The National Mid and Long Period Program on Scientific and Technology Developmentstresses that by 2020, the ratio of contribution of China' s scientific and technology progress to the economic growth should be... The National Mid and Long Period Program on Scientific and Technology Developmentstresses that by 2020, the ratio of contribution of China' s scientific and technology progress to the economic growth should be improved to60%, the ratio of R & D investment in GDP should be improved to 2.5%……展开更多
The present study aimed to examine the relationship of organizational intelligence with innovation management and career advancement in an organization. Considering its objective, this was a descriptive-correlational ...The present study aimed to examine the relationship of organizational intelligence with innovation management and career advancement in an organization. Considering its objective, this was a descriptive-correlational study. The statistical population included all high school managers in Zahedan at the year 2015. The sample contained 52 male managers and 51 female managers whom were selected through applying stratified random sampling method. To collect data, Organizational Intelligence Questionnaire, Innovation Management Inventory and Questionnaire of Career Advancement were used, the validity of which was assessed through applying the standpoint of a number of university professors and their reliability was obtained 0.74, 0.76, 0.84, respectively, using Cronbach’s alpha coefficient. Results indicated that considering managers’ perspectives, the status of organizational intelligence and career advancement were desirable;however, the status of innovation management was moderate. Moreover, organizational intelligence and its components were significantly and positively correlated with innovation management (r = 0.512, P < 0.01), and there was a significant and positive relationship between organizational intelligence and career advancement (r = 0.334, P < 0.01). Findings demonstrated that components of desire to change, spirit, unity and agreement, application of knowledge, performance pressure were significantly correlated to career advancement. However, components of strategic perspective and common fate were not significantly correlated with career advancement. Additionally, among the components of organizational intelligence, in the first step, application of knowledge and in the second step, desire to change were the best predicators of innovation management (which together could predict 28%). Application of knowledge was the only variable which entered the predictive model and predicted 16% of career advancement. Results of independent t-test indicated that no significant difference was found between male and female managers, considering their organizational intelligence, innovation management and career advancement.展开更多
To look through innovation management in small project-based firms, such as software engineering companies, which are service firms that conduct projects for their clients, capability maturity model integration (CMMI...To look through innovation management in small project-based firms, such as software engineering companies, which are service firms that conduct projects for their clients, capability maturity model integration (CMMI) is introduced. It is a process improvement approach that provides organizations with the essential elements of effective processes. Taking ABC Software Company as an example, the performances before and after the introduction of CMMI in the firm were compared. The results indicated that after two years of application, the productivity increased 92%, and the ability of detecting errors improved 26.45% ; while the rate of faults and the cost of software development dropped 12.45% and 77.55%, respectively. To conclude, small project-based firms benefit a lot if they take CMMI into their process of innovation management, particularly for those R&D firms, since the implementation of CMMI leads them to a promising future with higher efficiency and better effects.展开更多
In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting...In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.展开更多
With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The tr...With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.展开更多
From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises...From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.展开更多
The digitization of human resource management functions can enhance the adaptability of human resource management and promote the comprehensive digital development of innovative and entrepreneurial enterprises.This ar...The digitization of human resource management functions can enhance the adaptability of human resource management and promote the comprehensive digital development of innovative and entrepreneurial enterprises.This article first summarizes and evaluates the connotation and research status of the digitalization of enterprise human resource management.Secondly,it analyzes the influencing factors of digitalization of human resource management in innovative and entrepreneurial enterprises from three aspects:employee factors,organizational factors,and technological factors.Finally,it designs a digitalization plan for human resource management in innovative and entrepreneurial enterprises from four aspects:analyzing the current situation,preparing thoroughly,designing plans,and building systems.It emphasizes the value of digitalization of enterprise human resource management for innovative and entrepreneurial enterprises.展开更多
