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Institutions and Intellectuals That Configure the Concept of the Environment and Development in Latin America and Its Global Impact 被引量:1
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作者 Fernando Estenssoro Eduardo Déves 《Journal of Environmental Protection》 2013年第9期1002-1010,共9页
This paper is part of a research into the Latin American thinking on international affairs and a continuation of a line of work on Latin American contributions to the environmental discussion installed in the global p... This paper is part of a research into the Latin American thinking on international affairs and a continuation of a line of work on Latin American contributions to the environmental discussion installed in the global political agenda in the early 70s. The premise was that Latin American contributions were initially made by professionals closely related to ECLAC, UNEP and the Bariloche Foundation. These professionals and agencies understood how poverty and backwardness were endured by the majority of the regional and world’s population was one of the main causes of environmental degradation;consequently, overcoming the environmental crisis meant that underdevelopment should be eradicated without delay. This view of the environmental problems was synthesized in the combined concept of “environment and development”, which was also understood in the region as “eco development”. Finally, the broad phenomenon they wanted to describe using the terms “environment and development” was summarized in the concept of sustainable development as defined in the 1987 World Commission on Environment and Development report “Our Common Future”. 展开更多
关键词 Environment and DEVELOPMENT Environmental CRISIS LATIN American intellectuals World POLITICS
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Characterization of Intellectuals in Short Stories ofNam Cao (Viemam) and Lu Xun (China)
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作者 Van-Dau Quach 《Journal of Literature and Art Studies》 2016年第8期895-900,共6页
Nam Cao and Lu Xun are among high-profile writers who gain wide appreciation. The movements of literary assert this over the latter half of recent century in our country. That reality persistently points us to an urge... Nam Cao and Lu Xun are among high-profile writers who gain wide appreciation. The movements of literary assert this over the latter half of recent century in our country. That reality persistently points us to an urgent need for researches on Nam Cao and Lu Xun. Tints of literary worldviews of Nam Cao and Lu Xun, though upon which numberless research works, both domestic and foreign, have provided multi-directional insights and exploration of artistic creativities, remain misevaluated. B ich Thu, the author of Nam Cao, His Life and Legacies, counted out 191 articles and books themed Nam Cao. They were edited by writers of Nam Cao's generation namely Nguyen Huy Tuong, Nguyen Dinh Thi, To Hoai and Nguyen Hong, and even distinguished scholars such as Ha Minh Duc, Phong Le and Nguyen Dang Manh, so on. Regarding Lu Xun, there is no denying the fact of his brilliant artistic ideology. Although Vietnamese readers have gained a late knowledge of him for just a half of century, his name is laid somewhere in the heart of our people, integrally and consistently. Vietnam's reader generations restlessly learn about and research on Lu Xun. A pioneering merit badge should be rewarded to the renowned literary critic Dang Thai Mai, for his introduction and translation of Lu Xun to Vietnamese readers since 1943. The most interesting coincidence of Nam Cao and Lu Xun is that their profiles are imbued with the characters in their compositions. Mentioning Lu Xun cannot help a reference to AQ, meanwhile the name ofNam Cao apparently recalls a Philistine Chi. AQ as well as Philistine Chi have become characters of the society's spiritual life and long live with the eternal brilliance of their two creators. That coincidence draws countless number of researchers. The "matching point", referring to the subject of farmers and intellectuals, between Nam Cao and Lu Xun's works has been explored to some certain extent. This elicitly invites us for deeper studies. The author of this article, in response to such invitation, delves into the subject with respect to characterization of intellectuals in Nam Cao and Lu Xun's short stories. 展开更多
关键词 Nam Cao Lu Xun intellectuals CHARACTERIZATION short stories
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Industrialization and Transformation of Chinese Intellectuals
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《中山大学学报论丛》 1996年第3期132-143,共12页
ndustrializationandTransformationofChineseIntelectualsGaoWenping1.OutofPalace,OutofGraceAmbivalenceaboutSel... ndustrializationandTransformationofChineseIntelectualsGaoWenping1.OutofPalace,OutofGraceAmbivalenceaboutSelfIdentityThrough... 展开更多
