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益母草注射液通过其生物碱成分上调Tie-2、VEGFR2和VEGF促进斑马鱼血管新生
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作者 李玉芝 宋肖敏婷 +4 位作者 王雯雯 周欣雨 黎娅琳 任吉霞 曹治兴 《聊城大学学报(自然科学版)》 2024年第1期85-91,共7页
目的:研究益母草注射液在斑马鱼血管损伤模型中的促血管生成作用,并阐明潜在的物质基础和分子机制。方法:采用HPLC-PAD和TLC技术检测益母草注射液的主要成分;利用舒尼替尼诱导转基因Tg(flk1:eGFP)斑马鱼血管损伤模型,益母草注射液干预... 目的:研究益母草注射液在斑马鱼血管损伤模型中的促血管生成作用,并阐明潜在的物质基础和分子机制。方法:采用HPLC-PAD和TLC技术检测益母草注射液的主要成分;利用舒尼替尼诱导转基因Tg(flk1:eGFP)斑马鱼血管损伤模型,益母草注射液干预治疗后,测量斑马鱼节间血管(ISVs)长度,QT-PCR检测血管生成相关基因的表达水平。结果:发现益母草注射液的主要成分是水苏碱、胆碱和葫芦巴碱;其中,益母草注射液、葫芦巴碱和胆碱可减轻化学诱导的斑马鱼血管损伤,其作用机制涉及益母草注射液上调Tie-2、VEGF和VEGFR2的表达,其主要成分葫芦巴碱上调Tie-2和VEGF的表达,胆碱上调VEGF和VEGFR2的表达。结论:益母草注射液及其主要生物碱成分可通过上调Tie-2、VEGFR2和VEGF来促进血管生成。 展开更多
关键词 益母草注射液 血管生成 葫芦巴碱 胆碱 tie-2 VEGFR2 VEGF
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Effects of anti-pull ties on the bearing behaviors of shallow tunnel-type anchorages in soft rock 被引量:1
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作者 HAN Ya-feng LIU Xin-rong +5 位作者 ABI Erdi TU Yi-liang XU Bin ZHOU Xiao-han DENG Zhi-yun WANG Zhong-hao 《Journal of Mountain Science》 SCIE CSCD 2023年第9期2708-2730,共23页
Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and... Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and the principle of shallow TTAs in soft rock have not been fully studied.Hence,a structure suitable for improving the stability of shallow TTAs in soft rock strata,named the anti-pull tie(APT),was added to the floor of the back face.Physical tests and numerical models were established to study the influence of the APT on the load transfer of TTAs,the mechanical response of the surrounding rock,the stress distribution of the interface,and the failure model.The mechanical characteristics of APTs were also studied.The results show that the ultimate bearing capacity of TTAs with an APT is increased by approximately 11.8%,as compared to the TTAs without an APT.Also,the bearing capacity of TTAs increases approximately linearly with increasing height,width,length,and quantity of APTs,and decreases approximately linearly with increasing distance from the back face and slope angle of the tie slope.The normal squeezing between the tie slope and the surrounding rock increases the shear resistance of the interface and expands the range of the surrounding rock participating in bearing sharing.Both tension and compression zones exist in the APT during loading.The tension zone extends from the tie toe to the tie bottom along the tie slope.The range of the tie body tension zone constantly expands to the deep part of the APT with an increasing load.The peak tensile stress value is located at the tie toe.The distribution of compressive stress in the tie body is the largest at the tie top,followed by the tie slope,and then the tie bottom. 展开更多
关键词 Shallow tunnel-type anchorage Soft rock Anti-pull tie Bearing behaviors Stability control measures
