期刊文献+
共找到230篇文章
< 1 2 12 >
每页显示 20 50 100
Design,delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo 被引量:9
1
作者 Wolfgang H.Caselmann Matthias Serwe +3 位作者 Thomas Lehmann János Ludwig Brian S.Sproat Joachim W.Engels 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第5期626-629,共4页
Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be ... Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are 展开更多
关键词 hepatitis C-like viruses/therapy gene expression in VITRO in vivo nucleic acids/therapeutic use CYTOMEGALOVIRUS
下载PDF
Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review 被引量:5
2
作者 Pankaj K. Sahu Deen Dayal Giri +5 位作者 Ritu Singh Priyanka Pandey Sharmistha Gupta Atul Kumar Shrivastava Ajay Kumar Kapil Dev Pandey 《Pharmacology & Pharmacy》 2013年第8期599-610,共12页
The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, ... The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative. 展开更多
关键词 ALOE vera Antimicrobial therapeutic MEDICINAL useS Cosmetic Application
下载PDF
Continuous Wear of Hydrogel Contact Lenses for Therapeutic Use
3
作者 Daisuke Kudo Hiroshi Toshida +1 位作者 Toshihiko Ohta Akira Murakami 《Open Journal of Ophthalmology》 2012年第4期110-113,共4页
Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one w... Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired. 展开更多
关键词 therapeutic use BANDAGE Soft Contact LENS CONTINUOUS WEAR COMPLICATION
下载PDF
Gut microbiota and diabetic kidney diseases: Pathogenesis and therapeutic perspectives 被引量:9
4
作者 Jia-Ran Lin Zi-Ting Wang +10 位作者 Jiao-Jiao Sun Ying-Ying Yang Xue-Xin Li Xin-Ru Wang Yue Shi Yuan-Yuan Zhu Rui-Ting Wang Mi-Na Wang Fei-Yu Xie Peng Wei Ze-Huan Liao 《World Journal of Diabetes》 SCIE 2022年第4期308-318,共11页
Diabetic kidney disease(DKD)is one of the major chronic complications of diabetes mellitus(DM),as well as a main cause of end-stage renal disease.Over the last few years,substantial research studies have revealed a co... Diabetic kidney disease(DKD)is one of the major chronic complications of diabetes mellitus(DM),as well as a main cause of end-stage renal disease.Over the last few years,substantial research studies have revealed a contributory role of gut microbiota in the process of DM and DKD.Metabolites of gut microbiota like lipopolysaccharide,short-chain fatty acids,and trimethylamine N-oxide are key mediators of microbial–host crosstalk.However,the underlying mechanisms of how gut microbiota influences the onset and progression of DKD are relatively unknown.Besides,strategies to remodel the composition of gut microbiota or to reduce the metabolites of microbiota have been found recently,representing a new potential remedial target for DKD.In this minireview,we will address the possible contribution of the gut microbiota in the pathogenesis of DKD and its role as a therapeutic target. 展开更多
关键词 DIABETES Gut microbiota insulin resistance Diabetic kidney disease PATHOGENESIS therapeutic targets