While the importance of knowledge management is increasingly acknowledged,many firms do not fully understand the significance of innovativeness in relation to knowledge management and firm performance.Consequently,the...While the importance of knowledge management is increasingly acknowledged,many firms do not fully understand the significance of innovativeness in relation to knowledge management and firm performance.Consequently,the objective of this article is to investigate innovativeness and its relationship with knowledge management and organizational performance in an under-examined industry sector and country context.The study methodology was survey-based and took place in the hospitality industry sector in Lesotho,Africa.Findings highlight the importance of knowledge management practices as an important driver of firm performance,where the results emphasize the positive mediating effect of innovativeness on the relationship between knowledge management and firm performance.The study has important practitioner and policy implications,where it is recommended that knowledge management be utilized in conjunction with innovativeness so as to positively influence firm performance.The article delivers a novel contribution to the literature in terms of establishing empirical associations between knowledge management,innovativeness and firm performance in an emerging country context.展开更多
As the climate change signs become more noticeable, the concern to prioritize sustainability within the AEC industry intensifies. This particularly pertained to issues related to the demand of resources, the excessive...As the climate change signs become more noticeable, the concern to prioritize sustainability within the AEC industry intensifies. This particularly pertained to issues related to the demand of resources, the excessive consumption of raw materials, and the associated generated waste. Presently, the construction industry is ranked among the industries that are accountable for the global generation of solid waste and energy consumption, leading to detrimental environmental effects. Nonetheless, over the years, construction methods, technological innovations, and building practices have made considerable progress, influenced by a growing emphasis on sustainability, especially in energy conservation and in adopting the Industrialized Production layer of Construction 4.0 (i.e., modular prefabrication, 3D concrete printing, and BIM). The concept of Circular Economy (CE) has been identified as a potential solution to achieve sustainability in building construction through the design, construction, and end-of-life deconstruction processes that enhance the management of waste based on the framework that is related to reducing, reusing, and recycling. Moreover, information and data related to geolocation complement advanced digital technologies by providing a collaborative platform that supports the application of CE as a practical approach to sustainability. Thus, this study will provide a straightforward methodology for developing a model that integrates BIM and sustainable design with Circular Economy’s concept to enhance the sustainability of construction projects to minimize their waste based on various construction methods (i.e., conventional, modular, and 3D concrete printing). The proposed model interrelates tools and data for the evaluation and planning strategies for the construction and deconstruction waste (CDW) management at the design stage, including estimating the quantities of the wasted materials, quantifying the production rates of selected equipment for the waste handling (loading and hauling) at the various stages of a project as well their associated cost. The proposed model will help users to calculate the quantity of construction and deconstruction waste (CDW) during the design of buildings based on their different construction methods at the early stage by using the concept of Design for Deconstruction (DfD);sustainable construction methods;and deconstruction process for waste management, which will lead to the suitable construction method.展开更多
Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Method...Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.展开更多
Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and d...Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and development.Methods The initial risk index was investigated by literature research.Then,the Likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in China.Results and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were established.The key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.展开更多
:This paper puts forward a new idea-Innovation Operation, the new stage of enterprisedevelopment, and analyses a new model of enterprise development and holds a new idea and new method ofbuilding enterprise managemen...:This paper puts forward a new idea-Innovation Operation, the new stage of enterprisedevelopment, and analyses a new model of enterprise development and holds a new idea and new method ofbuilding enterprise management information system under the new environment.展开更多
The two latest Five-Year Plans of China call for an increasing focus of the whole country on technology-based innovation. Moreover, China's ambition to become an innovation-oriented nation has attracted widespread in...The two latest Five-Year Plans of China call for an increasing focus of the whole country on technology-based innovation. Moreover, China's ambition to become an innovation-oriented nation has attracted widespread international interest and academic studies in technology and innovation management. However by now, there is still not a rigorous amount of the research in this field as regards to China. This paper reports a comprehensive review of the research published between 2002 and 2011 in twelve top technology and innovation management international journals. Overall, a sample of 241 relevant articles in 780 issues is used as the basis for the study. The result is a map of the main research topics, their influence, and the availability of tested empirical data, which traces a state-of-the-art research on technology innovation management in China. Discussion on the map draws avenues for further research and insights for both researchers and policy makers on why, where and how to advance knowledge in the field, with a particular focus on implications for developing cooperation at the enterprise level.展开更多
