Integrated numerical simulation of hydraulic fracturing and production in shale gas well considering gas-water two-phase flow

Based on the displacement discontinuity method and the discrete fracture unified pipe network model,a sequential iterative numerical method was used to build a fracturing-production integrated numerical model of shale gas well considering the two-phase flow of gas and water.The model accounts for the influence of natural fractures and matrix properties on the fracturing process and directly applies post-fracturing formation pressure and water saturation distribution to subsequent well shut-in and production simulation,allowing for a more accurate fracturing-production integrated simulation.The results show that the reservoir physical properties have great impacts on fracture propagation,and the reasonable prediction of formation pressure and reservoir fluid distribution after the fracturing is critical to accurately predict the gas and fluid production of the shale gas wells.Compared with the conventional method,the proposed model can more accurately simulate the water and gas production by considering the impact of fracturing on both matrix pressure and water saturation.The established model is applied to the integrated fracturing-production simulation of practical horizontal shale gas wells.The simulation results are in good agreement with the practical production data,thus verifying the accuracy of the model.

Advances and outlook of integrated reservoir-wellbore-pipe network simulation technology

The integrated simulation and optimization technology of reservoir-wellbore-pipe network is developed to reflect the mutual influence and restriction among reservoir engineering,oil production engineering and surface engineering,and to obtain the scheme with minimum conflict and optimal benefit in each step.This technology is based on the concept of global optimization to maximize production and profit,reduce costs and increase benefit.This paper elaborates the current situation of integrated simulation technology of reservoir-wellbore-pipe network both at home and abroad,discusses its correlation with the primary business of Sinopec and its development from three aspects of modeling,cloud platform and intellectualization.Suggestions on its future development are put forward from underlying data,software platform,popularization and application,and cross-border integration to provide means and guidance for the construction of intelligent oil and gas fields.The results show that the integrated simulation of reservoir-wellbore-pipe network can better reflect the optimization requirements of each step,avoid the ineffective operation of field equipment,and effectively improve the efficiency of research and management.Coupling solution,global optimization method and pressure fitting,which can make the simulation results reflect the real situation,are the key technologies for the network.The theoretical technology and main function research of integrated simulation technology have been mature,but the large-scale application and local function improvement of oil and gas fields are yet to be promoted.In the future,the integrated simulation of reservoir-wellbore-pipe network will develop from digitalization to modeling and intellectualization,from local simulation to cloud computing,and from manual intervention to intelligent decision-making.We suggest speeding up the construction of the unified database and model base of the whole underlying platform,strengthening the construction of software integration and integration platform with independent intellectual property rights,speeding up the popularization and application of intelligent oil and gas field demonstration projects,and strengthening the integration of oil and gas industry with artificial intelligence(AI),big data and block chain for its development.

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

Clastic compaction unit classification based on clay content and integrated compaction recovery using well and seismic data

Compaction correction is a key part of paleogeomorphic recovery methods. Yet, the influence of lithology on the porosity evolution is not usually taken into account. Present methods merely classify the lithologies as sandstone and mudstone to undertake separate porositydepth compaction modeling. However, using just two lithologies is an oversimplification that cannot represent the compaction history. In such schemes, the precision of the compaction recovery is inadequate. To improve the precision of compaction recovery, a depth compaction model has been proposed that involves both porosity and clay content. A clastic lithological compaction unit classification method, based on clay content, has been designed to identify lithological boundaries and establish sets of compaction units. Also, on the basis of the clastic compaction unit classification, two methods of compaction recovery that integrate well and seismic data are employed to extrapolate well-based compaction information outward along seismic lines and recover the paleo-topography of the clastic strata in the region. The examples presented here show that a better understanding of paleo-geomorphology can be gained by applying the proposed compaction recovery technology.