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脓毒症诊治中Ang/Tie信号通路的研究进展
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作者 杨航 戴菁 王学锋 《诊断学理论与实践》 2024年第1期90-95,共6页
脓毒症以及伴随的多器官功能障碍是一组常见的临床综合征,其患病率随着人口老龄化逐年上升。全球每年发生2000万例脓毒症,死亡率为26%。早期准确诊断脓毒症,有利于及时采取针对性的治疗策略,这是降低病死率的关键。内皮细胞是外源病原... 脓毒症以及伴随的多器官功能障碍是一组常见的临床综合征,其患病率随着人口老龄化逐年上升。全球每年发生2000万例脓毒症,死亡率为26%。早期准确诊断脓毒症,有利于及时采取针对性的治疗策略,这是降低病死率的关键。内皮细胞是外源病原体或内源性损伤信号的早期作用对象。研究提示,内皮细胞的结构改变与功能活化在脓毒症的发生、发展中发挥重要作用。作为内皮细胞专属信号通路,血管生成素(angiopoietin,Ang)/酪氨酸激酶受体(tyrosine kinase receptor,Tie)在内皮细胞的异常激活和损伤中发挥重要作用。Ang/Tie信号通路主要包括2种位于内皮细胞中的酪氨酸激酶受体(Tie1、Tie2)和4种分泌性糖蛋白配体(Ang-1、Ang-2、Ang-3、Ang-4)。机制研究方面,Ang-1可持续性激活Tie2受体,维持细胞与细胞、细胞与基质间的相互作用,支持血管内皮细胞正常的生理功能;Ang-2是Ang-1拮抗剂,可竞争性阻断Ang-1与Tie2受体结合。脓毒症环境下,Ang-1下降,Ang-2升高,Ang-1/Ang-2的比值下降。Ang-2竞争性阻断Ang-1与可溶性Tie2受体结合,内皮细胞处于严重异常激活状态。Ang-2介导肝素酶的释放导致糖萼损伤,可引起血管通透性增加;Ang-2可促进炎症反应;Ang/Tie信号系统失调介导凝血功能障碍,Ang-2升高是弥散性血管内凝血的前哨性事件。临床病情监测方面,Ang-2>5.61 ng/mL,诊断脓毒症的灵敏度为74.36%;Ang-2持续升高,提示内皮功能难以恢复,器官发生功能性改变。早期动态监测Ang-2可用于预测脓毒症相关肺损伤、急性肾损伤。Ang-2/Ang-1比值上升、Ang1/可溶性Tie2比值下降可预测脓毒症患者90 d病死率(ROC曲线面积分别为0.787和0.704)。Ang-2和可溶性Tie-2水平下降,则提示脓毒症血浆置换有效。靶向Ang/Tie信号通路的动物实验获得一定成功,但目前临床试验未能获得有价值的结果。脓毒症相关Ang/Tie信号通路有待于进一步深入研究。 展开更多
关键词 脓毒症 血管生成素 酪氨酸激酶受体Ang/tie
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调控Ang/Tie信号通路治疗眼底新生血管性疾病的研究进展
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作者 杨婧研(综述) 魏文斌(审校) 《中华实验眼科杂志》 CAS CSCD 北大核心 2024年第5期467-472,共6页
抗血管内皮生长因子(VEGF)治疗应用于眼底新生血管疾病领域以来,在提高视力、稳定疾病病变和在某些情况下逆转疾病方面显示了卓越的效果。但抗VEGF治疗需要频繁玻璃体内注射给药,患者治疗负担重,长期疗效受影响。前期临床研究发现,调控... 抗血管内皮生长因子(VEGF)治疗应用于眼底新生血管疾病领域以来,在提高视力、稳定疾病病变和在某些情况下逆转疾病方面显示了卓越的效果。但抗VEGF治疗需要频繁玻璃体内注射给药,患者治疗负担重,长期疗效受影响。前期临床研究发现,调控血管生成素(Ang)/含免疫球蛋白样环和上皮生长因子样域酪氨酸激酶(Tie)通路在眼底新生血管疾病的治疗中有较好的效果。目前已发布了3个Ang/Tie通路阻断药物治疗眼底新生血管疾病的临床研究数据,其中靶向VEGF-A和Ang-2的双特异性免疫球蛋白G1抗体faricimab进入了Ⅲ期临床试验并达到终点,faricimab的2种延长治疗间隔(12周和16周)的给药方案均被证实有效。本文基于已发表的研究报告,就调控Ang/Tie通路在眼底新生血管性疾病治疗中的作用及临床应用作一综述,总结分析Ang/Tie通路的作用机制以及未来药物的应用前景。 展开更多
关键词 眼底新生血管疾病 抗新生血管生成 Ang/tie通路
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A SYMBOL OF STRONG CHINA-INDONESIA TIES
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作者 Yuan Yanan 《China Report ASEAN》 2023年第10期34-35,共2页
“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation A... “The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation Agency. 展开更多
关键词 cooperation Jakarta tie
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酸性成纤维细胞生长因子调控Ang1/Tie2信号通路抑制炎症促进血管内皮细胞功能恢复
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作者 张馨 尹翼虎 +2 位作者 毛俊楠 李秋波 林才 《温州医科大学学报》 CAS 2024年第7期528-538,共11页
