Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification

Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific manner.Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings.This atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets,addressing batch effects and conserving biological variance.This integration spans a broad spectrum of tissues,including both below-and above-ground parts.Utilizing a rigorous approach for cell type annotation,we identified 47 distinct cell types or states,largely expanding our current view of plant cell compositions.We systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene expression.Taken together,our study not only offers extensive plant cell atlas exploration that serves as a valuable resource,but also provides molecular insights into gene-regulatory programs that varies from different cell types.

Research on the Impact and Strategies of Rail Transit Network Integration in the Context of Metropolitan Area Development:A Case Study of the Wuhan Metropolitan Area

The metropolitan area is one of the key focal points in the construction and development of China’s new urbanization.Urban integration is an emerging trend in metropolitan areas.This paper explores the traffic demand characteristics and economic aspects of rail transit within metropolitan regions and argues that the construction of an integrated urban rail transit network is an effective approach to support their development.Rail transit in metropolitan areas offers both technical and economic advantages,improving the efficiency of time and space resource utilization,fostering economic cooperation,and ultimately contributing to an integrated development model.However,the integration of rail transit networks faces several challenges,including road network planning,technical standards,and operational organization.Using the Wuhan metropolitan area as a case study,this paper analyzes the challenges of rail transit network integration and proposes strategic solutions for development.

Optimal synthesis of heat-integrated distillation configurations using the two-column superstructure

In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocolumn configuration.However,this approach frequently necessitates tedious enumeration procedures,resulting in a considerable computational burden.To surmount this formidable challenge,the present study introduces an innovative remedy:The proposition of a superstructure that encompasses both single-column and multiple two-column configurations.Additionally,a simultaneous optimization algorithm is applied to optimize both the process parameters and heat integration structures of the twocolumn configurations.The effectiveness of this approach is demonstrated through a case study focusing on industrial organosilicon separation.The results underscore that the superstructure methodology not only substantially mitigates computational time compared to exhaustive enumeration but also furnishes solutions that exhibit comparable performance.

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in China.Integrated TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and treatment.However,the methodological defects in currently published clinical practice guidelines(CPGs)limit its development.The organic integration of TCM and WM is a deeper integration of TCM and WM.To realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is needed.Therefore,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

SOME PROPERTIES OF THE INTEGRATION OPERATORS ON THE SPACES F(p,q,s)

We study the closed range property and the strict singularity of integration operators acting on the spaces F(p,pα-2,s).We completely characterize the closed range property of the Volterra companion operator I_(g)on F(p,pα-2,s),which generalizes the existing results and answers a question raised in[A.Anderson,Integral Equations Operator Theory,69(2011),no.1,87-99].For the Volterra operator J_(g),we show that,for 0<α≤1,J_(g)never has a closed range on F(p,pα-2,s).We then prove that the notions of compactness,weak compactness and strict singularity coincide in the case of J_(g)acting on F(p,p-2,s).

Effectiveness of sensory integration therapy in children,focusing on Korean children:A systematic review and meta-analysis

BACKGROUND Sensory integration intervention is highly related to the child's effective interaction with the environment and the child's development.Currently,various sensory integration interventions are being applied,but research methodological problems are arising due to unsystematic protocols.This study aims to present the optimal intervention protocol by presenting scientific standards for sensory integration intervention through meta-analysis.AIM To prove the effectiveness of sensory integration therapy,examine the latest trend of sensory integration studies in Korea,and provide clinical evidence for sensory integration therapies.METHODS The database of Korean search engines,including RISS,KISS,and DBpia,was used to search for related literature published from 2001 to October 2020.The keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this search.Then,a meta-analysis was conducted on 24 selected studiesRISS,KISS,and DBpia,was used to search for related literature published from 2001 to October 2020.The keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this search.Then,a meta-analysis was conducted on 24 selected studies.RESULTS Sensory integration intervention has been proven effective in children with cerebral palsy,autism spectrum disorder,attention deficit/hyperactivity disorder,developmental disorder,and intellectual disability in relation to the diagnosis of children.Regarding sensory integration therapies,1:1 individual treatment with a therapist or a therapy session lasting for 40 min was most effective.In terms of dependent variables,sensory integration therapy effectively promoted social skills,adaptive behavior,sensory processing,and gross motor and fine motor skills.CONCLUSION The results of this study may be used as therapeutic evidence for sensory integration intervention in the clinical field of occupational therapy for children,and can help to present standards for sensory integration intervention protocols.

