Objective: Identification of colorectal cancer (CRC) metastasis genes is one of the most important issues in CRC research. For the purpose of mining CRC metastasis-associated genes, an integrated analysis of mJcroa...Objective: Identification of colorectal cancer (CRC) metastasis genes is one of the most important issues in CRC research. For the purpose of mining CRC metastasis-associated genes, an integrated analysis of mJcroarray data was presented, by combined with evidence acquired from comparative genornic hybridization (CGH) data. Methods: Gene expression profile data of CRC samples were obtained at Gene Expression Omnibus (GEO) website. The 15 important chromosomal aberration sites detected by using CGH technology were used for integrated genomic and transcriptomic analysis. Significant Analysis of Microarray (SAM) was used to detect significantly differentially expressed genes across the whole genome. The overlapping genes were selected in their corresponding chromosomal aberration regions, and analyzed by using the Database for Annotation, Visualization and Integrated Discovery (DAVID). Finally, SVM-T-RFE gene selection algorithm was applied to identify ted genes in CRC. Results: A minimum gene set was obtained with the minimum number [14] of genes, and the highest classification accuracy (100%) in both PRI and META datasets. A fraction of selected genes are associated with CRC or its metastasis. Conclusions- Our results demonstrated that integration analysis is an effective strategy for mining cancer- associated genes.展开更多
With the support of edge computing,the synergy and collaboration among central cloud,edge cloud,and terminal devices form an integrated computing ecosystem known as the cloud-edge-client architecture.This integration ...With the support of edge computing,the synergy and collaboration among central cloud,edge cloud,and terminal devices form an integrated computing ecosystem known as the cloud-edge-client architecture.This integration unlocks the value of data and computational power,presenting significant opportunities for large-scale 3D scene modeling and XR presentation.In this paper,we explore the perspectives and highlight new challenges in 3D scene modeling and XR presentation based on point cloud within the cloud-edge-client integrated architecture.We also propose a novel cloud-edge-client integrated technology framework and a demonstration of municipal governance application to address these challenges.展开更多
The visual integrity of mountains contributing to cultural landscapes as nature-culture attributes is often obscured by the vertical intrusive built environment,especially in bufer areas of protected heritage zones.Th...The visual integrity of mountains contributing to cultural landscapes as nature-culture attributes is often obscured by the vertical intrusive built environment,especially in bufer areas of protected heritage zones.Therefore,this study argued that even low/medium-rise buildings that inappropriately appear in the horizontal visual plane could be a factor increasing sensitivity to this panoramic view.An integrative tool–visual sensitivity assessment–consists of Viewshed and Skyline analysis considering the pedestrian’s visual limitation in identifying the sensitive areas of the mountain view corridor in the historic city of Chiang Mai.The visible mountain areas(VMAs)were determined as a baseline,and their relationship with the visible building areas(VBAs)was then examined using statistical correlation to defne a strong negative relationship as the visual sensitive areas in fve zones.The results showed that the bufer zone was found to have more areas with visual sensitivity values,but this varies depending on the characteristics of buildings and the assessment from the view corridor.Meanwhile,in height-restricted areas,such as historic area zone 5,there are some concerns about the visual intrusion,which necessitates continuous monitoring using the assessment result as a guideline.Incorporating the results into implementation could support cultural landscape conservation in Chiang Mai city.The method is applicable in historic cities with similar settings to produce the baseline for the built environment that is harmonious with the cultural and historical characteristics of the city and with respect to its broader setting.展开更多
Neurofeedback or electroencephalogram(EEG) biofeedback technology is widely used in clinical rehabilitation field. In this paper, we used a brain-computer interface(BCI) neurofeedback system for attention deficit hype...Neurofeedback or electroencephalogram(EEG) biofeedback technology is widely used in clinical rehabilitation field. In this paper, we used a brain-computer interface(BCI) neurofeedback system for attention deficit hyperactivity disorder(ADHD) children treatment.After 20 training sessions, integrated visual and auditory-conhnuous performance test(IVA-CPT), DSM-IV and conner scale results suggested that the attention ofsubjectshad been strengthened, which showed that the BCI neurofeedback system could provide an effective therapyfor treating ADHDchildren.展开更多