Integrated Development of Agricultural Recreation and Health and Wellness Industry in the Big Health Era

Deep integration of agricultural recreation and health and wellness industry is an inevitable choice for the development of China's agricultural recreation and the transformation and upgrading of the agricultural industry.The development of agricultural recreation and health and wellness industry is inseparable from the four dimensions:production,living,ecology,and life.Therefore,the integration of agricultural recreation and health and wellness industry should also be promoted from the four aspects:production content,living content,ecological content,and life content.At the current stage in China,insufficient integration of the two is mainly manifested as lagging infrastructure,insufficient effective supply,shallow cultural connotations,lack of professional talents,and incomplete industry chain.The path to promote the deep integration of China's agricultural recreation and health and wellness industry includes improving the recreation,health and wellness infrastructure and supporting facilities,developing specialty products and experience projects for recreation,health and wellness,building a brand of recreation,health and wellness culture,cultivating and introducing professional management and service talents,and planning systematic layout of the recreation,health and wellness industry.

Evaluation of Integrated Production Capacity of Well- facilitated Farmland in Jiangsu Province

The fundamental task of well-facilitated farmland construction is to continuously lift the integrated production capacity. External project construction for well-facilitated farmland can not completely solve existing problems in improvement of intrinsic quality of farmland.Based on research findings of integrated production capacity of farmland,starting from basic elements such as water,soil,seed,fertilizer,and pesticide,this paper introduced factors influencing the integrated production capacity of well-facilitated farmland,including natural quality of farmland,supporting infrastructure,agricultural technology level and management level,and labor quality. Besides,it establish an evaluation system for integrated production capacity of well-facilitated farmland in Jiangsu Province by Analytic Hierarchy Process( AHP),and made an empirical study using indicator data of 2010- 2014. Results indicated that the general index of integrated production capacity of farmland in Jiangsu Province in 2010- 2014 was ascending,reflecting improvement of integrated production capacity of farmland. With the aid of radar map,it further found that the coupling between water,soil,seed,fertilizer,and pesticide and other elements play a crucial role in lifting the integrated production capacity of farmland. Finally,based on existing problems in construction of well-facilitated farmland in Jiangsu Province,it came up with some pertinent recommendations from the perspective of coordinated development of all elements.

3D‑Printed Carbon‑Based Conformal Electromagnetic Interference Shielding Module for Integrated Electronics

Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.

Carbon nanotube integrated circuit technology:purification,assembly and integration

As the manufacturing process of silicon-based integrated circuits(ICs)approaches its physical limit,the quantum effect of silicon-based field-effect transistors(FETs)has become increasingly evident.And the burgeoning carbon-based semiconductor technology has become one of the most disruptive technologies in the post-Moore era.As one-dimensional nanomaterials,carbon nanotubes(CNTs)are far superior to silicon at the same technology nodes of FETs because of their excellent electrical transport and scaling properties,rendering them the most competitive material in the next-generation ICs technology.However,certain challenges impede the industrialization of CNTs,particularly in terms of material preparation,which significantly hinders the development of CNT-based ICs.Focusing on CNT-based ICs technology,this review summarizes its main technical status,development trends,existing challenges,and future development directions.

Pixelated non-volatile programmable photonic integrated circuits with 20-level intermediate states

Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this paper,we propose pixelated programmable Si_(3)N_(4)PICs with record-high 20-level intermediate states at 785 nm wavelength.Such flexibility in phase or amplitude modulation is achieved by a programmable Sb_(2)S_(3)matrix,the footprint of whose elements can be as small as 1.2μm,limited only by the optical diffraction limit of anin-house developed pulsed laser writing system.We believe our work lays the foundation for laser-writing ultra-high-level(20 levels and even more)programmable photonic systems and metasurfaces based on phase change materials,which could catalyze diverse applications such as programmable neuromorphic photonics,biosensing,optical computing,photonic quantum computing,and reconfigurable metasurfaces.