The Transmission,Establishment and Cross-cultural Integration of Chinese Medicine in the Mainstream Healthcare,through the Eyes of a Generation of Visionaries and Pioneers

It has historically been very difficult to trace the history of the westward transmission of Chinese medicine through the accounts of its protagonists. Many of the early scholars such as Jack Worsley, Dick Van Buren, and Joe Goodman were reluctant to divulge information about the source of their knowledge, or their professional qualifications. Others, such as John Shen and Hong Yuan-bain were early 20th century immigrants who transmitted highly personalized versions of acupuncture and Chinese medicine to select disciples. Eventually, a new class of scholars appeared, including names such as Ted Kaptchuk, Peter Deadman, Nigel Wiseman, William Morris, Peter Eckman, John Mc Donald, Charles Buck, and the late Giovanni Maciocia who looked for answers back in China, developed translation methodologies and terminology, compiled the main textbooks currently in use at TCM colleges, overcame enormous scholastic adversity, developed courses and pursued the regulation and accreditation of TCM in various countries. This special issue synopsizes the path towards the global acculturation of TCM over the last 50 years, the main protagonists, the enormous accomplishments they have achieved for the profession, their philosophy, their clinical perspectives and visions for the future.

Exploration into the Development of"Integration of Production and Education"in Vocational Education in China

In order to further clarify the function and important value of the integration of production and education for the development of vocational education,this paper combed the development context of the integration of production and education in China's vocational education from three dimensions:policy evolution,research evolution and practice promotion.Studies have shown that the integration of production and education,as a distinctive type characteristic of vocational education in China,has experienced four stages of evolution in policy:the period of combination of production and education,the preparation and presentation period,the full implementation period and the in-depth promotion period,and the initially-constructed institutional system reflects developmental characteristics.In academic research,there are obvious policy-driven characteristics.The theoretical framework tends to be perfect,and the concept connotation and promotion path are gradually getting clear,but the research on regional promotion modes is slightly insufficient.The empirical research is weak,and the operability of countermeasure research is not strong.Moreover,the problem of discussing integration based on education is more prominent.In practice and promotion,the characteristic of the integration of production and education is gradually highlighted and deepened in terms of talent training,school-running system and school-running mode,and the carriers and contents of the integration of production and education are gradually enriched.

Reform of Theory-practice Alternating Teaching of the Introduction to Architecture Course Oriented to“Employment Priority and Integration of Industry and Education”

In the new era of building a socialist modernization country with the goal of promoting high-quality development,we deeply analyze the knowledge system of the Introduction to Architecture course.This analysis is based on the cross-disciplinary specialties of local applied universities and the orientation of prioritizing employment and integrating industry and education.We propose the teaching reform of“theory-practice alternation”which is adapted to the current times and societal needs.Finally,we comprehensively summarize the effectiveness of curriculum construction,in order to provide theoretical references for the implementation of fostering character and civic virtue and deepening the reform of collaborative education mechanisms.

Average Secrecy Capacity of the Reconfigurable Intelligent Surface-Assisted Integrated Satellite Unmanned Aerial Vehicle Relay Networks

Integrated satellite unmanned aerial vehicle relay networks(ISUAVRNs)have become a prominent topic in recent years.This paper investigates the average secrecy capacity(ASC)for reconfigurable intelligent surface(RIS)-enabled ISUAVRNs.Especially,an eve is considered to intercept the legitimate information from the considered secrecy system.Besides,we get detailed expressions for the ASC of the regarded secrecy system with the aid of the reconfigurable intelligent.Furthermore,to gain insightful results of the major parameters on the ASC in high signalto-noise ratio regime,the approximate investigations are further gotten,which give an efficient method to value the secrecy analysis.At last,some representative computer results are obtained to prove the theoretical findings.

Exploring the Element Integration of Urban and Rural“Space of Flows”in the Context of Consumption Upgrading:A Case Study of Changsi Village in Anhui Province

The mobility and interaction between urban and rural areas are becoming more and more intensive,and their links and exchanges are increasingly closer due to constant flow of factors such as information,capital,personnel and technology.In this context,the element integration of urban and rural“space of flows”can promote the integrated development of urban and rural areas,improve the consumption environment and experience,and promote the industrial upgrading and technological progress.To realize the element integration of urban and rural“space of flows”,it is necessary to explore and innovate in infrastructure construction,information technology application,industrial cooperation and cultural exchanges.Government departments,enterprises and social organizations also need to work together to give play to their respective advantages and jointly promote the process of element integration of urban and rural“space of flows”.

Integration, Leading and Empowerment: Folk Culture Boosting the Development of Henan's Tourism Economy

During Chinese New Year holiday,characteristic folk customs activities significantly stimulated local tourism consumption potential and the high-quality development of tourism economy by integrating,leading and empowering local tourism projects.

High-quality Development of the Pearl River Night Tour in the Context of Deep Integration of Culture and Tourism

Urban night tourism is a new form of urban tourism development and an important driving force for the prosperity of urban night economy.As the most prestigious business card among many night tour projects in Guangzhou,the Pearl River water night tour has contributed to the development of Guangzhou s night economy,which cannot be underestimated.However,in the process of rapid development,there are also problems such as diversified operators,insufficient integration of intangible cultural elements,excessive commercial attributes,issues of tourism facilities and service facilities.Under the new stage of integrated development of culture and tourism,how to use mutual promotion of culture and tourism in the Pearl River night tour to seek innovative paths for high-quality development in the future is the main problem expected to be solved in this paper.Therefore,based on the perspective of culture and tourism integration,this paper analyzes the general situation and development status of the Pearl River night tour,and proposes five development strategies:the overall planning of culture and tourism integration,the deep integration of intangible cultural elements,the balance of commercial attributes and tourism attributes,the high integration of culture,business,tourism and education,and the creation of tourism atmosphere,in order to provide inspiration for the healthy,orderly and high-quality development of the Pearl River night tour.

