Evidence-based optimization of integrated traditional Chinese and Western medicine therapies for prevention and treatment of coronary heart disease： design and implementation

As a chronic disease that seriously endangers public health, the number of coronary heart disease （CHD） patients in China has increased in recent years. There is great potentiality to integrate traditional Chinese and Western medicine therapies to prevent and treat CHD in clinical practice. However, most of the current integrated therapies still lack sufficient high-quality evidence, and the key links in how to apply are unclear. It is urgent to optimize them through evidence-based research to further improve the effectiveness. Therefore, we propose strategies to conduct evidence-based optimization of integrated traditional Chinese and Western medicine therapies in prevention and treatment of progressive cardiovascular diseases. These are integrated clinical trial design, attention to the key links of taking effect, combination of clinical and basic research. Based on the strategies, we started the national key research and development project ＂Evidence-based optimization research of TCM therapies in prevention and treatment of CHD （angina pectoris - myocardial infarction - heart failure）＂, which is expected to be a new paradigm in the field.

Exploration and Research on the Integrated Development of“Internet Plus Medical Treatment”

Objective To analyze the development of“internet plus medical treatment”and to explore advantages.Methods The literature of“internet plus medical treatment”was systematically combed and analyzed.Results and Conclusion After exploring the status quo of“internet plus hospitals”,smart pharmacy and web-assisted health management in China,we find that there are some problems in the medical service at present,such as the imperfect laws and regulations,the hidden dangers of information security and the obstacles of medical insurance payment.Therefore,we propose that the development of web-assisted medical service should be led by the government and relevant policies must be improved.Then,self-regulation should be strengthened,and industry standards should be enhanced.Three suggestions are made to improve medical insurance payment and benefit both hospitals and patients,which can provide reference for promoting the development of“internet plus medical treatment”in China.

Exploration on the Implementation of the Integration of Medical and Preventive Model in China’s Primary Health Care Institutions

Objective To explore the different modes and approaches of medical and preventive integration in current primary health care institutions in China.Methods Through literature analysis,field research,telephone interviews,and other methods the implementation status was evaluated to systematically study the main experience and effect of implementing medical and preventive integration services in pilot areas.Results and Conclusion At present,there are three implementation modes of medical-prevention integration,namely,vertical mode based on the medical community,internal mode with optimized service process,and internal mode with great service capabilities.The three medical-prevention integration modes have their respective focuses,but they need to be further improved in terms of policy support,technical staffing,information system construction,and drug use.

Clinical Characteristics of 42 SARS Patients and Their Treatment of Integrative Chinese and Western Medicine

Objective:To understand the clinical manifestation of severe acute respiratory syndrome (SARS) and explore its effective treatment with integrative Chinese and western medicine (ICWM). Methods:The data of patients, whose diagnosis of SARS had been confirmed were summarized and analyzed, and clinical observation was conducted when the patients were treated with ICWM. Results:In the early stage of the 42 patients, the symptoms revealed were fever in 100% of SARS patients, headache in 92. 9%, aversion to cold in 76. 2%, chest stuffiness in 76. 2% , cough in 73. 8% and myalgia in 88.1%; pulmonary lesion involves >3 lobes in 42. 9%, 2 lobes in 47. 6% and 1 lobe in 9. 5%; 61. 9% of them showed liver function abnormality (increase of ALT or AST), 47. 6% showed elevated myocardial enzyme (CK or CK-MB) , 0. 48% showed an inclination of renal function (higher of BUN or Cr); in their T lymphocyte subsets, 91. 2% (31/34 patients) had lowered CD3 and 76. 5% (26/34 patients) lowered CD4/CD8 ratio. In the mid-late stage, the symptoms were lassitude and weakness in 85. 7%, scare in 81. 0%, short of breath or chest stuffiness in 71. 4%, loss of appetite in 64. 3%;light dark tongue proper in 52. 4%, yellow and white tongue coating in 45. 2%, and yellow thick coating on the middle-root part of the tongue in 21. 4%. Most of them were asymptomatic when discharged from hospital, with 92. 8% of their pulmonary lesion, according to chest film, completely absorbed and liver function, myocardial enzyme and renal function all normalized. However, of the 30 patients who had CD3 reexamination, 70% of the CD3 showed lower than normal range and 36. 7% showed their CD4/CD8 inclined to lower margin, follow-up should be done for these patients. Of the 42 patients, who received western medicine (WM) alone in the early stage and ICWM in the mid-late stage, 10 were severe cases and 3 critical cases, but none of them died. The mean defervescent time was 3. 52±0. 85 days, the time for complete absorption of pulmonary lesion judged by chest X-ray film was 26. 82±5. 98 days, and the mean hospitalization time was 33. 60±4. 37 days. Conclusion:The manifestation of SARS is multifarious, showing that there were damage in multiple organs. The T lymphocyte count percentage and its subsets, CD3 and CD4 /CD8 ratio, are valuable for early diagnosis and follow-up in the rehabilitation stage. Majority of the patients could be clinically cured. Combined treatment of WM and TCM according to syndrome differentiation and psychiatric intervention are beneficial to remit partial symptoms and promote rehabilitation.

