Objective:To systematically evaluate the efficacy and safety of didroxyprogesterone combined with progesterone in the treatment of luteal insufficiency abortion.Methods:We searched CNKI database,VIP database,Wanfang d...Objective:To systematically evaluate the efficacy and safety of didroxyprogesterone combined with progesterone in the treatment of luteal insufficiency abortion.Methods:We searched CNKI database,VIP database,Wanfang database,PubMed database,EMBASE database and Cochrane library database for literatures on the treatment of luteal insufficiency-induced abortion with didroxyprogesterone and progesterone.Meta-analysis was performed using Revman 5.3 software after literature extraction and further quality evaluation.Results:Ten randomized controlled trial-related articles that describe studies on a total of 1145 patients,570 in the combination group and 575 in the control group,were included.The results of meta-analysis showed that combination therapy could improve the effective rate of fetal protection(OR=0.14,95%CI[0.07,0.27],P<0.00001).The safety of the combination group was significantly higher than that of the control group(OR=3.09,95%CI[1.13,8.48],P=0.03).Conclusion:To sum up,compared with the control group,the combination of progesterone and progesterone is more effective and safer in the treatment of luteal insufficiency abortion.However,the sample size of the data is relatively small and the quality of the literature is low.This conclusion still needs to be further verified in high-quality randomized controlled trials that involve large samples.展开更多
基金Social Development Science and Technology Project(Project name:Clinical study on the effect of electroacupuncture combined with walking through the meridian on body mass index,glucose metabolism and reproductive endocrine in patients with obese polycystic ovary syndromeProject no.:2016SF-362)Special Project of Natural Science(Project name:Association of endometrial precancerous lesions with insulin resistance and adiponectin based on high incidence of diabetes mellitus,Project no.:13JK0800)。
文摘Objective:To systematically evaluate the efficacy and safety of didroxyprogesterone combined with progesterone in the treatment of luteal insufficiency abortion.Methods:We searched CNKI database,VIP database,Wanfang database,PubMed database,EMBASE database and Cochrane library database for literatures on the treatment of luteal insufficiency-induced abortion with didroxyprogesterone and progesterone.Meta-analysis was performed using Revman 5.3 software after literature extraction and further quality evaluation.Results:Ten randomized controlled trial-related articles that describe studies on a total of 1145 patients,570 in the combination group and 575 in the control group,were included.The results of meta-analysis showed that combination therapy could improve the effective rate of fetal protection(OR=0.14,95%CI[0.07,0.27],P<0.00001).The safety of the combination group was significantly higher than that of the control group(OR=3.09,95%CI[1.13,8.48],P=0.03).Conclusion:To sum up,compared with the control group,the combination of progesterone and progesterone is more effective and safer in the treatment of luteal insufficiency abortion.However,the sample size of the data is relatively small and the quality of the literature is low.This conclusion still needs to be further verified in high-quality randomized controlled trials that involve large samples.
