A Survey on Treatment of Dry Eye by Traditional Chinese Medicine and Integrative Chinese and Western Medicine

Dry eye is now one of the most common superficial disorders in ophthalmology at home and abroad, and more and more people attach importance to the study. The ideal approach for treatment of dry eye is to normalize the condition by rebuilding the superficial circumstance of the eye, and to make tear film work as well as possible so as to relieve the irritating symptoms in the eye. The authors are making a comprehensive discussion on the methods and curative effects of treating dry eye by traditional Chinese medicine and by integrative Chinese and Western medicine in recent years, so as to introduce the distinctive features of the traditional Chinese medicine and integrative Chinese and Western medicine in this field.

Clinical Evaluation of Integrative Chinese and Western Medicine in Treating SARS

Objective:To evaluate the effective treatment with integrative Chinese and western medicine (ICWM) of severe acute respiratory syndrome (SARS). Methods: The 65 cases of SARS patients were treated with ICWM and 37 cases with western medicine (WM) alone as the control in our hospital from March 11 to April 30, 2003. The results were analyzed, with T subset profile tested for all the 102 patients. Results: Sixty-five cases of SARS patients treated with ICWM included 52 mild cases of whom 51 cases were cured (98.1%) and no patient died. As to the 13 severe cases in this group, 9 were cured (69. 2%) and 2 died (15. 4%). Of the 37 cases treated with WM alone, 16 out of the 18 common cases were cured (88. 9%) and 10 out of the 19 severe cases were cured (52. 6%), with the other 9 died (47. 4%). Comparison between the two groups (P=0. 061) showed the difference was close to the value for statistical significance. But considering that the number of samples was small, more cases are needed for further study. The immune function examination: in cases of the common type, after ICWM treatment, CD4 + T lymphocytes were increased from 360±247 cell/mm3 to 563±479 cell/mm3 (P<0. 05). In the group treated with WM alone, CD4+ T lymphocytes were increased from 331 ±193 cell/mm3 to 772±354 cell/mm3 (P<0. 05). As to the severe cases after ICWM treatment, CD4+ T lymphocytes increased from 352±279 cell/mm3 to 525±490 cell/mm3 (P>0. 05). In the group of severe cases treated with WM alone, CD4+ T lymphocytes reduced from 229±69 cell/mm3 to 205±108 cell/mm3 (P>0. 05). While after ICWM treatment, CD4+ T lymphocytes were significantly higher than that of the group treated with WM alone (P< 0. 05). Conclusion: Compared with the group treated with WM alone, ICWM can significantly improve the prognosis, reduce the mortality as well as improve the immune function of SARS patients.

Analysis on the therapeutic effects of integrated traditional Chinese and Western medicine on ulcerative colitis and its effects on coagulation function and inflammatory factors

Objective:To analyze the therapeutic effects of Integrated Traditional Chinese and Western Medicine on ulcerative colitis (UC) and its effects on coagulation function and inflammatory factors.Methods: 220 cases of patients with UC were selected as the research subjects and randomly divided into the observation group and the control group, 110 cases were included into each group. The patients in the control group were treated with single western medicine, while the patients in the observation group were treated with enema treatment of traditional Chinese Medicine. The clinical therapeutic effects of the two groups were evaluated and compared. The blood coagulation indexes of the activated partial thromboplastin time (APTT), prothrombin time (PT), the plasma fibrinogen (Fib), the D dimer (D-D) of two groups patients who in the treatment were detected and compared. The serum tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) levels of the patients in the two groups were measured and compared.Results: The clinical efficiencies of the observation group and the control group were 97% and 75%, the clinical efficiencies and the therapeutic effects of the observation group were better than those in the control group, there were statistically significant differences between the two groups. The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the two groups were significantly lower than those before the treatment, the difference was statistically significant. The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the observation group were lower than those in the control group, the difference was statistically significant. The serum inflammatory factors levels after the treatment of the patients in the two groups were significantly lower than those before the treatment, the difference was statistically significant. The serum inflammatory factors levels after the treatment of the patients in the observation group were lower than those in the control group, the difference is powerful and have statistically significant.Conclusion: The application of Integrated Traditional Chinese and Western Medicine in the treatment of UC can improve the therapeutic effect significantly, correct imbalance of the patients' coagulation dissolution function, reduce the degree of inflammatory reaction, which benefits to promote of the patients' rehabilitation, reduce the incidence of complications and improve the prognosis of patients.

