Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds

Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage.However,it is still challenging to ensure the integrity,physiological function and regeneration ability of stratified OC scaffolds in clinical application.Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue.As a consequence,the researches on biomimetic design to achieve the tissue function of each layer,and additive manufacture(AM)to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress.In this review,the design methods of biomaterial and structure as well as computer-aided design,and performance prediction of biopolymer-based OC scaffolds are presented;then,the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized;finally,the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.

Cloud edge integrated security architecture of new cloud manufacturing system

With the rapid development of cloud manufacturing technology and the new generation of artificial intelligence technology,the new cloud manufacturing system(NCMS)built on the connotation of cloud manufacturing 3.0 presents a new business model of“Internet of everything,intelligent leading,data driving,shared services,cross-border integration,and universal innovation”.The network boundaries are becoming increasingly blurred,NCMS is facing security risks such as equipment unauthorized use,account theft,static and extensive access control policies,unauthorized access,supply chain attacks,sensitive data leaks,and industrial control vulnerability attacks.Traditional security architectures mainly use information security technology,which cannot meet the active security protection requirements of NCMS.In order to solve the above problems,this paper proposes an integrated cloud-edge-terminal security system architecture of NCMS.It adopts the zero trust concept and effectively integrates multiple security capabilities such as network,equipment,cloud computing environment,application,identity,and data.It adopts a new access control mode of“continuous verification+dynamic authorization”,classified access control mechanisms such as attribute-based access control,rolebased access control,policy-based access control,and a new data security protection system based on blockchain,achieving“trustworthy subject identity,controllable access behavior,and effective protection of subject and object resources”.This architecture provides an active security protection method for NCMS in the digital transformation of large enterprises,and can effectively enhance network security protection capabilities and cope with increasingly severe network security situations.

Research on Machine Tool Fault Diagnosis and Maintenance Optimization in Intelligent Manufacturing Environments

In the context of intelligent manufacturing,machine tools,as core equipment,directly influence production efficiency and product quality through their operational reliability.Traditional maintenance methods for machine tools,often characterized by low efficiency and high costs,fail to meet the demands of modern manufacturing industries.Therefore,leveraging intelligent manufacturing technologies,this paper proposes a solution optimized for the diagnosis and maintenance of machine tool faults.Initially,the paper introduces sensor-based data acquisition technologies combined with big data analytics and machine learning algorithms to achieve intelligent fault diagnosis of machine tools.Subsequently,it discusses predictive maintenance strategies by establishing an optimized model for maintenance strategy and resource allocation,thereby enhancing maintenance efficiency and reducing costs.Lastly,the paper explores the architectural design,integration,and testing evaluation methods of intelligent manufacturing systems.The study indicates that optimization of machine tool fault diagnosis and maintenance in an intelligent manufacturing environment not only enhances equipment reliability but also significantly reduces maintenance costs,offering broad application prospects.

Fog-IBDIS:Industrial Big Data Integration and Sharing with Fog Computing for Manufacturing Systems

Industrial big data integration and sharing(IBDIS)is of great significance in managing and providing data for big data analysis in manufacturing systems.A novel fog-computing-based IBDIS approach called Fog-IBDIS is proposed in order to integrate and share industrial big data with high raw data security and low network traffic loads by moving the integration task from the cloud to the edge of networks.First,a task flow graph(TFG)is designed to model the data analysis process.The TFG is composed of several tasks,which are executed by the data owners through the Fog-IBDIS platform in order to protect raw data privacy.Second,the function of Fog-IBDIS to enable data integration and sharing is presented in five modules:TFG management,compilation and running control,the data integration model,the basic algorithm library,and the management component.Finally,a case study is presented to illustrate the implementation of Fog-IBDIS,which ensures raw data security by deploying the analysis tasks executed by the data generators,and eases the network traffic load by greatly reducing the volume of transmitted data.