关键词 TRANSFORMATION and intellectuals CHINESE INDUSTRIALIZATION
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Intellectuals in Chinese Novels at the Dawn of the 21st Century
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作者 MENG Fanhua Jian'e Ling(Translated) 《Journal of Foreign Languages and Cultures》 2024年第1期111-121,共11页
The dawn of the 21st century saw images of intellectuals in novels change in a drastic way.Intellectuals,and those in the humanities in particular,are no longer portrayed as privileged Enlightenment thinkers or sages ... The dawn of the 21st century saw images of intellectuals in novels change in a drastic way.Intellectuals,and those in the humanities in particular,are no longer portrayed as privileged Enlightenment thinkers or sages with Confucian ideas of salvation.In the novels that take intellectuals as their subject matters,such characters often end up involved in betrayal,self-exile,or spiritual/mortal death.This is not a historical process,nor an inevitable course for intellectuals to be sure,but it remains a legitimate question to ask why these fictional intellectuals are becoming,more often than not,new tragic heroes.Why are they becoming misfits in their society and ending up in exile,abandonment,and even death?The present paper examines different images of intellectuals and the makings of their destinies. 展开更多
关键词 contemporary Chinese literature NOVELS intellectuals
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Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders 被引量:3
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作者 Helen M.Knight Merve DemirbugenÖz Adriana PerezGrovas-Saltijeral 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1256-1261,共6页
The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms.Methylation of N6 adenosine(m^(6)A)and C5 cytosine(m^(5)C)bases occur on mRNA... The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms.Methylation of N6 adenosine(m^(6)A)and C5 cytosine(m^(5)C)bases occur on mRNAs,tRNA,mt-tRNA,and rRNA species as well as non-coding RNAs.With emerging knowledge of RNA binding proteins that act as writer,reader,and eraser effector proteins,comes a new understanding of physiological processes controlled by these systems.Such processes when spatiotemporally disrupted within cellular nanodomains in highly specialized tissues such as the brain,give rise to different forms of disease.In this review,we discuss accumulating evidence that changes in the m^(6)A and m^(5)C methylation systems contribute to neurocognitive disorders.Early studies first identified mutations within FMR1 to cause intellectual disability Fragile X syndromes several years before FMR1 was identified as an m^(6)A RNA reader protein.Subsequently,familial mutations within the m^(6)A writer gene METTL5,m^(5)C writer genes NSUN2,NSUN3,NSUN5,and NSUN6,as well as THOC2 and THOC6 that form a protein complex with the m^(5)C reader protein ALYREF,were recognized to cause intellectual development disorders.Similarly,differences in expression of the m^(5)C writer and reader effector proteins,NSUN6,NSUN7,and ALYREF in brain tissue are indicated in individuals with Alzheimer's disease,individuals with a high neuropathological load or have suffered traumatic brain injury.Likewise,an abundance of m^(6)A reader and anti-reader proteins are reported to change across brain regions in Lewy bodies diseases,Alzheimer's disease,and individuals with high cognitive reserve.m^(6)A-modified RNAs are also reported significantly more abundant in dementia with Lewy bodies brain tissue but significantly reduced in Parkinson's disease tissue,whilst modified RNAs are misplaced within diseased cells,particularly where synapses are located.In parahippocampal brain tissue,m^(6)A modification is enriched in transcripts associated with psychiatric disorders including conditions with clear cognitive deficits.These findings indicate a diverse set of molecular mechanisms are influenced by RNA methylation systems that can cause neuronal and synaptic dysfunction underlying neurocognitive disorders.Targeting these RNA modification systems brings new prospects for neural regenerative therapies. 展开更多
关键词 5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification
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Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory 被引量:2
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作者 Baicheng Zhao Hang Zhang +5 位作者 Ying Liu Gaoyu Zu Yuxiao Zhang Jiayi Hu Shuai Liu Linya You 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1133-1141,共9页
Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/7.Brpf1,K... Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/7.Brpf1,KAT6A,and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual disability.Our previous work revealed strong and specific expression of Brpf1 in both the postnatal and adult forebrain,especially the hippocampus,which has essential roles in learning and memory.Here,we hypothesized that Brpf1 plays critical roles in the function of forebrain excitatory neurons,and that its deficiency leads to learning and memory deficits.To test this,we knocked out Brpf1 in forebrain excitatory neurons using CaMKIIa-Cre.We found that Brpf1 deficiency reduced the frequency of miniature excitatory postsynaptic currents and downregulated the expression of genes Pcdhgb1,Slc16a7,Robo3,and Rho,which are related to neural development,synapse function,and memory,thereby damaging spatial and fear memory in mice.These findings help explain the mechanisms of intellectual impairment in patients with BRPF1 mutation. 展开更多
关键词 behavioral test Brpf1 CAMKIIa-Cre intellectual disability miniature excitatory postsynaptic current MRNA-SEQ
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Transcriptional regulation in the development and dysfunction of neocortical projection neurons 被引量:1
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作者 Ningxin Wang Rong Wan Ke Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期246-254,共9页
Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord... Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations. 展开更多
关键词 autism spectrum disorders COGNITION DIFFERENTIATION excitatory circuits intellectual disability NEOCORTEX neurodevelopmental disorders projection neuron specification transcriptional regulation
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基于数据挖掘技术的税务风险检测方法评述
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作者 Qinghua Zheng Yiming Xu +3 位作者 Huixiang Liu Bin Shi Jiaxiang Wang Bo Dong 《Engineering》 SCIE EI CAS CSCD 2024年第3期43-59,共17页
Tax risk behavior causes serious loss of fiscal revenue,damages the country’s public infrastructure,and disturbs the market economic order of fair competition.In recent years,tax risk detection,driven by information ... Tax risk behavior causes serious loss of fiscal revenue,damages the country’s public infrastructure,and disturbs the market economic order of fair competition.In recent years,tax risk detection,driven by information technology such as data mining and artificial intelligence,has received extensive attention.To promote the high-quality development of tax risk detection methods,this paper provides the first comprehensive overview and summary of existing tax risk detection methods worldwide.More specifi-cally,it first discusses the causes and negative impacts of tax risk behaviors,along with the development of tax risk detection.It then focuses on data-mining-based tax risk detection methods utilized around the world.Based on the different principles employed by the algorithms,existing risk detection methods can be divided into two categories:relationship-based and non-relationship-based.A total of 14 risk detection methods are identified,and each method is thoroughly explored and analyzed.Finally,four major technical bottlenecks of current data-driven tax risk detection methods are analyzed and discussed,including the difficulty of integrating and using fiscal and tax fragmented knowledge,unexplainable risk detection results,the high cost of risk detection algorithms,and the reliance of existing algorithms on labeled information.After investigating these issues,it is concluded that knowledge-guided and datadriven big data knowledge engineering will be the development trend in the field of tax risk in the future;that is,the gradual transition of tax risk detection from informatization to intelligence is the future development direction. 展开更多
关键词 Tax risk detection Data mining Knowledge guide INFORMATIZATION Intellectualization
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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system
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作者 Lin Yin Yalan Xu +9 位作者 Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li 《Neural Regeneration Research》 SCIE CAS 2025年第8期2420-2432,共13页
The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKS... The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully understood.Research has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic spines.However,the function of CNKSR2 in the cytoplasm remains to be elucidated.In this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of CNKSR2.Through a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the centrosome.We also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker CEP290.Subsequent colocalization analysis confirmed the centrosomal localization of CNKSR2.When we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal genes.This manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and motility.Furthermore,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum disorder.Our findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders. 展开更多