目的:探讨酸性成纤维细胞生长因子(aFGF)对人脐静脉内皮细胞(HUVEC)功能的影响,以及Ang1/Tie2通路在其中的作用。方法:培养HUVEC细胞,不同浓度脂多糖(LPS)和aFGF刺激HUVEC,CCK-8实验确定刺激浓度,并观察生长活性;细胞划痕实验检测aFGF对... 目的:探讨酸性成纤维细胞生长因子(aFGF)对人脐静脉内皮细胞(HUVEC)功能的影响,以及Ang1/Tie2通路在其中的作用。方法:培养HUVEC细胞,不同浓度脂多糖(LPS)和aFGF刺激HUVEC,CCK-8实验确定刺激浓度,并观察生长活性;细胞划痕实验检测aFGF对HUVEC迁移能力的影响;Westernblot实验检测增殖蛋白PCNA,凋亡蛋白Cleavedcaspase3、Bax,抗凋亡蛋白Bcl2,炎症相关蛋白NLRP3、IL-1β、IL-6、TNF-α、IL-4和IL-10,血管生成相关蛋白CD31和通路相关蛋白Ang1、Tie2的表达水平;免疫荧光实验检测PCNA、Cleavedcaspase3、IL-6、IL-10以及CD31的荧光强度。分离小鼠主动脉,离体培养后进行免疫荧光实验,观察PCNA、Cleavedcaspase3、IL-6、IL-10以及CD31蛋白的荧光强度。结果:CCK-8实验显示LPS抑制HUVEC生长活性,5μg/mL为最适刺激浓度(P<0.01);aFGF促进HUVEC生长活性,其中100ng/mL为最适刺激浓度(P<0.01)。细胞划痕实验提示aFGF促进细胞迁移。Westernblot和免疫荧光实验结果显示,aFGF促进增殖蛋白和血管功能蛋白表达,抑制凋亡蛋白和炎症蛋白表达,上调Ang1/Tie2通路蛋白(P<0.05)。离体血管免疫荧光实验显示aFGF上调PCNA、IL-10以及CD31的荧光强度,下调Cleavedcaspase3和IL-6的荧光强度(P<0.05)。结论:aFGF增强HUVEC生长活性和迁移能力,促进其增殖,抑制其凋亡,并通过调控Ang1/Tie2通路抑制炎症反应,促进血管功能修复。 展开更多
关键词 酸性成纤维细胞生长因子 血管内皮细胞 Ang1/tie2 炎症 血管生成
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Influence of network structure on spreading dynamics via tie range
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作者 李敏 宋玉蓉 +3 位作者 宋波 李汝琦 蒋国平 张晖 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期606-613,共8页
There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of ... There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of network structure on network spreading. Motifs, as fundamental structures within a network, play a significant role in spreading. Therefore, it is of interest to investigate the influence of the structural characteristics of basic network motifs on spreading dynamics.Considering the edges of the basic network motifs in an undirected network correspond to different tie ranges, two edge removal strategies are proposed, short ties priority removal strategy and long ties priority removal strategy. The tie range represents the second shortest path length between two connected nodes. The study focuses on analyzing how the proposed strategies impact network spreading and network structure, as well as examining the influence of network structure on network spreading. Our findings indicate that the long ties priority removal strategy is most effective in controlling network spreading, especially in terms of spread range and spread velocity. In terms of network structure, the clustering coefficient and the diameter of network also have an effect on the network spreading, and the triangular structure as an important motif structure effectively inhibits the spreading. 展开更多
关键词 network spreading network motifs tie range edge removal strategy
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Seismic effectiveness evaluation and optimized design of tie up method for securing museum collections
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作者 Wang Meng Yan Yi +3 位作者 Yang Weiguo Liu Pei Ge Jiaqi Ma Botao 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第3期741-763,共23页
