Engineering of smart building molecules is key basis in designing intelligent drug delivery systems.As an emerging sophisticated delivery system strategy,the powerful functions of peptide drug conjugates(PDCs)are attr...Engineering of smart building molecules is key basis in designing intelligent drug delivery systems.As an emerging sophisticated delivery system strategy,the powerful functions of peptide drug conjugates(PDCs)are attributed to a smart linker and multifunctional peptide domain.Peptides exhibit a wide range of functions and properties,including easy chemical synthesis and versatile modification,tunable biocompatibility,diversified self-assembled nanostructures,specific recognition/binding,and deep penetration of the cell membrane/extracellular matrix.In addition,various types of linkers enable PDCs to release drugs responsively according to the disease microen-vironment or treatment needs.Owing to these inherent advantages,PDCs have been widely explored for drug delivery.Herein,the latest developments in functional peptides and linkers commonly used to construct smart PDCs are reviewed.The purpose is to bring widespread attention to PDC design strategies and their contribution to fighting various diseases,as well as to provide guidance for research on intelligent PDC drug delivery systems.展开更多
Hollow mesoporous silica nanoparticles(HMSNs)have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties,large specific surface area and facile functional...Hollow mesoporous silica nanoparticles(HMSNs)have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties,large specific surface area and facile functionalization,especially made into intelligent drug delivery systems(DDSs)for cancer therapy.HMSNS are employed to transport traditional anti-tumor drugs,which can solve the problems of drugs with instability,poor solubility and lack of recognition,etc.,while significantly improving the anti-tumor effect.And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment.Actually,HMSNs-based DDSS have developed relatively mature in recent years.This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS,as well as its degradation,different stimuli-responses,targets and combination therapy.These versatile intelligent nanoparticles show great potential in clinical aspects.展开更多
基金supported by National Natural Science Foundation of China(No.82173992,81773662,81973488,81804100)National Key R&D program of China(2018YFC1706905)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX_201491).
文摘Engineering of smart building molecules is key basis in designing intelligent drug delivery systems.As an emerging sophisticated delivery system strategy,the powerful functions of peptide drug conjugates(PDCs)are attributed to a smart linker and multifunctional peptide domain.Peptides exhibit a wide range of functions and properties,including easy chemical synthesis and versatile modification,tunable biocompatibility,diversified self-assembled nanostructures,specific recognition/binding,and deep penetration of the cell membrane/extracellular matrix.In addition,various types of linkers enable PDCs to release drugs responsively according to the disease microen-vironment or treatment needs.Owing to these inherent advantages,PDCs have been widely explored for drug delivery.Herein,the latest developments in functional peptides and linkers commonly used to construct smart PDCs are reviewed.The purpose is to bring widespread attention to PDC design strategies and their contribution to fighting various diseases,as well as to provide guidance for research on intelligent PDC drug delivery systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.51773162 and 21204071).
文摘Hollow mesoporous silica nanoparticles(HMSNs)have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties,large specific surface area and facile functionalization,especially made into intelligent drug delivery systems(DDSs)for cancer therapy.HMSNS are employed to transport traditional anti-tumor drugs,which can solve the problems of drugs with instability,poor solubility and lack of recognition,etc.,while significantly improving the anti-tumor effect.And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment.Actually,HMSNs-based DDSS have developed relatively mature in recent years.This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS,as well as its degradation,different stimuli-responses,targets and combination therapy.These versatile intelligent nanoparticles show great potential in clinical aspects.