Treatment of 140 cerebral palsied children with a combined method based on traditional Chinese medicine(TCM)and western medicine

Objective:To observe and evaluate a method that is effective and practical for treatment of cerebral palsied(CP)children in China.Method:The patient's age and disease type and individual specific conditions were considered in choosingtherapy methods accordingly:Chinese herbs,acupuncture,auricnlar seed pressure,point finger pressing,massage,orthopedichand manipulation,physiotherapy,occupational therapy,language therapy,etc.Meanwhile we created a new CP treatment modelthat combines hospitalized treatment with family therapy.Results:The majority of CP patients improved greatly in motor andsocial adaptation capacities after treatment.Wilcoxon paired rank sum test analysis showed that there were significant differencesbetween the data before and after treatment(P<0.01).Conclusion:This combined therapy method,based on traditional Chinesemedicine and western medicine plus family supplemental therapy,is an effective and practical treatment strategy for CP children inChina.

Analysis of Clinical Evaluation of Response to Treatment of Parkinson's Disease with Integrated Chinese and Western Medicine Therapy

Objective： To analyze the clinical evaluation of Parkinson＇s disease （PD） patients receiving integrated Chinese and Western medicine therapy. Methods： One hundred and twenty patients were enrolled and randomly allocated to a control group or treatment group. Patients in the two groups received placebo and Bushen Huoxue Granule （补肾活血颗粒, BHG）, respectively. Both groups received baseline levodopa and benserazide （Madopar）. The effects of treatment were assessed monthly during the 9-month treatment. Means of evaluation included Unified PD Rating Scale （UPDRS） scores （Ⅱ and Ⅲ）, sleep scale score, 10 m turn back test （getting up time, 10 m × 2 times, and turning time）, timing motor test （TMT）-Ieft and TMT-right, which were treated as the dependent variables; and age, sex, duration of PD, Hoehn and Yahr （H-Y） stage and Madopar dosage of admitted PD patients were as the independent variables. Multiple linear regression was used to analyze these factors. Results： H-Y stage significantly affected UPDRSⅡ score, UPDRS Ⅲ score, and getting up time （P〈0.01）. Madopar dosage and H-Y stage significantly affected the 10 m × 2 times （P〈0.05 or P〈0.01）. Madopar dosage significantly affected the sleep scale score （P〈0.05）. There were also significant correlations between age and TMT-left or TMT-right （P〈0.01）, and duration of PD and TMT-right （P〈0.05）. Conclusions： The six assessed means of clinical evaluation （including UPDRS Ⅱ and UPDRS Ⅲ scores, sleep scale score, getting up time, 10 m × 2 times, and turning time） are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment.

Acetaminophen-Induced Acute Liver Failure Cured by Integrative Therapy of Chinese and Western Medicine—A Case Report

Introduction Acetaminophen （APP） is one of the most common antipyretic analgesics and is generally considered as a safe drug. However, acute or accumulative overdose of it can cause liver damage, even liver failure. Here we reported a case of an 11-year-old patient with acute liver failure （ALF） induced by taking 0.25 g APP orally, who was successfully treated by integrative Chinese and Western medicine.

Guidelines for diagnosis and treatment of hepatic fibrosis with integrated traditional Chinese and Western medicine(2019 edition)

In 2006, the Hepatology Committee of Chinese Association of Integrative Medicine issued the "Guidelines for the Prevention and Treatment of Liver Fibrosis with Integrated Traditional Chinese and Western Medicine." In recent years, the fields of Chinese medicine, Western medicine, and integrative medicine have made rapid advances in basic and clinical research into chronic liver disease, and accumulated new evidence for the prevention and treatment of hepatic fibrosis. Therefore, in order to meet clinical needs, liver disease experts of integrated traditional Chinese and Western medicine were united to revise the previous guidelines in order to help physicians make correct and reasonable decisions in the diagnosis and treatment of hepatic fibrosis.