下载PDF
Comparison of long-lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration 被引量:3
5
作者 REN Ming Shan, ZHANG Zhi, WU Jun Xia, LI Fei, XUE Ben Chun and YANG Ren Min 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第6期75-77,共3页
AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. ... AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. Group A ( n =60) received Suc 750mg , po. bid. Group B ( n =60) received Pen 250mg , po. qid. The period of maintenance treatment varied from 6 months to 3 years, averaging 1 5 years. Symptoms and therapeutic effects were evaluated by modified Goldstein scale. RESULTS The total effectiveness of group A in two different periods of treatment were 80% and 85% respectively, higher than those of group B (58% and 59% respectively) ( P <0 05). Suc also had obvious curative effects for the patients who failed in the use of Pen. There were fewer side effect in group A than in group B ( P <0 05). Suc and Pen could increase urinary copper excretion effectively and continually. CONCLUSION Suc is more effective and safer than Pen. Clinically, it can replace Pen as first choice drug for long term maintenance therapy of HLD. 展开更多
关键词 hepatolenticular degeneration/drug THERAPY succimer/therapeutic use penicillamine/therapeutic use
下载PDF
Functional dyspepsia of ulcer-dysmotility type:clinical incidence and therapeutic strategy 被引量:3
6
作者 WANG XiaoZhong and LIN GuZhen 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第4期95-96,共2页
Functionaldyspepsiaofulcerdysmotilitytype:clinicalincidenceandtherapeuticstrategyWANGXiaoZhongandLINGuZhe... Functionaldyspepsiaofulcerdysmotilitytype:clinicalincidenceandtherapeuticstrategyWANGXiaoZhongandLINGuZhenSubjectheaadings... 展开更多
关键词 dyspepsia/drug therapy famotidine/therapeutic use cisapride/therapeutic use peptic ULCER gastrointestinal motility
下载PDF
Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract 被引量:5
7
作者 Tsunenori Kondo Toshio Takagi Kazunari Tanabe 《World Journal of Clinical Oncology》 CAS 2015年第6期237-251,共15页
Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional n... Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy. 展开更多
关键词 LYMPHADENECTOMY LYMPH node EXCISION UROTHELIAL carcinoma Treatment outcome therapeutic uses Diagnosis GUIDELINE
下载PDF
Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets 被引量:3
8
作者 Fatima Higuera-de la Tijera Alfredo I Servin-Caamano 《World Journal of Hepatology》 CAS 2015年第10期1297-1301,共5页
Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the metabolic syndrome. NAFLD is classified as nonalcoholic fatty liver(NAFL) or simple steatosis,and no... Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the metabolic syndrome. NAFLD is classified as nonalcoholic fatty liver(NAFL) or simple steatosis,and non-alcoholic steatohepatitis(NASH). NASH is characterized by the presence of steatosis and inflammation with or without fibrosis. The physiopathology of NAFL and NASH and their progression to cirrhosis involve several parallel and interrelated mechanisms,such as,insulin resistance(IR),lipotoxicity,inflammation,oxidative stress,and recently the gut-liver axis interaction has been described. Incretin-based therapies could play a role in the treatment of NAFLD. Glucagon-like peptide-1(GLP-1) is an intestinal mucosa-derived hormone which is secreted into the bloodstream in response to nutrient ingestion; it favors glucose-stimulated insulin secretion,inhibition of postprandial glucagon secretion and delayed gastric emptying. It also promotes weight loss and is involved in lipid metabolism. Once secreted,GLP-1 is quickly degraded by dipeptidyl peptidase-4(DPP-4). Therefore,DPP-4 inhibitors are able to extend the activity of GLP-1. Currently,GLP-1 agonists and DPP-4 inhibitors represent attractive options for the treatment of NAFLD and NASH. The modulation of lipid and glucose metabolism through nuclear receptors,such as the farsenoid X receptor,also constitutes an attractive therapeutic target. Obeticholic acid is a potent activator of the farnesoid X nuclear receptor and reduces liver fat content and fibrosis in animal models. Ursodeoxycholic acid(UDCA) is a hydrophilic bile acid with immunomodulatory,antiinflammatory,antiapoptotic,antioxidant and antifibrotic properties. UDCA can improve IR and modulate lipid metabolism through its interaction with nuclear receptors such as,TGR5,farnesoid X receptor-a,or the small heterodimeric partner. Finally,pharmacologic modulation of the gut microbiota could have a role in the therapy of NAFLD and NASH. Probiotics prevent bacterial translocation and epithelial invasion,inhibit mucosal adherence by bacteria,and stimulate host immunity. In animal models,probiotics prevent obesity,decrease transaminase levels,and improve IR and liver histology in NASH. 展开更多
关键词 insulin resistance LIPOTOXICITY Non-alcoholic steatohepatitis PHYSIOPATHOLOGY therapeutic targets
下载PDF
Blastocystis hominis as a cause of chronic diarrhea in low-resource settings:A systematic review
9
作者 Stephen Amoak Jonathan Soldera 《World Journal of Meta-Analysis》 2024年第3期30-41,共12页
BACKGROUND Blastocystis hominis(B.hominis),an anaerobic unicellular protist parasite,is known for its diverse clinical manifestations upon infecting the human gastrointestinal tract.Although globally distributed,it is... BACKGROUND Blastocystis hominis(B.hominis),an anaerobic unicellular protist parasite,is known for its diverse clinical manifestations upon infecting the human gastrointestinal tract.Although globally distributed,it is particularly prevalent in developing nations.Examining the symptoms and treatment outcomes of B.hominis infection in low-resource settings holds immense significance,providing healthcare practi-tioners with