INTEGRATED LAYOUT DESIGN OF CELLS AND FLOW PATHS

The integrated layout problem in manufacturing Systems is investigated. Anintegrated model for Concurrent layout design of cells and flow paths is formulated. A hybridapproach combined an enhanced branch-and-bound algorithm with a simulated annealing scheme isproposed to solve this problem. The integrated layout method is applied to re-layout the gear pumpshop of a medium-size manufacturer of hydraulic pieces. Results show that the proposed layout methodcan concurrently provide good solutions of the cell layouts and the flow path layouts.

Model of Production Planning and Scheduling in Shop Floor Based on Collaboration and Competition

The planning and scheduling in real shop floor is actually achieved by coordination between different persons. In this process, cooperation is mainstream, but competition also exists, for example, the competition between different groups, operators with the same skill, etc. In multi-agent based shop floor management and control system, this competition and cooperation relation must be embodied. The general process of shop floor production planning and scheduling is studied, and a colored Petri-net model for the competition and cooperation process of three main agents in such system to achieve shop floor production planning and scheduling is presented. The evaluating method of bids in bidding process that especially embodies the competition relationship is also presented. This colored Petri-net model gives a clear illustration of this complex coordination process to system designers, effectively promotes the cooperative development.

An Integration Framework for Digital Progressive Die Design and Manufacturing

This paper reports an effort to develop an intelligent integration framework for digital progressive die design and manufacturing. Both data-and process-centric integration functions are provided by the framework as if a special ight-weight PDM/PLM (Product Data Management/Product Lifecycle Management) and WM (Workflow Management) system is embedded in the integrated engineering environment. A flexible integration approach based on the CAD (Computer-Aided Design) framework tenet is employed to rapidly build up the system while the intrinsic characteristics of the process are comprehensively taken into account. Introduction of this integration framework would greatly improve the dynamic performance of the overall progressive die design and manufacturing process.

An Internet-enabled Integration of Concurrent Engineering with Co-design

In this paper,the Web-based integration methodology and framework have been developed to facilitate collabora- tive and concurrent engineering design in distributed manufacturing environments.The distributed concurrent engineering and co- design are discussed as key components in the mechanism.The related integration system is presented,which includes four function- al modules:co-design,Web-based visualization,manufacturing analysis and look-up service.It can be used for a design team geo- graphically distributed to organize a collaborative and concurrent engineering design effectively.In particular,the collaborative mechanism incorporated with Java-based and Internet-enabled technologies can generate extended strategies for design and planning. Thus,the proposed integration architecture enables the system to be generic,open and scalable.Finally,for the trend of global manufacturing,a case study of Internet-enabled collaborative optimization is introduced and a discussion on teamwork capability is made.

A Control System of Material Handlingin FMS

The design of a control system for the material transport as used in gear-box flexible manufacturing system is presented in this paper. The scope of investigation covers material transport control, automatic vehicle, material exchange station, multi-storeyed warehouse system, NC and CNC machines and host computer etc. The paper describes the transport control system and its design, and briefly describes the communication among devices and warehouse access principles.

Interaction of Units and Research Methods of Control Performances of Distributed Manufacturing Information System

In order to analyze the function demand of the distributed manufacturing information system as well as its control demand, and eliminate information ambiguity among system units to integrate semantics, the abstract Agent model and computational structure of each unit was presented based on flexible coupling automata. The autonomy of each unit was investigated in this foundation. The system unit was described using the Web Ontology Language (OWL) ontology. And the system semantics was also integrated. On these basics the communication among the system units was analyzed with an example of interaction between a machine and a warehouse. The control performances of information system units were investigated using Boolean matrix as a substitute for traditional process in RW theory, which reduced the computational complexity. This work established the foundation for the demand analysis, design and development of the distributed manufacture information system.