To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used ... To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used for typical museum collection replicas have been carried out.The influence of body shape and fixed measure parameters on the seismic responses of replicas and the interaction behavior between replicas and fixed measures have been explored.Based on the results,seismic effectiveness evaluation indexes of the tie up method are proposed.Reasonable suggestions for fixed strategies are given,which provide a basis for the exhibition of delicate museum collections considering the principle of minimizing seismic responses and intervention.The analysis results show that a larger ratio of height of mass center to bottom diameter led to more intense rocking responses.Increasing the initial pretension of fishing lines was conducive to reducing the seismic responses and stress variation of the lines.Through comprehensive consideration of the interaction forces and effective securement,it is recommended to apply 20%of breaking stress as the initial pretension.For specific museum collections that cannot be effectively protected by the independent tie up method,an optimized strategy of a combination of fishing lines and fasteners is recommended. 展开更多
关键词 tie up method museum collections shaking table test seismic effectiveness optimized design
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基于Ansys/Bow-Tie燃气泄漏的双向风险分析
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作者 袁亮 韩会亮 +3 位作者 骆成富 骆磊 王彦 党小峰 《石油化工安全环保技术》 CAS 2024年第4期34-38,I0003,共6页
燃气泄漏事故伴随着爆炸、中毒等多项风险威胁,造成经济损失和伤亡损失。利用Ansys/Bow-Tie建立扩散模型与分析计算模型,将燃气泄漏定性与定量分析。研究表明:在定性变化中,燃气泄漏后泄漏区域的燃气扩散速度呈指数大模块式上升,扩散速... 燃气泄漏事故伴随着爆炸、中毒等多项风险威胁,造成经济损失和伤亡损失。利用Ansys/Bow-Tie建立扩散模型与分析计算模型,将燃气泄漏定性与定量分析。研究表明:在定性变化中,燃气泄漏后泄漏区域的燃气扩散速度呈指数大模块式上升,扩散速度极快;在定量变化中,燃气泄漏的主要风险来源于巡检不足以及检维修不及时可能发生的概率最大,分别为0.039和0.046,通过加装有毒有害气体仪表报警监测群和对大风险问题加强监控可为风险管控提供帮助。 展开更多
关键词 燃气泄漏 ANSYS模型 Bow-tie模型 风险分析
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Bow-tie技术在CCUS项目注入系统的应用
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作者 房龙 杜勇 +4 位作者 杨雷 常振强 李山川 赵铁军 宋宝林 《安全、健康和环境》 2024年第7期53-58,共6页
二氧化碳捕集、利用与封存(CCUS)技术是实现化石能源低碳化利用的重要技术手段。但CCUS全流程存在二氧化碳泄漏、冻伤、窒息以及物体打击等风险,特别是注入系统涉及高压、低温及二氧化碳多相态变化等,易造成二氧化碳腐蚀、泄漏。通过Bow... 二氧化碳捕集、利用与封存(CCUS)技术是实现化石能源低碳化利用的重要技术手段。但CCUS全流程存在二氧化碳泄漏、冻伤、窒息以及物体打击等风险,特别是注入系统涉及高压、低温及二氧化碳多相态变化等,易造成二氧化碳腐蚀、泄漏。通过Bow-tie技术对某CCUS项目注入系统开展风险识别、分析和控制,重点对设备设施及作业活动危害因素分析并制定有效管控措施,研究结果可为CCUS注入系统长期安全平稳高效运行提供技术支持。 展开更多
关键词 Bow-tie技术 CCUS项目 注入系统 防控措施 安全运行
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浅谈TIE-固定篦床的优化升级
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作者 游磊 余先林 +4 位作者 邢涛 杨腾飞 郝帅起 徐一源 李福祥 《新世纪水泥导报》 CAS 2024年第2期16-19,I0013,共5页
TIE-固定篦床采用中心分区供风、微调风阀、水滴型高效篦板等技术,用水平出风的高速气流快速急冷熟料,不仅系统可获得温度较高且稳定的二次风,还能均布熟料,减少粗细熟料的离析分布,从源头上控制“红河”的产生;在稳定较高的二次风温下... TIE-固定篦床采用中心分区供风、微调风阀、水滴型高效篦板等技术,用水平出风的高速气流快速急冷熟料,不仅系统可获得温度较高且稳定的二次风,还能均布熟料,减少粗细熟料的离析分布,从源头上控制“红河”的产生;在稳定较高的二次风温下,还可将料层厚度总体降低至650mm左右,大幅减小后续所有冷却风机的总体负载阻力,进一步有利于熟料的冷却和降低冷却电耗。实践表明,使用TIE-固定篦床局部替换旧的固定篦床,能有效地提高二次风温,降低烧成系统的能耗,还可显著提高熟料的质量。 展开更多
关键词 tie-固定篦床 水滴型高效篦板 熟料急冷 PLUS篦冷机 节能降耗技改
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飞机风挡裂纹/破裂类事件统计及Bow-tie模型分析
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作者 刘俊杰 张晴 《科学技术与工程》 北大核心 2024年第7期3034-3042,共9页