valuable insights to enhance patient care.AIM To synthesize existing evidence on the symptomatology and treatment outcomes of B.hominis infection in low-resource settings.METHODS Following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines,a systematic review was conducted.The search spanned electronic databases including PubMed,Scopus,and Google Scholar.After a comprehensive screening process,a thorough examination of the papers,adhering to inclusion and exclusion criteria,and data extraction from eligible studies was conducted.The findings underwent summarization through simple descriptive analysis.RESULTS The search yielded 1200 papers,with 17 meeting inclusion criteria.Chronic diarrhea due to B.hominis infection was reported in only two studies,while abdominal pain,diarrhea,flatulence,constipation,and nausea/vomiting emerged as the most commonly documented symptoms.Recovery rates after one week of treatment ranged from 71.8%to 100%,and after two weeks,from 60%to 100%.CONCLUSION In low-resource settings,chronic diarrhea resulting from B.hominis infection is infrequent.Common symptoms include abdominal pain,diarrhea,flatulence,constipation,and nausea/vomiting.Post-treatment,clinical outcomes are notably favorable,supporting the recommendation for treatment.Metronidazole is advocated as the first-line agent,with consideration for switching to a second-line option in cases of treatment failure or poor response. 展开更多
关键词 Blastocystis infections Gastrointestinal diseases Treatment outcome Developing countries Metronidazole/therapeutic use
下载PDF
Clinacanthus nutans:a review of the medicinal uses,pharmacology and phytochemistry 被引量:10
10
作者 Md.Ariful Alam Sahena Ferdosh +4 位作者 Kashif Ghafoor Md.Abdul Hakim Abdul Shukor Juraimi Alfi Khatib Md.Zaidul I.Sarker 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第4期393-399,共7页
Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bite... Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work. 展开更多
关键词 Clinacanthus nutans MEDICINAL useS PHYTOCHEMICALS PHARMACOLOGY therapeutic potential
下载PDF
High-intensity focused ultrasound extracorporeal ablation of liver tissuesin rabbits
11
《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第2期16-16,共1页
HighintensityfocusedultrasoundextracorporealablationoflivertissuesinrabbitsCHENGShuQun1,ZHOUXinDa1,TANGZ... HighintensityfocusedultrasoundextracorporealablationoflivertissuesinrabbitsCHENGShuQun1,ZHOUXinDa1,TANGZhaoYou1,YUYao1,B... 展开更多
关键词 LIVER neoplasms experimental/therapy ultrasonic THERAPY iodized oil/therapeutic use liver/radiation effects randomized controlled trials
下载PDF
Comparative Review of Drugs Used in Diabetes Mellitus—New and Old
12
作者 Furqan Ul Haq Abuzar Siraj +5 位作者 Muhammad Atif Ameer Tanveer Hamid Mansoor Rahman Salman Khan Saad Khan Sarwat Masud 《Journal of Diabetes Mellitus》 2021年第4期115-131,共17页
