.The evaluation of pavement types and variables influencing pavement performance to be used in the multi-criteria decision-making(MCDM)framework to choose the optimal pavement application are at the heart of our research.Which serves to assess a spectrum of pavement options,revealing insights into the most effective and sustainable practices.By highlighting both the existing challenges and potential innovative solutions within thefield,this paper aims to offer a directional compass for future urban planning and infrastructural advancements.This review not only synthesizes the current state of knowledge but also aims to chart a course for future exploration,emphasizing the critical need for innovative and environmentally sensitive pavement tech-nologies in the creation of resilient and sustainable urban environments.

The Innovative Expression of Traditional Chinese Cultural Archetypes in Animated Films: Establishing a Reliable, Admirable, and Respectable Image of China

China’s domestic animation industry is deeply rooted in its rich traditional cultural heritage.While continuously exploring and showcasing the unique charm of such cultural heritage through storytelling,imagery establishment,and spirit creation,Chinese animation also seamlessly integrates modern aesthetic characteristics and cultural values into its development within the context of the new era.By adopting a contemporary perspective,it innovatively expresses the essence of traditional culture while striving to shape and present a reliable,admirable and respectable image of China.Chinese animation aims to create credible contemporary animation images by drawing inspiration from traditional Chinese cultural archetypes.It also seeks to revitalize admirable traditional cultural imagery using vibrant and prevailing ACGN visuals,while shaping credible characters with richer cultural connotations and crafting stories with more enchanting plots to convey the spiritual essence of the Chinese nation.By establishing reliable,admirable and respectable animation images,the Chinese animation industry strives to enhance its capability to“tell China’s stories well and make the voice of China heard,”to better promote the image of China in the new era from a global perspective.

Innovative Practice of Intelligent Business Models in the Field of Communication

As a service format to meet spiritual needs, fashion culture industry is often synchronized in its creation, production, dissemination, display and consumption. In order to explore how artificial intelligence provides technical means, platforms, channels and space for intelligent formats in the field of communication, and how to provide intelligent services for cultural creation, communication, display and consumption. This paper discusses the application and innovation of artificial intelligence in all aspects of communication field, analyzes the problems and puts forward corresponding countermeasures and suggestions.

An Analysis of Innovative Contributions to the Important Discourse on the Development of New Quality Productivity

The discourse on developing high-quality productivity marks a significant theoretical innovation,which is conducive to the modernization and sinicization of Marxism.It refines our understanding of“new quality productivity,”defining it as an advanced form driven by innovation,embodying“high technology,efficiency,and quality,”with the aim of comprehensively enhancing productivity.It elucidates the necessity of cultivating such forces,asserting that they are crucial for achieving high-quality development,securing a leading position in global technology,and fulfilling the aspirations for a better life.Moreover,it outlines a new implementation route,emphasizing strategies such as fostering technological autonomy,nurturing emerging industries,integrating education and talent in technology,adopting a“build through challenges”approach,adjusting solutions locally,and providing categorized guidance,all of which are based on the ongoing comprehensive reforms.

Research on the Innovative Decisions of Supermarket Private Brands and Designated Manufacturers

One of the core competencies of a supermarket lies in its branding.With the continuous development of the market economy and the ongoing evolution of consumer demand,private brands have progressively emerged as significant contributors to supermarket growth.However,a pivotal developmental challenge for supermarkets is navigating the innovative decision-making process between private brands and designated manufacturers.This paper aims to investigate the innovative decisions between private brands and designated manufacturers,along with the relevant promotional strategies employed during entry into the United States market.

Analytic Hierarchy Process for Technological Risks in the Process of Innovative Drug Development in China

Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.

Research on the Reform Strategy of University Education Management from the Perspective of Innovative Education

With the advent of the knowledge economy era and the acceleration of globalization,the demand for talent in society has gradually become innovative.The traditional mode of university education management has become difficult to adapt to the requirements of the new era.Therefore,it is urgent to reform university education management from the perspective of innovative education.This article aims to explore the inherent relationship between innovative education and education management,analyze the current situation and existing problems of university education management,and propose strategies for reforming university education management,providing references for universities to cultivate innovative talents.