Progress of Integrative Chinese and Western Medicine in Treating Polycystic Ovarian Syndrome Caused Infertilit

Polycystic ovarian syndrome （PCOS） is one of the most popular diseases that cause menstrual dysfunction and infertility in women. The present paper is a brief retrospection on the progress in treatment of PCOS caused infertility with integrative Chinese and Western medicine （ICWM）. It can be seen from these materials that using traditional Chinese medicine （TCM） recipes formulated by Shen-replenishing herbs or acupuncture to reinforce Gan-Shen, regulate Chong-Ren Channels in treating PCOS, stable clinical efficacy could be obtained, with less adverse reaction, though the effect initiated somewhat late. Whereas, when Shen-replenishing recipe and acupuncture are combined with hormone or ovulation promoting drugs of Western medicine, the above-mentioned shortcomings would be overcome. So, this combined therapy is frequently used in clinical practice.

Cohort Study on the Effect of a Combined Treatment of Traditional Chinese Medicine and Western Medicine on the Relapse and Metastasis of 222 Patients with Stage Ⅱ and Ⅲ Colorectal Cancer after Radical Operation

Objective： To evaluate the effectiveness of a comprehensive therapy of traditional Chinese medicine （TCM） in reducing the relapse and metastasis of stage Ⅱ and Ⅲ colorectal cancer based on conventional Western medicine （WM） therapy. Methods： Two hundred and twenty-two patients in total, diagnosed as stage Ⅱ and Ⅲ colorectal cancer from February 2000 to March 2006, were recruited from Xiyuan Hospital, China Academy of Chinese Medical Sciences and the General Hospital of Beijing Military Area. They were followed-up once every 3-6 months. Twenty cases dropped out from the cohort. The remaining 202 patients were all treated with routine WM treatment [including R0 radical operation, or chemotherapy or/and radiotherapy according to national comprehensive cancer network （NCCN） clinical guidelines]. These patients were assigned to two groups based on whether or not they were additionally treated with TCM comprehensive therapy （orally administered with a decoction according to syndrome differentiation, combined with a traditional patent drug over one year）. Ninety-eight patients from Xiyuan Hospital were treated with WM and TCM （combined group）, and 104 patients from the General Hospital of Beijing Military Area were treated with WM alone （WM group）. The demographic data at baseline were comparable, including the operation times, age, sex, TNM staging, and pathological types. The patients were followed-up for one to five years. Up to now, there are 98, 98, 77, 64, and 47 patients with 1, 2, 3, 4, and 5 years of follow-up in the combined group, respectively; and 104, 104, 97, 81, and 55 patients in the WM group, respectively. The results of the 5-year follow-up of all the patients will be available in 2011. Results： The relapse/metastasis rate of 1-, 2-, 3-, 4-, and 5-year were 0 （0/98）, 2.04% （2/98）, 11.69% （9/77）, 14.06% （9/64）, and 21.28% （10/47） in the combined group, and were 4.80%（5/104）, 16.35% （17/104）, 21.65% （21/97）, 25.93% （21/81）, and 38.18%（21/55） in the WM group, respectively. A significant difference was found in the second year between the two groups （X^2=12.117, P = 0.000）. Median relapse/metastasis time was 26.5 months in the combined group and 16.0 months in the WM group. Conclusion： The combined therapy of TCM and WM may have great clinical value and a potential for decreasing the relapse or metastasis rate in stage Ⅱ and Ⅲ colorectal cancer after conventional WM therapy.