Secondary prevention of ischaemic stroke

In spite of a documented reduction in incidence in highincome countries over the last decades, stroke is still a leading cause of death and disability worldwide. With the ageing of the population stroke-related economic burden is expected to increase, because of residual disability and its complications, such as cognitive impairment, high risk of falls and fractures, depression and epilepsy. Furthermore, because of the substantial rate of early and long-term vascular recurrences after the first event, secondary prevention after cerebral ischaemia is a crucial issue. This is even more important after minor stroke and transient ischaemic attack(TIA), in order to reduce the risk of potentially more severe and disabling events. To accomplish this aim, acute long-term medical and surgical treatments as well aslifestyle modifications are strongly recommended. However, apart from the well-established indications to thrombolysis, studies in acute phase after a first stroke or TIA are scarce and evidence is lacking. More trials are available for long-term secondary prevention with different classes of drugs, including antithrombotic medications for ischaemic events of arterial and cardiac origin, especially related to atrial fibrillation(antiplatelets and anticoagulants, respectively), lipid lowering agents(mainly statins), blood pressure lowering drugs, surgical and endovascular revascularization procedures.

走向健康现代化的战略转型与实现路径:从“三医”联动到健康治理

健康现代化是社会主义现代化的重要内容。面对健康脆弱性,公共健康治理面临着治理界限交互扩大、治理内容更迭扩展、治理进程压缩叠加等诸多挑战。秉持人民中心、生命至上、系统整合、全民参与的公共健康治理理念,中国在提升健康公平性方面探索出一条医保、医疗与医药协同改革的发展之路。新时代进一步提升健康福祉,需要从“三医”联动到健康治理,通过互助共享的健康保障战略、医防融合的健康支持战略、均衡协同的健康服务战略和多元合作的健康促进战略,实现全人群、全周期、全方位为特征的全民健康福祉。基于此,走向健康现代化的具体路径包括,依托健康资源配置体制、健康制度协同机制、健康服务递送体系和健康行动协同网络,最终促进资源互通、结构改革、服务融合和治理提升。

医防融合视角下我国医学人才培养的现实困境与突破路径

医防融合完善发展为医学人才培养工作增添新的内涵。医防融合的复合性决定医学人才培养需突破传统学科壁垒,融合医学、预防学、公共卫生等多个领域,以适应现代化医疗模式。当前医疗人才培养体系尚未贯彻健康中心理念,未形成跨学科协同培养体系,各学科之间有机联结、协同培养能力不足。为此,应筑牢院校基础教育体系,完善毕业后教育体系,创新继续教育体系,进而形成符合现代化医防融合内涵的医学人才培养体系。

Evaluation of the Clinical Efficacy of Qingqiao Capsule (清窍胶囊) in Treating Patients with Secretory Otitis Media