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be developed.The allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the future.By referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux pellets.The results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting properties.In comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was higher.The melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 kPa.The permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently improved.The acid pellets played a role in withstanding load during the softening process.The flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting process.The slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single burden.The segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

Optimal synthesis of heat-integrated distillation configurations using the two-column superstructure

In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocolumn configuration.However,this approach frequently necessitates tedious enumeration procedures,resulting in a considerable computational burden.To surmount this formidable challenge,the present study introduces an innovative remedy:The proposition of a superstructure that encompasses both single-column and multiple two-column configurations.Additionally,a simultaneous optimization algorithm is applied to optimize both the process parameters and heat integration structures of the twocolumn configurations.The effectiveness of this approach is demonstrated through a case study focusing on industrial organosilicon separation.The results underscore that the superstructure methodology not only substantially mitigates computational time compared to exhaustive enumeration but also furnishes solutions that exhibit comparable performance.

Optimization of integrated geological-engineering design of volume fracturing with fan-shaped well pattern

According to the variable toe-to-heel well spacing, combined with the dislocation theory, discrete lattice method, and finite-element-method(FEM) based fluid-solid coupling, an integrated geological-engineering method of volume fracturing for fan-shaped well pattern is proposed considering the geomechanical modeling, induced stress calculation, hydraulic fracturing simulation, and post-frac productivity evaluation. Besides, we propose the differential fracturing design for the conventional productivity-area and the potential production area for fan-shaped horizontal wells. After the fracturing of the conventional production area for H1 fan-shaped well platform, the research shows that the maximum reduction of the horizontal principal stress difference in the potential productivity-area is 0.2 MPa, which cannot cause the stress reversal, but this reduction is still conducive to the lateral propagation of hydraulic fractures. According to the optimized fracturing design, in zone-Ⅰ of the potential production area, only Well 2 is fractured, with a cluster spacing of 30 m and an injection rate of 12 m^(3)/min per stage;in zone-Ⅱ, Well 2 is fractured before Well 3, with a cluster spacing of 30 m and an injection rate of 12 m^(3)/min per stage. The swept area of the pore pressure drop in the potential production area is small, showing that the reservoir is not well developed. The hydraulic fracturing in the toe area can be improved by, for example, properly densifying the fractures and adjusting the fracture distribution, in order to enhance the swept volume and increase the reservoir utilization.

Application of multidisciplinary team-based integrated traditional Chinese medicine and Western medicine in rotator cuff injury patients undergoing arthroscopic surgery

BACKGROUND Arthroscopic rotator cuff repair is a common surgical treatment for rotator cuff injuries(RCIs).Although this procedure has certain clinical advantages,it requires rehabilitation management interventions to ensure therapeutic efficacy.AIM To investigate the effect of integrated traditional Chinese medicine and Western medicine(TCM-WM)under the multidisciplinary team(MDT)model on the postoperative recovery of patients undergoing arthroscopic surgery for RCIs.METHODS This study enrolled 100 patients who underwent arthroscopic rotator cuff repair for RCIs at the Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine between June 2021 and May 2024.They were divided into a control group(n=48)that received routine rehabilitation treatment and an experimental group(n=52)that received TCM-WM under the MDT model(e.g.,acupuncture,TCM traumatology and orthopedics,and rehabilitation).The results of the Constant–Murley Shoulder Score(CMS),Visual Analogue Scale(VAS),Shoulder Pain and Disability Index(SPADI),muscular strength evaluation,and shoulder range of motion(ROM)assessments were analyzed.RESULTS After treatment,the experimental group showed significantly higher CMS scores in terms of pain,functional activity,shoulder joint mobility,and muscular strength than the baseline and those of the control group.The experimental group also exhibited significantly lower VAS and SPADI scores than the baseline and those of the control group.In addition,the experimental group showed significantly enhanced muscular strength(forward flexor and external and internal rotator muscles)and shoulder ROM(forward flexion,abduction,and lateral abduction)after treatment compared with the control group.CONCLUSION TCM-WM under the MDT model improved shoulder joint function,relieved postoperative pain,promoted postoperative functional recovery,and facilitated the recovery of muscular strength and shoulder ROM in patients with RCIs who underwent arthroscopic rotator cuff repair.