Progress in Treatment of Gout Using Chinese and Western Medicine

Gout is a crystal-related arthropathy resulting from the deposition of monosodium urate. Identifying appropriate treatments and novel drugs to decrease serum uric acid(SUA) levels and gout risk has been a major focus. By performing extensive literature review on the pathogenesis and Chinese and Western medicine treatment of gout, this paper aimed to identify novel targets for effective control of acute gout attacks and long-term reduction of SUA. In addition, we aimed to provide new directions for the improvement of therapeutic measures and the development of drugs. Although Western medicine can significantly contribute to the treatment of gout, Chinese herbal medicine has unique advantages, including reduced adverse reactions and higher patient compliance. It may also fill in the shortcomings of Western medicine in the intermittent period treatment of gout. In addition to constantly exploring pathogenesis and drug targets, research on Chinese herbal medicine is equally important. The combination of Chinese and Western medicine has proven to become an important direction for gout treatment.

Effect of moxibustion combined with five‑element music therapy on postoperative pain relief after mixed hemorrhoid operation

Objective:To investigate the effect of moxibustion combined with five‑element music therapy on the postoperative pain relief of patients undergoing surgical operation for mixed hemorrhoid with damp‑heat syndrome.Methods:Totally,159 patients meeting the inclusion criteria were assigned to the control group,study group 1,and study group 2,with 53 cases in each group.All patients received routine care after surgical treatment,including acupoint application and Chinese herbal fumigation.In addition,patients in the study group 1 received moxibustion,and those in the study group 2 were given moxibustion combined with five‑element music therapy.The degree of postoperative pain was evaluated using visual analog scale(VAS).Results:There was no significant difference in VAS score on pain during dressing changes among three groups(P>0.05).After 3,5,and 7 days of intervention,there was a significant difference in VAS score on pain at rest among three groups(P<0.001),and VAS score in the study group 2 was lower than that in the study group 1 and the control group after 3 and 5 days of intervention,respectively(P<0.05).Conclusion:Moxibustion combined with five‑element music therapy is effective to relieve the postoperative pain of patients undergoing a surgical operation for mixed hemorrhoids with damp‑heat syndrome.

Nursing Based on Syndrome Differentiation Combined with Auricular Plaster Therapy in Alleviating Insomnia

Objective:To observe the effect of auricular point pressing combined with nursing based on syndrome differentiation in the treatment of insomnia patients.Methods:Totally 92 patients with insomnia were randomly divided into the observation groupgiven auricular point pressing combined with nursing care based on syndrome differentiation and the control group treated with auricular point pressing alone.The improvement of Pittsburgh Sleep Quality Index(PSQI),TCM Syndrome Score and nursing satisfaction were compared between the 2 groups.Results:The time effect of PSQI total score and 6 factors in both groups were statistically significant(P<0.05).The time effect,interaction effect and inter-group effect of subjective sleep quality,PSQI total score were statistically significant(P<0.05);the 4 inter-group factors of sleep quality,sleep latency,sleep duration and daytime function were statistically significant(P<0.05).The total score of TCM syndromes in the observation group was lower than that in the control group(P<0.05),and the satisfaction rate in the observation group higher than that in the control group(80.43%vs.60.86%,P<0.05).Conclusion:Auricular point pressing combined withnursing based on syndrome differentiation can effectively improve the sleep quality of insomnia patients,and has significant advantages in improving TCM syndromes,as well as gained higher nursing satisfaction from patients.