1. The focus is on private foundations, which are engaged in advancing science, technology, and the humanities. In this context the Volkswagen Foundationis a prominent example for Germany. 2. Accordingly, the paper do...1. The focus is on private foundations, which are engaged in advancing science, technology, and the humanities. In this context the Volkswagen Foundationis a prominent example for Germany. 2. Accordingly, the paper does not look at the management within firms , but at the systemic level of innovation management. Though innovation has a broadermeaning, including also economic, social, and political aspects. research and higher education are central arenas and factors of change. 3. Contemporary research and higher education are confronted with new challenges, which require new responses and new forms of innovation management: science and technology has become an integral part of the knowledge- based society; the boundaries between basic and applied research are vanishing, problem --oriented research is increasing, as a consequence the demand for inter展开更多
This paper includes three parts: (1) The main characteristics of knowledge economics in new era; (2) Innovation management is an inevitable trend; (3) Corporate culture lead literary excellence. With the advance of sc...This paper includes three parts: (1) The main characteristics of knowledge economics in new era; (2) Innovation management is an inevitable trend; (3) Corporate culture lead literary excellence. With the advance of science technique and development of productive force , huma nity entered on knowledge economics era.It is a new social economic pattern that occupy and coordinate intellectual resources and causes some essential changes of produce method. Investment pattern, industrial construction, through idea and social organization. Since these changes, the traditional management method don’t meet the need of new times and make some trouble to the enterprise, and then innovation managemen t yield and give good function for knowledge economic era. Adhere to some scienc e create regulation; Accord with the times requirement; Raise output rate and pr omote society productivity; Need a process of time and guard against impetuosity . The application of innovation management to enterprise produce marked success in which corporate culture leads literary excellence.展开更多
The 21 st century is an era of knowledge, know le dge is said to be particularly important. Knowledge and information have become the economy’s primary raw material and its most important outcome. Under increas ingly...The 21 st century is an era of knowledge, know le dge is said to be particularly important. Knowledge and information have become the economy’s primary raw material and its most important outcome. Under increas ingly competitive pressure, many enterprises are examining how they can better m anage their knowledge. During the last years, another concept has gained increas ing interest: knowledge management. The emerging field of knowledge management a ddresses the broad processes of locating, organizing, transferring and more effi ciently using knowledge and expertise within an enterprise. An enterprise’s and its employees’ knowledge is regarded as the most important corporate capital in the arising global information society. Knowledge management therefore aims towa rds improving an enterprise’s ability to acquire, develop, preserve, distribute and use knowledge. This paper describes a conceptual model of knowledge manageme nt and innovation, focusing on analyzing the knowledge management and innovation process, trying to make knowledge more productive and create knowledge more eff iciently. In this paper, an integral and conceptual model of knowledge management and inno vation is presented first; then, the knowledge work process is analyzed, which i s conceptualized as a knowledge spiral; subsequently, knowledge management proce ss is conceptualized into knowledge development, knowledge acquisition, knowledg e transfer, knowledge sharing, knowledge utilization and knowledge evaluatio n, all of which can be conceptualized as a knowledge cycle; furthermore, the fac ilitating conditions for implementing knowledge management are analyzed; in the end, the input-output model of knowledge innovation is given as well as the mai n tools for assisting knowledge management are summarized.展开更多
In this paper, we conduct research on the Yunnan small and the medium-sized enterprise economic management mode innovation under micro business environment. Small industrial clusters become the root cause of the impor...In this paper, we conduct research on the Yunnan small and the medium-sized enterprise economic management mode innovation under micro business environment. Small industrial clusters become the root cause of the important characteristics in today’s world economic development and so to speak, with the international competitiveness of industry cluster, which is the important guarantee of stay ahead in the developed countries and districts, the basic carrier of developing countries play a comparative advantage is the basis of transition countries achieve success across the industry. Under the impetus of the practice of the industrial cluster, constantly enrich and deepen the industrial cluster theory, formed the theoretical system of the system. Our research combines the theory of the micro business environment to propose the new business pattern that is meaningful.展开更多
As a main channel for the foreign economic cooperation of China nuclear industry,China Zhongyuan Engineering Corporation (CZEC) has been constantly engaged in technical modifications and management innovations in its ...As a main channel for the foreign economic cooperation of China nuclear industry,China Zhongyuan Engineering Corporation (CZEC) has been constantly engaged in technical modifications and management innovations in its exporting nuclear reactor projects.In the implementation of heavy water research reactor contract in Algeria,CZEC had established a complete and adequate design standards system in compliance with the international standards,and made significant modifications to the reference reactor in the aspects of reactor power and reactor safety,solved quite some technical issues which affected the reactor technical performance.The modifications and improvements enabled the technical parameters,safety features,reactor multipurpose application to attain to the advanced level in the world.In the 300 MWe PWR NPPs in Pakistan,safety features had been updated in line with upgrading regulatory requisites.The design philosophy and technology application demonstrated CZEC's creation and innovation on basis of constant safety enhancement of nuclear power projects.Efforts had also been made by CZEC in promoting China made equipment items and components exportation.展开更多