IMPROVEMENT OF PRODUCT QUALITY AND PRODUCTION PROCESS PERFORMANCE IN JEWELLERY MANUFACTURING THROUGH “INTEGRATED CRAFTSMANSHIP”

This paper attempts to identify the loss of quality of craftsmanship intensive products. It shows that errors in production process and degradation in the jewellery pro duct quality in the (complex) transition from hand crafted silver model making to mass production are largely due to the ignorance of the importance of design——craftsmanship in production process. In fact, the design can be employed to solve the problems of the quality degradation or even as a tool to prevent error in the stages of product design, development and production. In testing this hypo thesis, production processes (from designing, model making, casting, polishing, buffing to texturing) are all examined in order to identify the root causes of product quality degradation in mass production. After the analysis, the concept of “integrated craftsmanship” is proposed to assist integration of traditional goldsmith′s and je wellery designers′ techniques in jewellery designing and making, and to change the attitudes to quality control in mass production systems. Finally, the model of “integra ted design craftsmanship” as a comprehensive design conceptual and quality organizational tool is formulated for managing and improving product quality.

Building Integrated Photovoltaic Systems for Single Family Dwellings: Innovation Concepts

Growing consumer interest in distributed Building Integrated Photovoltaic (BIPV) Systems and industry competition to reduce installation costs are stimulating the development of deploying these materials to the residential sector of the building industry. This emerging market continues to attract the attention of many stakeholders, yet cohesive opportunities to deploy in residential sectors, specifically detached single-family dwellings, is scattered. As a result, this study of literature and implementation strategies through simple examples looks to identify several characteristics related to BIPV. Characteristics that were studied in this initial pilot study were design considerations for system selection, applicability to residential construction, and system and material options and enhancements. A case-study home was analyzed demonstrating opportunity for implementation of BIPV on an existing residence. Strategies for maximizing the energy-generating capacity of the system to achieve net-zero energy performance, including all building surfaces and landscaping were also explored. This body of work provides a state-of-the-art review on common materials as well as the more customizable types.

Command filtered integrated estimation guidance and control for strapdown missiles with circular field of view

In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets.

Impacts of Integrated Multi-Trophic Aquaculture on Phytoplankton in Sanggou Bay

Integrated multi-trophic aquaculture(IMTA)has been considered as an ecofriendly culture system providing a potential solution to environmental risks caused by intensive monoculture system.However,the impact of IMTA on phytoplankton remains unclear.In this study,the spatial and temporal variations of phytoplankton in Sanggou Bay were investigated seasonally based on 21 sampling sites covering three cultivation zones(bivalve zone,IMTA zone,and kelp zone)and one control zone(without aquatic cultivation).In total,128 phytoplankton species,with diatoms and dinoflagellates as the dominant groups,were obtained across the whole year,and the mean Shannon diversity index(H')and species richness(SR)were determined as 1.39 and 9.39,respectively.The maximum chlorophyll a(Chl-a)(6.32μg L^(-1))and plankton diversity(H'of 1.97)occurred in summer and autumn,respectively.Compared to other zones,the bivalve zone displayed significantly higher Chl-a and lower H'in majority of time.Pairwise PERMANOVA analysis indicated that the phytoplankton assemblage in the bivalve zone was significantly different with the control and kelp zones,while the IMTA zone maintained close to other three zones.Based on generalized additive models,temperature,NO_(2)^(-)-N,N/P ratio,SiO_(3)^(2-)-Si,and salinity were determined as the key factors underlying Chl-a and phytoplankton diversity.Addi-tionally,the results of redundancy analysis further indicated that the phytoplankton assemblage in the bivalve zone is positively re-lated with nutrients such as NO_(3)^(-)-N and NH_(4)^(+)-N as well as water depth,while the phytoplankton assemblages in the kelp,control,and IMTA zones are associated with NO_(2)^(-)-N,SiO_(3)^(2-)-Si,and salinity.Taken all observations into consideration together,it can be inferred that IMTA can effectively reduce Chl-a level compared to bivalve monoculture by reducing the nutrients.However,the SR,H’,and species composition of phytoplankton are primarily determined by local environment factors such as temperature,water depth,salinity and SiO_(3)^(2-)-Si.

