This study investigated the integration of geospatial technologies within smart city frameworks to achieve the European Union’s climate neutrality goals by 2050. Focusing on rapid urbanization and escalating climate ...This study investigated the integration of geospatial technologies within smart city frameworks to achieve the European Union’s climate neutrality goals by 2050. Focusing on rapid urbanization and escalating climate challenges, the research analyzed how smart city frameworks, aligned with climate neutrality objectives, leverage geospatial technologies for urban planning and climate action. The study included case studies from three leading European cities, extracting lessons and best practices in implementing Climate City Contracts across sectors like energy, transport, and waste management. These insights highlighted the essential role of EU and national authorities in providing technical, regulatory, and financial support. Additionally, the paper presented the application of a WEBGIS platform in Limassol Municipality, Cyprus, demonstrating citizen engagement and acceptance of the proposed geospatial framework. Concluding with recommendations for future research, the study contributed significant insights into the advancement of urban sustainability and the effectiveness of geospatial technologies in smart city initiatives for combating climate change.展开更多
The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to ...The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.展开更多
With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Techn...With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.展开更多
The core education function of higher vocational colleges is to train technical talents with high quality,so as to meet the needs of talents in the development stage of our society.Under the guidance of talent trainin...The core education function of higher vocational colleges is to train technical talents with high quality,so as to meet the needs of talents in the development stage of our society.Under the guidance of talent training,higher vocational colleges need to pay attention to establishing an all-round and three-dimensional education model,and promote innovation of higher vocational education on the basis of this.It is also a way to promote the innovation of higher vocational education to vigorously promote the construction of“post,course,competition,certificate”mode in the construction of education mode.Through the construction of“post,course,competition,certificate”mode,the education mode of higher vocational colleges is gradually improved,so as to strengthen the effectiveness of talent training in higher vocational colleges.Therefore,in this paper,the author puts forward some suggestions to promote the construction of the integrated education mode of the electronic information engineering technology major in higher vocational colleges,so as to help improve the talent training level of higher vocational colleges.展开更多
Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Da...Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Data mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative diseases.Importantly,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain profile.In this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple sclerosis.We then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics layers.We further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain networks.Finally,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease mechanisms.We conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personalized medicine.展开更多
Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy industry.Multi-omics approaches enable the comprehensive investigation of the complex interactions between ...Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy industry.Multi-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease pathogenesis.Therefore,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus chromogenes.Results Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical mastitis.The abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),respectively.Next,5 factors presenting the principal variation of differential multi-omics signatures were identified.The important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were revealed.Each of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical mastitis.Also,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regulatory mechanisms underlying subclinical mastitis.Furthermore,multi-omics integration enabled the association of the epigenomic regulatory factors(dMHBs,DELs and DEMs)of altered genes in important pathways,such as‘Staphylococcus aureus infection pathway’and‘natural killer cell mediated cyto-toxicity pathway’,etc.,which provides further insights into mastitis regulatory mechanisms.Moreover,few multi-omics signatures(14 dMHBs,25 DEGs,18 DELs and 5 DEMs)were identified as candidate discriminant signatures with capac-ity of distinguishing subclinical mastitis cows from healthy cows.Conclusion The integration of genomic and epigenomic data by multi-omics approaches in this study provided a better understanding of the molecular mechanisms underlying subclinical mastitis and identified multi-omics candidate discriminant signatures for subclinical mastitis,which may ultimately lead to the development of more effective mastitis control and management strategies.展开更多