Objective： To observe the clinical efficacy of Qingqiao Capsule （清窍胶囊, QQC） in treating patients with secretory otitis media （SOM）. Methods： A total of 90 patients were randomly assigned into the treated group （n：45） and the control group （n=45）. Patients in the treated group were administrated with QQC, 5 capsules each time, 3 times a day for totally 10-14 days, and those in the control group were given per os cefaclor capsules 0.5g each time for adult, 3 times a day, or 20mg/（kg·d） for children, for 10-14 days. The therapeutic efficacy of treatment on the patients was observed and compared after treatment and followed up for 3-6 months. Results： （1） The clinical efficacy in the treated group was superior to that in the control group with significant statistical difference （P〈0.01）; （2） Comparison of the efficacies in patients of three different TCM syndrome types （the external pathogenic wind invasion caused auditory orifice stuffiness type, the Gan-Dan damp-heat steaming up auditory orifice type and the Pi-deficiency dysfunction induced dirty dampness blocking ear type） showed no statistically significant difference（P〉0.05）; （3） The vanishing rate and time needed of the main symptoms and signs in the treated group were superior to those in the control group on ear muffle, tinnitus, hearing impairment, hydrotypanum, pure tone threshold and abnormal tongue figure, and the difference was statistically significant （P〈0.05 or P〈0.01）, only those of earache, otopiesis and abnornal pulse figure were insignificantly different between the two groups （P〉0.05）. Conclusion： QQC is an effective Chinese composite medicine on patients with SOM, and shows no obvious adverse reaction.

医防融合的关键问题、机制创新与实现路径

我国医疗服务与公共卫生服务相互割裂的问题由来已久,医防融合是新时代背景下实现健康中国战略的重要举措。当前,在医防融合试点实践中,存在医疗卫生服务体系多头管理、紧密型医联体尚未真正形成、医院“重医轻防”理念仍未转变、医防信息不能互联互通等问题。对此,可以借鉴宿迁的经验,从组织管理、医防服务供给、卫生筹资、医防人才与医防信息等方面入手,实现医防融合的机制创新,在此基础上,将医防融合作为常态化制度持续向纵深推进。

Experiences on the Integrative Medical Diagnosis and Treatment of Acute Kidney Injury

The definition of acute renal failure（ARF） has not gotten common understanding yet in a long time,which leads to the difficulty in comparing the outcomes of some different studies,and has impacted the advance of diagnosis and treatment on the illness to certain extents. Most of the scholars hold that the attention paid to the early diagnosis and intervention of ARF was insufficient in recent years. Lots of clinical researchers indicated that even a slight impairment of renal function could result in the increasing of the morbidity and mortality of ARF.

Current Status and Prospect of Prevention and Treatment of Oral Diseases by Integrative Medicine

To carry out integrative medical prevention and treatment of oral diseases, based on the inheritance and development of traditional medicine as well as the application of modern scientific, technique and medical theory, is of great significance in oral health maintenance. Certain achievements of the integrative traditional Chinese and Western medicine （TCM-WM） have been obtained in the recent several years in clinical and experimental studies and theoretic exploration of oral diseases, which are introduced briefly as follows.

县域医共体医防融合实现机制与典型路径

目的:构建县域医共体医防融合实现机制,总结医防融合的典型路径,为其他地区开展基层医防融合提供借鉴和参考。方法:基于扎根理论并借助Nvivo软件进行数据编码及定性分析。结果:确定县域医共体开展医防融合的7个核心维度为体系融、管理融、服务融、人员融、信息融、绩效融和资金融,在实践中仅有少数县域医共体实现了较多维度的融合。结论:将服务融、管理融、信息融放在开展医防融合的首要位置,注重体系融和资金融的均衡设置,参考县域医共体医防融合实践的典型路径,进一步推动医防融合的发展。