A Hybrid Integrated and Low-Cost Multi-Chip Broadband Doherty Power Amplifier Module for 5G Massive MIMO Application

In this paper,a hybrid integrated broadband Doherty power amplifier(DPA)based on a multi-chip module(MCM),whose active devices are fabricated using the gallium nitride(GaN)process and whose passive circuits are fabricated using the gallium arsenide(GaAs)integrated passive device(IPD)process,is proposed for 5G massive multiple-input multiple-output(MIMO)application.An inverted DPA structure with a low-Q output network is proposed to achieve better bandwidth performance,and a single-driver architecture is adopted for a chip with high gain and small area.The proposed DPA has a bandwidth of 4.4-5.0 GHz that can achieve a saturation of more than 45.0 dBm.The gain compression from 37 dBm to saturation power is less than 4 dB,and the average power-added efficiency(PAE)is 36.3%with an 8.5 dB peak-to-average power ratio(PAPR)in 4.5-5.0 GHz.The measured adjacent channel power ratio(ACPR)is better than50 dBc after digital predistortion(DPD),exhibiting satisfactory linearity.

Integrated analysis of plasma rotation effect on HL-3 hybrid scenario

The hybrid scenario,which has good confinement and moderate MHD instabilities,is a proposed operation scenario for international thermonuclear experimental reactor(ITER).In this work,the effect of plasma rotation on the HL-3 hybrid scenario is analyzed with the integrated modeling framework OMFIT.The results show that toroidal rotation has no obvious effect on confinement with a high line averaged density of n_(bar)~(7)×10^(19)m^(-3).In this case,the ion temperature only changes from 4.7 keV to 4.4 keV with the rotation decreasing from 10^(5) rad/s to 10^(3) rad/s,which means that the turbulent heat transport is not dominant.While in the scenarios characterized by lower densities,such as n_(bar)~4×10^(19)m^(-3),turbulent transport becomes dominant in determining heat transport.The ion temperature rises from 3.8 keV to 6.1 keV in the core as the rotation velocity increases from 10^(3) rad/s to 10^(5) rad/s.Despite the ion temperature rising,the rotation velocity does not obviously affect electron temperature or density.Additionally,it is noteworthy that the variation in rotation velocity does not significantly affect the global confinement of plasma in scenarios with low density or with high density.

Design of a Novel Macro-Micro Integrated Brain Surgery Robot Based on Modular Parallel Mechanisms

The advancement and development of medical surgical robots have provided new technological support for brain surgery and neurosurgical procedures,improving the reliability of highly complex and precise surgeries.In turn,this urges the design and development of novel surgical robots to possess higher precision,stability,and enhanced motion capabilities.In response to this practical demand,this paper introduces a macro-micro integrated medical brain surgery robot system based on the concept of modular PMs(parallel mechanisms),which have a total of 13 active DOFs(degrees of freedom).This system divides the motion process of brain surgery into a large-scale macro-motion space and a small-scale high-precision motion space for design and planning control.The introduction of the design concept that combines multiple modular parallel sub-mechanisms has brought a significant level of decoupling characteristics to the mechanism itself.A comprehensive introduction and analysis of the surgical robot are provided,covering aspects such as design,kinematics,motion planning,and performance indicators.To address the pose allocation and coordination of motion between the macro platform and the micro platform,a pose allocation algorithm based on the decoupling and non-decoupling characteristics in various dimensions of the macro-micro platform is proposed.The designed measurement experiments have demonstrated that the repeatability in positioning accuracy of the macro and micro platform reaches the level of micron and submicron respectively.Practical experiments of motion control and simulated brain electrode implantation validate the excellent performance and stability of the entire surgical robot system.This research contributes innovative insights to the development of medical surgical robot systems,particularly in the domain of mechanism design.