Smart Design and Manufacturing the Welded Q350 Steel Frames via Lifecycle Management Strategy of Digital Twin

Artificial intelligent aided design and manufacturing have been recognized as one kind of robust data-driven and data-intensive technologies in the integrated computational material engi-neering(ICME)era.Motivated by the dramatical developments of the services of China Railway High-speed series for more than a decade,it is essential to reveal the foundations of lifecycle man-agement of those trains under environmental conditions.Here,the smart design and manufacturing of welded Q350 steel frames of CR200J series are introduced,presenting the capability and opportu-nity of ICME in weight reduction and lifecycle management at a cost-effective approach.In order to address the required fatigue life time enduring more than 9×10^(6)km,the response of optimized frames to the static and the dynamic loads are comprehensively investigated.It is highlighted that the maximum residual stress of the optimized welded frame is reduced to 69 MPa from 477 MPa of previous existing one.Based on the measured stress and acceleration from the railways,the fatigue life of modified frame under various loading modes could fulfil the requirements of the lifecycle man-agement.Moreover,our recent developed intelligent quality control strategy of welding process mediated by machine learning is also introduced,envisioning its application in the intelligent weld-ing.

Internationalization and the Creation of New Products and Processes in the Mexican Manufacturing Industry

This paper analyzes the relationship between internationalization and the generation of new products and processes, using data from 2,285 Mexican manufacturing firms during the 2008-2009 period. The purpose is to understand how the insertion in international markets, either through exporting, importing, receiving foreign direct investment, or outsourcing affects the innovative outcomes of manufacturing finns. Using logistic regressions, this paper contributes to the literature analyzing the case of a single developing country and concludes that, after controlling for the size of the firm, its innovative effort, and the market concentration of the industry where the firm is situated, exporting does not promote product or process innovations but promotes the generation of innovation for the world; being an importer does not affect the innovative outcomes of the firm; Foreign Direct Investment （FDI） also promotes innovation for the world, while outsourcing inhibits the generation of both products and innovations for the world.

Should China's Manufacturing Industry Transition Towards Both Ends of the "Smiling Curve" ?——A Comparative Analysis between China and Traditional Manufacturing Powers

The manufacturing sector in China has surpassed that of the United States in terms of scale.Yet it still suffers from the shocks of an international economic downturn,the lack of core technologies,and the impact of "re-industrialization" of the developed economies.Based on an evaluation of the "smiling curve" theory and selected trade data from 1991 to 2011,this paper performs a comparative analysis of the differences between the manufacturing sectors of China and those of the traditional manufacturing powers in terms of product categories and architecture.This analysis is conducted in order to explore the question of whether China should transition from being the "world's manufacturing plant" to both ends of the "smiling curve".The paper then introduces Japan's "inverted smiling curve " to explore whether profit margins remain in the manufacturing sector.Research shows that China's manufacturing capacity,especially its "integrated" product assembly capacity,has not been fully realized,and that the development of the manufacturing sector can still yield high market returns.As a result,it is necessary for China to continue the path of being the "world's manufacturing plant".

The Advanced Manufacture Theory and Practice Based on the Management Science

The paper points out that the science and technology, social productivity and economic form are the decisive strengths in facilitating the reformation of the production method of the manufacturing industry. This kind of strength happens through making an influence on the theory of management and science. It analyses the stage and the characteristic of the development model of manufacturing industry of human society, and on this basis does the detailed research on the several patterns of the advanced manufacturing theory and practice： the computer integrated making, concurrent engineering, lean production, agile manufacturing, planning of enterprise resources, global manufacturing. Finally, it thinks that the development model of the advanced manufacture theory and practice embodies a continuous curve of the technical innovation, which is on the basis of the theory of management science.

Empirical Study of the Relations between Executive Compensation Gap and R&D Investment in Pharmaceutical Manufacturing Enterprises

Objective To study the correlation between executive compensation gap and R&D investment of pharmaceutical manufacturing enterprises in China by taking 53 pharmaceutical manufacturing companies in Shanghai and Shenzhen stock exchanges from 2015 to 2017 as research samples. Methods Multiple linear regression methods was used to study the relationship and influence between executive compensation gap and R&D investment in pharmaceutical manufacturing industry based on championship theory and principal-agent theory. Results and Conclusion There is a significant positive correlation between executive compensation gap in pharmaceutical manufacturing industry and enterprise R&D investment. Listed pharmaceutical manufacturing enterprises should design reasonable salary gap between senior executives and carry out reasonable research and development activities to promote the sustainable development of pharmaceutical manufacturing enterprises. This study provides theoretical basis for optimizing executive compensation gap and increasing R&D investment in pharmaceutical manufacturing industry.