Technical and accessibility issues in hospitals often prevent patients from receiving optimal mental and physical health care,which is essential for independent living,especially as societies age and chronic diseases ...Technical and accessibility issues in hospitals often prevent patients from receiving optimal mental and physical health care,which is essential for independent living,especially as societies age and chronic diseases like diabetes and cardiovascular disease become more common.Recent advances in the Internet of Things(IoT)-enabled wearable devices offer potential solutions for remote health monitoring and everyday activity recognition,gaining significant attention in personalized healthcare.This paper comprehensively reviews wearable healthcare technology integrated with the IoT for continuous vital sign monitoring.Relevant papers were extracted and analyzed using a systematic numerical review method,covering various aspects such as sports monitoring,disease detection,patient monitoring,and medical diagnosis.The review highlights the transformative impact of IoTenabled wearable devices in healthcare,facilitating real-time monitoring of vital signs,including blood pressure,temperature,oxygen levels,and heart rate.Results from the reviewed papers demonstrate high accuracy and efficiency in predicting health conditions,improving sports performance,enhancing patient care,and diagnosing diseases.The integration of IoT in wearable healthcare devices enables remote patient monitoring,personalized care,and efficient data transmission,ultimately transcending traditional boundaries of healthcare and leading to better patient outcomes.展开更多
Urbanization strategic environmental assessment (SEA) is an effective instrument to enhance the harmo-nious development of urban complex system, integrating of environment and development in decision-making. Ur-baniza...Urbanization strategic environmental assessment (SEA) is an effective instrument to enhance the harmo-nious development of urban complex system, integrating of environment and development in decision-making. Ur-banization strategic environmental assessment integration technology system (SEA-ITS) is composed of "3S" (RS, GIS and GPS), environmental expert system and environmental model system, coupling with appropriate SEA working process closely. In this paper, the structure and components of SEA-ITS are analyzed based on Chinese characteristics, meanwhile methods to fulfill the following system functions are discussed: urbanization SEA in-quiring, analysis, discrimination, assessment, prediction, decision-making and output. Moreover, methods and tech-nologies employed in different urbanization SEA hierarchies are summarized. As a case study, urbanization SEA-ITS is applied in Changchun City to solving complex real problems. Methods such as system dynamics and grey cluster are adopted to achieve the environmental impact assessment on the eco-industrial system planning. It is revealed that the system designed is capable of reflecting the dynamic behavior of eco-industrial system under different sce-narios, meanwhile accomplishing strategy optimization and supplying scientific reference. The 4th strategy, namely concerning on economy increase and its interaction with science, technology and environment progress, would have the best efficiency. Further, more attention should be paid to the secondary development of integration techniques and function modification system of urbanization SEA-ITS.展开更多
The globalization and the intensive competition of th e automotive market require shortening the product development cycle, improving the quality and reducing the cost. Optimizing the product development process, b ui...The globalization and the intensive competition of th e automotive market require shortening the product development cycle, improving the quality and reducing the cost. Optimizing the product development process, b uilding product’s consistent defining model for life cycle, and realizing the in tegration of CAD/CAM/CAE and Concurrent Engineering (CE) become the means to acc ept the challenge. A new product modeling technology, Multi Model Technology (MM T), is provided in this paper to meet the needs of the challenge for automotive powertrain product development. First, the paper introduces the concept of Multi Model Technology. MMT introduce s Object-oriented Technology (OT) into product modeling process and combine OT with feature-based modeling technology. With the help of OT, MMT builds product object model to support system level management in product development. The obj ect model of the product is a Multi Model Structure. The MMS consists of finish part model level (assembly model level), rough part model level (part model leve l), function model level and basic model level. Every models in the MMS is creat ed by feature-based technology in design process. In this case, models in the M MS of product can be shared by casting mould, sand core and sand core mould. The refore, CAD engineers, CAE engineers and CAM engineers can work concurrently and the integration of CAD/CAM/CAE can be realized. Second, MMT is applied in cylinder head development. The multi model structures of cylinder head, its casting mould, sand core and sand core mould are built, an d the process-oriented feature models of every objects in the multi model struc tures are modeled, the application of different model objects in development pro cess is analyzed. The integrated modeling technology of cylinder head, its casti ng mould, sand core and sand core mould under MMT is studied. And the concurrent engineering oriented integration method of CAD/CAE and the method to realize th e integration of CAD/CAE under MMT are also discussed. Based on above, the integ ration of CAD/CAM/CAE of cylinder head is realized in automotive powertrain prod uct. The practice results shows that the modeling technology in this paper can optimi ze the development process, realize the data sharing and concurrent engineering in the product development process.展开更多