关键词 autism spectrum disorder CENTROSOME CNKSR2 intellectual disability INTERACTOME mass spectrometry MICROTUBULE neurodevelopmental disease protein complexes protein-protein interactions
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元宇宙视域下的IP运营研究:概念层次、风险机制和口碑传播
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作者 方凌智 唐柳 《新闻爱好者》 2024年第3期93-96,共4页
元宇宙的出现推动了文化数字化的进程,通过整理相关文献可以看出,现有的IP研究依旧存在若干理论缺口。首先,鲜有研究针对IP具体提炼出其在运营过程中存在的风险机制,以及对口碑造成的影响。其次,目前研究也依旧缺乏对IP的概念化讨论。因... 元宇宙的出现推动了文化数字化的进程,通过整理相关文献可以看出,现有的IP研究依旧存在若干理论缺口。首先,鲜有研究针对IP具体提炼出其在运营过程中存在的风险机制,以及对口碑造成的影响。其次,目前研究也依旧缺乏对IP的概念化讨论。因此,对在元宇宙视域下IP运营和概念化的深化研究十分必要。使用深入访谈法,访谈了35名IP粉丝,IP概念的三个层次得以提炼,包括作为基础的知识产权、延伸的文化品牌和进阶的元宇宙。同时探讨了在元宇宙时代,IP运营中出现的风险机制和口碑传播机制。 展开更多
关键词 IP(Intellectual Property) IP运营 元宇宙 文化数字化 口碑传播
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The Role of Music Therapy in Supporting Intellectually Disabled Youth in Senegal
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作者 Raymond Birane Youm Kadidiatou Diarra +1 位作者 Mathias Pouye Jean Augustin Diégane Tine 《Health》 2024年第5期521-534,共14页
Introduction: Music therapy is a practice for helping and supporting people with intellectual and relational difficulties. This study illustrated the benefits of music therapy for young people living with intellectual... Introduction: Music therapy is a practice for helping and supporting people with intellectual and relational difficulties. This study illustrated the benefits of music therapy for young people living with intellectual disabilities (YLID) in an African context. Methodology: This study investigated six young individuals with intellectual disabilities who had undergone three years of music therapy. They were participants in the inclusive non-academic training program at the National School of Arts in Dakar from 2017 to 2019. Data collection utilized individual interviews with the youths, evaluation grids from teachers and psychiatrists. Guardians provided informed consent along with the assent of the young participants. Results: The six young were aged between 18 and 30 years old, with an average age of 24.6 years. Four of the YLID were male. Three young people with intellectual disabilities had delayed psychomotor development. Observations revealed the beneficial influence of music therapy on the health and well-being of young individuals. Music played a role in alleviating stress and anxiety among youth with intellectual disabilities (YLID), enhancing their mood and mental health. It assisted in navigating challenging situations and heightened alertness among YLID. Additionally, music therapy contributed to improvements in dyslexia, fine and gross motor skills, and memory development among intellectually disabled youth, ultimately facilitating their integration into society. Conclusion: In light of our results, music therapy makes a major contribution to the empowerment of YLID. Engaging in musical activities helps young people connect with others through instrumental expression and a sense of accomplishment. By facilitating music therapy, it becomes possible to combat discrimination and stigmatization, thus promoting the social inclusion of intellectually disabled youth. Therefore, it is important to promote music therapy in Senegal to meet the needs of YLID. 展开更多
关键词 Music Therapy YOUNG Intellectual Disabilities Senegal
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Promoting High-quality Development of Grain and Oil in Ethnic Areas of the Yangtze River Economic Belt from the Perspective of Agricultural Power
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作者 Li GAO Jianjun ZHANG +2 位作者 Yuanpeng SUN Zhiyang LIU Zhiguo SUN 《Asian Agricultural Research》 2024年第2期1-7,11,共8页
Accelerating the construction of agricultural power,further promoting the high-quality development of the Yangtze River Economic Belt,and better supporting and serving Chinese-style modernization are the key issues at... Accelerating the construction of agricultural power,further promoting the high-quality development of the Yangtze River Economic Belt,and better supporting and serving Chinese-style modernization are the key issues at present.This paper first introduces the Yangtze River Economic Belt and its ethnic areas,and studies the characteristics of the grain and oil industry in the ethnic autonomous areas of the economic belt,as well as the current situation of various types of intellectual property resources,such as industrial cultural heritage,scientific and tech-nological innovation,and brand marking intellectual property.Besides,it analyzes the main problems in the high-quality development of grain and oil in the Yangtze River Economic Belt ethnic areas.Finally,it comes up with recommendations,including protecting the intellectual prop-erty rights of cultural heritage in the field of grain and oil,leading the inheritance and development of excellent traditional Chinese culture,use scientific and technological innovation intellectual property rights to promote the innovation-driven development strategy of the grain and oil in-dustry,and providing counterpart assistance to ethnic autonomous areas in the Yangtze River Economic Belt to further promote the high-quality development of the Yangtze River Economic Belt. 展开更多