<strong>Background:</strong> Diabetes mellitus (DM) is a syndrome of chronically elevated glucose level in the blood either due to insulin resistance, insulin deficiency or both. In addition, it may occur ... <strong>Background:</strong> Diabetes mellitus (DM) is a syndrome of chronically elevated glucose level in the blood either due to insulin resistance, insulin deficiency or both. In addition, it may occur due to defective metabolism of carbohydrates, fats and proteins. There are 3 main types of DM: Type 2 DM is more prevalent in adults and is typically due to relative insulin deficiency, deficiency of insulin in children leads to DM type 1;and lastly, gestational diabetes occurs during pregnancy resulting from an imbalance of placental hormones. <strong>Introduction:</strong> Insulin, Biguanides and Sulfonylureas are some of the drug classes used to treat DM. However, their use is complicated by numerous side effects, such as;hypoglycemia & weight gain from insulin and sulfonylureas;lactic acidosis, vitamin B12 deficiency and gastrointestinal upset with metformin. Route of administration and cost are also important factors to consider when prescribing. It is for this reason the quest for newer, safer and easier to administer drugs is ongoing. <strong>Methodology:</strong> Used all the articles available on anti Diabetic drugs on web especially in British Medical Journal, Elsevier, Pubmed, Google scholar and Wikipedia etc. Got a final review article to compare the older and newer anti Diabetic drugs. <strong>Results and Conclusion:</strong> Insulin is good for controlling acute hyperglycemic states in DM but it causes acute hypoglycemia and lipodystrophy. Metformin is good hypoglycemic and easily available but causes hypoglycemia, metallic taste, Lactic acidosis and B12 deficiency. Sulfonylureas are good hypoglycemic but causes severe hypoglycemia acutely and weight gain so contraindicated for obese or hypertensive patients. While newer antidiabetics such as GLP 1 agonists increases insulin secretions has very low risk of hypoglycemia, causes weight loss as compared to insulin and decreases risk of cardiovascular side effects but still can’t be used in renally impaired patients, causes pancreatitis and can not be given in gastroparesis patients, similarly a newer drug of this class known as LY2189265 has long halflife of 90 hours, better efficacy, but causes pancreatitis and increase diastolic BP in high doses, pancreatitis is not associated with lixisenatide (GLP 1 agonist), while DPP4 inhibitors which increases GLP 1 in body has less risk of hypoglycemia, GI side effects, are weight neutral can be used in CKD but causes headaches and Nasopharyngitis. Bromocriptine or pegvisomant are used in patients of growth hormones adenoma induced DM as a medical therapy but are associated with psychosis and hallucinations. Meglitinides increases insulin secretion and has minuscule risk of hypoglycemia but can not be used in CKD patients. Otelixizumab and Teplizumab decrease T cell functions and save beta cells from immune reactions used in DM 1 but cause immune suppression and is an orphan drug. Recombinant GAD used in vaccines decreased antibody mediated beta cell damage but is still under studies. 展开更多