An 8×10 GHz receiver optical sub-assembly (ROSA) consisting of an 8-channel arrayed waveguide grating (AWG) and an 8-channel PIN photodetector (PD) array is designed and fabricated based on silica hybrid in...An 8×10 GHz receiver optical sub-assembly (ROSA) consisting of an 8-channel arrayed waveguide grating (AWG) and an 8-channel PIN photodetector (PD) array is designed and fabricated based on silica hybrid integration technology. Multimode output waveguides in the silica AWG with 2% refractive index difference are used to obtain fiat-top spectra. The output waveguide facet is polished to 45° bevel to change the light propagation direction into the mesa-type PIN PD, which simplifies the packaging process. The experimentM results show that the single channel I dB bandwidth of AWG ranges from 2.12nm to 3.06nm, the ROSA responsivity ranges from 0.097 A/W to 0.158A/W, and the 3dB bandwidth is up to 11 GHz. It is promising to be applied in the eight-lane WDM transmission system in data center interconnection.展开更多
Building energy saving needs solar energy, but the promotion of solar energy has to be integrated with the constructions. Through analyzing the energy-saving significance of solar energy, and the status and features o...Building energy saving needs solar energy, but the promotion of solar energy has to be integrated with the constructions. Through analyzing the energy-saving significance of solar energy, and the status and features of it, this paper has discussed the solar energy and building integration technology and application in the residential building, and explored a new way and thinking for the close combination of the solar technology and residence.展开更多
The stockpiling,delivery,and provision of emergency material were in the public gaze of millions of people when the coronavirus disease 2019(COVID-19)broke out.Civil-military integra-tion emergency logistics silently ...The stockpiling,delivery,and provision of emergency material were in the public gaze of millions of people when the coronavirus disease 2019(COVID-19)broke out.Civil-military integra-tion emergency logistics silently opened up the“second battlefield”of anti-epidemic,and estab-lished a lifeline under that emergency situation.Research on the construction of civil-military integ-rated logistics system plays an extremely important role and occupies a significant position in en-suring social stability and security as well as the stable development of social economy in China.The modern economy driven by the Internet,Internet of Things,and big data demonstrates a rap-id growing trend calling for efficient,fast,and convenient logistics.It is urgent to upgrade or build an intelligent logistics system with intelligent technology and unmanned technology as the core to meet the international and domestic market demand.As mentioned above,this paper analyzes and expounds the construction problem and practical significance of civil-military integration emer-gency logistics system based on unmanned technology,and puts forward the strategy of construct-ing civil-military integration emergency logistics system with unmanned technology under the new system.展开更多
The causes and the problems of integration of scientific & technical innovation (ISTI) and inevitability are proposed. The status of domestic scientific & technical innovation is analysed. A series of emergent man...The causes and the problems of integration of scientific & technical innovation (ISTI) and inevitability are proposed. The status of domestic scientific & technical innovation is analysed. A series of emergent managerial problems caused by the system ISTI (SISTI) are pointed out. Because of Hall three dimensions structure's enlightenment, a three dimensional logical net diagram in which the system integration of innovation based on problem in real world but not on disciplinary logic is drawn. The intelligent group' s need span is greater under the conditions of relatively low material level than common groups who have lower degree of education. The SISTI is composed by multi-rule and intelligent multi-agent behavior. It is concluded that the logical relationships of integrated technology which based on the author's experience and observation must be considerded for a valid management of SISTI.展开更多
In the book"The Essence of Technology",Brian Arthur,the founder of complexity science and technology thinker,talked about the three most essential cores of technological innovation:phenomenon,combination and...In the book"The Essence of Technology",Brian Arthur,the founder of complexity science and technology thinker,talked about the three most essential cores of technological innovation:phenomenon,combination and recursion.Phenomenon Whether it is simple technology or complex technology,it is a collection of phenomena that have been captured and used,and it is a purposeful programming of phenomena.展开更多
The electrical new technology is a new frontier science.This kind of technology, with the development and progress of society, makes the continuous development and innovation.It is the future development trend of elec...The electrical new technology is a new frontier science.This kind of technology, with the development and progress of society, makes the continuous development and innovation.It is the future development trend of electrical engineering system,which plays a very important role in technological innovation.The principle and theoretical support for the development of electrical new technology includes Bio- electro magnetics, plasma physics, electromagnetic fluid mechanics and gas discharge physics etc.In addition, under the application of permanent magnetic materials and other new materials, the electrical new technology and obtained further development also promote the development and application of electronic power supply, strong magnetic field technology, solar photovoltaic power generation, and superconducting power technology.This paper mainly analyzes the application of electrical new technology in electromechanical integration.展开更多