关键词 The Yangtze River Economic Belt Ethnic areas Grain and oil Intellectual property Agricultural power
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Scientific Data Intellectual Property Research by Literature Statistics
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作者 ZHANG Jia WANG Xirong 《Cultural and Religious Studies》 2024年第2期87-94,共8页
The main obstacle to the open sharing of scientific data is the lack of a legal protection system for intellectual property.This article analyzes the progress of research papers on intellectual property in scientific ... The main obstacle to the open sharing of scientific data is the lack of a legal protection system for intellectual property.This article analyzes the progress of research papers on intellectual property in scientific data in China through literature search and statistics.Currently,research subjects are unbalanced,research content is uneven,research methods are intellectual single,and research depth is insufficient.It is recommended that different stakeholders engage in deep cross disciplinary cooperation,further improve China’s legal and policy protection system for scientific data intellectual property,and promote the open sharing of scientific data. 展开更多
关键词 scientific data intellectual property BIBLIOMETRICS STAKEHOLDERS INTERDISCIPLINARY
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Associated Factors of Dental Caries among Intellectually Disabled Persons in Specialized Centers of Ouagadougou
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作者 Jocelyne Valerie Gare Filwende Dan Kientega +3 位作者 Ouedraogo Carole Nathaie Tenin Ouattara Seydou Kabore Wendpoulomde Aime Désire Nicolas Meda 《Open Journal of Epidemiology》 2024年第2期297-311,共15页
Introduction: Several studies have reported a high prevalence of dental caries among the people with intellectual disabilities. In order to identify the sociodemographic, clinical and behavioral factors associated wit... Introduction: Several studies have reported a high prevalence of dental caries among the people with intellectual disabilities. In order to identify the sociodemographic, clinical and behavioral factors associated with it, we conducted a study in specialized centers welcoming subjects with intellectual disabilities in Ouagadougou (Burkina Faso). Objectives: The objective of this study was to identify the factors associated with it among intellectually disabled in the specialized centers of Ouagadougou. Methods: The study was cross-sectional analytical. The survey took place between November 2020 and January 2021 among people with intellectual disabilities in reception centers receiving a grant from the Ministry of Women, National Solidarity, Family and Humanitarian Action. Data collection was done with a questionnaire adapted from the World Health Organization (WHO) and dental caries was recorded according to WHO criteria in decayed, missing or filled teeth generating a DMF index. Logistic regression was used to identify factors associated with the presence of dental caries. Results: A total of 193 participants were included in the study with an average age of 12.4 years ± 7.9. The overall prevalence of caries measured with the DMF index was 58.6% 95% CI [51.2 - 65.8]. It was significantly associated with female gender (OR = 4.2;95% CI [1.4 - 12.5], p = 0,01), the clinical form of mental illness (epilepsy OR = 3.8 95%;CI [1.2 - 12.7], p = 0,02, trisomy OR = 5.0;95% CI [1.1 - 22.9], p = 0,03, motor autonomy OR = 0.2 95%;CI [0.1 - 0.7], p = 0,01) and at use of toothpaste OR = 9.33;95% CI [1.05 - 82.7], p = 0,04. Conclusion: Dental caries remains a very present pathology in most people living with an intellectual disability. Also, it is necessary to put in place prevention strategies to reduce its prevalence and improve access to oral care for these people. 展开更多
关键词 Dental Caries Mental Disability Intellectual Disability Associated Factors OUAGADOUGOU
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Understanding Behavioral Manifestations of Obsessive-Compulsive Disorder in People with Intellectual Disabilities—A Qualitative Study
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作者 Lena Grüter Matthias Grünke 《Open Journal of Psychiatry》 2024年第2期67-90,共24页