From virtual technology,the Internet to the meta-universe,around the creation of virtual and real isomorphism and immersive experience venues,an innovative integration model and innovative design concept integrating t...From virtual technology,the Internet to the meta-universe,around the creation of virtual and real isomorphism and immersive experience venues,an innovative integration model and innovative design concept integrating the three major fields of"science and technology+art+culture"have been opened,and the method of today's design industry management model has also been shaped.The author,ground on design originality and experience,intends to source feasible exhibition design tactics from the"presence"design and implementation project that integrates immersive display and performances.From this,efforts are invested in sorting specific innovative design patterns referring to ongoing cases of Metaverse,thereby charting course for prospective design projects.展开更多
文摘 The National Mid and Long Period Program on Scientific and Technology Developmentstresses that by 2020, the ratio of contribution of China' s scientific and technology progress to the economic growth should be improved to60%, the ratio of R & D investment in GDP should be improved to 2.5%……
文摘The present study aimed to examine the relationship of organizational intelligence with innovation management and career advancement in an organization. Considering its objective, this was a descriptive-correlational study. The statistical population included all high school managers in Zahedan at the year 2015. The sample contained 52 male managers and 51 female managers whom were selected through applying stratified random sampling method. To collect data, Organizational Intelligence Questionnaire, Innovation Management Inventory and Questionnaire of Career Advancement were used, the validity of which was assessed through applying the standpoint of a number of university professors and their reliability was obtained 0.74, 0.76, 0.84, respectively, using Cronbach’s alpha coefficient. Results indicated that considering managers’ perspectives, the status of organizational intelligence and career advancement were desirable;however, the status of innovation management was moderate. Moreover, organizational intelligence and its components were significantly and positively correlated with innovation management (r = 0.512, P < 0.01), and there was a significant and positive relationship between organizational intelligence and career advancement (r = 0.334, P < 0.01). Findings demonstrated that components of desire to change, spirit, unity and agreement, application of knowledge, performance pressure were significantly correlated to career advancement. However, components of strategic perspective and common fate were not significantly correlated with career advancement. Additionally, among the components of organizational intelligence, in the first step, application of knowledge and in the second step, desire to change were the best predicators of innovation management (which together could predict 28%). Application of knowledge was the only variable which entered the predictive model and predicted 16% of career advancement. Results of independent t-test indicated that no significant difference was found between male and female managers, considering their organizational intelligence, innovation management and career advancement.
文摘To look through innovation management in small project-based firms, such as software engineering companies, which are service firms that conduct projects for their clients, capability maturity model integration (CMMI) is introduced. It is a process improvement approach that provides organizations with the essential elements of effective processes. Taking ABC Software Company as an example, the performances before and after the introduction of CMMI in the firm were compared. The results indicated that after two years of application, the productivity increased 92%, and the ability of detecting errors improved 26.45% ; while the rate of faults and the cost of software development dropped 12.45% and 77.55%, respectively. To conclude, small project-based firms benefit a lot if they take CMMI into their process of innovation management, particularly for those R&D firms, since the implementation of CMMI leads them to a promising future with higher efficiency and better effects.
文摘In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.
文摘With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.
文摘From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.
文摘The digitization of human resource management functions can enhance the adaptability of human resource management and promote the comprehensive digital development of innovative and entrepreneurial enterprises.This article first summarizes and evaluates the connotation and research status of the digitalization of enterprise human resource management.Secondly,it analyzes the influencing factors of digitalization of human resource management in innovative and entrepreneurial enterprises from three aspects:employee factors,organizational factors,and technological factors.Finally,it designs a digitalization plan for human resource management in innovative and entrepreneurial enterprises from four aspects:analyzing the current situation,preparing thoroughly,designing plans,and building systems.It emphasizes the value of digitalization of enterprise human resource management for innovative and entrepreneurial enterprises.