基金supported by a grant from the National Natural Science Foundation of China(Grant No.61373057)a grant from the Zhejiang Provincial Natural Science Foundation of China(Grant No.Y1110763)
文摘Objective: Identification of colorectal cancer (CRC) metastasis genes is one of the most important issues in CRC research. For the purpose of mining CRC metastasis-associated genes, an integrated analysis of mJcroarray data was presented, by combined with evidence acquired from comparative genornic hybridization (CGH) data. Methods: Gene expression profile data of CRC samples were obtained at Gene Expression Omnibus (GEO) website. The 15 important chromosomal aberration sites detected by using CGH technology were used for integrated genomic and transcriptomic analysis. Significant Analysis of Microarray (SAM) was used to detect significantly differentially expressed genes across the whole genome. The overlapping genes were selected in their corresponding chromosomal aberration regions, and analyzed by using the Database for Annotation, Visualization and Integrated Discovery (DAVID). Finally, SVM-T-RFE gene selection algorithm was applied to identify ted genes in CRC. Results: A minimum gene set was obtained with the minimum number [14] of genes, and the highest classification accuracy (100%) in both PRI and META datasets. A fraction of selected genes are associated with CRC or its metastasis. Conclusions- Our results demonstrated that integration analysis is an effective strategy for mining cancer- associated genes.
基金the National Natural Science Foundation of China(U22B2034)the Fundamental Research Funds for the Central Universities(226-2022-00064).
文摘With the support of edge computing,the synergy and collaboration among central cloud,edge cloud,and terminal devices form an integrated computing ecosystem known as the cloud-edge-client architecture.This integration unlocks the value of data and computational power,presenting significant opportunities for large-scale 3D scene modeling and XR presentation.In this paper,we explore the perspectives and highlight new challenges in 3D scene modeling and XR presentation based on point cloud within the cloud-edge-client integrated architecture.We also propose a novel cloud-edge-client integrated technology framework and a demonstration of municipal governance application to address these challenges.
基金JSPS KAKENHI Grant Numbers JP20KK0101,JP20F40066.
文摘The visual integrity of mountains contributing to cultural landscapes as nature-culture attributes is often obscured by the vertical intrusive built environment,especially in bufer areas of protected heritage zones.Therefore,this study argued that even low/medium-rise buildings that inappropriately appear in the horizontal visual plane could be a factor increasing sensitivity to this panoramic view.An integrative tool–visual sensitivity assessment–consists of Viewshed and Skyline analysis considering the pedestrian’s visual limitation in identifying the sensitive areas of the mountain view corridor in the historic city of Chiang Mai.The visible mountain areas(VMAs)were determined as a baseline,and their relationship with the visible building areas(VBAs)was then examined using statistical correlation to defne a strong negative relationship as the visual sensitive areas in fve zones.The results showed that the bufer zone was found to have more areas with visual sensitivity values,but this varies depending on the characteristics of buildings and the assessment from the view corridor.Meanwhile,in height-restricted areas,such as historic area zone 5,there are some concerns about the visual intrusion,which necessitates continuous monitoring using the assessment result as a guideline.Incorporating the results into implementation could support cultural landscape conservation in Chiang Mai city.The method is applicable in historic cities with similar settings to produce the baseline for the built environment that is harmonious with the cultural and historical characteristics of the city and with respect to its broader setting.
基金Produce-Study-Research program,Guangdong Province and Ministry of Educationgrant number:2008809050023
文摘Neurofeedback or electroencephalogram(EEG) biofeedback technology is widely used in clinical rehabilitation field. In this paper, we used a brain-computer interface(BCI) neurofeedback system for attention deficit hyperactivity disorder(ADHD) children treatment.After 20 training sessions, integrated visual and auditory-conhnuous performance test(IVA-CPT), DSM-IV and conner scale results suggested that the attention ofsubjectshad been strengthened, which showed that the BCI neurofeedback system could provide an effective therapyfor treating ADHDchildren.