整合型服务体系构建背景下医防融合实现机制研究

背景实现基层医防融合,创新医防协同、医防融合机制是我国医疗卫生领域在“十四五”期间的重要任务。目的分析整合型服务体系构建背景下医防融合的实现机制,为探索适应健康中国战略的医防融合路径提供参考。方法以2018年为时间节点,以“医防融合”“医防协同”“防治结合”为关键词检索中国知网和万方数据知识服务平台相关文献,筛选出对医共体、医联体等整合型服务体系案例政策措施和实施效果进行研究的文献,最终筛选出文献18篇,案例15个。基于彩虹模型,从宏观、中观、微观三个层面以及支持要素确定系统整合、组织整合、专业整合、服务整合、功能整合、规范整合为条件变量,以良好医防融合效果为结果变量,采用定性比较分析方法探索整合型服务体系构建背景下的医防融合实现机制。结果共有4条组态路径能有效提升医防融合效果,4条路径分别符合多层面整合型、中微观整合型路径,同时得出以下结果:(1)依托整合型服务体系开展医防融合更为有效,在整合型服务体系下存在多种路径可有效提升医防融合效果;(2)服务整合对提升医防融合效果起着基础保障作用;(3)对提升医防融合的系统整合、专业整合和功能整合相关政策指标设置尚不健全。结论(1)依托医联体、医共体等中国特色的整合型服务体系提升医防融合效果;(2)充分发挥服务整合的基础保障作用;(3)参考多层面整合型案例的成功经验,均衡设置宏观、中观、微观层面政策指标,同时完善系统整合、专业整合以及支持要素的整合。

基于治未病理论灸药同治对实体恶性肿瘤化疗患者骨髓抑制的预防作用

目的:基于治未病理论探讨灸药同治对实体恶性肿瘤化疗患者骨髓抑制的预防作用。方法:选取2019年1月至2022年1月于武汉科技大学附属武汉亚心总医院接受治疗的实体恶性肿瘤化疗患者120例作为研究对象,采用随机数字表法分为对照组和观察组,每组60例。对照组常规接受化疗,观察组化疗前连续3 d给予灸药同治(艾灸+加味八珍汤)。比较治疗前、化疗后7 d 2组患者中医证候积分、血常规[血红蛋白(Hb)、白细胞计数(WBC)、血小板计数(PLT)、中性粒细胞计数(NEUT)]、生命质量[卡诺夫斯凯计分(KPS)、中国癌症患者生命质量(QOL_(2))调查问卷],比较化疗后7 d 2组患者骨髓抑制情况[发生率、严重程度、重组人粒细胞集落刺激因子(rhG-CSF)使用情况]。结果:化疗后7 d,2组患者中医证候积分升高,但观察组低于对照组(P<0.05);Hb、WBC、PLT、NEUT、KPS评分及QOL_(2)评分降低,但观察组高于对照组(均P<0.05);观察组骨髓抑制发生率、rhG-CSF使用率低于对照组,0、Ⅰ度比例高于对照组(均P<0.05)。结论:基于治未病理论,灸药同治能够改善实体恶性肿瘤化疗患者临床症状及血常规,提高患者生命质量,减少骨髓抑制的发生。

妇产科学课程思政教学的探索与实践——以宫颈癌防治课程为例

为大力贯彻新时代人才培养的基本要求,全面强化高校立德树人的根本任务,通过构建课程思政体系将思想政治工作贯穿教学全过程,实现思政教育与专业课程教育的有机统一。该文通过分析妇产科学课程融入思政教育的重要性,引出“宫颈癌防治”这一课程思政案例,从宫颈癌三级预防的角度展开讲解,启发学生自尊自爱、创新求索、关爱患者的意识,展示专业知识和思政教育深度结合的教学路径,并系统阐述妇产科学融入课程思政的实践探索和相关策略,以期为妇产科学课程思政发展提供有益探索和参考意见。

医养结合服务的有效模式及其实现机制研究——基于陕西省汉阴县鸿济医养中心的案例分析

医养结合是优化老年健康和养老服务供给的重要举措。如何实现医养结合的真正落地和可持续发展,是在多年试点后进一步推进医养结合发展中需要优先解答的关键问题。文章对陕西省汉阴县鸿济医养中心的服务模式进行了总结,并借鉴社会-生态系统适应性理论,剖析了鸿济医养中心作为一家民营医院如何推动县域医养结合服务优质高效和可持续运行的实现机制。研究发现:汉阴县鸿济医养中心通过“从民办民营到公办民营”的成长路径,形成了以民营医院转型为驱动、服务延伸为抓手、从机构逐步走向居家社区的医养结合发展模式。该模式破解了医养结合服务中存在的服务连续性、可持续性不足等问题,有效满足了老年人的医养结合需求,其有效运行的关键在于能够主动适应环境变迁,把握时机、顺势而为,实现了医养结合从外部需求压力向内在发展动力的转变。与此同时,政府的支持和引导也增强了该模式的稳定性和可持续发展能力。因此,应通过激活医疗机构提供医养结合服务的内生性动力、发挥民营医疗机构的作用、强化政府的支持和引导等措施,推进我国医养结合服务健康、高质量发展。研究结果不仅为县域层次推进医养结合服务发展提供了借鉴,也为破解民营医院的发展困境提供了一种新思路。