Background: There is limited knowledge about obsessive-compulsive disorder (OCD) in people with intellectual disabilities (IDs). This paper describes the manifestation of compulsive behaviors associated with OCD at th... Background: There is limited knowledge about obsessive-compulsive disorder (OCD) in people with intellectual disabilities (IDs). This paper describes the manifestation of compulsive behaviors associated with OCD at the behavioral level in people with ID in institutionalized settings. The aim was to gain nuanced insight into appropriate understanding and classification in this specific context, and derive implications for research and practice. Methods: Individual cases of people with ID (n = 7) were studied to assess compulsive symptoms through two days of on-site observation of the person with ID within the institution, guided group discussions (n = 28), and semi-structured interviews with key informants and caregivers of the person with ID (n = 20). Caregiver ratings of the compulsive behavior checklist were compiled. Data were analyzed using qualitative content analysis. Results: All forms of OCD were present. Characteristics of compulsive behaviors in people with ID at the behavioral level included less complex and more obvious compulsive acts, immediate responses, signs of tension, motor restlessness, facial expression changes, repetition, need for predictability, time-consuming behaviors, and aggressive reactions when these acts were interrupted. Some of the compulsive behaviors corresponded to the ICD-11 OCD code 6B20, and others to compulsions as a psychological symptom (MB23.4). Conclusions: OCD may manifest atypically at the behavioral level in people with ID, posing significant challenges for accurate classification due to symptom ambiguity. Follow-up differential diagnostic studies are needed to more accurately identify and differentiate OCD symptoms in people with ID. Further, disorder-specific guidelines for recognizing OCD in people with ID are needed for institutionalized settings without psychiatric-psychotherapeutic expertise. 展开更多
关键词 People with Intellectual Disabilities Obsessive-Compulsive Disorder Compulsive Behavior DIAGNOSTICS Differential Diagnosis
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Application of Automation and Intellectualization Technology in Steelmaking Plant
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作者 Yue Li Danjing Zhen 《Frontiers of Metallurgical Industry》 2024年第1期19-22,共4页
Steelmaking plant of Fujian San Gang min Guang Co.,Ltd.is keeping pace with the trend of the times.Under the new situation that the labor cost is rising day by day.Constantly introducing intelligent technology to impr... Steelmaking plant of Fujian San Gang min Guang Co.,Ltd.is keeping pace with the trend of the times.Under the new situation that the labor cost is rising day by day.Constantly introducing intelligent technology to improve the level of automation operation and reducing labor intensity of staff and workers.Especially under the support of MES information system.Advanced and practical technology is adopted in converter,refining and continuous casting process.In recent years,production management and control,energy management and control,material tracking,cost control and equipment operation and maintenance and reducing personnel to new achieve-ments in reducing personnel. 展开更多
关键词 Intellectual technology Automtic level CONVERTER continuous casting REFINING
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The Death of an Auteur:Qiu Huadong’s Confessionat Noon and the Spiritual Crisis of Intellectuals
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作者 Fang-yu LI 《Frontiers of Literary Studies in China-Selected Publications from Chinese Universities》 2020年第1期76-98,共23页
Written by Qiu Huadong in 2000,Confession at Noon(Zhengwu de gongci)is a novel about the life of a renowned auteur one year after his suicide.Set at the end of the twentieth century,the story highlights the social and... Written by Qiu Huadong in 2000,Confession at Noon(Zhengwu de gongci)is a novel about the life of a renowned auteur one year after his suicide.Set at the end of the twentieth century,the story highlights the social and political change of the 1990s and its impact on the spiritual condition of intellectuals.The novel also addresses the changing role of writers as they confront new challenges presented by the rapid modernization and economic progress at the turn of the century.In this paper,I illustrate the ways in which Qiu unravels the spiritual agony of intellectuals through the portrayal of a film director’s dramatic life.I focus particularly on how Qiu uses narrative devices such as intertexuality and pastiche to illuminate the spiritual crisis and changing social position of intellectuals in the 1990s,and how he inserts fictional selves in the storytelling process to rethink his role as a writer-intellectualin the new era. 展开更多