Work exchange is a promising innovative technology in recovering residual pressure energy. However, at the systematic level, the comprehensive utilization of different energy resources in an energy system has become a...Work exchange is a promising innovative technology in recovering residual pressure energy. However, at the systematic level, the comprehensive utilization of different energy resources in an energy system has become an issue of concern. In this work, a systematic approach is proposed, one that successively integrates heat, work and adjusts operation parameters. A detailed procedure for building a heat-work coupling transfer network is provided. The synthesis mainly consists of constructing a work exchange sub-network with pinch analysis based on positive displacement type work exchangers. Simultaneously, another kind of sub-network based on turbine-type work exchangers is built as a schematic comparison. The influence of applying a positive displacement work exchanger on the system is investigated. Finally, as a case study, a renovation design of a typical rectisol process in the coal-water slurry gasification section of an ammonia plant is presented. The results show that the added work exchanger has little impact on the existing heat exchange sub-network. Moreover,extra pressure energy is recovered by coupling the transfer network. It is concluded that the heat-work systematic design is a promising and powerful method to use energy more efficiently.展开更多
Flexibly in recent years, the army strategy, earnestly implement the talent of military science and technology talents of military and civilian integration type development has carried on the positive exploration and ...Flexibly in recent years, the army strategy, earnestly implement the talent of military science and technology talents of military and civilian integration type development has carried on the positive exploration and obtained certain achievements. But there are low levels, pertinence is not strong, the introduction of fewer problems, it has both idea lag, the train of thought is not open, also has the system and mechanism is not perfect, imperfect laws and regulations and so on. We should start from mastering the characteristics of civil-military integration rule, renew the idea, and actively push forward scientific and technological personnel civil-military integration to a higher level, the deeper development.展开更多
An integrated 3.3V/1.2V SC DC-DC converter operating under 10MHz with a fixed duty radio of 0.5 is presented.To improve the output current of the converter,CMOS technology is adopted to fabricate the switching devices...An integrated 3.3V/1.2V SC DC-DC converter operating under 10MHz with a fixed duty radio of 0.5 is presented.To improve the output current of the converter,CMOS technology is adopted to fabricate the switching devices,and mutually compensatory circuitry technology is also employed to double the output current furthermore.The simulation results using Hspice simulation software,show that the output currents of a single unit circuit and two unit circuits connected in a mutually compensatory manner of the improved converter is about 12.5mA and 26mA,respectively.The power conversion efficiency of the mutually compensatory circuit can amount to 73%,while its output voltage ripple is less than 1.5%.The converter is fabricated in standard Rohm 0.35μm CMOS technology in Tokyo University of Japan.The test result indicates that the output current of 9.8mA can be obtained from a single unit circuit of the improved converter.展开更多
文摘This study investigated the integration of geospatial technologies within smart city frameworks to achieve the European Union’s climate neutrality goals by 2050. Focusing on rapid urbanization and escalating climate challenges, the research analyzed how smart city frameworks, aligned with climate neutrality objectives, leverage geospatial technologies for urban planning and climate action. The study included case studies from three leading European cities, extracting lessons and best practices in implementing Climate City Contracts across sectors like energy, transport, and waste management. These insights highlighted the essential role of EU and national authorities in providing technical, regulatory, and financial support. Additionally, the paper presented the application of a WEBGIS platform in Limassol Municipality, Cyprus, demonstrating citizen engagement and acceptance of the proposed geospatial framework. Concluding with recommendations for future research, the study contributed significant insights into the advancement of urban sustainability and the effectiveness of geospatial technologies in smart city initiatives for combating climate change.
文摘The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.
文摘With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.
文摘The core education function of higher vocational colleges is to train technical talents with high quality,so as to meet the needs of talents in the development stage of our society.Under the guidance of talent training,higher vocational colleges need to pay attention to establishing an all-round and three-dimensional education model,and promote innovation of higher vocational education on the basis of this.It is also a way to promote the innovation of higher vocational education to vigorously promote the construction of“post,course,competition,certificate”mode in the construction of education mode.Through the construction of“post,course,competition,certificate”mode,the education mode of higher vocational colleges is gradually improved,so as to strengthen the effectiveness of talent training in higher vocational colleges.Therefore,in this paper,the author puts forward some suggestions to promote the construction of the integrated education mode of the electronic information engineering technology major in higher vocational colleges,so as to help improve the talent training level of higher vocational colleges.