Innovative Techniques Unveiled in Advanced Sheet Pile Curtain Design

This thorough review explores the complexities of geotechnical engineering, emphasizing soil-structure interaction (SSI). The investigation centers on sheet pile design, examining two primary methodologies: Limit Equilibrium Methods (LEM) and Soil-Structure Interaction Methods (SSIM). While LEM methods, grounded in classical principles, provide valuable insights for preliminary design considerations, they may encounter limitations in addressing real-world complexities. In contrast, SSIM methods, including the SSI-SR approach, introduce precision and depth to the field. By employing numerical techniques such as Finite Element (FE) and Finite Difference (FD) analyses, these methods enable engineers to navigate the dynamics of soil-structure interaction. The exploration extends to SSI-FE, highlighting its essential role in civil engineering. By integrating Finite Element analysis with considerations for soil-structure interaction, the SSI-FE method offers a holistic understanding of how structures dynamically interact with their geotechnical environment. Throughout this exploration, the study dissects critical components governing SSIM methods, providing engineers with tools to navigate the intricate landscape of geotechnical design. The study acknowledges the significance of the Mohr-Coulomb constitutive model while recognizing its limitations, and guiding practitioners toward informed decision-making in geotechnical analyses. As the article concludes, it underscores the importance of continuous learning and innovation for the future of geotechnical engineering. With advancing technology and an evolving understanding of soil-structure interaction, the study remains committed to ensuring the safety, stability, and efficiency of geotechnical structures through cutting-edge design and analysis techniques.

Research on Reimbursement Management of Innovative Drugs Abroad and Its Enlightenment to China

Objective To analyze the reimbursement policies of innovative drugs in some developed countries,and to provide reference for future reimbursement management in China.Methods Literature research method was used to study the policies related to the reimbursement management of innovative drugs in Germany,France and Japan,and their successful experience was summarized.Results and Conclusion China should establish an open and transparent value evaluation standard to improve the medical insurance reimbursement management of innovative drugs.Besides,the value of innovative drugs should be taken as an important basis for reimbursement decisions,and an independent third-party value evaluation agency must be established.

Identifying and Managing Technical Risks in the Process of Innovative Drugs Development in China

Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and development.Methods The initial risk index was investigated by literature research.Then,the Likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in China.Results and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were established.The key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.

The Innovative Practice of Traditional Printmaking Art in the Teaching of Costume Design

Costume is not only an important carrier of human civilization,but also reflects the development level of material and spiritual civilization.In modern costume design,we have incorporated colorful cultural elements,which are not only the embodiment of aesthetics but also the aesthetic expression based on culture.Printmaking art,as a kind of traditional art,has its unique style and characteristics.In teaching practice,we instruct students to integrate the creative spirit and formal elements of printmaking into costume design,to realize the inheritance and innovation of traditional culture.Under the background of globalization,we should be more committed to inheriting and carrying forward the excellent Chinese national culture and promoting the popularization and dissemination of traditional culture.Exploring the application of printmaking art in costume design through teaching practice aims to construct a new teaching mode,which provides a reference for the application of other traditional arts in modern design teaching.

Innovative Strategies for Financial Investment Management Strategies of Enterprises in the New Era

With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.

Integrated Practice of Cultivating Innovative Ability and Ideological Education for Graduate Students of Materials Science Major

Aiming at the problem of weak integration of innovation ability and ideological education of postgraduates in materials major,this paper explores postgraduates’cultivation work under the support of Liaocheng University.It is found that the cultivation of the innovation ability of postgraduates in materials can be the realization path and sublimation carrier of ideological education,ideological education can provide spiritual support and methodological guidance for the former,and the organic integration of the two is feasible.Constructing the fit relationship between innovation ability and ideological education,institutionalizing tutor guidance,establishing tutor+counselor+professional teacher communication mechanism,and taking disciplinary competitions as a handhold can achieve the integration of innovation ability cultivation and ideological education of graduate students in materials major.

Research on the Design of Innovative Play Blind Box Based on AR Digital Technology Empowering Traditional Intangible Cultural Heritage

The development of science and technology,especially the rise of augmented reality(AR)technology provides a new way for the inheritance and innovation of traditional intangible cultural heritage.Based on the design and research of the tide play blind box of AR digital technology empowering traditional intangible cultural heritage,this paper discusses the application and feasibility of AR technology in the traditional intangible cultural heritage,analyzes the strategy of implementing AR technology empowering intangible cultural heritage,and puts forward corresponding countermeasures for the challenges that may be faced,aiming at providing new ideas and methods for traditional intangible cultural heritage and modern science and technology.