基于医防融合预防医学专业临床课程的教学改革

在新冠疫情期间,我国采用医防结合的策略,在较短的时间内控制了疫情,充分展示了预防医学与临床医学融合的重要性。在大卫生、大健康的理念指引下,通过优化预防医学专业临床课程教学体系,改善教学方法,整合教学内容,将“课程思政”建设贯穿始终,促进预防医学专业临床综合素养水平的全面提升,对构建“医防融合”公共卫生人才培养模式具有一定意义。

县域医共体急性上消化道出血医工交叉防治融合体系建设探索

基于县域医共体及一体化医疗信息系统,针对县域内发病率较高又严重威胁患者生命安全的急性上消化道出血(acuteuppergastrointestinalbleeding,AUGIB)疾病,构建一套以县域内三级综合医院为中心、联合下属医共体单位、以危重症AUGIB疾病患者为主要服务对象的院前、院内一体化预防救治体系,建立“基层智能化筛查识别-院前高危患者快速分级转诊-院内多学科联动快速救治绿色通道-恢复期智能化随访管理”的分级联动精准防治新体系。

新医科背景下医防融合医学人才培养模式的研究

为顺应国家对医学教育创新发展的规划和布局,改革医学人才培养模式势在必行。现行医学人才培养体系存在课程体系不完善、医防融合理念不足、实践教育薄弱等问题。提出基于知识—能力—情感的医学人才培养模式,改革临床医学与公共卫生课程设置;加大公共卫生实践技能培养;创新医防融合师资队伍建设途径;推行思政与人文协同育人;实施灵活多样的教学方法等应对策略,为促进医学教育的改革和构建医防融合的人才培养模式提供依据。

低分子肝素联合医护一体化快速康复外科干预对结直肠癌术后下肢DVT的预防效果

目的探究低分子肝素(LMWH)联合医护一体化快速康复外科(ERAS)干预对结直肠癌(CRC)术后下肢深静脉血栓(DVT)的预防效果。方法回顾性收集2021年1月至2023年10月杭州市中医院CRC术后患者,根据干预方式分为联合干预组(LMWH联合ERAS)和对照组(LMWH)。本研究主要观察指标为下肢DVT的发生率。次要观察指标为干预前后凝血指标[D-二聚体(D-D)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(Fib)]变化;双侧腘静脉、髂外静脉和股静脉血流速度;术后肛门排气恢复时间、进食时间、下床活动时间和住院时间;术后并发症率和药物不良反应率。结果研究共纳入患者110例,联合干预组和对照组各55例。两组患者的基线资料、干预前凝血相关指标及下肢静脉血流速度差异无统计学意义(P>0.05);干预7 d和14 d后,两组患者的TT、PT、APTT和Fib均干预前较升高,D-D水平较干预前下降(P<0.05)。两组的TT、PT和APTT差异无统计学意义(P>0.05),但联合干预组D-D水平较对照组下降(P<0.05),Fib水平较对照组升高(P<0.05)。干预14 d后,联合干预组的双侧腘静脉、髂外静脉和股静脉血流速度高于对照组(P<0.05);DVT的发生率更低(1.82%vs.7.27%),但差异无统计学意义(P=0.363)。联合干预组的术后肛门排气恢复时间、进食时间、下床活动时间和住院时间较观察组缩短(P<0.05)。两组患者在术后并发症和LMWH不良反应的发生率上差异无统计学意义(P>0.05)。结论LMWH联合ERAS干预可以有效改善CRC术后患者高凝状态,提高下肢静脉血流速度,减少DVT发生率,促进术后康复,并具有较好的安全性。