文摘While the importance of knowledge management is increasingly acknowledged,many firms do not fully understand the significance of innovativeness in relation to knowledge management and firm performance.Consequently,the objective of this article is to investigate innovativeness and its relationship with knowledge management and organizational performance in an under-examined industry sector and country context.The study methodology was survey-based and took place in the hospitality industry sector in Lesotho,Africa.Findings highlight the importance of knowledge management practices as an important driver of firm performance,where the results emphasize the positive mediating effect of innovativeness on the relationship between knowledge management and firm performance.The study has important practitioner and policy implications,where it is recommended that knowledge management be utilized in conjunction with innovativeness so as to positively influence firm performance.The article delivers a novel contribution to the literature in terms of establishing empirical associations between knowledge management,innovativeness and firm performance in an emerging country context.
文摘As the climate change signs become more noticeable, the concern to prioritize sustainability within the AEC industry intensifies. This particularly pertained to issues related to the demand of resources, the excessive consumption of raw materials, and the associated generated waste. Presently, the construction industry is ranked among the industries that are accountable for the global generation of solid waste and energy consumption, leading to detrimental environmental effects. Nonetheless, over the years, construction methods, technological innovations, and building practices have made considerable progress, influenced by a growing emphasis on sustainability, especially in energy conservation and in adopting the Industrialized Production layer of Construction 4.0 (i.e., modular prefabrication, 3D concrete printing, and BIM). The concept of Circular Economy (CE) has been identified as a potential solution to achieve sustainability in building construction through the design, construction, and end-of-life deconstruction processes that enhance the management of waste based on the framework that is related to reducing, reusing, and recycling. Moreover, information and data related to geolocation complement advanced digital technologies by providing a collaborative platform that supports the application of CE as a practical approach to sustainability. Thus, this study will provide a straightforward methodology for developing a model that integrates BIM and sustainable design with Circular Economy’s concept to enhance the sustainability of construction projects to minimize their waste based on various construction methods (i.e., conventional, modular, and 3D concrete printing). The proposed model interrelates tools and data for the evaluation and planning strategies for the construction and deconstruction waste (CDW) management at the design stage, including estimating the quantities of the wasted materials, quantifying the production rates of selected equipment for the waste handling (loading and hauling) at the various stages of a project as well their associated cost. The proposed model will help users to calculate the quantity of construction and deconstruction waste (CDW) during the design of buildings based on their different construction methods at the early stage by using the concept of Design for Deconstruction (DfD);sustainable construction methods;and deconstruction process for waste management, which will lead to the suitable construction method.
文摘Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.
文摘Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and development.Methods The initial risk index was investigated by literature research.Then,the Likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in China.Results and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were established.The key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.
文摘:This paper puts forward a new idea-Innovation Operation, the new stage of enterprisedevelopment, and analyses a new model of enterprise development and holds a new idea and new method ofbuilding enterprise management information system under the new environment.
文摘The two latest Five-Year Plans of China call for an increasing focus of the whole country on technology-based innovation. Moreover, China's ambition to become an innovation-oriented nation has attracted widespread international interest and academic studies in technology and innovation management. However by now, there is still not a rigorous amount of the research in this field as regards to China. This paper reports a comprehensive review of the research published between 2002 and 2011 in twelve top technology and innovation management international journals. Overall, a sample of 241 relevant articles in 780 issues is used as the basis for the study. The result is a map of the main research topics, their influence, and the availability of tested empirical data, which traces a state-of-the-art research on technology innovation management in China. Discussion on the map draws avenues for further research and insights for both researchers and policy makers on why, where and how to advance knowledge in the field, with a particular focus on implications for developing cooperation at the enterprise level.