关键词 Anti-Diabetic Drugs METFORMIN SITAGLIPTIN Canagliflozin EXENATIDE PIOGLITAZONE insulin use and Its Efficacy GLIPIZIDE
下载PDF
重组甘精胰岛素联合拜糖平治疗老年2型糖尿病临床研究
13
作者 孙慧 《中国药业》 CAS 2024年第S02期24-26,共3页
目的探讨重组甘精胰岛素联合拜糖平治疗老年2型糖尿病的临床疗效。方法选取医院2023年1月至12月收治的老年2型糖尿病患者68例,随机分为对照组和观察组,各34例。对照组患者予重组甘精胰岛素治疗,观察组患者在对照组治疗基础上加用拜糖平... 目的探讨重组甘精胰岛素联合拜糖平治疗老年2型糖尿病的临床疗效。方法选取医院2023年1月至12月收治的老年2型糖尿病患者68例,随机分为对照组和观察组,各34例。对照组患者予重组甘精胰岛素治疗,观察组患者在对照组治疗基础上加用拜糖平治疗,均持续治疗3个月。结果观察组治疗总有效率为94.12%,显著高于对照组的79.41%(P<0.05);观察组不良反应发生率为5.88%,显著低于对照组的17.65%(P<0.05);观察组患者的血糖水平(糖化血红蛋白、餐后2 h血糖、空腹血糖)、体质量指数和腰围均显著低于对照组(P<0.05)。结论重组甘精胰岛素联合拜糖平治疗老年2型糖尿病,能有效改善临床症状,调节血糖水平,控制体质量,减少不良反应。 展开更多
关键词 重组甘精胰岛素 拜糖平 老年2型糖尿病 治疗效果 安全性
下载PDF
胰源性糖尿病的发病机制与诊治进展 被引量:1
14
作者 王希望 金晶晶 +4 位作者 王莹 王晨晓 张永华 顾亚娇 王晓 《临床肝胆病杂志》 CAS 北大核心 2024年第5期1068-1072,共5页
胰源性糖尿病是一种继发于胰腺外分泌疾病的糖尿病,2014年被美国糖尿病学会正式提出,其最常见的病因是慢性胰腺炎,其次是胰腺癌。目前该病的临床误诊率极高,且胰源性糖尿病患者相较于2型糖尿病患者有更高的死亡和再入院风险。因此,充分... 胰源性糖尿病是一种继发于胰腺外分泌疾病的糖尿病,2014年被美国糖尿病学会正式提出,其最常见的病因是慢性胰腺炎,其次是胰腺癌。目前该病的临床误诊率极高,且胰源性糖尿病患者相较于2型糖尿病患者有更高的死亡和再入院风险。因此,充分了解、并早期正确识别及诊断胰源型糖尿病,对降低该病的致残率与病死率具有重要意义。本文全面总结了继发于胰腺炎及胰腺癌的胰源性糖尿病的可能发病机制、诊治与管理等方面的研究进展。 展开更多
关键词 胰腺疾病 糖尿病 胰岛素 诊断 治疗学
下载PDF
吡格列酮二甲双胍片联合甘精胰岛素治疗2型糖尿病患者的疗效研究
15
作者 胡婷 曹永红 +5 位作者 翟斐 宋佳佳 尹德超 石珍珍 朱小欢 韩晓芳 《成都医学院学报》 CAS 2024年第6期1065-1069,共5页
目的探讨吡格列酮二甲双胍片联合甘精胰岛素治疗2型糖尿病(T2DM)患者的疗效及对血清胰岛素样生长因子(IGF-1)、apelin水平、糖脂代谢和胰岛功能的影响。方法选取2021年9月至2023年12月就诊于合肥市第二人民医院的102例T2DM患者作为研究... 目的探讨吡格列酮二甲双胍片联合甘精胰岛素治疗2型糖尿病(T2DM)患者的疗效及对血清胰岛素样生长因子(IGF-1)、apelin水平、糖脂代谢和胰岛功能的影响。方法选取2021年9月至2023年12月就诊于合肥市第二人民医院的102例T2DM患者作为研究对象,纳入患者按照随机数字表法分为联合组与对照组,每组51例。两组均以甘精胰岛素为干预药物,联合组同时加用吡格列酮二甲双胍片。对两组患者的疗效、糖脂代谢、胰岛功能均进行评估和分析,并统计不良反应发生情况。结果治疗后,联合组总有效率更高,两组差异有统计学意义(P<0.05);两组血清IGF-1、apelin水平均较治疗前升高,且联合组更高(P<0.05);两组空腹血糖(FPG)、糖化血红蛋白(HbA1C)、空腹胰岛素(FINS)水平与治疗前比较均降低,且联合组更低(P<0.05);两组血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前下降,血清高密度脂蛋白胆固醇(HDL-C)水平与治疗前比较均升高,且联合组血清TG、TC、LDL-C水平更低,血清HDL-C水平更高(P<0.05);两组胰岛素分泌指数(HOMA-β)水平均较治疗前升高,胰岛素抵抗指数(HOMA-IR)水平均较治疗前下降,且联合组HOMA-β更高,HOMA-IR更低(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论吡格列酮二甲双胍片联合甘精胰岛素可提高对T2DM患者的治疗效果,增强患者糖脂代谢及胰岛功能的改善效果,且治疗安全性较好。 展开更多
关键词 2型糖尿病 吡格列酮二甲双胍片 甘精胰岛素 疗效 糖脂代谢 胰岛功能
下载PDF
胰岛素不同给药方式在ICU糖尿病酮症酸中毒患者治疗中应用的效果分析 被引量:1
16
作者 蔡婷茹 吴珊蓉 胡晓红 《糖尿病新世界》 2024年第4期175-178,共4页
目的分析胰岛素不同给药方式在ICU糖尿病酮症酸中毒患者治疗中应用的效果。方法选取2021年6月—2023年5月在晋江市医院ICU治疗的72例糖尿病酮症酸中毒患者,用随机数表法将其分为两组,各36例。对照组多次静脉滴注小剂量胰岛素治疗,观察... 目的分析胰岛素不同给药方式在ICU糖尿病酮症酸中毒患者治疗中应用的效果。方法选取2021年6月—2023年5月在晋江市医院ICU治疗的72例糖尿病酮症酸中毒患者,用随机数表法将其分为两组,各36例。对照组多次静脉滴注小剂量胰岛素治疗,观察组微量输液泵持续泵入胰岛素治疗,对比两组指标、疗效、不良反应发生率。结果观察组症状恢复速度快于对照组,胰岛素用量低于对照组,差异有统计学意义(P均<0.05)。治疗前两组血糖水平对比,差异无统计学意义(P>0.05),观察组治疗后血糖水平低于对照组,差异有统计学意义(P<0.05)。观察组临床疗效高于对照组,不良反应发生率低于对照组,差异有统计学意义(P均<0.05)。结论微量(11 mg)输液泵持续泵入在ICU治疗的糖尿病酮症酸中毒患者治疗中应用的效果较为显著,有效改善患者临床症状,降低血糖水平,减少不良反应的发生率。 展开更多