为分析航空器风挡裂纹/破裂类事件的安全风险,收集1 629份风挡裂纹/破裂类事件,对样本事件涉及故障状况、飞行阶段、故障原因等特征进行统计分析,确定风挡裂纹/破裂类事件的可能原因、潜在后果及其预防、减缓控制措施并绘制了风挡裂纹/... 为分析航空器风挡裂纹/破裂类事件的安全风险,收集1 629份风挡裂纹/破裂类事件,对样本事件涉及故障状况、飞行阶段、故障原因等特征进行统计分析,确定风挡裂纹/破裂类事件的可能原因、潜在后果及其预防、减缓控制措施并绘制了风挡裂纹/破裂类事件Bow-tie模型图。结果表明:风挡损伤的主要情形包括裂开、裂缝、结冰、烟雾、划伤等;涉及风挡及相关部件故障以加温故障、雨刷故障为主;飞行阶段以巡航、爬升为主;风挡裂纹/破裂事件的主要原因为鸟击、零部件缺失/故障、系统失效/故障、冰击,最终有针对性地提出预防措施:机务、机组等相关人员应做好航前、航后检查;对零部件缺失/损坏/磨损、系统失效、鸟击等高发事件类型进行重点关注,提高机组人员对此类突发事件的应对能力等。 展开更多
关键词 航空安全 事件分析 风挡 鸟击 Bow-tie模型
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基于Bow-Tie的复杂场景保护层分析方法研究
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作者 金浩 汪宏 +1 位作者 李雁 赵积洲 《化肥设计》 CAS 2024年第2期8-13,35,共7页
为解决复杂场景保护层分析中采用最大值法或加和法存在的问题,将Bow-Tie融入LOPA分析中,建立复杂场景的Bow-Tie计算模型。通过采用事故树分析方法,计算Bow-Tie模型中顶上事件发生的概率,确定预防类保护层及减缓类保护层的失效概率,给出... 为解决复杂场景保护层分析中采用最大值法或加和法存在的问题,将Bow-Tie融入LOPA分析中,建立复杂场景的Bow-Tie计算模型。通过采用事故树分析方法,计算Bow-Tie模型中顶上事件发生的概率,确定预防类保护层及减缓类保护层的失效概率,给出了复杂场景事故发生概率合理的计算方法;通过计算Bow-Tie模型中事故树底事件的概率重要度和临界重要度,提出了判断复杂场景保护层重要度的方法。运用上述方法对某LNG储罐超压损坏的复杂场景进行了计算。研究表明,本方法能实现包含多重初始事件的复杂事故场景后果风险更合理的计算及保护层重要度的判定,从而为提高系统安全性及风险决策提供依据。 展开更多
关键词 保护层分析(LOPA) 领结图分析(Bow-tie) 事故树 复杂场景 风险计算
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基于改进Bow-tie模型的煤矿瓦斯爆炸事故分析与研究
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作者 侯玮 林倩 +1 位作者 马润泽 徐子怡 《煤炭与化工》 CAS 2024年第2期120-125,共6页
针对我国伤亡人数较多的采矿行业,对伤亡人数最多的瓦斯爆炸事故进行了分析,提出了改进Bow-tie模型。在原因辨识环节将瓦斯爆炸事故的原因归纳为人因、物因、环境、管理4个方面进行论述,利用屏障思维对主动屏障进行量化分级提出预防措施... 针对我国伤亡人数较多的采矿行业,对伤亡人数最多的瓦斯爆炸事故进行了分析,提出了改进Bow-tie模型。在原因辨识环节将瓦斯爆炸事故的原因归纳为人因、物因、环境、管理4个方面进行论述,利用屏障思维对主动屏障进行量化分级提出预防措施,通过模型分析事故可能产生的安全、经济、环境、社会后果,提出消减措施作为被动屏障,绘制改进Bow-tie图,并在此基础上运用层次分析进行评价分析。研究表明,管理体系欠缺以及人的不安全行为是导致事故发生的主要因素。 展开更多
关键词 煤矿 瓦斯爆炸事故 改进Bow-tie模型 屏障思维
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基于Bow-Tie模型和未确知测度理论的煤矿透水风险分析
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作者 侯玮 马润泽 +1 位作者 林倩 毕昊媛 《煤炭与化工》 CAS 2024年第1期110-114,共5页
为了克服煤矿井下透水事故安全性评价相关因子的不确定性,以及权重指标赋值模糊的问题,采用Bow-Tie模型分析法通过对煤矿井下的人、物、环境、管理4个方面的分析研究,建立出煤矿透水事故的Bow-Tie评价模型,把得到的12项透水事故的影响... 为了克服煤矿井下透水事故安全性评价相关因子的不确定性,以及权重指标赋值模糊的问题,采用Bow-Tie模型分析法通过对煤矿井下的人、物、环境、管理4个方面的分析研究,建立出煤矿透水事故的Bow-Tie评价模型,把得到的12项透水事故的影响因子作为煤矿透水事故风险评估的评价指标。通过层次分析法对指标进行权重的赋值,最后由未确知测度法确定煤矿透水事故风险评价等级。通过对小回沟煤矿进行实例评估分析,评价结果与该煤矿实际相符合,可见该法的合理性和适用性,可以为煤矿透水事故的风险评价提出一些指导。 展开更多
关键词 煤矿透水 Bow-tie模型 未确知测度理论 风险评价
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Studies of Soil Physical Properties and Community Characteristics of Different Abandoned Lands in the Minqin Oasis,Downstream of the Shiyang River
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作者 郭春秀 何芳兰 +6 位作者 马剑平 安富博 马俊梅 袁宏波 赵鹏 刘克彪 申国峰 《Agricultural Science & Technology》 CAS 2016年第7期1697-1701,共5页