INTEGRATION OF GENERIC SHOP FLOOR CONTROL

Based on the discussion of functions, components, control structure and network computing architecture of generic shop floor control (GSFC) in computer integrated manufacturing system (CIMS), the internal integration between components of GSFC and the external integration between GSFC and the other components of CIMS are studied. The integration models on the aspects of function, information, processing and interface are put forward. The integration models and the methods are implemented and applied in CIMS projects successfully.

Integrated and Intelligent Manufacturing： Perspectives and Enablers

With ever-increasing market competition and advances in technology, more and more countries are prioritizing advanced manufacturing technology as their top priority for economic growth. Germany announced the Industry 4.0 strategy in 2013. The US government launched the Advanced Manufacturing Partnership （AMP） in 2011 and the National Network for Manufacturing Innovation （NNMI） in 2014. Most recently, the Manufacturing USA initiative was officially rolled out to further ＂leverage existing resources... to nurture manufacturing innovation and accelerate commercialization＂ by fostering close collaboration between industry, academia, and government partners. In 2015, the Chinese government officially published a 10- year plan and roadmap toward manufacturing： Made in China 2025. In all these national initiatives, the core technology development and implementation is in the area of advanced manufacturing systems. A new manufacturing paradigm is emerging, which can be characterized by two unique features： integrated manufacturing and intelligent manufacturing. This trend is in line with the progress of industrial revolutions, in which higher efficiency in production systems is being continuously pursued. To this end, 10 major technologies can be identified for the new manufacturing paradigm. This paper describes the rationales and needs for integrated and intelligent manufacturing （i2M） systems. Related technologies from different fields are also described. In particular, key technological enablers, such as the Intemet of Things and Services （IoTS）, cyber-physical systems （CPSs）, and cloud computing are discussed. Challenges are addressed with applica- tions that are based on commercially available platforms such as General Electric （GE）＇s Predix and PTC＇s ThingWorx.

Additive manufacturing of promising heterostructure for biomedical applications

As a new generation of materials/structures,heterostructure is characterized by heterogeneous zones with dramatically different mechanical,physical or chemical properties.This endows heterostructure with unique interfaces,robust architectures,and synergistic effects,making it a promising option as advanced biomaterials for the highly variable anatomy and complex functionalities of individual patients.However,the main challenges of developing heterostructure lie in the control of crystal/phase evolution and the distribution/fraction of components and structures.In recent years,additive manufacturing techniques have attracted increasing attention in developing heterostructure due to the unique flexibility in tailored structures and synthetic multimaterials.This review focuses on the additive manufacturing of heterostructure for biomedical applications.The structural features and functional mechanisms of heterostructure are summarized.The typical material systems of heterostructure,mainly including metals,polymers,ceramics,and their composites,are presented.And the resulting synergistic effects on multiple properties are also systematically discussed in terms of mechanical,biocompatible,biodegradable,antibacterial,biosensitive and magnetostrictive properties.Next,this work outlines the research progress of additive manufacturing employed in developing heterostructure from the aspects of advantages,processes,properties,and applications.This review also highlights the prospective utilization of heterostructure in biomedical fields,with particular attention to bioscaffolds,vasculatures,biosensors and biodetections.Finally,future research directions and breakthroughs of heterostructure are prospected with focus on their more prospective applications in infection prevention and drug delivery.

Scheduling optimization of task allocation in integrated manufacturing system based on task decomposition

How to deal with the collaboration between task decomposition and task scheduling is the key problem of the integrated manufacturing system for complex products. With the development of manufacturing technology, we can probe a new way to solve this problem. Firstly, a new method for task granularity quantitative analysis is put forward, which can precisely evaluate the task granularity of complex product cooperation workflow in the integrated manufacturing system, on the above basis; this method is used to guide the coarse-grained task decomposition and recombine the subtasks with low cohesion coefficient. Then, a multi-objective optimieation model and an algorithm are set up for the scheduling optimization of task scheduling. Finally, the application feasibility of the model and algorithm is ultimately validated through an application case study.