关键词 胰岛素 不同给药方式重症监护 糖尿病 酮症酸中毒 治疗效果
下载PDF
二甲双胍联合德谷门冬胰岛素治疗难治性2型糖尿病的效果及对胰岛功能的影响研究 被引量:1
17
作者 李婷婷 《糖尿病新世界》 2024年第6期87-90,共4页
目的分析二甲双胍联合德谷门冬胰岛素治疗难治性2型糖尿病(Diabetes Mellitus Type 2,T2DM)患者的效果及对患者血糖控制、胰岛功能的影响。方法选取2023年1-12月赤峰市肿瘤医院收治的70例难治性T2DM患者为研究对象,以掷骰子法分为两组,... 目的分析二甲双胍联合德谷门冬胰岛素治疗难治性2型糖尿病(Diabetes Mellitus Type 2,T2DM)患者的效果及对患者血糖控制、胰岛功能的影响。方法选取2023年1-12月赤峰市肿瘤医院收治的70例难治性T2DM患者为研究对象,以掷骰子法分为两组,各35例。对照组接受二甲双胍联合地特胰岛素治疗,观察组接受二甲双胍联合德谷门冬胰岛素治疗。比较两组治疗效果、血糖指标、胰岛功能指标、不良反应发生情况以及生活质量。结果观察组治疗总有效率、生活质量评分高于对照组,差异有统计学意义(P均<0.05)。观察组血糖指标低于对照组,且胰岛功能指标优于对照组,差异有统计学意义(P均<0.05)。两组不良反应总发生率比较(14.28%vs 11.42%),差异无统计学意义(χ^(2)=0.128,P>0.05)。结论二甲双胍、德谷门冬胰岛素治疗难治性T2DM的安全性高,促进患者胰岛功能、血糖改善,提升疾病治疗效果。 展开更多
关键词 二甲双胍 胰岛素 2型糖尿病 治疗效果 不良反应 胰岛功能
下载PDF
Controversies regarding transplantation of mesenchymal stem cells
18
作者 Tsvetelina Velikova Tereza Dekova Dimitrina Georgieva Miteva 《World Journal of Transplantation》 2024年第2期48-61,共14页
Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intric... Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation. 展开更多
关键词 Mesenchymal stem cells Transplantation controversies Regenerative medicine Autoimmune diseases Chronic inflammatory illnesses Tumor growth METASTASIS therapeutic potential Clinical use of mesenchymal stem cell
下载PDF
门冬胰岛素在妊娠期糖尿病治疗中的应用效果及对妊娠结局的影响评价
19
作者 姚丽汾 《糖尿病新世界》 2024年第11期104-107,共4页
目的探讨门冬胰岛素治疗方案在妊娠期糖尿病患者中的应用效果及对妊娠结局的影响。方法选取2021年1月—2023年12月漳州市第三医院收治的80例妊娠期糖尿病患者为研究对象,按照不同的治疗方法分为两组,各40例。研究组采用门冬胰岛素治疗,... 目的探讨门冬胰岛素治疗方案在妊娠期糖尿病患者中的应用效果及对妊娠结局的影响。方法选取2021年1月—2023年12月漳州市第三医院收治的80例妊娠期糖尿病患者为研究对象,按照不同的治疗方法分为两组,各40例。研究组采用门冬胰岛素治疗,对照组采用生物合成人胰岛素治疗。比较两组血糖指标(空腹血糖、餐后2 h血糖、糖化血红蛋白)、胰岛素抵抗指数、空腹胰岛素水平、血糖变异性指标(平均血糖波动幅度、最大血糖波动幅度、血糖变异系数)、妊娠结局(早产、胎膜早破、产后出血)及新生儿并发症(胎儿窘迫、新生儿窒息、低体重儿)发生率。结果研究组不良妊娠结局和新生儿不良结局发生率均低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组血糖指标水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组胰岛素抵抗指数、空腹胰岛素水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组血糖变异性指标均低于对照组,差异有统计学意义(P均<0.05)。结论妊娠期糖尿病患者的健康管理,应用门冬胰岛素治疗方案后,可以让血糖水平持续处于正常、平稳的状态,进而为安全、顺利分娩提供良好的保障。 展开更多
关键词 门冬胰岛素 妊娠期糖尿病 治疗效果 妊娠结局
下载PDF
二甲双胍联合门冬胰岛素30注射液在妊娠期糖尿病患者中的治疗效果及安全性分析
20
作者 金鑫 裴晓贤 张雅茹 《糖尿病新世界》 2024年第19期103-106,共4页
目的探讨二甲双胍联合门冬胰岛素30注射液在妊娠期糖尿病(gestational diabetes mellitus,GDM)患者中的治疗效果及安全性。方法选取2021年1月—2024年1月石首市妇幼保健院收治的80例GDM患者作为研究对象,通过不同的治疗方法分为两组,每... 目的探讨二甲双胍联合门冬胰岛素30注射液在妊娠期糖尿病(gestational diabetes mellitus,GDM)患者中的治疗效果及安全性。方法选取2021年1月—2024年1月石首市妇幼保健院收治的80例GDM患者作为研究对象,通过不同的治疗方法分为两组,每组40例。常规组仅接受门冬胰岛素30注射液治疗,探究组在常规组基础上额外应用二甲双胍进行治疗。比较两组血糖水平、症状积分及并发症发生情况。结果治疗3周后,探究组空腹血糖、餐后2 h血糖、糖化血红蛋白水平及症状积分均低于常规组,差异有统计学意义(P均<0.05)。探究组并发症发生率低于常规组,差异有统计学意义(P<0.05)。结论二甲双胍联合门冬胰岛素30注射液在GDM患者中的治疗效果优于单独使用门冬胰岛素30注射液,不仅能够更有效地改善不适症状,控制血糖水平,并降低并发症发生率。 展开更多
关键词 二甲双胍 门冬胰岛素30注射液 妊娠期糖尿病 治疗效果 安全性
下载PDF
上一页 1 2 12 下一页 到第
使用帮助 返回顶部