[Objective] The aim was to explore physical properties and community characteristics of abandoned lands in different years in Minqin Oasis, downstream of the Shiyang River, [Method] The evolution of environment and pl... [Objective] The aim was to explore physical properties and community characteristics of abandoned lands in different years in Minqin Oasis, downstream of the Shiyang River, [Method] The evolution of environment and plant community characteristics in different abandoned lands were analyzed after abandonment for 1, 2, 3, 4, 5, 8, 15, 24 and 31 years, and the plant community characteristics, water content, bulk density, porosity and mechanical composition of soil in the different a- bandoned lands were also researched in the Minqin Oasis, downstream of the Shiyang River. [Result] Plant of 32 species spread over 14 family live through fifty years appeared in abandoned lands in the study area. Shrubs was 6 species, herbs was 26 species among them, which were 18.75%, 81.25% respectively. The goose- foot family (6 species), the composite family(4 species),the grass family(4 species), caltrop family(3 species) were 53.13% among them. Within the range of 0-40 cm of different abandoned Land, the soil moisture content showed a trend of first increase and then decrease with the increase of soil depth changes in soil bulk density and porosity of less obvious. In the range of 0-40 cm soil depth, the largest proportion of fine sand, followed by silt and clay and the smallest proportion of coarse sand in every plot, but the proportion of the each silt size varies little with the years aban- doned. [Conclusion] The research provides references for vegetation reconstruction and eco-environment construction in abandoned lands in downstream of Shiyang River. 展开更多
关键词 Minqin Oasis Abandoned land Years abandoned Soil physical proper- ties Vegetation characteristics
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Critical role of risk management in ground engineering and opportunities for improvement 被引量:2
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作者 Jim Galvin 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2017年第5期725-731,共7页
Green mining is concerned with mining in a sustainable manner, such that the needs of the present are met without compromising future generations. The achievement of this objective depends on balancing social, environ... Green mining is concerned with mining in a sustainable manner, such that the needs of the present are met without compromising future generations. The achievement of this objective depends on balancing social, environmental and economic objectives and has to have regard to both active mining operations and legacy issues associated with mine closure. Ground engineering has a critical role in achieving green mining objectives but its contribution is characterised by pervasive uncertainty. Uncertainty equates to risk. This means that ground engineering should be practiced within a risk management framework that aims to both prevent unwanted outcomes and to mitigate their consequences to an acceptable level. This keynote address presents the fundamentals of risk management and demonstrates its effectiveness