发酵虫草菌粉治疗慢性肾脏病4期患者的预后效果:基于回顾性队列研究

背景慢性肾脏病(CKD)是世界性公共卫生问题,CKD 4期是CKD病程中一个关键的阶段,标志着肾功能的显著下降和症状的明显出现。发酵虫草菌粉虽然长期应用于CKD的治疗之中,但其对CKD的预后影响尤其是CKD 4期的疗效缺乏循证医学证据。目的 探索发酵虫草菌粉治疗CKD 4期患者的长期预后情况及影响预后的潜在相关因素。方法 选取2013—2022年于上海中医药大学附属龙华医院肾病科住院诊断为CKD 4期的患者631例为研究对象。在中西医结合治疗的基础上,根据是否使用发酵虫草菌粉分为虫草治疗组(339例)和中西医结合治疗组(252例)。收集患者基本信息、是否伴随糖尿病、发生终点事件情况及进入终点事件时间、确诊CKD 4期时间及确诊时相关实验室指标等资料。采用倾向性得分匹配消除组间基线差异后,通过Cox比例风险回归分析影响CKD 4期患者预后的潜在相关因素;采用Kaplan-Meier法绘制CKD 4期患者预后的生存曲线,采用Log-rank检验比较组间生存情况差异。结果 按1∶1比例匹配后最终共纳入378例患者。多因素Cox比例风险回归分析结果显示,使用发酵虫草菌粉(HR=0.79,95%CI=0.64~0.98,P=0.030),估算肾小球滤过滤(HR=0.97,95%CI=0.94~1.00,P=0.025)、血清白蛋白(HR=0.97,95%CI=0.96~0.99,P=0.002)水平升高可延长CKD 4期患者的生存时间;男性(HR=1.37,95%CI=1.09~1.71,P=0.006)、脑利钠肽(HR=1.00,95%CI=1.00~1.00,P=0.003)、血磷(HR=2.44,95%CI=1.63~3.67,P<0.001)和24 h尿蛋白(HR=1.00,95%CI=1.00~1.00,P<0.001)水平升高可缩短CKD 4期患者的生存时间。生存曲线分析结果显示,虫草治疗组累积生存率高于中西医结合治疗组(HR=0.70,95%CI=0.57~0.86,P<0.001);低尿蛋白水平亚组中,虫草治疗患者累积生存率高于中西医结合治疗患者(HR=0.67,95%CI=0.52~0.85,P=0.001);高尿蛋白水平亚组中,两治疗组累积生存率比较,差异无统计学意义(P=0.518)。结论 长期使用发酵虫草菌粉能够延缓CKD 4期患者肾功能进展,在积极控制尿蛋白的前提下可发挥更好的临床疗效。较低水平的脑利钠肽和血磷、较高水平的血清白蛋白也是CKD 4期患者良好预后的潜在因素。

金锁固精丸加味治疗糖尿病肾病G3期临床研究

目的:观察金锁固精丸加味治疗糖尿病肾病G3期患者的临床疗效。方法:将80例糖尿病肾病G3期患者按照随机数字表法分为对照组和试验组,每组各40例。两组患者均给予基础药物治疗,对照组给予氯沙坦钾片治疗,试验组在对照组治疗的基础上联合金锁固精丸加味治疗。比较两组患者的临床疗效及治疗前后中医证候积分、肾功能与代谢类指标[尿微量蛋白/尿肌酐比值(MAlb/cre,ACR)、胱抑素C(cystatin C,CYSC)、血肌酐(serum creatinine,Scr)、血尿素氮(blood urea nitrogen,BUN)、内生肌酐清除率(creatinine clearance,CCr)、24 h尿蛋白定量(24-hour urinary protein quantity,24 h UPQ)]、C反应蛋白(C-reactive protein,CRP)、血清白蛋白(albumin,Alb)、血红蛋白(hemoglobin,Hb)、内皮功能指标[内皮素-1(endothelin-1,ET-1)、可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)及肱动脉内皮依赖性舒张功能(flow-mediated vasodilation,FMD)]变化情况。结果:两组患者治疗后ACR、CYSC、Scr、Urea、CCr、24 h UPQ水平低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。治疗后,两组患者CRP低于本组治疗前(P<0.05),试验组治疗后CRP为(10.26±2.14)mg·dL^(-1),低于同期对照组(P<0.05)。治疗后,两组患者Alb、Hb高于本组治疗前(P<0.05),试验组治疗后Alb为(3.02±3.10)g·L^(-1)、Hb为(121.69±23.25)g·L^(-1),高于同期对照组(P<0.05)。治疗后,两组患者ET-1、sICAM-1水平低于本组治疗前,FMD高于本组治疗前(P<0.05),试验组治疗后ET-1为(87.27±18.73)ng·L^(-1)、sICAM-1为(469.31±35.02)μg·L^(-1),低于同期对照组,FMD为(10.27±0.23)%,高于同期对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者中医证候积分低于本组治疗前,试验组治疗后中医证候积分为(1.02±0.13)分,低于同期对照组(P<0.05)。试验组有效率为97.50%,高于对照组的80.00%(P<0.05)。结论:金锁固精丸加味治疗糖尿病肾病临床疗效确切,可有效改善患者的肾功能及营养状态,降低机体炎症状态,缓解中医证候。