基金supported by a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship(021207-00001)from Nanyang Technological University(NTU)Singapore and a Mistletoe Research Fellowship(022522-00001)from the Momental Foundation USA.Jialiu Zeng is supported by a Presidential Postdoctoral Fellowship(021229-00001)from NTU Singapore and an Open Fund Young Investigator Research Grant(OF-YIRG)(MOH-001147)from the National Medical Research Council(NMRC)SingaporeSu Bin Lim is supported by the National Research Foundation(NRF)of Korea(Grant Nos.:2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(Grant No.:HR22C1734).
文摘Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Data mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative diseases.Importantly,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain profile.In this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple sclerosis.We then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics layers.We further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain networks.Finally,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease mechanisms.We conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personalized medicine.
基金The help and support of owners of the dairy farms enrolled in this study is gratefully acknowledged.The financial support from the program of China Scholarship Council during the PhD study of Mengqi Wang in Canada is acknowledged(No.202008880009).
文摘Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy industry.Multi-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease pathogenesis.Therefore,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus chromogenes.Results Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical mastitis.The abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),respectively.Next,5 factors presenting the principal variation of differential multi-omics signatures were identified.The important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were revealed.Each of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical mastitis.Also,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regulatory mechanisms underlying subclinical mastitis.Furthermore,multi-omics integration enabled the association of the epigenomic regulatory factors(dMHBs,DELs and DEMs)of altered genes in important pathways,such as‘Staphylococcus aureus infection pathway’and‘natural killer cell mediated cyto-toxicity pathway’,etc.,which provides further insights into mastitis regulatory mechanisms.Moreover,few multi-omics signatures(14 dMHBs,25 DEGs,18 DELs and 5 DEMs)were identified as candidate discriminant signatures with capac-ity of distinguishing subclinical mastitis cows from healthy cows.Conclusion The integration of genomic and epigenomic data by multi-omics approaches in this study provided a better understanding of the molecular mechanisms underlying subclinical mastitis and identified multi-omics candidate discriminant signatures for subclinical mastitis,which may ultimately lead to the development of more effective mastitis control and management strategies.
文摘Technical and accessibility issues in hospitals often prevent patients from receiving optimal mental and physical health care,which is essential for independent living,especially as societies age and chronic diseases like diabetes and cardiovascular disease become more common.Recent advances in the Internet of Things(IoT)-enabled wearable devices offer potential solutions for remote health monitoring and everyday activity recognition,gaining significant attention in personalized healthcare.This paper comprehensively reviews wearable healthcare technology integrated with the IoT for continuous vital sign monitoring.Relevant papers were extracted and analyzed using a systematic numerical review method,covering various aspects such as sports monitoring,disease detection,patient monitoring,and medical diagnosis.The review highlights the transformative impact of IoTenabled wearable devices in healthcare,facilitating real-time monitoring of vital signs,including blood pressure,temperature,oxygen levels,and heart rate.Results from the reviewed papers demonstrate high accuracy and efficiency in predicting health conditions,improving sports performance,enhancing patient care,and diagnosing diseases.The integration of IoT in wearable healthcare devices enables remote patient monitoring,personalized care,and efficient data transmission,ultimately transcending traditional boundaries of healthcare and leading to better patient outcomes.
基金Under the auspices of Major State Basic Research Development Program of China (973 Program) (No. 2005CB724207)
文摘Urbanization strategic environmental assessment (SEA) is an effective instrument to enhance the harmo-nious development of urban complex system, integrating of environment and development in decision-making. Ur-banization strategic environmental assessment integration technology system (SEA-ITS) is composed of "3S" (RS, GIS and GPS), environmental expert system and environmental model system, coupling with appropriate SEA working process closely. In this paper, the structure and components of SEA-ITS are analyzed based on Chinese characteristics, meanwhile methods to fulfill the following system functions are discussed: urbanization SEA in-quiring, analysis, discrimination, assessment, prediction, decision-making and output. Moreover, methods and tech-nologies employed in different urbanization SEA hierarchies are summarized. As a case study, urbanization SEA-ITS is applied in Changchun City to solving complex real problems. Methods such as system dynamics and grey cluster are adopted to achieve the environmental impact assessment on the eco-industrial system planning. It is revealed that the system designed is capable of reflecting the dynamic behavior of eco-industrial system under different sce-narios, meanwhile accomplishing strategy optimization and supplying scientific reference. The 4th strategy, namely concerning on economy increase and its interaction with science, technology and environment progress, would have the best efficiency. Further, more attention should be paid to the secondary development of integration techniques and function modification system of urbanization SEA-ITS.