Research on the Comparison and Integration of Chinese and Western Music Cultures

This research undertakes a nuanced examination of the intersections and distinctions between these two diverse musical traditions.Employing a meticulous comparative analysis,the study scrutinizes fundamental musical elements such as scales,modes,and compositional styles,illuminating shared threads and distinctive attributes that characterize Chinese and Western music.Against the backdrop of contemporary global dynamics,the research investigates the ongoing integration of these musical cultures.It explores the impact of globalization and technological advancements,revealing instances of cross-cultural collaboration and the emergence of hybrid musical forms.Augmenting theoretical discussions with concrete case studies,the paper offers illuminating examples of how Chinese and Western musical elements interweave,contributing to the evolving landscape of global music.This research not only advances scholarly understanding but also contributes practical insights for musicians,educators,and enthusiasts navigating the evolving dynamics of cross-cultural musical expression.By elucidating the intricate relationship between Chinese and Western music cultures,the paper underscores the richness borne out of their interaction and the cultural synthesis that defines contemporary musical landscapes.

Exploration of the Construction and Path Selection of the Deep Integration Model of Industry-Education in Universities

Against the backdrop of continuous development in the field of education,universities are encouraged to innovate their talent cultivation systems and objectives.The deep integration of industry and education has emerged as an effective strategy,aligning with the basic requirements of the new engineering education initiative and exerting a positive impact on socioeconomic development.However,an analysis of the current state of industry-education integration in universities reveals several issues that require optimization,affecting the ultimate effectiveness of integration.To optimize this phenomenon and achieve high-quality development,universities need to further explore the construction of a deep integration model of industry and education,adhering to corresponding principles to form a comprehensive system.On this basis,pathways for deep industry-education integration can be summarized.

A Study on the Integration of Chinese Culture in High School English Teaching

The inseparable relationship between language and culture indicates that culture teaching is indispensable in English teaching.The ultimate goal of culture teaching in English teaching is to cultivate learners’cross-cultural communication skills.Cross-cultural communication is a two-way process,which requires not only knowledge of English culture but also the use of English as a medium for disseminating Chinese culture to the outside world.However,in actual English teaching,the teaching of Chinese culture is a mere formality,and the teaching effect is not obvious.Therefore,it is necessary to conduct a survey and research on Chinese culture teaching in high school English classrooms to understand its current situation,existing problems,and their causes,so as to provide suggestions for Chinese culture teaching in high school.

The Impact of Industry-Education Integration on College Students’ Motivation to Learn English under the TPACK Framework

This paper explores the impact of industry-education integration on students’motivation in college English courses under the TPACK(Technological Pedagogical Content Knowledge)framework using a comprehensive approach combining quantitative and qualitative methods.Quantitative data analysis indicates a significant positive correlation between the perception of industry-education integration and the level of student learning motivation.There is also a clear association between the perception scores of TPACK framework integration and learning motivation.Qualitative data analysis reveals students’positive experiences and recognition of the TPACK framework integration in practical application projects.The study concludes that industry-education integration and the TPACK framework play a crucial role in enhancing students’learning motivation.It suggests optimizing teaching practices through faculty training,designing practical application projects,and promoting student interaction.This comprehensive analysis provides substantial guidance for the future development of English courses.

Exploration of Innovation Strategy in the Deep Integration of Information Technology and Education and Teaching

The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.

Research on the Deep Integration Mechanism of National Fitness Campaign and College Physical Education Teaching:Taking Guangdong University of Science and Technology as an Example

By using the methods of literature review,questionnaire survey,and expert interview,this paper discusses and analyzes the deep integration mechanism of national fitness campaign and college physical education teaching,in order to promote the development of college physical education teaching reform,expand ideas,explore new fields,and provide novel development directions.The purpose is to enhance the national physical quality,improve the public service system,enhance the health awareness of the citizens,and provide guidelines for promoting the development of sports.

Exploration of the Mining of Ideological and Political Elements and Teaching Integration of Bridge Engineering Courses in Applied Undergraduate Programs

The questions of what kind of individuals university education should cultivate,how to cultivate them,and for whom they are being trained are pressing issues that require immediate solutions.Implementing ideological and political education is a fundamental way to address these challenges.Integrating political education into professional courses is just as important as imparting knowledge,fostering interest,transmitting values,and shaping students’character and spirit.The excavation of ideological and political elements in bridge engineering courses should comprehensively consider the dependent subject of ideological and political elements,the source of cases,the depth of excavation,the trade-offs between courses,the commonality and multifaceted nature of ideological and political elements,as well as the two ways of ideological and political elements integration.Ideological and political elements should be integrated into all stages of classroom lectures,course assignments,final examinations,course design,discipline competitions,school-enterprise cooperation,etc.,so as to achieve the effect of educating people in the whole process.