参芪归芎方联合注射用重组人脑利钠肽治疗慢性心力衰竭急性加重期临床研究

目的:观察自拟参芪归芎方联合注射用重组人脑利钠肽治疗慢性心力衰竭急性加重期(acute exacerbation of chronic heart failure, ADHF)的临床疗效及其对炎症因子、心肌损伤指标、生活质量等方面的影响。方法:将102例ADHF患者按照随机数字表法分为西药组和联合组,每组各51例。西药组采用注射用重组人脑利钠肽治疗,联合组在西药组治疗的基础上加用自拟参芪归芎方。比较两组的临床疗效、不良反应发生率及治疗前后中医证候积分、心功能指标[左心室收缩末期内径(left ventricular end systolic diameter, LVESD)、每搏输出量(stroke volume, SV)、左心室射血分数(left ventricular ejection fraction, LVEF)]、炎症因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C reactive protein, CPR)]、心肌损伤指标[N端脑钠肽前体(nterminal pro-brain natriuretic peptide, NT-proBNP)、心肌肌钙蛋白I(cardiac troponin I,cTnI)]、生活质量评分变化情况。结果:西药组有效率为76.47%,联合组有效率为92.16%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后主症、次症积分均低于本组治疗前,且治疗后联合组低于西药组(P<0.05)。两组患者治疗后LVEF、SV水平高于本组治疗前,LVESD低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后TNF-α、CRP、NT-proBNP、cTnI、生活质量评分低于本组治疗前,且治疗后联合组低于西药组(P<0.05)。两组患者治疗期间皮疹、低血压等不良反应率比较,差异无统计学意义(P>0.05)。结论:自拟参芪归芎方联合注射用重组人脑利钠肽治疗ADHF,可有效保护机体心功能,减轻炎症损伤,提高患者生活质量。

加味芍药甘草汤治疗原发性胆汁性肝硬化的临床研究

目的:观察加味芍药甘草汤治疗原发性胆汁性肝硬化的临床疗效。方法:选取南通市第三人民医院2022年5月至2024年5月收治的180例原发性胆汁性肝硬化患者为研究对象,依据随机数字表法分为对照组和观察组,每组各90例。对照组给予熊去氧胆酸胶囊治疗,观察组在对照组治疗的基础上联合加味芍药甘草汤治疗。比较两组患者的临床疗效、不良反应发生率及治疗前后肝功能指标、肝纤维化指标、免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化情况。结果:观察组有效率为98.89%,高于对照组的92.22%,差异具有统计学意义(P<0.05)。两组患者治疗后出现纳差、乏力、皮肤瘙痒、肝区症状、黄疸症状的比例均低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。两组患者治疗后各项肝功能及肝纤维化指标低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。两组患者治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于本组治疗前,CD8^(+)低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。结论:加味芍药甘草汤治疗原发性胆汁性肝硬化疗效确切,可有效改善患者肝功能及肝纤维化指标,提高免疫功能。

蒲地蓝消炎口服液治疗湿热蕴结证中度寻常痤疮的随机对照研究

目的观察蒲地蓝消炎口服液治疗湿热蕴结证中度寻常痤疮的有效性和安全性。方法采取多中心随机双盲对照研究设计,选取5家中心,筛选240例湿热蕴结证中度寻常痤疮受试者,随机分为试验组和对照组,每组各120例;试验组给予蒲地蓝消炎口服液,对照组给予蒲地蓝消炎口服液模拟剂;两组均联合外用克林霉素磷酸酯凝胶,每天2次,洁面后涂于患处。治疗4周,比较两组治疗前后皮损(丘疹、脓疱、粉刺)数量以及中医证候(面红、皮疹痒痛、舌苔厚腻、尿黄、便秘)积分变化,记录不良反应。结果229例受试者完成试验,其中试验组117例、对照组112例。与基线相比,用药4周的两组患者的丘疹计数、脓疱计数显著减少,试验组粉刺计数和中医证候积分显著减少,且试验组均优于对照组(P<0.05)。试验组痤疮皮损改善有效率为87.2%,高于对照组的58.0%(P<0.05)。试验组仅1例患者出现外用药膏刺激性反应。结论蒲地蓝消炎口服液可有效改善湿热蕴结证中度寻常痤疮患者皮损数量及中医证候,值得临床推广应用。