by reference to improvements in the safety performance of the NSW coal sector over the past three decades.Nevertheless, ground control remains a mix of art and science, relying heavily on judgements which should be premised on knowledge, skill and experience(that is, competence). Risk management has now been enshrined in mining legislation and operating practice in Australia for over two decades.Notwithstanding this, near-hit and accident and incident investigations, commissions of inquiry and legal proceedings almost invariably identify deficiencies and opportunities for improvements necessary to achieve the objectives of sustainable mining. Three of the more important opportunities which have global application in relation to ground engineering are discussed. These relate to the vexing issue of defining competency in ground engineering; the criteria for undertaking rigorous risk assessment; and the need for ground engineers to become involved in mine rehabilitation and closure planning over the full life cycle of a mine, commencing at the prefeasibility stage. 展开更多
关键词 BOW tie analysis MINE safety MINE CLOSURE RISK assessment RISK management Sustainable mining Uncertainty
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基于Ang1/Tie2信号通路研究周细胞调控腹膜血管新生的作用机制 被引量:1
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作者 黄丽嫣 唐蕾 +6 位作者 朱晓琳 单云 史俊 俞曼殊 孙谨怡 盛莉 盛梅笑 《中国病理生理杂志》 CAS CSCD 北大核心 2023年第5期884-892,共9页
目的:本研究旨在通过观察血管周细胞与血管内皮细胞间的相互作用,探讨周细胞调控腹膜血管新生的作用机制。方法:使用转化生长因子β1(TGF-β1)干预人微血管周细胞(HMPCs)24、48和96 h,Western blot检测HMPCs中血管生成素1(Ang1)的表达... 目的:本研究旨在通过观察血管周细胞与血管内皮细胞间的相互作用,探讨周细胞调控腹膜血管新生的作用机制。方法:使用转化生长因子β1(TGF-β1)干预人微血管周细胞(HMPCs)24、48和96 h,Western blot检测HMPCs中血管生成素1(Ang1)的表达。收集TGF-β1干预HMPCs后的上清液作为条件培养基(T-HMPCs-CM),用T-HMPCs-CM处理人腹膜血管内皮细胞(HPVECs)构建间接共培养模式;将TGF-β1处理过的HMPCs与HPVECs共同接种于基质胶上,构建直接共培养模式;以未经TGF-β1处理的HMPCs作为阴性对照组,以外源性Ang1处理的HPVECs作为阳性对照组,以人血管生成素受体Tie2抑制剂处理的HPVECs作为抑制剂组。采用CCK-8法、细胞划痕实验、Transwell实验、成管实验和细胞膜荧光探针染色法观察HPVECs增殖、迁移、血管生成情况,以及HPVECs与HMPCs共定位情况;Western blot检测HPVECs中Tie2蛋白及其磷酸化水平。结果:TGF-β1处理96 h,HMPCs中Ang1蛋白表达水平显著升高(P<0.01)。与阴性对照组相比,T-HMPCs-CM能够抑制HPVECs迁移、血管新生,并增加Tie2磷酸化以稳定血管状态,其作用类似于外源性Ang1;而使用Tie2抑制剂阻断Ang1/Tie2信号通路后,上述作用一定程度上被逆转。结论:TGF-β1可刺激HMPCs分泌Ang1,进而激活HPVECs的Tie2信号通路,从而抑制HPVECs血管新生,发挥维持腹膜血管稳定的作用。 展开更多
关键词 腹膜血管内皮细胞 血管新生 微血管周细胞 Ang1/tie2信号通路
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Inter-ethnic marriages and severity of coronary artery disease:A multicenter study of Arabian Gulf States 被引量:2
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作者 Amin Daoulah Salem Al-kaabi +13 位作者 Amir Lotfi Mushabab Al-Murayeh S Ali Nasseri Waleed Ahmed Salah N Al-Otaibi Mohamed N Alama Osama E Elkhateeb Amy J Plotkin Majed M Malak Khalid Alshali Mohamed Hamzi Saleh Al Khunein Mohammed Abufayyah Alawi A Alsheikh-Ali 《World Journal of Cardiology》 CAS 2017年第4期371-377,共7页
AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sect... AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates,in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to March 30^(th),2014. Ethnicities of spouses were available only for male patients. Of those enrolled,687 were married men and constituted the cohort for the present analysis. Intra-ethnic marriages were reported in 70% and inter-ethnic marriages in 30%. After adjusting for baseline differences,interethnic marriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or multi-vessel disease(MVD) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left main disease showed a similar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic marriage and the presence of significant CAD and MVD was not modified by number of concurrent wives(P interaction > 0.05 for both).CONCLUSION Among married men undergoing coronary angiography,inter-ethnic,as compared to intra-ethnic,marriage is associated with lower odds of significant CAD and MVD. 展开更多
关键词 Arabian Gulf inter-ethnic marriage Coronary artery disease Cardiac epidemiology Coronary angiography
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Firm review revelation policy considering social ties among consumers 被引量:1
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作者 Liu Xueyu Mei Shu'e Zhong Weijun 《Journal of Southeast University(English Edition)》 EI CAS 2021年第1期98-103,共6页
An optimization model is proposed to analyze the optimal review revelation policies and consumer online social network management strategies of e-commerce firms.The results show that displaying friend reviews to consu... An optimization model is proposed to analyze the optimal review revelation policies and consumer online social network management strategies of e-commerce firms.The results show that displaying friend reviews to consumers does not necessarily increase firms profits.Only when positive reviews account for a large proportion of all the reviews and when the cost of showing friend reviews is not high,can showing friend reviews be more profitable than not showing such information.The distribution of social ties among consumers can affect firms profits.Even in the case that showing friend reviews to consumers is more profitable,an increase in the proportion of strong ties is not necessarily beneficial to firms.Only when the proportion of positive reviews is large enough,can firms profits increase with the increase in the proportion of strong ties among consumers.Moreover,the degree of consumer distrust in the average quality rating can also affect firms strategies for managing consumer online social networks.As the degree of consumer distrust in the average quality rating rises,firms are more likely to obtain higher profits by taking measures to increase the proportion of strong ties among consumers on their websites. 展开更多
关键词 online product review social tie review revelation policy social commerce
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