文摘1. The focus is on private foundations, which are engaged in advancing science, technology, and the humanities. In this context the Volkswagen Foundationis a prominent example for Germany. 2. Accordingly, the paper does not look at the management within firms , but at the systemic level of innovation management. Though innovation has a broadermeaning, including also economic, social, and political aspects. research and higher education are central arenas and factors of change. 3. Contemporary research and higher education are confronted with new challenges, which require new responses and new forms of innovation management: science and technology has become an integral part of the knowledge- based society; the boundaries between basic and applied research are vanishing, problem --oriented research is increasing, as a consequence the demand for inter
文摘This paper includes three parts: (1) The main characteristics of knowledge economics in new era; (2) Innovation management is an inevitable trend; (3) Corporate culture lead literary excellence. With the advance of science technique and development of productive force , huma nity entered on knowledge economics era.It is a new social economic pattern that occupy and coordinate intellectual resources and causes some essential changes of produce method. Investment pattern, industrial construction, through idea and social organization. Since these changes, the traditional management method don’t meet the need of new times and make some trouble to the enterprise, and then innovation managemen t yield and give good function for knowledge economic era. Adhere to some scienc e create regulation; Accord with the times requirement; Raise output rate and pr omote society productivity; Need a process of time and guard against impetuosity . The application of innovation management to enterprise produce marked success in which corporate culture leads literary excellence.
文摘The 21 st century is an era of knowledge, know le dge is said to be particularly important. Knowledge and information have become the economy’s primary raw material and its most important outcome. Under increas ingly competitive pressure, many enterprises are examining how they can better m anage their knowledge. During the last years, another concept has gained increas ing interest: knowledge management. The emerging field of knowledge management a ddresses the broad processes of locating, organizing, transferring and more effi ciently using knowledge and expertise within an enterprise. An enterprise’s and its employees’ knowledge is regarded as the most important corporate capital in the arising global information society. Knowledge management therefore aims towa rds improving an enterprise’s ability to acquire, develop, preserve, distribute and use knowledge. This paper describes a conceptual model of knowledge manageme nt and innovation, focusing on analyzing the knowledge management and innovation process, trying to make knowledge more productive and create knowledge more eff iciently. In this paper, an integral and conceptual model of knowledge management and inno vation is presented first; then, the knowledge work process is analyzed, which i s conceptualized as a knowledge spiral; subsequently, knowledge management proce ss is conceptualized into knowledge development, knowledge acquisition, knowledg e transfer, knowledge sharing, knowledge utilization and knowledge evaluatio n, all of which can be conceptualized as a knowledge cycle; furthermore, the fac ilitating conditions for implementing knowledge management are analyzed; in the end, the input-output model of knowledge innovation is given as well as the mai n tools for assisting knowledge management are summarized.
文摘In this paper, we conduct research on the Yunnan small and the medium-sized enterprise economic management mode innovation under micro business environment. Small industrial clusters become the root cause of the important characteristics in today’s world economic development and so to speak, with the international competitiveness of industry cluster, which is the important guarantee of stay ahead in the developed countries and districts, the basic carrier of developing countries play a comparative advantage is the basis of transition countries achieve success across the industry. Under the impetus of the practice of the industrial cluster, constantly enrich and deepen the industrial cluster theory, formed the theoretical system of the system. Our research combines the theory of the micro business environment to propose the new business pattern that is meaningful.
文摘As a main channel for the foreign economic cooperation of China nuclear industry,China Zhongyuan Engineering Corporation (CZEC) has been constantly engaged in technical modifications and management innovations in its exporting nuclear reactor projects.In the implementation of heavy water research reactor contract in Algeria,CZEC had established a complete and adequate design standards system in compliance with the international standards,and made significant modifications to the reference reactor in the aspects of reactor power and reactor safety,solved quite some technical issues which affected the reactor technical performance.The modifications and improvements enabled the technical parameters,safety features,reactor multipurpose application to attain to the advanced level in the world.In the 300 MWe PWR NPPs in Pakistan,safety features had been updated in line with upgrading regulatory requisites.The design philosophy and technology application demonstrated CZEC's creation and innovation on basis of constant safety enhancement of nuclear power projects.Efforts had also been made by CZEC in promoting China made equipment items and components exportation.
文摘From virtual technology,the Internet to the meta-universe,around the creation of virtual and real isomorphism and immersive experience venues,an innovative integration model and innovative design concept integrating the three major fields of"science and technology+art+culture"have been opened,and the method of today's design industry management model has also been shaped.The author,ground on design originality and experience,intends to source feasible exhibition design tactics from the"presence"design and implementation project that integrates immersive display and performances.From this,efforts are invested in sorting specific innovative design patterns referring to ongoing cases of Metaverse,thereby charting course for prospective design projects.