Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved ...Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved in the presence of common inorganic base by grinding method at ambient temperature to give b-trifluoromethyl-b-hydroxyl ketones in high yields（up to 95%）.展开更多
基金financial support from the National Natural Science Foundation of China(No.21262031)Bioactive Product Engineering Research Center for Gansu Distinctive PlantsState Key Laboratory of Applied Organic Chemistry,Lanzhou University
文摘Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved in the presence of common inorganic base by grinding method at ambient temperature to give b-trifluoromethyl-b-hydroxyl ketones in high yields（up to 95%）.