关键词 QIU Huadong intellectuals WRITERS identity SPIRITUAL CRISIS
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The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms
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作者 Zhe Xu Zi-Xin Li +3 位作者 Zi-Yao Geng Rong-Li Shu Hui-Fang Zhou Yu-Hong Bian 《Pharmacology Discovery》 2024年第1期21-30,共10页
Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the world.Traditional Chinese medicine(TCM)formulae have played an important role in the prevention and treatmen... Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the world.Traditional Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of COVID-19.WHO evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM formulae.However,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those formulae.Methods:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association rules.We then determined the BC-TCM and screened main compounds and therapeutic targets.Finally,the potential molecular mechanisms were explored by using enrichment analyses and molecular docking.Results:This study screened 123 patented TCM formulae,including 312 herbs.According to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie Geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the BC-TCM.The BC-TCM involved 166 main compounds and 48 therapeutic targets.The active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking results.Interestingly,Hederagenin might be a potential compound for the prevention and treatment of COVID-19.Conclusion:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on COVID-19.This has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research. 展开更多
关键词 COVID-19 traditional Chinese medicine China national intellectual property administration data mining network pharmacology
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Iranian Intellectuals on“Islam and Democracy”Compatibility:Views of Abdulkarim Soroush and Hasan Yousuf Eshkevari
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作者 Tauseef Ahmad PARRAY 《Asian Journal of Middle Eastern and Islamic Studies》 2013年第3期43-64,I0003,共23页
Islam-democracy discourse,a hotly debated topic and a burning issue,has highly intensified over the last few decades and throughout the world with several Muslim thinkers/intellectuals having taken strides to shape Mu... Islam-democracy discourse,a hotly debated topic and a burning issue,has highly intensified over the last few decades and throughout the world with several Muslim thinkers/intellectuals having taken strides to shape Muslim understanding of“Islamic democracy”.To offer a new direction and advance this discourse some steps further,this paper seeks to address this issue in the thought and writings,by way of a comparative study,of two prominent intellectuals of Iran:Abdulkarim Soroush(b.1945),who sees no contradiction between Islam and the freedoms inherent in democracy,and Hasan Yousuf Eshkevari(b.1949/50),who is at the forefront of articulating the relationship between Islam and democracy.The essay argues that(i)the efforts of Soroush and Eshkevari,along with those of many other religious reformist intellectuals and political activists,have collectively given rise to a vibrant,intellectually sophisticated,and expansive discourse of Islamic reformism;(ii)although,theoretically,there is no doubt in the argument that Islam and democracy are indeed compatible(on many grounds),there is lack and scarcity of literature on the practical framework/implementation of this envisioned formula of“Islamic democracy”—a challenge still faced by Muslim political theorists especially in the 21st century. 展开更多
关键词 Islam-Democracy Compatibility Iranian intellectuals Abdulkarim Saroush Hasan Yousuf Eshkevari Islamic Democracy
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Cyberattack Ramifications, The Hidden Cost of a Security Breach
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作者 Meysam Tahmasebi 《Journal of Information Security》 2024年第2期87-105,共19页
In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term ... In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain. 展开更多
关键词 Artificial Intelligence (AI) Business Continuity Case Studies Copyright Cost-Benefit Analysis Credit Rating Cyberwarfare Cybersecurity Breaches Data Breaches Denial Of Service (DOS) Devaluation Of Trade Name Disaster Recovery Distributed Denial of Service (DDOS) Identity Theft Increased Cost to Raise Debt Insurance Premium Intellectual Property Operational Disruption Patent Post-Breach Customer Protection Recovery Point Objective (RPO) Recovery Time Objective (RTO) Regulatory Compliance Risk Assessment Service Level Agreement Stuxnet Trade Secret
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