文摘The globalization and the intensive competition of th e automotive market require shortening the product development cycle, improving the quality and reducing the cost. Optimizing the product development process, b uilding product’s consistent defining model for life cycle, and realizing the in tegration of CAD/CAM/CAE and Concurrent Engineering (CE) become the means to acc ept the challenge. A new product modeling technology, Multi Model Technology (MM T), is provided in this paper to meet the needs of the challenge for automotive powertrain product development. First, the paper introduces the concept of Multi Model Technology. MMT introduce s Object-oriented Technology (OT) into product modeling process and combine OT with feature-based modeling technology. With the help of OT, MMT builds product object model to support system level management in product development. The obj ect model of the product is a Multi Model Structure. The MMS consists of finish part model level (assembly model level), rough part model level (part model leve l), function model level and basic model level. Every models in the MMS is creat ed by feature-based technology in design process. In this case, models in the M MS of product can be shared by casting mould, sand core and sand core mould. The refore, CAD engineers, CAE engineers and CAM engineers can work concurrently and the integration of CAD/CAM/CAE can be realized. Second, MMT is applied in cylinder head development. The multi model structures of cylinder head, its casting mould, sand core and sand core mould are built, an d the process-oriented feature models of every objects in the multi model struc tures are modeled, the application of different model objects in development pro cess is analyzed. The integrated modeling technology of cylinder head, its casti ng mould, sand core and sand core mould under MMT is studied. And the concurrent engineering oriented integration method of CAD/CAE and the method to realize th e integration of CAD/CAE under MMT are also discussed. Based on above, the integ ration of CAD/CAM/CAE of cylinder head is realized in automotive powertrain prod uct. The practice results shows that the modeling technology in this paper can optimi ze the development process, realize the data sharing and concurrent engineering in the product development process.
基金Supported by the National High Technology Research and Development Program of China under Grant No 2015AA016902the National Natural Science Foundation of China under Grant Nos 61435013 and 61405188the K.C.Wong Education Foundation
文摘An 8×10 GHz receiver optical sub-assembly (ROSA) consisting of an 8-channel arrayed waveguide grating (AWG) and an 8-channel PIN photodetector (PD) array is designed and fabricated based on silica hybrid integration technology. Multimode output waveguides in the silica AWG with 2% refractive index difference are used to obtain fiat-top spectra. The output waveguide facet is polished to 45° bevel to change the light propagation direction into the mesa-type PIN PD, which simplifies the packaging process. The experimentM results show that the single channel I dB bandwidth of AWG ranges from 2.12nm to 3.06nm, the ROSA responsivity ranges from 0.097 A/W to 0.158A/W, and the 3dB bandwidth is up to 11 GHz. It is promising to be applied in the eight-lane WDM transmission system in data center interconnection.
文摘Building energy saving needs solar energy, but the promotion of solar energy has to be integrated with the constructions. Through analyzing the energy-saving significance of solar energy, and the status and features of it, this paper has discussed the solar energy and building integration technology and application in the residential building, and explored a new way and thinking for the close combination of the solar technology and residence.
基金supported in part by the National Natural Sci-ence Foundation of China(Nos.62088101,62103015)in part by Beijing Institute of Technology Research Fund Program for Young Scholars(Nos.XSQD-202121004,XSQD-202121009).
文摘The stockpiling,delivery,and provision of emergency material were in the public gaze of millions of people when the coronavirus disease 2019(COVID-19)broke out.Civil-military integra-tion emergency logistics silently opened up the“second battlefield”of anti-epidemic,and estab-lished a lifeline under that emergency situation.Research on the construction of civil-military integ-rated logistics system plays an extremely important role and occupies a significant position in en-suring social stability and security as well as the stable development of social economy in China.The modern economy driven by the Internet,Internet of Things,and big data demonstrates a rap-id growing trend calling for efficient,fast,and convenient logistics.It is urgent to upgrade or build an intelligent logistics system with intelligent technology and unmanned technology as the core to meet the international and domestic market demand.As mentioned above,this paper analyzes and expounds the construction problem and practical significance of civil-military integration emer-gency logistics system based on unmanned technology,and puts forward the strategy of construct-ing civil-military integration emergency logistics system with unmanned technology under the new system.