近5年油腻型头皮脂溢性皮炎的研究进展

脂溢性皮炎是发生在皮脂腺丰富部位的慢性、复发性、炎症性皮肤病,多发于头面部,若发于头部则称为“头皮脂溢性皮炎”。油腻型头皮脂溢性皮炎以头发油腻多脂、瘙痒起白屑为主要特征,因此临床见头发油腻兼其他症状者,可参照此病论治。头发油腻发亮极大程度地影响了人们的外在形象,故此病的治疗受到了广泛的关注。文章整理近5年油腻型头皮脂溢性皮炎治疗的相关文献,从现代医学、中医学、中西医结合以及日常清洁控油护理的角度,总结其研究进展。

中西医结合阶梯疗法治疗肥胖症临床报道1例

肥胖是一种慢性代谢性疾病,与2型糖尿病、心血管疾病、高血压病、癌症、代谢综合征和慢性肾脏疾病的患病风险呈线性相关,未来由此引起的肥胖健康负担将急剧增加。因此如何治疗肥胖及其继发性疾病,已成为患者、医生和社会迫切需要解决的问题。目前防治肥胖的中西医方法较多,但如何将中西医方法进行整合,实现临床效果最大化,仍然是值得探索的问题。近几年,作者在代谢与肥胖专病门诊的临床实践中,尝试使用中西医结合阶梯疗法治疗肥胖症,希冀探索出整合中西医方法的治疗模式。此文呈现1例疗程近2年的中西医结合阶梯疗法治疗肥胖症的典型案例。

消增强骨片联合西医常规治疗肝肾亏虚兼气滞血瘀型骨质疏松症的临床观察

目的 观察消增强骨片结合西医常规治疗肝肾亏虚兼气滞血瘀型骨质疏松症的临床疗效。方法 选取2019年5月至2020年5月间四川省骨科医院骨质疏松专科门诊收治的肝肾亏虚兼气滞血瘀型骨质疏松症患者60例,按照随机数字表法分为2组,每组30例。对照组予西医常规治疗,治疗组在对照组的基础上联合消增强骨片治疗。比较较2组治疗前后骨密度(BMD)、骨代谢标志物[包括β-胶原降解产物(β-CROSSL)、总1型胶原氨基酸端延长链(t-P1NP)及25羟基维生素D(25-OH-D)]及中医证候(包括腰膝酸痛、腰膝酸软、下肢抽筋、步履艰难、持重困难)评分变化情况。结果 治疗后2组BMD水平均较治疗前增加(P<0.05),且治疗组治疗后BMD水平高于对照组(P<0.05)。治疗后2组25-OH-D水平均较前显著增加(P<0.05),t-PINP、β-CROSSL水平均降低(P<0.05),其中治疗组治疗后对25-OH-D、β-CROSSL水平改善均优于对照组(P<0.05),2组t-PINP水平治疗后组间比较差异无统计学意义(P<0.05)。治疗后治疗组中医证候分腰膝酸痛、腰膝酸软、下肢抽筋评分及总分较治疗前降低(P<0.05),对照组中医证候腰膝酸痛、腰膝酸软评分及总分较治疗前降低(P<0.05),其中治疗组治疗后腰膝酸痛、腰膝酸软、下肢抽筋评分及总分均低于对照组(P<0.05)。结论 消增强骨片联合西医常规治疗肝肾亏虚兼气滞血瘀型骨质疏松症疗效确切,可提高患者BMD水平,改善骨代谢,改善中医证候表现,可为临床骨质疏松症治疗用药起到重要的补充作用。