基金Sponsored bythe National Innovation Basein Management on National Defense Science Technology National Economy Mobilization of the SecondPhase of"985"Project
文摘The causes and the problems of integration of scientific & technical innovation (ISTI) and inevitability are proposed. The status of domestic scientific & technical innovation is analysed. A series of emergent managerial problems caused by the system ISTI (SISTI) are pointed out. Because of Hall three dimensions structure's enlightenment, a three dimensional logical net diagram in which the system integration of innovation based on problem in real world but not on disciplinary logic is drawn. The intelligent group' s need span is greater under the conditions of relatively low material level than common groups who have lower degree of education. The SISTI is composed by multi-rule and intelligent multi-agent behavior. It is concluded that the logical relationships of integrated technology which based on the author's experience and observation must be considerded for a valid management of SISTI.
文摘In the book"The Essence of Technology",Brian Arthur,the founder of complexity science and technology thinker,talked about the three most essential cores of technological innovation:phenomenon,combination and recursion.Phenomenon Whether it is simple technology or complex technology,it is a collection of phenomena that have been captured and used,and it is a purposeful programming of phenomena.
文摘The electrical new technology is a new frontier science.This kind of technology, with the development and progress of society, makes the continuous development and innovation.It is the future development trend of electrical engineering system,which plays a very important role in technological innovation.The principle and theoretical support for the development of electrical new technology includes Bio- electro magnetics, plasma physics, electromagnetic fluid mechanics and gas discharge physics etc.In addition, under the application of permanent magnetic materials and other new materials, the electrical new technology and obtained further development also promote the development and application of electronic power supply, strong magnetic field technology, solar photovoltaic power generation, and superconducting power technology.This paper mainly analyzes the application of electrical new technology in electromechanical integration.
基金supported by the National Natural Science Foundation of China (No. 20936004 and No. 21376187)
文摘Work exchange is a promising innovative technology in recovering residual pressure energy. However, at the systematic level, the comprehensive utilization of different energy resources in an energy system has become an issue of concern. In this work, a systematic approach is proposed, one that successively integrates heat, work and adjusts operation parameters. A detailed procedure for building a heat-work coupling transfer network is provided. The synthesis mainly consists of constructing a work exchange sub-network with pinch analysis based on positive displacement type work exchangers. Simultaneously, another kind of sub-network based on turbine-type work exchangers is built as a schematic comparison. The influence of applying a positive displacement work exchanger on the system is investigated. Finally, as a case study, a renovation design of a typical rectisol process in the coal-water slurry gasification section of an ammonia plant is presented. The results show that the added work exchanger has little impact on the existing heat exchange sub-network. Moreover,extra pressure energy is recovered by coupling the transfer network. It is concluded that the heat-work systematic design is a promising and powerful method to use energy more efficiently.
文摘Flexibly in recent years, the army strategy, earnestly implement the talent of military science and technology talents of military and civilian integration type development has carried on the positive exploration and obtained certain achievements. But there are low levels, pertinence is not strong, the introduction of fewer problems, it has both idea lag, the train of thought is not open, also has the system and mechanism is not perfect, imperfect laws and regulations and so on. We should start from mastering the characteristics of civil-military integration rule, renew the idea, and actively push forward scientific and technological personnel civil-military integration to a higher level, the deeper development.
文摘An integrated 3.3V/1.2V SC DC-DC converter operating under 10MHz with a fixed duty radio of 0.5 is presented.To improve the output current of the converter,CMOS technology is adopted to fabricate the switching devices,and mutually compensatory circuitry technology is also employed to double the output current furthermore.The simulation results using Hspice simulation software,show that the output currents of a single unit circuit and two unit circuits connected in a mutually compensatory manner of the improved converter is about 12.5mA and 26mA,respectively.The power conversion efficiency of the mutually compensatory circuit can amount to 73%,while its output voltage ripple is less than 1.5%.The converter is fabricated in standard Rohm 0.35μm CMOS technology in Tokyo University of Japan.The test result indicates that the output current of 9.8mA can be obtained from a single unit circuit of the improved converter.